perk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T38732	PERK-IN-4		PERK
	PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.		PERK
T72053	PERK-IN-6		PERK
	PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).		PERK
T12410	PERK-IN-3		ERK
	PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).		ERK
T10299	AMG PERK 44		ERK
	AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) and induces autophagy. It has 1000-fold and 160-fold selectivity over GCN2 (IC50: 7300 nM) and B-Raf (IC50 >1000 nM), respectively.		ERK
T12409	PERK-IN-2		ERK
	PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).		ERK
T63008	PERK-IN-5
	PERK-IN-5 is a highly selective, potent, orally active inhibitor of the protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) that acts on PERK (IC50: 2 nM) and p-eIF2α (IC50: 9 nM). PERK-IN-5 significantly inhi...
T63007	(S)-PERK-IN-5
	(S)-PERK-IN-5 is the S-enantiomer of PERK-IN-5. (S)-PERK-IN-5 is a PERK inhibitor (IC50: 0.101-0.250 μM).
T21976	ONO-8130		Prostaglandin Receptor
	ONO-8130 is an orally available antagonist of EP1 receptor.		Prostaglandin Receptor
T6854	GSK621		Apoptosis , AMPK , Autophagy
	GSK621 is a specific and potent AMPK activator.		Apoptosis , AMPK , Autophagy
T2654	GSK2656157		Apoptosis , PERK , Autophagy
	GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 kinases.		Apoptosis , PERK , Autophagy
T2614	GSK2606414		Apoptosis , PERK , Autophagy
	GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).		Apoptosis , PERK , Autophagy
T9196	IACS-13909	BBP-398	Phosphatase
	IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.		Phosphatase
T22436	Takeda-6d		VEGFR
	Takeda-6d, a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, inhibits B-RAF and VEGFR2 with IC50 of 7.0nM and 2.2nM.		VEGFR
T6183	ISRIB (trans-isomer)	ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB	Apoptosis , PERK , Autophagy
	ISRIB (trans-isomer) (ISRIB trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).		Apoptosis , PERK , Autophagy
T2027	ISRIB		PERK
	ISRIB is a potent and selective PERK inhibitor.		PERK
T61859	MK-28		Antiviral , PERK
	MK-28 is a selective PERK agonist that reduces toxicity and prolongs survival in a Huntington's disease model.MK-28 has a significant killing effect on MK28 gastric cancer cells.		Antiviral , PERK
T14902	CCT020312		PERK
	CCT020312 is a selective activator of EIF2AK3 and PERK. CCT020312 durably inhibits cell proliferation and elicits the phosphorylation of EIF2A.		PERK
T11374	GCN2-IN-6		Others , PERK
	GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells). GCN2-IN-6 is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8...		Others , PERK
T73053	BAY 2965501		PERK
	BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.		PERK
T8423	ML417		Dopamine Receptor , Arrestin
	ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM).		Dopamine Receptor , Arrestin
T11738	K-Ras G12C-IN-4		Ras
	K-Ras G12C-IN-4, is a potent Covalent Inhibitor of KRASG12C..		Ras
T39117	PLX7922	PLX7922
	PLX7922, a RAF inhibitor, demonstrates binding affinity with BRAF V600E and exhibits inhibitory effects on pERK in BRAF V600E cell lines, while inducing pERK activation in mutant NRAS cell lines.
T62371	SOS1-IN-12
	SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).
T79123	PF-07284892	ARRY-558
	PF-07284892 (ARRY-558) is an orally active, potent inhibitor of SHP2, demonstrating an IC50 of 21 nM, and is known to reduce the expression of pERK [1] [2].
T22104	ML-291
	ML291 is a sufonamidebenzamide compound that induces the unfolded protein response (UPR) and overwhelms the adaptive capacity of UPR, resulting in apoptosis in various solid cancer models. It activates the PERK/eIF2a/CHO...
T69106	Avarol
	Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheim...
T74356	PROTAC SOS1 degrader-2
	PROTAC SOS1 degrader-2, a potent degrader of PROTAC SOS1, effectively reduces the expression of pERK and RAS-GTP in a dose-dependent manner. It significantly inhibits tumor growth in vivo [1].
T62003	SOS1-IN-13
	SOS1-IN-13 is a potent inhibitor of son of sevenless homolog 1 (SOS1). SOS1-IN-13 shows IC 50 s of 6.5 nM and 327 nM for SOS1 and pERK, respectively. SOS1-IN-13 has research value in anticancer.
T73364	MEK-IN-5
	MEK-IN-5, a potent MEK inhibitor and nitric oxide (NO) donor, effectively decreases pMEK and pERK levels in a dose-dependent and time-dependent fashion. Additionally, it induces apoptosis in MDA-MB-231 cells.
T71722	Angiogenesis inhibitor BT2
	Angiogenesis inhibitor BT2 is a novel inhibitor of angiogenesis and vascular permeability, inhibiting ERK phosphorylation and the expression of FosB/ΔFosB, VCAM-1, and many genes involved in proliferation, migration, ang...
T39874	GSK143 dihydrochloride
	GSK143 dihydrochloride is a highly selective, orally active inhibitor of spleen tyrosine kinase (SYK), exhibiting a pIC 50 value of 7.5. It effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. The c...
T38626	GSK143
	GSK143 is a potent orally active and highly selective inhibitor of spleen tyrosine kinase (SYK) with a pIC 50 of 7.5. Furthermore, GSK143 effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. In addi...
T73179	HDAC-IN-50
	HDAC-IN-50, a potent, orally active inhibitor targeting both FGFR (Fibroblast Growth Factor Receptor) and HDAC (Histone Deacetylase), exhibits IC50 values of 0.18, 1.2, 0.46, 1.4, 1.3, 1.6, 2.6, 13 nM for FGFR1, FGFR2, F...
T74844	Antiproliferative agent-23
	Antiproliferative agent-23, a microtubule-destabilizing agent (MDA), disrupts the tubulin-microtubule system, leading to apoptosis through a mitochondrion-dependent pathway. This involves downregulation of Bcl-2 protein,...
T71891	G-573
	G-573 is an allosteric inhibitor of MEK that is both potent and selective. The IC(50) value for pERK inhibition in HCT116 tumours by G-573 was estimated to be 0.406 ÂµM. The IC(50) values for tumour growth inhibition in...
T79072	KRAS G12D modulator-1		Ras
	KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and is utilized in cancer research [1].		Ras
T36642	RAS/RAS-RAF-IN-1
	RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity[1]. RAS/RAS-RAF-IN-1 (compound 89; for ...
T39726	SHP389	SHP389
	SHP389 is an allosteric SHP2 inhibitor, with an IC 50 of 36 nM for both SHP2 and p-ERK.
T36887	8(E),10(E),12(Z)-Octadecatrienoic Acid
	8(E),10(E),12(Z)-Octadecatrienoic acid is a conjugated polyunsaturated fatty acid (PUFA) that has been found inC. officinalisseed oil and has anticancer activity.1,2,3It inhibits the growth of Caco-2 cells when used at c...

