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Search Results for " pyk2 "

Targets

12

Compounds

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T2314 PF-431396 FAK , PYK2
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
T2465 PF-562271 PF562271,PF 562271 FAK , PYK2 , CDK
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
T6177 PF-562271 besylate PF-00562271 Besylate FAK , PYK2 , CDK
PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, exc...
T1918 NVP-TAE 226 TAE226 Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.
T21768 PF-562271 hydrochloride PF-562271 HCl FAK , PYK2 , CDK
PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other pr...
T22397 PF-4618433 Others
PF-4618433 is a dual inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2).
T70751 PF-719 free base
PF-719 is a potent, selective Pyk2 inhibitor with IC50 of 17 nM.
T14997 Conteltinib SY-707,CT-707 FAK , PYK2 , ALK
Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK, and Pyk2.Conteltinib exhibits significant inhibition of FAK, overcomes hypoxia-mediated sorafenib resistance in hepatocellular carci...
T10372 ARQ 069 Others
ARQ 069 (3.8-60 μM; for 2 hours) reduces the degree of phosphorylation of FGFR (predominantly FGFR2) in a concentration-dependent manner, without decreasing β-actin. ARQ 069 shows an affinity for FGFR2 of 5.2 μM. ARQ 069...
T13564L AZ7550 hydrochloride AZ7550 hydrochloride (1421373-99-0 free base) EGFR , IGF-1R
AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T13564 AZ7550 MLK , FAK , EGFR , FLT , Tyrosine Kinases , PYK2 , MNK , IGF-1R , ACK , BTK , ALK , Drug Metabolite
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T12102 Mps1-IN-1 Others
Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-03753 MYLK Protein, Human, Recombinant (His) Human E. coli
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phos...
TMPJ-00396 SEMA4D Protein, Human, Recombinant (aa 22-734, His) Human Human Cells
Semaphorin-4D is also known as A8,BB18, GR3, CD100. Semaphorin-4D belongs to the semaphorin family containing 1 Ig-like C2-type domain, 1 PSI domain and 1 Sema domain. It is the cell surface receptor for PLXN1B and PLXNB...
TMPJ-00395 SEMA4D Protein, Mouse, Recombinant (hFc) Mouse Human Cells
SEMA4D is a member of the semaphorin family,contains one Ig-like C2-type domain, one PSI domain and one Sema domain. SEMA4D is strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous t...
TMPH-02041 ARHGEF12 Protein, Human, Recombinant (His) Human E. coli
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TC...
TargetMol