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Search Result

Search Results for " pcaf "

28

Compounds

2

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T60762 PCAF-IN-1
PCAF-IN-1 is a antitumor agents used in tumor treatment research. PCAF-IN-1 is a highly selective inhibitor of PCAF [1].
T60452 PCAF-IN-2
PCAF-IN-2 (compound 17) is a potent inhibitor of PCAF with an IC50 of 5.31 µM. PCAF-IN-2 exhibits anti-tumor activity. CAF-IN-2 induces cell apoptosis and arrest the cell cycle at the G2/M phase[1].
T60558 NSC 694623 Histone Acetyltransferase
NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with IC50 of 15.9 μM against recombinant HAT p300/CBP associated factor (PCAF). NSC 694623 shows anti-proliferative activity against some cancer cells, whi...
T5468 YF-2 Others , Epigenetic Reader Domain , Histone Acetyltransferase
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
T28471 PU139 PU 139,PU-139 Histone Acetyltransferase
PU139 is a novel inhibitor of histone acetyltransferase (HAT).
T11495L GSK 4027 Others
GSK 4027 is a PCAF/GCN5 bromodomain chemical probe. In a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, it has a pIC50 of 7.4±0.11 for PCAF.
T10604 BRD-IN-3 Others
BRD-IN-3 is a highly potent PCAF bromodomain (BRD) inhibitor (IC50: 7 nM). It also exhibits activity against GCN5 and FALZ.
T11495 GSK4028 Others
GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe. The pIC50 of GSK4028 is 4.9 in a TR-FRET assay.
T71724 F2276-0099
F2276-0099 is a PCAF/GCN5 BRD inhibitor
T71721 F2276-0106
F2276-0106 is a PCAF/GCN5 BRD inhibitor
T71720 F2276-0104
F2276-0104 is a PCAF/GCN5 BRD inhibitor
T23745 APA-APA-MPO APA APA MPO,APAAPAMPO
APA-APA-MPO is a PCAF bromodomain/Tat-AcK50 association inhibitor.
T23746 APA-H-MPO APAHMPO
APA-H-MPO is a PCAF bromodomain/Tat-AcK50 association inhibitor.
T25215 CCT077791 CCT 077791,CCT-077791 Epigenetic Reader Domain , Histone Acetyltransferase
CCT077791 is a potent inhibitor of p300 and PCAF histone acetyltransferase activity for cancer research.
T11807 L002 Others , Histone Acetyltransferase , STAT
L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By ...
T71723 F2276-0008
F2276-0008 is a PCAF/GCN5 BRD inhibitor.
T32010 GSK699 GSK-699,GSK 699
GSK699 is a potent, cell penetrant PCAF/GCN5 PROTAC.
T38711 YF-2 hydrochloride
YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μ...
T60018 NSC 694621
NSC 694621 is a potent PCAF inhibitor with an IC 50 of 5.71 μM ( PCAF/H3 1-21 ). NSC 694621 exhibits good activity of inhibiting the proliferation of cancer cells that has the potential to be the new anticancer agent[1].
T11796L L-Moses L-45 Others
L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM).
T36109 L Moses dihydrochloride
High affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (Ki = 47 nM). Exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (Kd = 600 nM). Exhibits >4500-fo...
T60479 NSC 698600
NSC 698600 is a potent inhibitor of PCAF(p300/CBP-associated factor) with IC 50 of 6.51 μM that shows good inhibition activity of cancer cell proliferation [1].
T62424 L-Moses dihydrochloride
L-Moses (L-45) dihydrochloride is the first, potent, selective p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor (Kd: 126 nM).
T73951 Lys-CoA TFA
Lys-CoA TFA, a selective p300 histone acetyltransferase (HAT) inhibitor (IC 50 =50-500 nM), exhibits a specificity that exceeds 100-fold over PCAF (IC 50 =200 μM). This compound effectively suppresses transcriptional act...
T35818 CAY10669
CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor; IC50 = 662 μM), displaying a 2-fold improvement in inhibitory potency over anacardic acid . At 30-60 μM, CAY106...
T63565 CBP/p300-IN-19 hydrochloride
CBP/p300-IN-19 hydrochloride is a selective and potent inhibitor of p300/CBP HAT, capable of acting on p300-HAT (IC50: 1.4 μM), CBP-HAT (IC50: 2.2 μM), PCAF (IC50>100 μM), Myst3 (IC50>100 μM). CBP/p300-IN-19 hydrochlorid...
T36626 Lys-CoA
Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo. Lau et a...
T63122 CBP/p300-IN-19
CBP/p300-IN-19 is a potent inhibitor of p300/CBP HAT, which can act on P300-HAT (IC50: 1.4 μM), CBP-HAT (IC50: 1.4 μm), 2.2 μM), PCAF (IC50>100 μM), and Myst3 (IC50>100 μM). CBP/p300-IN-19 has anti-tumor activity.
Cat No. Product Name Synonyms Targets
T11366 Garcinol Apoptosis , Endogenous Metabolite , Histone Acetyltransferase , AChR , AChE
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone...
T6389 Anacardic Acid 6-pentadecylsalicylic Acid,Hydroginkgolic acid Others , Epigenetic Reader Domain , Histone Acetyltransferase , Antibacterial
Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostagland...

Natural Products

Garcinol
T11366
Synonym:
Target: Apoptosis, Endogenous Metabolite, Histone Acetyltransferase, AChR, AChE
Anacardic Acid
T6389
Synonym: 6-pentadecylsalicylic Acid,Hydroginkgolic acid
Target: Others, Epigenetic Reader Domain, Histone Acetyltransferase, Antibacterial

Recombinant Proteins

Species：
Human (2)
Expression System：
E. coli (2)
Tag：
His (1)
N-terminal GST-tagged (1)
Cat No. Product Name Species Expression System
TMPH-02175 TAF5L Protein, Human, Recombinant (GST) Human E. coli
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex....
TMPY-01869 SIRT1 Protein, Human, Recombinant (His) Human E. coli
SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent prote...
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