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Search Results for " pf04449913 "

Targets

2

Compounds

Cat No. Product Name Synonyms Targets
T6514 Glasdegib PF-04449913 Hedgehog/Smoothened , Smo
Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
T36910 PF 04449913 maleate
Potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells. Munchhof et al (2011) Discov...
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