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Search Results for " nampt "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T67925	Nampt activator-1		NAMPT
	NAMPT Activator-1 (compound 1) is an effective and specific activator of niacinamide phosphotransferase (Compound 1) with a wide range of EC50 (3.3-3.7 μM). NAMPT activator-1 effectively protects cultured cells from FK86...		NAMPT
T12171	Nampt-IN-5		P450 , NAMPT
	Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .		P450 , NAMPT
T4376	Nampt-IN-1	LSN3154567	c-Fms , NAMPT , CSF-1R
	Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.		c-Fms , NAMPT , CSF-1R
T72617	Nampt activator-2		P450 , NAMPT
	Nampt activator-2 is a NAMPT activator (EC50: 0.023 μM). Nampt activator-2 has an affinity for CYP2C9, 2D6, and 2C19 with affinity values of 0.060 μM, 0.41 μM, and 0.59 μM, respectively.Nampt activator-2 can be used in t...		P450 , NAMPT
T18477	NAMPT inhibitor-linker 1		Others
	NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong ef...		Others
T13792	Nampt-IN-3		Others
	Nampt-IN-3 simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC (IC50s of 31 nM and 55 nM, respectively).		Others
T18478	NAMPT inhibitor-linker 2		Others
	NAMPT inhibitor-linker 2, a drug-linker conjugate for antibody-drug conjugates (ADCs), comprises an NAMPT inhibitor payload and a linker. When combined with an anti-c-Kit monoclonal antibody to form ADC-4, it demonstrate...		Others
T72623	Nampt activator-3
	NAMPT Activator-3, a derivative of NAT, is a potent activator of NAMPT, demonstrating an EC50 of 2.6 μM and KD of 132 nM. It effectively shields cultured cells against toxicity induced by FK866 and has demonstrated signi...
T64057	Nampt-IN-8
	Nampt-IN-8 is a NAMPT inhibitor (IC50: 0.183 μM) and a good substrate for NQO1. Nampt-IN-8 induces reactive oxygen species (ROS) production and apoptosis.
T62748	Nampt-IN-9
	Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.
T61597	Nampt-IN-7
	Nampt-IN-7, also known as compound GF8, is a powerful NAMPT inhibitor exhibiting an IC50 value of 7.31 μM. It possesses significant cytotoxic effects against the human HepG2 hepatocellular carcinoma cell line, with an IC...
T75023	Nampt degrader-2
	Nampt degrader-2, a fluorescent PROTAC, exhibits efficient degradation of NAMPT at an IC50 of 41.9 nM. It operates by binding to both NAMPT and VHL, initiating the formation of a ternary complex that triggers NAMPT degra...
T74615	NAMPT degrader-1
	NAMPT Degrader-1 (Compound A3), a nicotinamide phosphoribosyltransferase (NAMPT) degrader, exhibits potent antitumor activity in cells by specifically inducing the degradation of NAMPT via the autophagy-lysosomal pathway...
T79437	NAMPT degrader-3		NAMPT
	NAMPT Degrader-3 (compound C5) is a NAMPT degrader that functions through a VHL- and proteasome-dependent mechanism. It exhibits cytotoxic properties and inhibits the proliferation of A2780 cells [1].		NAMPT
T74562	Nampt-IN-10 trihydrochloride
	Nampt-IN-10 trihydrochloride (Compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor exhibiting cellular potency against A2780 and CORL23 cell lines, with IC50 values of 5 nM and 19 nM, respectively. I...
T64273	Nampt-IN-10 TFA
	Nampt-IN-10 TFA (compound 4) is a phosphoribosyltransferase (NAMPT) inhibitor with cellular efficacy against A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM). The Nampt-IN-10 TFA can be used as a non-antimitotic payload for A...
T4335	GNE-617	GNE617	NAMPT
	GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.		NAMPT
T6682	STF-118804	STF 118804,STF118804	Apoptosis , NAMPT
	STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.		Apoptosis , NAMPT
T1998	CHS-828	CHS 828,GMX1778	Apoptosis , NAMPT
	CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).		Apoptosis , NAMPT
T12854	SBI-797812		NAMPT
	SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).		NAMPT
T2644	(E)-Daporinad	Daporinad,(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE,APO866,FK866	NAMPT , Transferase , Autophagy
	(E)-Daporinad (FK866) is a small molecule inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase), with potential antineoplastic and antiangiogenic activities.		NAMPT , Transferase , Autophagy
T4354	KPT9274	KPT-9274,KPT 9274,PAK4-IN-1	NAMPT , PAK
	KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.		NAMPT , PAK
T11823	LB-60-OF61		NAMPT
	LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.		NAMPT
T26254	Teglarinad chloride	GMX 1777 chloride,EB1627,GMX1777,GMX1777 chloride,GMX 1777,GMX-1777 chloride,EB-1627,EB-1627 chloride,EB1627 chloride	NAMPT
	Teglarinad chloride (GMX-1777 chloride) is a potent inhibitor of NAMPT, the precursor of GMX1778.Teglarinad chloride has antitumor activity and acts by interfering with DNA repair and inhibiting angiogenesis.		NAMPT
T12330	OT-82		NAMPT
	OT-82 is a potent, selective and orally active NAMPT inhibitor.		NAMPT
T62938	GNE-617 hydrochloride
	GNE-617 hydrochloride is a specific inhibitor of NAMPT and inhibits NAMPT activity (IC50: 5 nM).
T70833	A-1293201
	A-1293201 is a potent and selective NAMPT inhibitor.
T14882	CB30865	ZM 242421	Others
	CB30865 is a potent inhibitor of Nampt, an enzyme present in the NAD biosynthetic pathway.		Others
T22804	GPP 78 hydrochloride (1202580-59-3 free base)	GPP 78 hydrochloride	Others
	NAMPT inhibitor		Others
T60667	NAT
	NAT, an initial NAMPT activator, targets NAMPT, a crucial enzyme in the NAD salvage pathway and a key focal point for researching a variety of diseases linked to NAD depletion, including neurodegenerative diseases[1].
T15412	GPP78	CAY10618	Autophagy
	GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-...		Autophagy
T40855	LB-60-OF61 hydrochloride	LB-60-OF61 hydrochloride
	LB-60-OF61 hydrochloride is a highly effective inhibitor of NAMPT, a key enzyme involved in the transfer of nicotinamide phosphoribosyl groups. This compound, known for its cytotoxic properties, specifically targets cell...
T37578	GPP 78 hydrochloride
	GPP 78 hydrochloride is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt) with an IC50 of 3 nM for NAD depletion. GPP 78 hydrochloride is toxic to neuroblastoma cells SH-SY5Y via induction of autophagy...
T36874	7-Bromoheptanoic Acid
	7-Bromoheptanoic acid is a building block.1,2It has been used in the synthesis of azide-based nicotinamide phosphoribosyltransferase (Nampt) inhibitors with anticancer activity and SAHA derivatives that inhibit histone d...
T71361	CHS-828 nicotinate
	CHS-828 nicotinate is a CHS-828 salt with Nicotinic acid.. CHS-828 also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting ...
T15403	GNE-618		NAMPT
	GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM). GNE-618 depletes NAD levels and induces tumor cell death. It has anti-tumor activity.		NAMPT