Compounds

PERK-IN-4

T38732

Target: Prostaglandin Receptor

GSK621

T6854

Synonym:

Target: Apoptosis, AMPK, Autophagy

GSK2656157

T2654

Synonym:

Target: Apoptosis, PERK, Autophagy

GSK2606414

T2614

Synonym:

Target: Apoptosis, PERK, Autophagy

Synonym: ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB

Target: Apoptosis, PERK, Autophagy

Target: Antiviral, PERK

Target: Others, PERK

Target: Dopamine Receptor, Arrestin

PROTAC SOS1 degrader-2

Angiogenesis inhibitor BT2

T71722

Synonym:

Target:

GSK143 dihydrochloride

Antiproliferative agent-23

KRAS G12D modulator-1

8(E),10(E),12(Z)-Octadecatrienoic Acid

T36887

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T5A2461	Bufotalin	Bufotaline	Apoptosis , Others , Reactive Oxygen Species
	1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.		Apoptosis , Others , Reactive Oxygen Species
T79951	Piperkadsin A		Reactive Oxygen Species
	Piperkadsin A effectively inhibits reactive oxygen species (ROS) production, specifically targeting PMA-induced ROS in human polymorphonuclear neutrophils, exhibiting an inhibition concentration (IC50) of 4.3 μM [1].		Reactive Oxygen Species

Cat No.	Product Name	Species	Expression System
TMPJ-01464	IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F)	Human	Human Cells
	Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system，belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or m...

Cat No.	Product Name
L9700	Endoplasmic Reticulum Stress Compound Library		193 compounds
	A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);

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