rorγ — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T67943	RORγ inverse agonist 1
	RORγ inverse agonist 1 has anti-inflammatory activity and can be used to treat rheumatism and psoriasis.
T39797	RORγ agonist 1
	RORγ agonist 1 is a highly potent and orally bioavailable compound that activates the RORγ receptor. Its efficacy is demonstrated by an EC50 value of 21 nM and it exhibits antitumor activity.
T79464	RORγ antagonist 1		ROR
	RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM. It demonstrates anti-proliferative effects in the HPAF-II pancreatic ca...		ROR
T4050	GSK2981278	ROR gama modulator 1	ROR
	GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).		ROR
T6690	T0901317		Apoptosis , FXR , Liver X Receptor , ROR
	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).		Apoptosis , FXR , Liver X Receptor , ROR
T9623	RORγt inverse agonist 13		ROR
	RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].		ROR
T12753	RORγt Inverse agonist 6		ROR
	RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.		ROR
T12752	RORγt Inverse agonist 3		Others
	RORγt Inverse agonist 3 is a potent, selective and orally active inverse agonist of RORγ(EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively).		Others
T72596	RORγt modulator 5
	RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM. This compound holds promise for the treatment of diseases mediated by RORγ, including inflammatory, metabolic, and autoimmun...
T64145	RORγt/DHODH-IN-1
	RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant in vivo anti-inflammatory effects.
T63609	RORγt modulator 3
	RORγt modulator 3 is a modulator of retinol-related orphan receptor γt (RORγt) and can be used to study RORγt-mediated diseases such as pain, COPD, inflammation, asthma, colitis, multiple sclerosis, rheumatoid arthritis,...
T64146	RORγt/DHODH-IN-3
	RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 has significant in vivo anti-inflammatory effects.
T72252	RORγt inverse agonist 14		ROR
	RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity. It is employed in researching rheumatoid arthritis and psoriasis [1].		ROR
T63124	RORγt modulator 4
	RORγt modulator 4 is a RORγt modulator that regulates IL-17A production activity in cells derived from mouse spleen.
T79470	RORγt inverse agonist 31		ROR
	RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (IC50) of 0.428 μM. It has demonstrated efficacy in mitigatin...		ROR
T72254	RORγt inverse agonist 26
	RORγt inverse agonist 26, a potent reverse agonist of RORγt, effectively modulates Th17 cell differentiation and suppresses IL-17 production. This compound shows promising potential for researching inflammation and autoi...
T12755	RORγt Inverse agonist 2		Others
	RORγt Inverse agonist 2 is a selective, orally active inverse agonist of RORγt(EC50 of 119 nM).		Others
T63678	RORγt modulator 2
	RORγt modulator 2 is a modulator of retinol-related orphan receptor γt (RORyt) (IC50<50 nM) and can be used in the study of RORγt-mediated diseases such as pain, inflammation, asthma, rheumatoid arthritis, COPD, multiple...
T40043	RORγt Inverse agonist 10
	RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectivel...
T64140	RORγt agonist 2
	RORγt agonist 2 is a potent agonist of RORγt. RORγt agonist 2 induces Th17 cell differentiation, increases levels of pro-inflammatory cytokines and thus enhances lymphocyte cytotoxicity. rorγt agonist 2 exhibits an inhib...
T62956	RORγt inverse agonist 29
	RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM. RORγt inverse agonist 29 can be used in the study of autoimmune diseases such as skin inflammation and pso...
T62462	RORγt/DHODH-IN-2
	RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor that can be used in the study of inflammatory bowel disease (IBD).
T39038	RORγt inhibitor 1
	RORγt inhibitor 1 is a RORγt allosteric inhibitor with an IC 50 value of 1 nM.
