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Search Result

Search Results for " nmdar "

Targets

NMDAR Others iGluR

45

Compounds

8

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T5522 NMDAR antagonist 1 Others , iGluR
NMDAR antagonist 1 is an orally active, NR2B-selective NMDAR antagonist.
T72662 NMDAR/TRPM4-IN-2 ERK , TRP/TRPV Channel , NMDAR , iGluR
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprot...
T61451 NMDAR/HDAC-IN-1
NMDAR/HDAC-IN-1 (Compound 9d) is a potent dual inhibitor of N-methyl-D-aspartate receptors (NMDARs) and histone deacetylases (HDACs). It exhibits a high affinity (Ki = 0.59 μM) for NMDARs, while demonstrating significant...
T62126 (Rac)-NMDAR antagonist 1
(Rac)-NMDAR antagonist 1 is a racemate of NMDAR antagonist 1. NMDAR antagonist 1 is a potent, orally active, NR2B-selective NMDAR antagonist.
T74854 GluN2B-NMDAR antagonist-1
GluN2B-NMDAR Antagonist-1, an orally active compound, functions as a GluN2B-NMDAR antagonist with neuroprotective properties. It is applicable in the research of ischemic injury [1].
T7870 TCN 201 TCN-201 NMDAR , iGluR
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T2556 Nandrolone decanoate 19-Nortestosterone decanoate Others , HIV Protease
Nandrolone decanoate (19-Nortestosterone decanoate) is the decanoate salt form of nandrolone, an anabolic steroid analog of testosterone with androgenic, anabolic, and erythropoietin stimulating effects. Nandrolone enter...
T6504 Flupirtine maleate Katadolon maleate Potassium Channel , NMDAR , iGluR
Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel opener.
T0556 6-Methoxy-2-naphthoic acid Naproxen impurity O,6-Methoxy-2-naphthalenecarboxylic acid NMDAR , iGluR
6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) is an modulator of NMDAR.
T8450 TCN 213 TCN213 NMDAR
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
T13112L1 Tat-NR2B9c acetate Tat-NR2B9c acetate (500992-11-0 Free base),NA-1 acetate Others
Tat-NR2B9c acetate (NA-1 acetate) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c acetate disrupts the PSD-...
T7355 IC87201 Others , iGluR
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.
T10781 CGP 78608 hydrochloride PAMQX NMDAR , iGluR
CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1/GluN3A-...
T4171 PEAQX NVP-AAM077 NMDAR , iGluR
PEAQX (NVP-AAM077)(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 nM).
T22798 Gavestinel GV 150526,Gavestinel sodium salt NMDAR , iGluR
Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally active.Gavestinel binds to the glycine site of the NMDA receptor with a binding affinity (pKi value) of 8.5.Gavest...
TQ0233 Traxoprodil CP101606 NMDAR , iGluR
Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
T3320 Dizocilpine Maleate (+)-Mk-801 Hydrogen Maleate,MK 801,Dizocilpine hydrogen maleate,(+)-MK 801 maleate,(+)-MK 801 (Maleate) NMDAR , iGluR
Dizocilpine Maleate (MK 801) is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has been considered for the wide variety of ne...
T1946 Felbamate W-554,ADD-03055 NMDAR , iGluR
Felbamate (W-554) is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T16451 PEAQX tetrasodium hydrate NVP-AAM077 tetrasodium hydrate,PEAQX tetrasodium hydrate (459836-30-7 free base),PEAQX tetrasodium hydrate Apoptosis , NMDAR , iGluR
PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base) again...
T1308 Orphenadrine hydrochloride Mebedrol,Mephenamin Sodium Channel , NMDAR , Norepinephrine , iGluR , Histamine Receptor
Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T15408 GNE 5729 Others
GNE 5729 is an NMDAR of brain permeable positive allosteric modulator (EC50: 37 nM for GluN2A; 4.7 and 9.5 μM for GluN2C and GluN2D, respectively).
T3407 Rapastinel GLYX-13,Thr-Pro-Pro-Thr-NH2,TPPT-amide NMDAR , iGluR
Rapastinel (TPPT-amide) (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.
T62376 GNE-9278
GNE-9278 is a highly selective NMDAR orthosteric modulator that acts on the GluN1 transmembrane structural domain (TMD).GNE-9278 acts on activated NMDAR and increases peak current and agonist affinity.
T82296 GluN1(359-378)
GluN1 (359-378) is an antibody targeting the N-methyl-D-aspartate receptor (NMDAR) capable of crossing the blood-brain barrier and is utilized in researching therapies for anti-NMDAR encephalitis that focus on the immune...
T12733 Rislenemdaz CERC-301,MK-0657 iGluR
Rislenemdaz (CERC-301) (CERC-301) is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B).
