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Search Result

Search Results for " pparα "

Targets

PPAR

83

Compounds

14

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T10505 PPARα-MO-1 PPAR
PPARα-MO-1 is a potent modulator of PPARα.
T62968 PPARα/δ agonist 1
PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist with EC50 values of 7.0 nM for PPARα and 8.4 nM for PPARδ. PPARα/δ agonist 1 exhibits high selectivity for PPARγ (EC50: 1316.1 nM). agonist 1 has potential for non-a...
T62266 PPARα agonist 1
PPARα agonist 1 is a complete and potent PPARα agonist.
T60535 PPARα/γ agonist 1
PPARα/γ agonist 1 is a potent and dual PPARα/γ partial agonist which is a promising prototype for the research of dyslipidemia and diabetes. PPARα/γ agonist 1 has EC50 values of 28 nM and 69 nM for PPARα and PPARγ, respe...
T14933 Cetaben Others
Cetaben is a PPARα-independent peroxisome proliferator and is a non-fibrate hypolipidemic drug. It potent reduces the concentration of cholesterol and triglycerides.
T10900 CUDA PPAR , Epoxide Hydrolase
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR...
T15821 LY518674 LY-674 PPAR
LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα).
T4328 OSS_128167 SIRT6-IN-1 HBV , Sirtuin
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
T6893 MK-886 MK886,L 663536 Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP
MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
T15453 GW7647 PPAR
GW7647 is a potent agonist of PPARα (EC50s: 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ, and PPARδ, respectively).
T8374 LJ570 PPAR
LJ570 is the first PPARα/γ dual agonist (PPARα,PPARγ with EC50s of 1.05 and 0.12 μM, respectively[)
T17044 Tesaglitazar PPAR
Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα and human PPARα were 13.4 μM and 3.6 μM, respectively, and 0...
T8699 GFT505 Elafibranor PPAR
GFT505 (Elafibranor) (Elafibranor) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
TQ0107 Pemafibrate (R)-K-13675 PPAR
Pemafibrate ((R)-K-13675) is a highly specific PPARα agonist (EC50: 1 nM).
TQ0120 CDDO-Im RTA-403,CDDO-Imidazolide,TP-235 Others , Ferroptosis , Nrf2 , PPAR
CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
T14176 Aleglitazar RO0728804,R1439 PPAR
Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes.
T12835 Saroglitazar Lipaglyn PPAR
Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.
T12834 Saroglitazar Magnesium Others
Saroglitazar Magnesium is a novel peroxissome proliferator-activated receptor (PPAR) agonist with significant activation activity against PPARα (EC50 0.65pM) and moderate activation against PPARγ (EC50 3 nM).
T7395 Lanifibranor IVA337 PPAR
Lanifibranor (IVA337) is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively, for transactivation activ...
T9766 GW590735 PPAR
GW590735 is an effective and selective PPARα agonist with an EC50 of 4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW590735 can be used in dyslipidemia studies.
T5532 BMS-687453 PPAR
BMS-687453 is a potent and selective PPAR alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays.
T21764 MCC-555 Isaglitazone,Netoglitazone PPAR
MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.
T2269 Pirinixic Acid Wy-14643,NSC 310038 PPAR
Pirinixic Acid (NSC 310038) is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates specific peroxisome proliferator-activated recepto...
T6689 T0070907 PPAR
T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
T8486 GW6471 GW 6471 PPAR
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.
T28501 Ragaglitazar NNC61-0029,NN-622,(-)-DRF-2725,NNC-61-0029,NN 622,NNC 61-0029 PPAR
Ragaglitazar(NNC-61-0029) is a potent dual PPARα and PPARγ agonist that has shown potent lipid-lowering and insulin sensitizing effects in animal models.Ragaglitazar can be used to study type 2 diabetes.
T21587 Muraglitazar Pargluva,BMS-298585 PPAR
Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM r...
T2260 GW9662 TIMTEC-BB SBB006523,GW 9662 PPAR
GW9662 (TIMTEC-BB SBB006523) is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα/δ in cells.
T6524 GW0742 GW610742 PPAR
GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1 nM/1.1 μM/2 μM, for human PPARδ/α/γ).
T1298 Clofibrate Clofibrato,Clofibratum,Ethyl clofibrate PPAR
Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.
T63898 Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- PPAR
Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM. Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-p...
T9808 Tetradecylthioacetic acid PPAR
Tetradecylthioacetic acid is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including acti...
T0841 Bezafibrate BM15075 PPAR
Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
T1149 Fenofibrate Procetofen,Lipanthyl,Lipantil P450 , PPAR , Autophagy
Fenofibrate (Lipanthyl) is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.
T1402 Fenofibric acid Trilipix,FNF acid,NSC 281318 MMP , COX , PPAR
Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
T7796 TUG-1375 GPR
TUG-1375 is an Agonist of Thiazolidine Free Fatty Acid Receptor 2
T1264 Ciprofibrate Win35833 PPAR
Ciprofibrate (Win35833) is a fibrate derivative with antilipidemic activity.
T0061 Clofibric acid Chlorofibrinic acid PPAR , Drug Metabolite
Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
T14356 AVE-8134 PPAR
AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively.
T14948 Chiglitazar PPAR
Chiglitazar is a dual agonist of PPARα/γ (EC50s: 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ).
T4628 Seladelpar MBX 8025 PPAR
Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.
T15243 Ertiprotafib PTP 112 Phosphatase , PPAR
Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ).
T27519 GW 9578 GW9578,GW-9578 PPAR
GW 9578 is a selective and potent PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.
T12278 NXT629 Estrogen/progestogen Receptor
NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
T22686 CP 775146 Others
PPARα agonist
T4408 Elafibranor GFT505 PPAR
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively.
T37833 CAY10767
CAY10767 is an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50= 37 nM in a reporter assay).1It is greater than 2,700-fold selective for PPARα over PPARγ or PPARδ.
T30539 BMS-711939 BMS 711939,BMS711939
BMS-711939 is a potent and specific peroxisome proliferator-activated receptor (PPARα) agonist that has demonstrated excellent efficacy and safety in vivo in preclinical studies with an EC50 of 4 nM for PPARα in humans.
T68974 MHY553
MHY 553 is a PPARα agonist that improved aged-induced hepatic steatosis.
T31083 CP-868388 free base CP868388,CP 868388,(-)-CP-868388,UNII-999KY5ZIGB,CP-868388 PPAR
CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia.