Compounds

Target: P450, NAMPT

Nampt-IN-1

T4376

Synonym: LSN3154567

Target: c-Fms, NAMPT, CSF-1R

Nampt activator-2

T72617

Synonym:

Target: P450, NAMPT

NAMPT inhibitor-linker 1

NAMPT inhibitor-linker 2

Nampt-IN-10 trihydrochloride

Synonym: STF 118804,STF118804

Target: Apoptosis, NAMPT

CHS-828

T1998

Synonym: CHS 828,GMX1778

Target: Apoptosis, NAMPT

Synonym: Daporinad,(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE,APO866,FK866

Target: NAMPT, Transferase, Autophagy

KPT9274

T4354

Synonym: KPT-9274,KPT 9274,PAK4-IN-1

Synonym: GMX 1777 chloride,EB1627,GMX1777,GMX1777 chloride,GMX 1777,GMX-1777 chloride,EB-1627,EB-1627 chloride,EB1627 chloride

GNE-617 hydrochloride

GPP 78 hydrochloride (1202580-59-3 free base)

T22804

Synonym: GPP 78 hydrochloride

LB-60-OF61 hydrochloride

T40855

Synonym: LB-60-OF61 hydrochloride

7-Bromoheptanoic Acid

Cat No.	Product Name	Synonyms	Targets
T4721	β-Nicotinamide mononucleotide	β-NM	Others , Endogenous Metabolite
	β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD...		Others , Endogenous Metabolite

Natural Products

β-Nicotinamide mononucleotide

T4721

Synonym: β-NM

Target: Others, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00968	NAMPT Protein, Human, Recombinant (His)	Human	E. coli
	Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular e...
TMPH-03760	NAMPT Protein, Mouse, Recombinant	Mouse	E. coli
	The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low lev...
TMPH-02810	NAMPT Protein, Mouse, Recombinant (His)	Mouse	Yeast
	The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low lev...
TMPY-02577	NAMPT Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B-cell colony-enhancing factor 1 (PBEF1) or visfatin, is an enzyme belonging to the family of glycosyltransferases, to be specific, the pentosyltransferas...
TMPH-03761	NAMPT Protein, Mouse, Recombinant (HA & His)	Mouse	E. coli
	The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low lev...