T24917 UBP684 UBP-684,UBP 684
UBP684 is an NMDAR pan-PAM. UBP684 increases the maximal l-glutamate/glycine response while having minor subunit-specific effects on agonist potency. It robustly potentiates responses at all GluN1/GluN2 subtypes and at n...
T82297 GluN1(356-385)
GluN1 (356-385) is an antigenic peptide implicated in N-methyl-D-aspartate receptor (NMDAR) encephalitis and has been shown to decrease the density of NMDAR surface clusters in hippocampal neurons. It serves as a tool to...
T15407 GNE-0723 Others
GNE 0723 is an NMDAR brain permeable positive allosteric modulator (EC50: 21 nM for GluN2A; 7.4 and 6.2 μM for GluN2C and GluN2D, respectively).
T79611 DQP-26 iGluR
DQP-26, a potent negative allosteric modulator of NMDA receptors (NMDARs), exhibits IC50 values of 0.77 μM for GluN2C and 0.44 μM for GluN2D subunits, indicating potential application in research on NMDAR-associated neur...
T76078 Neurogranin (48-76), mouse
Neurogranin (48-76), mouse, is a peptide comprising residues 48-76 of Neurogranin, a post-synaptically exclusive calmodulin-binding protein that mediates NMDAR-driven synaptic plasticity by regulating the calcium-calmodu...
T24919 UBP714 UBP 714,UBP-714
UBP714 is a derivative of the NMDA receptor negative allosteric modulator UBP608. It also enhanced NMDAR mediated field EPSPs in the CA1 region of the hippocampus. UBP714 is a novel template for the development of potent...
T60306 NMDA receptor antagonist 4
NMDA receptor antagonist 4 (IIc) is an uncompetitive, voltage-dependent, orally active NMDAR blocker, with an IC 50 of 1.93 μM. NMDA receptor antagonist 4 shows a positive predicted blood-brain-barrier (BBB) permeability...
T8435 YM90K YM90K hydrochloride,6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)- GluR , iGluR
YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.
T73491 TP-050
TP-050 is a potent, selective NMDAR agonist that is orally active, showing EC50 values of 0.51 µM for GluN2A and 9.6 µM for GluN2D. This compound can cross the blood-brain barrier (BBB), enhancing hippocampal long-term (...
TP1023 NT 13 TPPT
NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.
T73359 NYX-2925
NYX-2925, an orally active NMDAR (N-methyl-D-aspartate receptor) modulator, enhances activated Src levels and Src phosphorylation at GluN2A and GluN2B sites in the mPFC (medial prefrontal cortex), without affecting CAMKI...
T82528 DQP-997-74
Dihydroquinoline-pyrazoline DQP-997-74 (compound 2i) is a selective N-methyl-d-aspartate receptor (NMDAR) inhibitor that preferentially targets GluN2C/D subunits, with IC50 values of 0.069 μM and 0.035 μM, respectively, ...
T76250 VSGLNPSLWSIFGLQFILLWLVSGSRHYLW
VSGLNPSLWSIFGLQFILLWLVSGSRHYLW, a 30-amino-acid peptide, mirrors the C-terminal domain of α2δ-1 and is recognized as the α2δ-1Tat peptide. It disrupts the α2δ-1 - NMDAR interaction both in vitro and in vivo, offering a p...
T76250L VSGLNPSLWSIFGLQFILLWLVSGSRHYLW TFA
VSGLNPSLWSIFGLQFILLWLVSGSRHYLW (TFA), a 30-amino-acid peptide, mimics the C-terminal domain of α2δ-1, known as α2δ-1Tat peptide. This compound disrupts the α2δ-1 - NMDAR interaction both in vitro and in vivo, demonstrati...
T80210 TAT-GluN2BCTM DAPK
TAT-GluN2BCTM is a membrane-permeable peptide that selectively targets active DAPK1 (Death-associated protein kinase 1) for lysosomal degradation, thereby protecting neurons against oxidative stress and NMDAR-mediated ex...
T35924 Tat-NR2Baa Tat-NR2Baa
Tat-NR2BAA is an inactive control peptide of Tat-NR2B9c. It shares a similar sequence with Tat-NR2B9c, but possesses a double-point mutation in the COOH terminal tSXV motif. This mutation renders Tat-NR2BAA unable to bin...
T0802 Procaine hydrochloride Novocaine HCl,Procaine HCl Histone Demethylase , 5-HT Receptor , DNA/RNA Synthesis , Sodium Channel , NMDAR , AChR
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannel...
T76069 Tat-NR2Baa TFA
Tat-NR2BAA TFA serves as the inactive control peptide for Tat-NR2B9c, featuring a comparable sequence with a crucial distinction: a double-point mutation in its COOH-terminal tSXV motif. This alteration renders Tat-NR2BA...
T23231 Remacemide hydrochloride Others
Remacemide hydrochloride is a NMDA receptor antagonist.
T22435 Tacrine hydrochloride Tacrine HCl Others
Tacrine is a indirect cholinergic agonist and centrally acting anticholinesterase. Tacrine hydrochloride hydrate is an inhibitor of acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respecti...