Compounds

PPARα-MO-1
T10505
Synonym:
Target: PPAR
PPARα/δ agonist 1
T62968
Synonym:
Target:
PPARα agonist 1
T62266
Synonym:
Target:
PPARα/γ agonist 1
T60535
Synonym:
Target:
Cetaben
T14933
Synonym:
Target: Others
CUDA
T10900
Synonym:
Target: PPAR, Epoxide Hydrolase
LY518674
T15821
Synonym: LY-674
Target: PPAR
OSS_128167
T4328
Synonym: SIRT6-IN-1
Target: HBV, Sirtuin
MK-886
T6893
Synonym: MK886,L 663536
Target: Apoptosis, Leukotriene Receptor, COX, PPAR, FLAP
GW7647
T15453
Synonym:
Target: PPAR
LJ570
T8374
Synonym:
Target: PPAR
Tesaglitazar
T17044
Synonym:
Target: PPAR
GFT505
T8699
Synonym: Elafibranor
Target: PPAR
Pemafibrate
TQ0107
Synonym: (R)-K-13675
Target: PPAR
CDDO-Im
TQ0120
Synonym: RTA-403,CDDO-Imidazolide,TP-235
Target: Others, Ferroptosis, Nrf2, PPAR
Aleglitazar
T14176
Synonym: RO0728804,R1439
Target: PPAR
Saroglitazar
T12835
Synonym: Lipaglyn
Target: PPAR
Saroglitazar Magnesium
T12834
Synonym:
Target: Others
Lanifibranor
T7395
Synonym: IVA337
Target: PPAR
GW590735
T9766
Synonym:
Target: PPAR
BMS-687453
T5532
Synonym:
Target: PPAR
MCC-555
T21764
Synonym: Isaglitazone,Netoglitazone
Target: PPAR
Pirinixic Acid
T2269
Synonym: Wy-14643,NSC 310038
Target: PPAR
T0070907
T6689
Synonym:
Target: PPAR
GW6471
T8486
Synonym: GW 6471
Target: PPAR
Ragaglitazar
T28501
Synonym: NNC61-0029,NN-622,(-)-DRF-2725,NNC-61-0029,NN 622,NNC 61-0029
Target: PPAR
Muraglitazar
T21587
Synonym: Pargluva,BMS-298585
Target: PPAR
GW9662
T2260
Synonym: TIMTEC-BB SBB006523,GW 9662
Target: PPAR
GW0742
T6524
Synonym: GW610742
Target: PPAR
Clofibrate
T1298
Synonym: Clofibrato,Clofibratum,Ethyl clofibrate
Target: PPAR
Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
T63898
Synonym:
Target: PPAR
Tetradecylthioacetic acid
T9808
Synonym:
Target: PPAR
Bezafibrate
T0841
Synonym: BM15075
Target: PPAR
Fenofibrate
T1149
Synonym: Procetofen,Lipanthyl,Lipantil
Target: P450, PPAR, Autophagy
Fenofibric acid
T1402
Synonym: Trilipix,FNF acid,NSC 281318
Target: MMP, COX, PPAR
TUG-1375
T7796
Synonym:
Target: GPR
Ciprofibrate
T1264
Synonym: Win35833
Target: PPAR
Clofibric acid
T0061
Synonym: Chlorofibrinic acid
Target: PPAR, Drug Metabolite
AVE-8134
T14356
Synonym:
Target: PPAR
Chiglitazar
T14948
Synonym:
Target: PPAR
Seladelpar
T4628
Synonym: MBX 8025
Target: PPAR
Ertiprotafib
T15243
Synonym: PTP 112
Target: Phosphatase, PPAR
GW 9578
T27519
Synonym: GW9578,GW-9578
Target: PPAR
NXT629
T12278
Synonym:
Target: Estrogen/progestogen Receptor
CP 775146
T22686
Synonym:
Target: Others
Elafibranor
T4408
Synonym: GFT505
Target: PPAR
CAY10767
T37833
Synonym:
Target:
BMS-711939
T30539
Synonym: BMS 711939,BMS711939
Target:
MHY553
T68974
Synonym:
Target:
CP-868388 free base
T31083
Synonym: CP868388,CP 868388,(-)-CP-868388,UNII-999KY5ZIGB,CP-868388
Target: PPAR
1 2
Cat No. Product Name Synonyms Targets
T7052 Gnetol Tyrosinase , COX , HDAC , AChR
Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ...
T2855 Icariin Ieariline PDE , PPAR , Autophagy
Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
T3362 Eupatilin NSC 122413 PPAR , Autophagy
Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.
T8184 Fucosterol PARP , Endogenous Metabolite , PPAR
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression.
T4S2128 Bilobetin PKA , PPAR
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
TN1990 Norathyriol Akt , DNA/RNA Synthesis , AMPK , PPAR
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
T3S1701 Dihydrocurcumin PPAR , Fatty Acid Synthase
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, incr...
T3254 PHYTOL trans-Phytol,(E)-Phytol Antibacterial , PPAR , Parasite
PHYTOL (trans-Phytol) , a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects....
T6926 Palmitoylethanolamide Mackpeart DR 14V,N-palmitoylethanolamine,Loramine P 256,Impulsin,AM 3112,Palmidrol Influenza Virus , Endogenous Metabolite , PPAR
Palmitoylethanolamide (Impulsin) is an endogenously fatty acid amide. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective agent and an anticonvulsant.Upon administration, palmitoyleth...
T75690 Wistin
Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] .
T10044 13-Oxo-9E,11E-octadecadienoic acid PPAR
13-Oxo-9E,11E-octadecadienoic acid, a potent PPARα activator derived from tomato juice and an isomer of 9-oxo-ODA, exhibits the ability to decrease plasma and hepatic triglyceride levels in obese diabetic mice[1].
TN5149 Tirotundin NF-κB , COX , PPAR
Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activation of NF-kappa B, thereby, the synthesis of inflammatory me...
T3056 Bavachinin Bavachinin A,7-O-Methylbavachin PPAR
Bavachinin (Bavachinin A)(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae with potent anti-angiogenic activity.
TN5091 Tagitinin A PPAR , Antifection
Tagitinin A is a plant insecticidal compound, it has phytotoxic activity, it shows significant inhibition of wheat coleoptile growth, seed germination, and the growth of STS and weeds. Tagitinin A is also a PPARα/γ dual ...

