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Search Results for " p-glycoprotein "

Targets

116

Compounds

35

Natural Products

23

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T12341 P-gp inhibitor 1 Others , P-gp
P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).
T8596 Ceefourin 1 MRP
Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.
T8426 Encequidar HM30181,HM30181A P-gp
Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.
T16561 Polyoxyethylene stearate POES Antibacterial , P-gp
Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.
T6287 Tariquidar XR9576 P-gp
Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.
T11071 Dofequidar fumarate MS-209 P-gp
Dofequidar fumarate (MS-209)(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1.
T0351 Risperidone Risperidal,R 64 766 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , P-gp
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
T4059 Selamectin UK-124114 Chloride channel , P-gp , Parasite
Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, sel...
T11578L Encequidar mesylate HM30181 mesylate,HM30181A mesylate P-gp
Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
T13383 Zamicastat BIA 5-1058 BCRP , Hydroxylase , P-gp
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).
TQ0311 GSK163090 Dopamine Receptor , 5-HT Receptor
GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3).
T8389 Trifluoperazine trifluoroperazine CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
T1634 Glibenclamide Glyburide Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T0100L Atazanavir Zrivada,Reyataz,Latazanavir,BMS-232632 P450 , SARS-CoV , HIV Protease , P-gp
Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T6541 Ibutilide Fumarate Corvert Fumarate,U70226E Calcium Channel , Sodium Channel
Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outwar...
T20656 Verapamil NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil P450 , Calcium Channel , P-gp
Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias...
T16339 Norverapamil hydrochloride (±)-Norverapamil hydrochloride,D591 hydrochloride Calcium Channel , P-gp , Drug Metabolite
Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
T21640 Talinolol Adrenergic Receptor
(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.
T1222 Trifluoperazine dihydrochloride Trifluoperazine 2HCl,SKF5019,Urinox CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
T1010 Verapamil hydrochloride Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride P450 , Calcium Channel , P-gp
Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
T0100 Atazanavir sulfate BMS-232632,BMS-232632 sulfate P450 , SARS-CoV , HIV Protease , P-gp
Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.
T2657 Elacridar GW0918,GW120918,GF120918,GG918 BCRP , P-gp
Elacridar (GG918) (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor.
T6018 Zosuquidar trihydrochloride Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride P-gp
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.
T16026 MCI826 P-gp , LTR
MCI826 is a potent and selective antagonist of P-glycoprotein (P-gp) and peptide leukotrienes (p-LTs), showing anti-asthmatic activity in a guinea pig model of advanced asthma.
T9173 HM-30181 mesylate monohydrate P-gp
HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.
T28396 PGP-4008 PGP 4008,PGP4008 P-gp
PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.
T17216 Valspodar PSC 833 P-gp
Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.
T6200 Ledipasvir GS-5885 HCV Protease , SARS-CoV
