Search Result

Search Results for " ptk2 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9576	AMP-945		FAK
	AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.		FAK
T2001	PF-573228	PF 573228	Apoptosis , FAK
	PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.		Apoptosis , FAK
T9973	FAK-IN-7		FAK
	FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.		FAK
T6997	SU6656		FAK , Akt , Src
	SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.		FAK , Akt , Src
T2314	PF-431396		FAK , PYK2
	PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).		FAK , PYK2
T2281	GSK2256098	GSK 2256098,GSK-2256098,GTPL7939	Apoptosis , FAK
	GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.		Apoptosis , FAK
T5480	BI-4464		FAK , Ligands for Target Protein for PROTAC
	BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC		FAK , Ligands for Target Protein for PROTAC
T1996	Defactinib	PF-04554878,VS-6063	FAK
	Defactinib (VS-6063) is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.		FAK
T2465	PF-562271	PF562271,PF 562271	FAK , PYK2 , CDK
	PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).		FAK , PYK2 , CDK
T24730	Roslin 2 bromide	Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2	FAK , p53
	Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effects.		FAK , p53
T0263	Chloropyramine hydrochloride	Nilfan,Alergosan,Halopyramine hydrochloride	FAK , VEGFR , Histamine Receptor
	Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.		FAK , VEGFR , Histamine Receptor
T6177	PF-562271 besylate	PF-00562271 Besylate	FAK , PYK2 , CDK
	PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, exc...		FAK , PYK2 , CDK
T2609	Masitinib	AB1010	Apoptosis , FAK , c-Fms , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Hck
	Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet...
T3041	ALK inhibitor 2		FAK , ALK
	ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.		FAK , ALK
T2655	CEP-37440	CEP37440	FAK , ALK
	CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).		FAK , ALK
T1918	NVP-TAE 226	TAE226	Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
	NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.		Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
T21768	PF-562271 hydrochloride	PF-562271 HCl	FAK , PYK2 , CDK
	PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other pr...		FAK , PYK2 , CDK
T10285	ALK inhibitor 1		FAK , IGF-1R , ALK
	ALK inhibitor 1 is a selective ALK kinase inhibitor.		FAK , IGF-1R , ALK
T1950	PND-1186	PND1186,PND 1186,VS-4718,SR-2516	Apoptosis , FAK
	PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).		Apoptosis , FAK
T7119	Y15	1,2,4,5-Benzenetetramine tetrahydrochlor,FAK Inhibitor 14	FAK
	Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.		FAK
T17543	BI-3663		Others
	BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 linked to Pomalido...		Others
T17133	Tos-PEG4-t-butyl ester	Tos-PEG4-Boc	Others
	Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition. This compound plays a crucial role in the synthesis of a range of PROTACs, including BI-3663, a highly selective PTK2/FAK PRO...		Others
T82385	FMF-06-098-1		PROTACs
	FMF-06-098-1 is a multitargeted depressant capable of promoting the degradation of a wide array of kinases, including AAK1, ABL2, AURKA, AURKB, BUB1B, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDK6, CDK7, CDK9, CHEK1, CSNK1D...		PROTACs

Compounds

Target: Apoptosis, FAK

Target: FAK, Akt, Src

Synonym: GSK 2256098,GSK-2256098,GTPL7939

Target: Apoptosis, FAK

BI-4464

T5480

Synonym:

Target: FAK, Ligands for Target Protein for PROTAC

Defactinib

T1996

Synonym: PF-04554878,VS-6063

Target: FAK

PF-562271

T2465

Synonym: PF562271,PF 562271

Target: FAK, PYK2, CDK

Roslin 2 bromide

T24730

Synonym: Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2

Target: FAK, p53

Chloropyramine hydrochloride

T0263

Synonym: Nilfan,Alergosan,Halopyramine hydrochloride

Target: FAK, VEGFR, Histamine Receptor

PF-562271 besylate

T6177

Synonym: PF-00562271 Besylate

Target: FAK, PYK2, CDK

Masitinib

T2609

Synonym: AB1010

Target: Apoptosis, FAK, c-Fms, FGFR, Bcr-Abl, PDGFR, Src, c-Kit, Hck

Target: Apoptosis, FAK, c-Met/HGFR, PYK2, IGF-1R

PF-562271 hydrochloride

T21768

Synonym: PF-562271 HCl

Target: FAK, PYK2, CDK

ALK inhibitor 1

T10285

Synonym:

Target: FAK, IGF-1R, ALK

PND-1186

T1950

Synonym: PND1186,PND 1186,VS-4718,SR-2516

Target: Apoptosis, FAK

Y15

T7119

Synonym: 1,2,4,5-Benzenetetramine tetrahydrochlor,FAK Inhibitor 14

Tos-PEG4-t-butyl ester

T17133

Synonym: Tos-PEG4-Boc

Cat No.	Product Name	Synonyms	Targets
TN1433	Batatasin III		FAK , Others , Akt
	Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-...		FAK , Others , Akt
T5S0761	Nitidine chloride		Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite
	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id...
T3122	Fangchinoline	Tetrandrine B,(+)-Limacine,Hanfangichin B,(+)-Fangchinoline	Apoptosis , FAK , HIV Protease , Autophagy
	Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.		Apoptosis , FAK , HIV Protease , Autophagy

Natural Products

Batatasin III

TN1433

Synonym:

Target: FAK, Others, Akt

Nitidine chloride

T5S0761

Synonym:

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Fangchinoline

T3122

Synonym: Tetrandrine B,(+)-Limacine,Hanfangichin B,(+)-Fangchinoline

Target: Apoptosis, FAK, HIV Protease, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-06064	CD146/MCAM Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like d...
TMPY-01034	CD146/MCAM Protein, Human, Recombinant (His)	Human	HEK293
	The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like d...
TMPY-00879	CD146/MCAM Protein, Human, Recombinant (hFc)	Human	HEK293
	The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like d...
TMPY-02502	CD146/MCAM Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like d...
TMPY-02270	RET Protein, Human, Recombinant (His)	Human	HEK293
	RET proto-oncogene, also known as RET, is a cell-surface molecule that transduce signals for cell growth and differentiation. It contains 1 cadherin domain and 1 protein kinase domain. RET proto-oncogene belongs to the p...
TMPY-04418	RET Protein, Human, Recombinant (aa 658-1114, His & GST)	Human	Baculovirus-Insect Cells
	RET proto-oncogene, also known as RET, is a cell-surface molecule that transduce signals for cell growth and differentiation. It contains 1 cadherin domain and 1 protein kinase domain. RET proto-oncogene belongs to the p...