T12751	RORγt agonist 1		Others
	RORγt agonist 1 is a potent, orally bioavailable agonist of RORγt(EC50 of 20.8 nM).		Others
T63874	RORγt inverse agonist 28
	RORγt inverse agonist 28 is a potent RORγt inverse agonist. RORγt inverse agonist 28 regulates the differentiation of Th17 cells and inhibits the production of IL-17. RORγt inverse agonist 28 has shown research potential...
T72595	RORγt inhibitor 2
	RORγt Inhibitor 2, a potent inhibitor of RORγt, exhibits an IC50 of 9.2 nM and is utilized in the study of cancer, inflammation, or autoimmune diseases that are mediated by RORγt.
T62564	RORγt inverse agonist 30
	RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist (IC50: 46 nM). Targeting the nuclear receptor RORγt is effective in the treatment of autoimmune diseases.
T12754	RORγt Inverse agonist 8		ROR
	RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).		ROR
T64017	RORγt agonist 3
	RORγt agonist 3 is a potent agonist of RORγt. RORγt agonist 3 induces Th17 cell differentiation, increases levels of pro-inflammatory cytokines and thus increases lymphocyte cytotoxicity. rorγt agonist 3 blocks the produ...
T39720	RORγt inverse agonist 23
	RORγt inverse agonist 23, an orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist, is a potent and selective RORγt inverse agonist.
T13362	XY101		ROR
	XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).		ROR
T16929	SR2211		ROR
	SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).		ROR
T14369	AZD-0284		ROR
	AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].		ROR
TQ0007	Cintirorgon	LYC-55716	ROR
	Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.		ROR
T5163	SR1001		ROR
	SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).		ROR
T4594	SR1078	SR 1078	ROR
	SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.		ROR
T37587	ML 209		ROR
	ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM...		ROR
T16787	Vimirogant	VTP-43742	ROR
	Vimirogant is a RORγ inhibitor (Ki: <100 nM).		ROR
T15404	GNE-6468		Others
	GNE-6468 is a potent and selective agonist of RORγ(RORc) (EC50: 13 nM for HEK-293 cell).		Others
T24213	XY018	XY 018,XY-018
	XY 018 is a RORγ antagonist. It also suppresses androgen receptor expression in prostate cancer cell lines and inhibits the growth of tumors in androgen receptor-positive xenograft models.
T35321	Zymostenol	delta(8)-Cholestenol,5a-Cholest-8-en-3b-ol,Δ8-Cholesterol	Endogenous Metabolite , ROR
	Zymostenol (5a-Cholest-8-en-3b-ol) is a RORγ agonist with an EC50 of 1 μM.Zymostenol is a late stage precursor of cholesterol biosynthesis.		Endogenous Metabolite , ROR
T5164	Cabozantinib hydrochloride	XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351	VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
	Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).		VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
T39960	SHR168442	SHR168442
	SHR168442 is a potent RORγ modulator, exhibiting an IC50 value of 0.035 μM.
T70398	JTE-151
	JTE-151 is a novel RORγ inverse agonist.
T69695	Izumerogant
	Izumerogant is an inverse agonist of the retinoid-related orphan receptor-gamma (RORγ).
T23387	SR 1555 (hydrochloride) (1386439-51-5 free base)	SR 1555 (hydrochloride)	Others
	SR 1555 is a novel RORγ-specific synthetic ligand.		Others
T25109	ARN-6039	ARN 6039,ARN6039
	ARN-6039 is an orally available inverse agonist of RORγ for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORγ was demonstrated in a RORγ-activated IL-17A Prom/LUCPorter assay in HE...
T25216	CD12681	CD 12681,CD-12681
	CD12681 is an effective RORγ inverse agonist, preclinical Candidate for the topical therapy of psoriasis.
T23794	BIO592	BIO-592,BIO 592
	BIO592 is a modulator of RORγt. BIO592 triggers inverse agonism of RORγ.
T15398	GNE-0946		Others
	GNE-0946 is a potent and selective agonist of RORγ (EC50: 4 nM for HEK-293 cell).		Others