Compounds

NMDAR antagonist 1
T5522
Synonym:
Target: Others, iGluR
NMDAR/TRPM4-IN-2
T72662
Synonym:
Target: ERK, TRP/TRPV Channel, NMDAR, iGluR
NMDAR/HDAC-IN-1
T61451
Synonym:
Target:
(Rac)-NMDAR antagonist 1
T62126
Synonym:
Target:
GluN2B-NMDAR antagonist-1
T74854
Synonym:
Target:
TCN 201
T7870
Synonym: TCN-201
Target: NMDAR, iGluR
Nandrolone decanoate
T2556
Synonym: 19-Nortestosterone decanoate
Target: Others, HIV Protease
Flupirtine maleate
T6504
Synonym: Katadolon maleate
Target: Potassium Channel, NMDAR, iGluR
6-Methoxy-2-naphthoic acid
T0556
Synonym: Naproxen impurity O,6-Methoxy-2-naphthalenecarboxylic acid
Target: NMDAR, iGluR
TCN 213
T8450
Synonym: TCN213
Target: NMDAR
Tat-NR2B9c acetate
T13112L1
Synonym: Tat-NR2B9c acetate (500992-11-0 Free base),NA-1 acetate
Target: Others
IC87201
T7355
Synonym:
Target: Others, iGluR
CGP 78608 hydrochloride
T10781
Synonym: PAMQX
Target: NMDAR, iGluR
PEAQX
T4171
Synonym: NVP-AAM077
Target: NMDAR, iGluR
Gavestinel
T22798
Synonym: GV 150526,Gavestinel sodium salt
Target: NMDAR, iGluR
Traxoprodil
TQ0233
Synonym: CP101606
Target: NMDAR, iGluR
Dizocilpine Maleate
T3320
Synonym: (+)-Mk-801 Hydrogen Maleate,MK 801,Dizocilpine hydrogen maleate,(+)-MK 801 maleate,(+)-MK 801 (Maleate)
Target: NMDAR, iGluR
Felbamate
T1946
Synonym: W-554,ADD-03055
Target: NMDAR, iGluR
PEAQX tetrasodium hydrate
T16451
Synonym: NVP-AAM077 tetrasodium hydrate,PEAQX tetrasodium hydrate (459836-30-7 free base),PEAQX tetrasodium hydrate
Target: Apoptosis, NMDAR, iGluR
Orphenadrine hydrochloride
T1308
Synonym: Mebedrol,Mephenamin
Target: Sodium Channel, NMDAR, Norepinephrine, iGluR, Histamine Receptor
GNE 5729
T15408
Synonym:
Target: Others
Rapastinel
T3407
Synonym: GLYX-13,Thr-Pro-Pro-Thr-NH2,TPPT-amide
Target: NMDAR, iGluR
GNE-9278
T62376
Synonym:
Target:
GluN1(359-378)
T82296
Synonym:
Target:
Rislenemdaz
T12733
Synonym: CERC-301,MK-0657
Target: iGluR
UBP684
T24917
Synonym: UBP-684,UBP 684
Target:
GluN1(356-385)
T82297
Synonym:
Target:
GNE-0723
T15407
Synonym:
Target: Others
DQP-26
T79611
Synonym:
Target: iGluR
Neurogranin (48-76), mouse
T76078
Synonym:
Target:
UBP714
T24919
Synonym: UBP 714,UBP-714
Target:
NMDA receptor antagonist 4
T60306
Synonym:
Target:
YM90K
T8435
Synonym: YM90K hydrochloride,6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-
Target: GluR, iGluR
TP-050
T73491
Synonym:
Target:
NT 13
TP1023
Synonym: TPPT
Target:
NYX-2925
T73359
Synonym:
Target:
DQP-997-74
T82528
Synonym:
Target:
VSGLNPSLWSIFGLQFILLWLVSGSRHYLW
T76250
Synonym:
Target:
VSGLNPSLWSIFGLQFILLWLVSGSRHYLW TFA
T76250L
Synonym:
Target:
TAT-GluN2BCTM
T80210
Synonym:
Target: DAPK
Tat-NR2Baa
T35924
Synonym: Tat-NR2Baa
Target:
Procaine hydrochloride
T0802
Synonym: Novocaine HCl,Procaine HCl
Target: Histone Demethylase, 5-HT Receptor, DNA/RNA Synthesis, Sodium Channel, NMDAR, AChR
Tat-NR2Baa TFA
T76069
Synonym:
Target:
Remacemide hydrochloride
T23231
Synonym:
Target: Others
Tacrine hydrochloride
T22435
Synonym: Tacrine HCl
Target: Others
Cat No. Product Name Synonyms Targets
T6975 Sarcosine Sarcosinic acid,Methylaminoacetic acid,Sarcosin,Methylglycine,N-Methylaminoacetic acid,N-methylglycine Others , GlyT , Endogenous Metabolite
Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
T8394 D-Serine (R)-Serine Endogenous Metabolite , NMDAR , iGluR
D-Serine ((R)-Serine) is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
T3826 Polygalasaponin F NF-κB , TLR , Akt , PI3K
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...
T1186 Ifenprodil Tartrate Potassium Channel , NMDAR , iGluR
Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
T4752 1-Aminocyclopropane-1-carboxylic acid 1-Aminocyclopropanecarboxylic acid,1-Amino-1-carboxycyclopropane,ACC Endogenous Metabolite , NMDAR
1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecul...
T75571 Withaphysalin D
Withaphysalin D, isolated from water lilies, is a selective antagonist for the N-methyl-D-aspartate receptor (NMDAR) containing GluN2B with neuroprotective properties. This compound is capable of crossing the blood-brain...
T79959 6-Hydroxykynurenic acid 6-HKA iGluR
6-Hydroxykynurenic acid (6-HKA), a kynurenic acid (KYNA) derivative isolated from Ginkgo leaves, functions as a low-affinity NMDAR antagonist with an IC50 of 59 μM [1].
T0051 Urethane Ethyl carbamate,Ethylurethane,Carbamic acid ethyl ester Chloride channel , GABA Receptor , Antibacterial , GluR , NMDAR , AChR , Parasite
Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes.

