Search Result

Search Results for " pdk "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T79723	PDK-IN-2
	PDK-IN-2 (Compound 1F), with an IC50 of 68 nM, is a potent PDK inhibitor that downregulates the expression of PDK1 and PDK4 in cells. It promotes mitochondrial bioenergetics, reduces glycolytic activity, and triggers apo...
T74830	PDK-IN-1
	PDK-IN-1 (compound 7o), a pyruvate dehydrogenase kinase (PDK) inhibitor, exhibits IC50 values of 0.03 and 0.1 μM against PDK1 and HSP90, respectively. This compound effectively targets the PDH/PDK axis, significantly red...
T2348	GSK2334470		PDK
	GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.		PDK
T1837	BX-912		Apoptosis , VEGFR , PKA , Chk , CDK , PDK
	BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC etc.		Apoptosis , VEGFR , PKA , Chk , CDK , PDK
T1830	BX795		IκB/IKK , Chk , CDK , c-Kit , PDK , Autophagy
	BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than...		IκB/IKK , Chk , CDK , c-Kit , PDK , Autophagy
T24677	PS47	PS 47,PS-47	PDK
	PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.		PDK
T4046	BX517	PDK1 inhibitor 2,BX 517,BX-517	Akt , PDK
	BX517 (PDK1 inhibitor 2) is a potent and selective inhibitor of PDK1.		Akt , PDK
T16670	PS210		PDK
	PS210 is a potent and selective activator of PDK1 (Kd: 3 μM), specifically targeting the PIF-binding pocket of PDK1, without acting against other protein kinases such as S6K, PKB/Akt, or GSK3. Its prodrug, PS423, serves ...		PDK
T12398	MP7	PDK1 inhibitor	PDK
	MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).		PDK
T12412L	PDK4-IN-1 hydrochloride		Apoptosis , PDK
	PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM)		Apoptosis , PDK
T12412	PDK4-IN-1		Others
	PDK4-IN-1 is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM).		Others
T16450	PDK1-IN-RS2		PDK
	PDK1-IN-RS2 inhibits the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 is a mimic of the peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor (Kd: 9 μM).		PDK
T24741	RS1-PDK1 inhibitor	RS-1,RS1,RS 1	PDK
	RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.		PDK
T61339	LDHA/PDKs-IN-1
	LDHA/PDKs-IN-1 (compound 20e) is a highly effective dual inhibitor of PDKs and LDHA, displaying IC50 values of 0.8 μM and 0.15 μM, respectively. It significantly suppresses A549 cell proliferation (EC50 = 13.2 μM), reduc...
T60995	LDHA/PDKs-IN-2
	LDHA/PDKs-IN-2 (compound 20k) is a potent LDHA and PDKs dual inhibitor with IC50 values of 0.7 and 1.6 μM, respectively. LDHA/PDKs-IN-2 increases oxygen consumption as well as decreases the lactate formation. LDHA/PDKs-I...
T74814	PKM2/PDK1-IN-1
	PKM2/PDK1-IN-1, a shikonin thioether derivative, serves as a dual inhibitor for PKM2/PDK1. This compound effectively inhibits the proliferation and induces apoptosis in NSCLC cells. It promotes intercellular ROS producti...
T17224	VER-246608		Dehydrogenase , PDK
	VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism an...		Dehydrogenase , PDK
T22350	JX06		Apoptosis , Dehydrogenase , PDK
	JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.		Apoptosis , Dehydrogenase , PDK
T11765	KPLH1130		Dehydrogenase , PDK
	KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions.		Dehydrogenase , PDK
T19783	Dehydroabiethylamine	NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine	P450 , PDK
	Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular cholesterol transport with anti-tumor activity.		P450 , PDK
T12566	PS10		PDK
	PS10 is a ATP-competitive inhibitor of pan-PDK(PDK2, PDK4, PDK1, and PDK3 with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM , respectively).		PDK

Compounds

Target: Apoptosis, VEGFR, PKA, Chk, CDK, PDK

BX795

T1830

Synonym:

Target: IκB/IKK, Chk, CDK, c-Kit, PDK, Autophagy

Synonym: PDK1 inhibitor 2,BX 517,BX-517

Synonym: PDK1 inhibitor

Target: PDK

PDK4-IN-1 hydrochloride

T12412L

Synonym:

Target: Apoptosis, PDK

Synonym: RS-1,RS1,RS 1

Target: Dehydrogenase, PDK

JX06

T22350

Synonym:

Target: Apoptosis, Dehydrogenase, PDK

KPLH1130

T11765

Synonym:

Target: Dehydrogenase, PDK

Dehydroabiethylamine

T19783

Synonym: NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine

Cat No.	Product Name	Synonyms	Targets
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
T3604	Sodium dichloroacetate	Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA)	Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
	Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion chann...		Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK

Natural Products

Polyphyllin I

T3895

Synonym:

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Sodium dichloroacetate

T3604

Synonym: Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA)

Target: Apoptosis, Dehydrogenase, Reactive Oxygen Species, PDK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04568	PDK1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Pyruvate dehydrogenase kinase, isozyme 1, also known as [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial and PDK1, is a member of the PDK / BCKDK protein kinase family. PDK-1 is expressed predominantl...
TMPY-04445	PDK4 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient...
TMPH-02469	PDK1 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus
	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, a...
TMPH-00515	PPDK Protein, Entamoeba histolytica, Recombinant (His & SUMO)	Entamoeba histolytica	E. coli
	Catalyzes the reversible phosphorylation of pyruvate and phosphate. In E.histolytica and C.symbiosus, PPDK functions in the direction of ATP synthesis.
TMPH-02470	PDK3 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and incre...
TMPH-00422	Ppdk Protein, Clostridium symbiosum, Recombinant (His & Myc)	Clostridium symbiosum	E. coli
	Ppdk Protein, Clostridium symbiosum, Recombinant (His & Myc) is expressed in E. coli.