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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6904 | Necrosulfonamide | (E)-Necrosulfonamide | MLK |
(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during nec... | |||
T11474 | GSK-843 | GSK'843 | RIP kinase |
GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase.GSK-843 has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the ... | |||
T11501 | GSK840 | GSK'840 | RIP kinase |
GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC50: 0.3 nM). | |||
T4074 | GSK-872 | GSK872,GSK'872,GSK2399872A | RIP kinase |
GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM). | |||
T4074L | GSK872 HCl(1346546-69-7 free base) | GSK2399872A | RIP kinase |
GSK872 HCl(1346546-69-7 free base) (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM). | |||
T6815 | HS-1371 | RIP kinase | |
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM. | |||
T11484 | GSK2593074A | GSK'074 | TNF , RIP kinase |
GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3. | |||
T62569 | RIPK3-IN-2 | ||
RIPK3-IN-2 is a RIP3 inhibitor that can be used in studies of diseases caused by or associated with activated necrotic pathways. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3240 | Citronellol | dihydrogeraniol,(±)-β-Citronellol | Reactive Oxygen Species |
Citronellol ((±)-β-Citronellol) is used in insect repellents and perfumes and as a mite attractant. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00361 | Pellino-1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant ce... |