Ledipasvir (GS-5885) is a Hepatitis C Virus NS5A Inhibitor. The mechanism of action of ledipasvir is as a P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein Inhibitor.
T68124 Pafenolol Adrenergic Receptor , P-gp
Pafenolol is a P-glycoprotein modulator with a Ki value of 5.5 µM. pafenolol is an orally available and selective beta-adrenergic receptor antagonist.
T77575 P-gb-IN-1 P-gp
P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow. P-gb-IN-1 has been shown to inhibit P-gp by hydrogen bonding with residues Asn 721 and Met 986. P-gb-IN-1 s...
T1782 Canagliflozin JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754 SGLT
Canagliflozin (JNJ 28431754AAA), a sodium-glucose transporter 2( SGLT2) and P-Glycoprotein inhibitor, is used in type 2 diabetes.
T72055 FM04 P-gp
FM04 is an orally active and potent P-glycoprotein (P-gp) inhibitor with an EC50 value of 83 nM.FM04 interacts with Q1193 and I1115 in the human P-gp nucleotide-binding domain 2 (NBD2). This disrupts the R262-Q1081-Q1118...
T2060 ELR510444 LR-510444,LR510444,LR 510444 Apoptosis , Microtubule Associated
ELR510444 (LR510444) is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpress...
T64133L Laniquidar TFA Laniquidar TFA(197509-46-9 Free base),R101933 P-gp
Laniquidar TFA (R101933) is a novel orally available non-competitive P-glycoprotein (P-gp) inhibitor with an IC50 value of 0.51 μM.Laniquidar has limited bioavailability and can be used to modulate the multidrug resistan...
T4595 YHO-13177 YHO 13177,YHO13177 BCRP
YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.
T12343 Benzquinamide BZQ,P2647,Benzoquinamide Adrenergic Receptor
Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer drugs in multidrug-resistant cells.The Ki values of Benzqui...
T1434 Clarithromycin A-56268 P450 , ribosome , MRP , Antibacterial , Antibiotic , Autophagy
Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classif...
T15713 Larotaxel XRP9881 P-gp
Larotaxel (XRP9881) is a taxane analogue that has anticancer activity, exerts its cytotoxic effects by promoting tubulin assembly and stabilizing microtubules, and ultimately induces cell death through apoptosis. Larotax...
T6075 Epothilone B Patupilone,EPO 906 Apoptosis , Microtubule Associated , Antibiotic , Antifungal
Epothilone B (EPO 906) is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditi...
T1146 Nifedipine BAY-a-1040,Procardia XL,Procardia,Adalat CaMK , Potassium Channel , Calcium Channel , Autophagy
Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation ...
T69515 R 101933
R 101933 is a P-glycoprotein (P-gp) inhibitor.
T29169 XR9051 Hydrochloride
XR9051 Hydrochloride, a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR), inhibits the binding of cytotoxics to P-glycoprotein.
T27985 MC-70 MC70,MC 70
MC-70 is a potent P-glycoprotein (P-gp) inhibitor (EC50 = 0.69 μM).
T16352 NSC23925 Nrf2
NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
T12340 P-gp modulator 1 Others
P-gp modulator 1 is a high affinity and orally available P-glycoprotein (Pgp) modulator
T31069 CP-615003 CP 615003
CP-615003 is a Mdr1 P-glycoprotein substrate.
T14616 Biricodar VX-710 Others
Biricodar is a P-glycoprotein and MRP-1 modulator.
T6287L Tariquidar dimesylate D 06008,XR9576,D06008,XR 9576,Tariquidar dimesilate,XR-9576
Tariquidar is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane t...
TQ0043 Dofequidar MS-209 P-gp
Dofequidar (MS-209) is a quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
T13087 Tariquidar methanesulfonate, hydrate XR9576 methanesulfonate, hydrate Others
Tariquidar methanesulfonate, hydrate is a potent and specific P-glycoprotein (P-gp) inhibitor(Kd of 5.1 nM).

