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Cat No. | Product Name | Synonyms | Targets |
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T11857 | LIT-001 | Oxytocin Receptor | |
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM. | |||
T11696 | Ivachtin | Caspase-3 Inhibitor VII | Caspase |
Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases. | |||
T16850 | SB-265610 | GSK-CXCR2 | CXCR |
SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and... | |||
T6288 | Mozavaptan | OPC31260l,OPC-31260 | Vasopressin Receptor |
Mozavaptan (OPC-31260) is a competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively. | |||
T12870 | SCH79797 dihydrochloride | Apoptosis , Others , Protease-activated Receptor | |
SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects. | |||
T3178 | BIBS 39 | RAAS | |
BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. | |||
T21790 | BMS 182874 hydrochloride | Endothelin Receptor | |
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist. | |||
T27762 | L-162,313 | L-162313,L 162,313,L162,313 | RAAS |
L-162,313 is an ANG II receptor agonist, a nonpeptide that mimics the biological actions of angiotensin II and induces an increase in MAP. | |||
T1520 | Aliskiren hemifumarate | CGP 60536,SPP 100,CGP60536B | RAAS , Autophagy |
Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity. | |||
T3347 | PF3274167 | PF 3274167,Cligosiban,PF-3274167 | OX Receptor |
PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. | |||
T39229 | YNT-185 | OX Receptor | |
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of ... | |||
T6281 | TW-37 | TW 37 | BCL |
TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM). | |||
T26594 | Allisartan Isoproxil | RAAS | |
Allisartan Isoproxil is a nonpeptide antagonist of angiotensin II receptor and can be used in studies about hypertension and heart diseases. | |||
T25615 | Lanepitant | LY303870,LY-303870,LY 303870 | Others |
Lanepitant (LY303870) is a nonpeptide neurokinin-1 (NK-1) antagonist with analgesic activity that inhibits neurogenic dura mater inflammation and is used for the prevention of migraine. | |||
T9692 | Paltusotine | Somatostatin | |
Paltusotine is a nonpeptide, small molecule somatostatin type 2 (SST2) receptor agonist with high oral bioavailability. Paltusotine maintains GH and IGF-1 levels in acromegaly patients | |||
TQ0057 | AVE 0991 | Others | |
AVE 0991, a nonpeptide analog of angiotensin-(1-7) [Ang-(1-7)], is an orally active Mas agonist with inhibitory effects on [125I]-Ang-(1-7) binding to bovine aortic endothelial cell membranes, and inhibits astrocyte-medi... | |||
T11174 | (R)-Elagolix | NBI-56418 | GNRH Receptor |
(R)-Elagolix (NBI-56418) is a short-acting, nonpeptide, GnRH antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively. administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a do... | |||
T8691 | PD 168368 | PD168368 | Bombesin Receptor |
PD 168368 is a novel, potent, competitive and selective nonpeptide neuromodulin B receptor (NMB-R) antagonist with inhibitory effects on the gastrin-releasing peptide receptor (GRPR).PD 168368 is a potent mixed agonist o... | |||
T6825 | Eltrombopag Olamine | Promacta Olamine,Revolade,Eltrombopag diethanolamine salt,SB497115,SB-497115GR | Thrombin |
Eltrombopag Olamine (Eltrombopag diethanolamine salt) is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrom... | |||
T2531L | Eprosartan | KF-108566J free base,Teveten | RAAS |
Eprosartan (SKF-108566J free base) is a selective and competitive nonpeptide angiotensin II receptor antagonist with high affinity for AT1 receptor subtypes and can be used as an antihypertensive agent.Eprosartan has an ... | |||
T28814 | SM19712 free acid | SM 19712,SM-19712,SM19712 | |
SM19712 is an inhibitor of nonpeptide endothelin converting enzyme. | |||
T70136 | CAM 4750 | ||
CAM 4750 is a nonpeptide tachykinin NK1 receptor antagonist. | |||
T28813 | SM19712 sodium | SM 19712,SM19712,SM-19712 | |
SM19712 sodium is an inhibitor of nonpeptide endothelin converting enzyme. | |||
T12331 | OT-R antagonist 2 | Oxytocin receptor antagonist 2 | Others |
OT-R antagonist 2 is a nonpeptide low molecular weight antagonist of OT-R . | |||