Natural Products

Gnetol
T7052
Synonym:
Target: Tyrosinase, COX, HDAC, AChR
Icariin
T2855
Synonym: Ieariline
Target: PDE, PPAR, Autophagy
Eupatilin
T3362
Synonym: NSC 122413
Target: PPAR, Autophagy
Fucosterol
T8184
Synonym:
Target: PARP, Endogenous Metabolite, PPAR
Bilobetin
T4S2128
Synonym:
Target: PKA, PPAR
Norathyriol
TN1990
Synonym:
Target: Akt, DNA/RNA Synthesis, AMPK, PPAR
Dihydrocurcumin
T3S1701
Synonym:
Target: PPAR, Fatty Acid Synthase
PHYTOL
T3254
Synonym: trans-Phytol,(E)-Phytol
Target: Antibacterial, PPAR, Parasite
Palmitoylethanolamide
T6926
Synonym: Mackpeart DR 14V,N-palmitoylethanolamine,Loramine P 256,Impulsin,AM 3112,Palmidrol
Target: Influenza Virus, Endogenous Metabolite, PPAR
Wistin
T75690
Synonym:
Target:
13-Oxo-9E,11E-octadecadienoic acid
T10044
Synonym:
Target: PPAR
Tirotundin
TN5149
Synonym:
Target: NF-κB, COX, PPAR
Bavachinin
T3056
Synonym: Bavachinin A,7-O-Methylbavachin
Target: PPAR
Tagitinin A
TN5091
Synonym:
Target: PPAR, Antifection

Recombinant Proteins

Species：
Human (2)
Mouse (1)
Expression System：
E. coli (3)
Tag：
His (3)
Cat No. Product Name Species Expression System
TMPY-06830 PPAR alpha/PPARA Protein, Human, Recombinant (His) Human E. coli
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcell...
TMPY-06837 PPAR alpha/PPARA Protein, Mouse, Recombinant (His) Mouse E. coli
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcell...
TMPY-03499 CARHSP1 Protein, Human, Recombinant (His) Human E. coli
CARHSP1 is a biomarker for diabetic complications. Adenovirus-mediated CARHSP1 overexpression and siRNA-mediated knockdown experiments were performed to characterize the role of CARHSP1 in the regulation of gluconeogen...
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