Compounds

P-gp inhibitor 1
T12341
Synonym:
Target: Others, P-gp
Ceefourin 1
T8596
Synonym:
Target: MRP
Encequidar
T8426
Synonym: HM30181,HM30181A
Target: P-gp
Polyoxyethylene stearate
T16561
Synonym: POES
Target: Antibacterial, P-gp
Tariquidar
T6287
Synonym: XR9576
Target: P-gp
Dofequidar fumarate
T11071
Synonym: MS-209
Target: P-gp
Risperidone
T0351
Synonym: Risperidal,R 64 766
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, P-gp
Selamectin
T4059
Synonym: UK-124114
Target: Chloride channel, P-gp, Parasite
Encequidar mesylate
T11578L
Synonym: HM30181 mesylate,HM30181A mesylate
Target: P-gp
Zamicastat
T13383
Synonym: BIA 5-1058
Target: BCRP, Hydroxylase, P-gp
GSK163090
TQ0311
Synonym:
Target: Dopamine Receptor, 5-HT Receptor
Trifluoperazine
T8389
Synonym: trifluoroperazine
Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy
Glibenclamide
T1634
Synonym: Glyburide
Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy
Atazanavir
T0100L
Synonym: Zrivada,Reyataz,Latazanavir,BMS-232632
Target: P450, SARS-CoV, HIV Protease, P-gp
Ibutilide Fumarate
T6541
Synonym: Corvert Fumarate,U70226E
Target: Calcium Channel, Sodium Channel
Verapamil
T20656
Synonym: NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil
Target: P450, Calcium Channel, P-gp
Norverapamil hydrochloride
T16339
Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride
Target: Calcium Channel, P-gp, Drug Metabolite
Talinolol
T21640
Synonym:
Target: Adrenergic Receptor
Trifluoperazine dihydrochloride
T1222
Synonym: Trifluoperazine 2HCl,SKF5019,Urinox
Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy
Verapamil hydrochloride
T1010
Synonym: Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride
Target: P450, Calcium Channel, P-gp
Atazanavir sulfate
T0100
Synonym: BMS-232632,BMS-232632 sulfate
Target: P450, SARS-CoV, HIV Protease, P-gp
Elacridar
T2657
Synonym: GW0918,GW120918,GF120918,GG918
Target: BCRP, P-gp
Zosuquidar trihydrochloride
T6018
Synonym: Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride
Target: P-gp
MCI826
T16026
Synonym:
Target: P-gp, LTR
HM-30181 mesylate monohydrate
T9173
Synonym:
Target: P-gp
PGP-4008
T28396
Synonym: PGP 4008,PGP4008
Target: P-gp
Valspodar
T17216
Synonym: PSC 833
Target: P-gp
Ledipasvir
T6200
Synonym: GS-5885
Target: HCV Protease, SARS-CoV
Pafenolol
T68124
Synonym:
Target: Adrenergic Receptor, P-gp
P-gb-IN-1
T77575
Synonym:
Target: P-gp
Canagliflozin
T1782
Synonym: JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754
Target: SGLT
FM04
T72055
Synonym:
Target: P-gp
ELR510444
T2060
Synonym: LR-510444,LR510444,LR 510444
Target: Apoptosis, Microtubule Associated
Laniquidar TFA
T64133L
Synonym: Laniquidar TFA(197509-46-9 Free base),R101933
Target: P-gp
YHO-13177
T4595
Synonym: YHO 13177,YHO13177
Target: BCRP
Benzquinamide
T12343
Synonym: BZQ,P2647,Benzoquinamide
Target: Adrenergic Receptor
Clarithromycin
T1434
Synonym: A-56268
Target: P450, ribosome, MRP, Antibacterial, Antibiotic, Autophagy
Larotaxel
T15713
Synonym: XRP9881
Target: P-gp
Epothilone B
T6075
Synonym: Patupilone,EPO 906
Target: Apoptosis, Microtubule Associated, Antibiotic, Antifungal
Nifedipine
T1146
Synonym: BAY-a-1040,Procardia XL,Procardia,Adalat
Target: CaMK, Potassium Channel, Calcium Channel, Autophagy
R 101933
T69515
Synonym:
Target:
XR9051 Hydrochloride
T29169
Synonym:
Target:
MC-70
T27985
Synonym: MC70,MC 70
Target:
NSC23925
T16352
Synonym:
Target: Nrf2
P-gp modulator 1
T12340
Synonym:
Target: Others
CP-615003
T31069
Synonym: CP 615003
Target:
Biricodar
T14616
Synonym: VX-710
Target: Others
Tariquidar dimesylate
T6287L
Synonym: D 06008,XR9576,D06008,XR 9576,Tariquidar dimesilate,XR-9576
Target:
Dofequidar
TQ0043
Synonym: MS-209
Target: P-gp
Tariquidar methanesulfonate, hydrate
T13087
Synonym: XR9576 methanesulfonate, hydrate
Target: Others
1 2 3
Cat No. Product Name Synonyms Targets
TN4761 Phellamurin P-gp
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini...
TN1651 Furanodiene Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T3S0012 Coniferyl ferulate P-gp , GST
Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ...
T2S0223 Isosinensetin 6-Demethoxynobiletin Antioxidant , HIV Protease , Antibacterial , P-gp
1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.
T3002 Piperine 1-Piperoylpiperidine,Bioperine P450 , Endogenous Metabolite , P-gp , Autophagy