Natural Products

Sarcosine
T6975
Synonym: Sarcosinic acid,Methylaminoacetic acid,Sarcosin,Methylglycine,N-Methylaminoacetic acid,N-methylglycine
Target: Others, GlyT, Endogenous Metabolite
D-Serine
T8394
Synonym: (R)-Serine
Target: Endogenous Metabolite, NMDAR, iGluR
Polygalasaponin F
T3826
Synonym:
Target: NF-κB, TLR, Akt, PI3K
Ifenprodil Tartrate
T1186
Synonym:
Target: Potassium Channel, NMDAR, iGluR
1-Aminocyclopropane-1-carboxylic acid
T4752
Synonym: 1-Aminocyclopropanecarboxylic acid,1-Amino-1-carboxycyclopropane,ACC
Target: Endogenous Metabolite, NMDAR
Withaphysalin D
T75571
Synonym:
Target:
6-Hydroxykynurenic acid
T79959
Synonym: 6-HKA
Target: iGluR
Urethane
T0051
Synonym: Ethyl carbamate,Ethylurethane,Carbamic acid ethyl ester
Target: Chloride channel, GABA Receptor, Antibacterial, GluR, NMDAR, AChR, Parasite

Recombinant Proteins

Species：
Human (2)
Mouse (1)
Expression System：
HEK293 (3)
Tag：
His (3)
Cat No. Product Name Species Expression System
TMPY-01692 NETO1 Protein, Human, Recombinant (His) Human HEK293
Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDAR...
TMPY-01726 Neuroligin-1 Protein, Human, Recombinant (His) Human HEK293
Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction...
TMPY-02750 Neuroligin-1 Protein, Mouse, Recombinant (His) Mouse HEK293
Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction...
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