T28322 | PD 123177 | PD-123177,PD123177,Exp-655,Exp655,Exp 655 | |
PD 123177 is an inhibitor of Nonpeptide angiotensin AII-2. | |||
T70272 | L-162782 | ||
L-162782 is a nonpeptide agonist of angiotensin AT1 receptor. | |||
T68486 | Fasitibant | ||
Fasitibant is a potent and selective nonpeptide kinin B2 receptor antagonist. | |||
T69097 | ARD-353 | ||
ARD-353 is a nonpeptide delta receptor agonist with cardioprotective effects. | |||
T29234 | ZM 253270 | ZM253270,ZM-253270 | |
ZM 253270 is an nonpeptide neurokinin A antagonist. | |||
T27940 | LY301875 | LY 301875,LY-301875 | |
LY301875 is an antagonist of nonpeptide angiotensin receptor. | |||
T16085 | MK-0429 | L-000845704 | Others |
MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM). | |||
T70137 | CAM 4515 | ||
CAM 4515 is a nonpeptide tachykinin NK1 receptor antagonist. | |||
T25895 | NVP-SAA164 | SAA 164,SAA164,SAA-164,NVP SAA164 | |
NVP-SAA164 is a nonpeptide bradykinin B1 receptor antagonist agent. | |||
T16935 | SR 146131 | Others | |
SR 146131 is a potent and selective agonist of the nonpeptide receptor. | |||
T25608 | Lamifiban trifluoroacetate | Lamifiban trifluoroacetate salt | |
Lamifiban trifluoroacetate is an antagonist of the nonpeptide platelet fibrinogen receptor (GPIIb/IIIa). | |||
T29177 | YM 218 | YM218,YM-218 | |
YM 218 is a novel, potent, selective antagonist of nonpeptide vasopressin V1A receptor. | |||
T70295 | MDL-105212A HCl | ||
MDL-105212A HCl is a nonpeptide NK-1 and NK-2 receptor antagonist. | |||
T25607 | Lamifiban | Ro-44-9883/000,Ro 44-9883/000,Ro44-9883/000 | |
Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass. | |||
T70225 | L-159884 | ||
L-159884 is a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging | |||
T70658 | Ici D8731 | ||
Ici D8731 is a nonpeptide angiotensin II antagonist with potential as a treatment for hypertension and heart failure. | |||
T26802 | BIBS-222 | BIBS 222 | |
BIBS-222, a nonpeptide angiotensin II (Ang II) receptor antagonist, appears to be an effective antihypertensive in the model of the renal hypertensive rat. | |||
T16895 | SL910102 | Others | |
SL910102 is a nonpeptide angiotensin antagonist of the AT1 receptor. | |||
T70410 | Cam 2445 | ||
Cam 2445 is a nonpeptide, alpha-methyltryptophan derivative; an NK1 neurokinin receptor antagonist that is a potentially useful treatment for arthritis, asthma, migraine, anxiety, psychosis, and emesis. | |||
T12331L | OT-R antagonist 1 | Oxytocin receptor antagonist 1 | Others |
OT-R antagonist 1 inhibits oxytocin-evoked intracellular Ca2+ mobilization (IC50 = 8 nM). OT-R antagonist 1 is a new effective and selective nonpeptide low molecular weight OT-R antagonist. | |||
T11862 | LMD-009 | Others | |
LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM. LMD-009 is a selective CCR8 nonpeptide agonist. | |||
T15680 | L-159282 | MK 996 | Others |
L-159282 is an orally active and nonpeptide angiotensin II receptor antagonist. It also has anti-hypertensive activity. | |||
T61079 | RXFP3 agonist 1 | ||
RXFP3 agonist 1 is a nonpeptide RXFP3 agonist ( EC 50 =6937 nM) [1]. | |||
T15101 | Devazepide | L-364,718,MK-329 | Others |
Devazepide is a competitive and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor (IC50s: 81 pM, 45 pM, and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respective... | |||
T36481 | BIIE 0246 hydrochloride | ||
Potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays > 650-fold selectivity for NPY Y2 over Y1, Y4 and Y5 receptors. Active in vivo. | |||
T29151 | WAY267464 HCl | WAY267464,WAY-267464,WAY 267,464 dihydrochloride,WAY-267,464 dihydrochloride,WAY 267464 dihydrochloride,WAY 267464 | |
WAY267464 is a nonpeptide small-molecule OT agonists with anxiolytic activity. WAY267464 may be used for modulation of potency, selectivity over the structurally similar vasopressin receptors, CNS penetration, and oral b... |
Cat No. | Product Name | Synonyms | Targets |
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T4954L | Smilagenin | PYM50028,Cogane,AI3-44895,PYM 50028 | |
Smilagenin is an orally active inducer of nonpeptide neurotrophic factor. It also prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons, and by MPTP in a mouse model of Parkinson's disease. |