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
TJS1159 Chrysosplenetin Chrysosptertin B P450 , Ferroptosis , P-gp
Chrysosplenetin is a metabolic inhibitor of artemisinin.
T2S0271 Voacamine Voacanginine Cannabinoid Receptor , P-gp
Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.Voacangini...
T2S1200 Sinapine Antioxidant , P-gp , AChE
1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.
T12540 Pristinamycin IA Mikamycin IA,Mikamycin B Others , Antibiotic , P-gp
Pristinamycin IA (Mikamycin B) is a substrate for the P-glycoprotein and a cyclo-peptidic macrolactone antibiotic.
T4034 Solamargine Solamargin,δ-Solanigrine Apoptosis , p38 MAPK , P-gp , STAT
Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cel...
T3392 Sinapine thiocyanate P-gp , AChE
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o...
T2799 (20S)-Protopanaxadiol 20-Epiprotopanaxadiol,20(S)-APPD Apoptosis , Reactive Oxygen Species , P-gp
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
TN1525 Convallatoxin NF-κB , P-gp , PPAR
Convallatoxin is a natural product
TN1757 Hypophyllanthin Potassium Channel , Calcium Channel , P-gp
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
T4085 Paris saponin VII Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy
Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
TCS2336 Evodine P-gp
1. Evodine has antinociceptive activity.
T6S1917 Schisandrol B Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B P450 , Reactive Oxygen Species , Autophagy
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...
T3S2019 Lathyrol Others
1.Lathyrol diterpenes is a modulator of P-glycoprotein dependent multidrug resistance.
TN2554 1-Monopalmitin P-gp
1-Monopalmitin has dielectric properties. 1-Monopalmitin inhibits the P-glycoprotein activity in intestinal Caco-2 cells.
TN5118 Taxol C P-gp
Taxol C can reduce interaction with the P-glycoprotein transporter that may allow for increased permeation of taxanes into the brain.
T3868 Agnuside chasteberry oil COX , Prostaglandin Receptor , P-gp
Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at conce...
T0945 Cyclosporin A Cyclosporine A,Ciclosporin,Cyclosporine Phosphatase , Antibiotic , Complement System
Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.
TMA2270 Alisol F 24-acetate P-gp
Alisol F 24-acetate is a natural product isolated from Alisma plantago-aquatica Linn[1]. Alisol F 24 Acetate enhances chemosensitivity and apoptosis of MCF-7/DOX Cells by inhibiting P-Glycoprotein-Mediated drug efflux[2]...
TN2256 Taccalonolide B Microtubule Associated
Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM.
T6S0653 Linarin Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine TNF , AChE
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediat...
TN2254 Taccalonolide A Apoptosis , Microtubule Associated
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these ...
T6S0119 Dauricine Apoptosis , Others , NF-κB
1. Dauricine has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. 2. Dauricinec can pass the blood-brain barrier, and that P-glycoprotein has an important ro...
TN5124 Taxuspine X P-gp
Taxuspine X may have p-glycoprotein inhibitory activity.
TN1099 Dihydroevocarpine MAO , P-gp , Antifection
Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it s...
T75524 Mutabilol
Mutabilol (compound 1) is a potent p-glycoprotein (P-gp) regulator. Mutabilol is a nature product could be isolated from Plectranthus mutabilis leaves. Mutabilol increases the P-gp expression in NCI-H460/R cells [1] .
TN5114 Taxinine P-gp
Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.
TN5113 Taxinine B Others
Taxinine and taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. Taxinine B shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arach...
T72802 Spongionellol A
Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis . Spongionellol A can be used in the rese...
T15097 Deoxynivalenol Vomitoxin,4-Deoxynivalenol
Deoxynivalenol (Vomitoxin) is a mycotoxin produced by Fusarium spp. of the single trichothecene family and is commonly found in contaminated food and feed.Deoxynivalenol crosses the intestinal mucosa via a cellular bypas...
T37810 6',7'-Epoxybergamottin
6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, a...

Natural Products

Phellamurin
TN4761
Synonym:
Target: P-gp
Furanodiene
TN1651
Synonym:
Target: Apoptosis, PARP, Reactive Oxygen Species, Caspase, CDK, P-gp
coniferyl ferulate
T3S0012
Synonym:
Target: P-gp, GST
Isosinensetin
T2S0223
Synonym: 6-Demethoxynobiletin
Target: Antioxidant, HIV Protease, Antibacterial, P-gp
Piperine
T3002
Synonym: 1-Piperoylpiperidine,Bioperine
Target: P450, Endogenous Metabolite, P-gp, Autophagy
Chrysosplenetin
TJS1159
Synonym: Chrysosptertin B
Target: P450, Ferroptosis, P-gp
Voacamine
T2S0271
Synonym: Voacanginine
Target: Cannabinoid Receptor, P-gp
Sinapine
T2S1200
Synonym:
Target: Antioxidant, P-gp, AChE
Pristinamycin IA
T12540
Synonym: Mikamycin IA,Mikamycin B
Target: Others, Antibiotic, P-gp
Solamargine
T4034
Synonym: Solamargin,δ-Solanigrine
Target: Apoptosis, p38 MAPK, P-gp, STAT
Sinapine thiocyanate
T3392
Synonym:
Target: P-gp, AChE
(20S)-Protopanaxadiol
T2799
Synonym: 20-Epiprotopanaxadiol,20(S)-APPD
Target: Apoptosis, Reactive Oxygen Species, P-gp
Convallatoxin
TN1525
Synonym:
Target: NF-κB, P-gp, PPAR
Hypophyllanthin
TN1757
Synonym:
Target: Potassium Channel, Calcium Channel, P-gp
Paris saponin VII
T4085
Synonym: Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII
Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy
Evodine
TCS2336
Synonym:
Target: P-gp
Schisandrol B
T6S1917
Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B
Target: P450, Reactive Oxygen Species, Autophagy
Lathyrol
T3S2019
Synonym:
Target: Others
1-Monopalmitin
TN2554
Synonym:
Target: P-gp
Taxol C
TN5118
Synonym:
Target: P-gp
Agnuside
T3868
Synonym: chasteberry oil
Target: COX, Prostaglandin Receptor, P-gp
Cyclosporin A
T0945
Synonym: Cyclosporine A,Ciclosporin,Cyclosporine
Target: Phosphatase, Antibiotic, Complement System
Alisol F 24-acetate
TMA2270
Synonym:
Target: P-gp
Taccalonolide B
TN2256
Synonym:
Target: Microtubule Associated
Linarin
T6S0653
Synonym: Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine
Target: TNF, AChE
Taccalonolide A
TN2254
Synonym:
Target: Apoptosis, Microtubule Associated
Dauricine
T6S0119
Synonym:
Target: Apoptosis, Others, NF-κB
Taxuspine X
TN5124
Synonym:
Target: P-gp
Dihydroevocarpine
TN1099
Synonym:
Target: MAO, P-gp, Antifection
Mutabilol
T75524
Synonym:
Target:
Taxinine
TN5114
Synonym:
Target: P-gp
Taxinine B
TN5113
Synonym:
Target: Others
Spongionellol A
T72802
Synonym:
Target:
Deoxynivalenol
T15097
Synonym: Vomitoxin,4-Deoxynivalenol
Target:
6',7'-Epoxybergamottin
T37810
Synonym:
Target:

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00257 PSGL-1/CD162 Protein, Human, Recombinant (hFc) Human Human Cells
PSGL-1 (CD162), is a mucintype glycoprotein that plays a key role in leukocyte adhesion. Human PSGL-1 cDNA encodes 412 amino acids (aa). It expressed on neutrophils, monocytes and most lymphocytes. The mature PSGL-1 (aa ...
TMPJ-01145 ABCB5 Protein, Human, Recombinant (Trx) Human E. coli
ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progen...
TMPY-03531 PSGL-1/CD162 Protein, Human, Recombinant (His) Human HEK293
P-selectin glycoprotein ligand-1 (PSGL-1), also known as SELPLG or CD162, is the high affinity ounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 is a mucin-type glycoprotein...
TMPY-05013 PSGL-1/CD162 Protein, Human, Recombinant (mFc) Human HEK293
P-selectin glycoprotein ligand-1 (PSGL-1), also known as SELPLG or CD162, is the high affinity ounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 is a mucin-type glycoprotein...
TMPY-03016 CD24 Protein, Mouse, Recombinant (hFc) Mouse HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-01730 CD24 Protein, Human, Recombinant (hFc) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-00979 HRG/HPRG Protein, Human, Recombinant (His) Human HEK293
Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. In humans, five distinct domains are recognized ...
TMPY-02353 PSGL-1/CD162 Protein, Mouse, Recombinant (hFc) Mouse HEK293
P-selectin glycoprotein ligand-1 (PSGL-1), also known as SELPLG or CD162, is the high affinity ounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 is a mucin-type glycoprotein...
TMPY-03354 PSGL-1/CD162 Protein, Mouse, Recombinant Mouse HEK293
P-selectin glycoprotein ligand-1 (PSGL-1), also known as SELPLG or CD162, is the high affinity ounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 is a mucin-type glycoprotein...
TMPY-00906 PSGL-1/CD162 Protein, Human, Recombinant (His & hFc) Human HEK293
P-selectin glycoprotein ligand-1 (PSGL-1), also known as SELPLG or CD162, is the high affinity ounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 is a mucin-type glycoprotein...
TMPJ-00612 PSGL-1/CD162 Protein, Mouse, Recombinant (aa 42-307, hFc) Mouse Human Cells
P-selectin glycoprotein ligand 1 is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. As such, it plays a critical role in the tethering of these cells to activat...
TMPK-00830 P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated Human HEK293
Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. A SLe(x)-type proteoglycan, which through high a...
TMPK-01033 PSGL-1/CD162 Protein, Mouse, Recombinant (His) Mouse HEK293
P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 als...
TMPK-00565 PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 als...
TMPJ-00382 P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated Mouse Human Cells
P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothel...
TMPY-03611 PMM2 Protein, Human, Recombinant (His) Human E. coli
Phosphomannomutase 2, also known as PMM2 and CDG1, belongs to the eukaryotic PMM family. Phosphomannomutase 2 catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate. Mannose 1-phosphate is a precursor ...
TMPY-03032 CD24 Protein, Rat, Recombinant (hFc) Rat HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05299 CD24 Protein, Human, Recombinant (mFc) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05298 CD24 Protein, Human, Recombinant (rFc) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-06940 CD24 Protein, Human, Recombinant (hFc & Avi), Biotinylated Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPH-02787 Muellerian-inhibiting factor/AMH Protein, Mouse, Recombinant (His) Mouse Yeast
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides includ...
TMPY-04788 HRG/HPRG Protein, Rat, Recombinant (His) Rat HEK293
Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. In humans, five distinct domains are recognized ...
TMPY-02050 DDOST Protein, Human, Recombinant Human E. coli
The enzyme oligosaccharyltransferase (dolichyl-diphosphooligosaccharide-protein glycosyltransferase) (DDOST), or 48-kDa subunit (OST48) is one of the catalytic subunits in this complex, exerts a typical type I membrane t...
PSGL-1/CD162 Protein, Human, Recombinant (hFc)
TMPJ-00257
Species: Human
Expression System: Human Cells
ABCB5 Protein, Human, Recombinant (Trx)
TMPJ-01145
Species: Human
Expression System: E. coli
PSGL-1/CD162 Protein, Human, Recombinant (His)
TMPY-03531
Species: Human
Expression System: HEK293
PSGL-1/CD162 Protein, Human, Recombinant (mFc)
TMPY-05013
Species: Human
Expression System: HEK293
CD24 Protein, Mouse, Recombinant (hFc)
TMPY-03016
Species: Mouse
Expression System: HEK293
CD24 Protein, Human, Recombinant (hFc)
TMPY-01730
Species: Human
Expression System: HEK293
HRG/HPRG Protein, Human, Recombinant (His)
TMPY-00979
Species: Human
Expression System: HEK293
PSGL-1/CD162 Protein, Mouse, Recombinant (hFc)
TMPY-02353
Species: Mouse
Expression System: HEK293
PSGL-1/CD162 Protein, Mouse, Recombinant
TMPY-03354
Species: Mouse
Expression System: HEK293
PSGL-1/CD162 Protein, Human, Recombinant (His & hFc)
TMPY-00906
Species: Human
Expression System: HEK293
PSGL-1/CD162 Protein, Mouse, Recombinant (aa 42-307, hFc)
TMPJ-00612
Species: Mouse
Expression System: Human Cells
P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated
TMPK-00830
Species: Human
Expression System: HEK293
PSGL-1/CD162 Protein, Mouse, Recombinant (His)
TMPK-01033
Species: Mouse
Expression System: HEK293
PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His)
TMPK-00565
Species: Cynomolgus
Expression System: HEK293
P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated
TMPJ-00382
Species: Mouse
Expression System: Human Cells
PMM2 Protein, Human, Recombinant (His)
TMPY-03611
Species: Human
Expression System: E. coli
CD24 Protein, Rat, Recombinant (hFc)
TMPY-03032
Species: Rat
Expression System: HEK293
CD24 Protein, Human, Recombinant (mFc)
TMPY-05299
Species: Human
Expression System: HEK293
CD24 Protein, Human, Recombinant (rFc)
TMPY-05298
Species: Human
Expression System: HEK293
CD24 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPY-06940
Species: Human
Expression System: HEK293
Muellerian-inhibiting factor/AMH Protein, Mouse, Recombinant (His)
TMPH-02787
Species: Mouse
Expression System: Yeast
HRG/HPRG Protein, Rat, Recombinant (His)
TMPY-04788
Species: Rat
Expression System: HEK293
DDOST Protein, Human, Recombinant
TMPY-02050
Species: Human
Expression System: E. coli
TargetMol