Search Result

Search Results for " myd88 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T77353	MyD88-IN-1		IL Receptor , NF-κB , TLR , MyD88
	MyD88-IN-1 is a potent MyD88 inhibitor MyD88-IN-1 has anti-inflammatory activity and inhibits downstream inflammatory signaling pathways, including the NF-κB pathway, of members of the Toll-like receptor (TLR) and interl...		IL Receptor , NF-κB , TLR , MyD88
T9765	TJ-M2010-5		MyD88
	TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain to interfere with its homodimerization and suppress MyD88 signaling. TJ-M2010-5 can be used in myocardial ischemia/reperfusion injury studies.		MyD88
T13932	TLR1		Others , MyD88
	TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.		Others , MyD88
T9203	JH-X-119-01		IRAK
	JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.		IRAK
T9027	CA-4948	Emavusertib	IRAK , FLT
	CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.		IRAK , FLT
TQ0181	Resatorvid	CLI-095,TAK-242	TNF , TLR , Autophagy , Interleukin
	Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid binds directly to Cys747 and prevents TLR4 from binding to TIRAP, thereby blocking downstream signaling. Resatorvid has antitumor a...		TNF , TLR , Autophagy , Interleukin
T13063	T6167923		MyD88
	T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6...		MyD88
T27034	CL075	3M002,CL-075	NF-κB , TLR , MyD88
	CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to elicit the production of inflammatory cytokines and type I i...		NF-κB , TLR , MyD88
T41142	EM 163		IL Receptor , p38 MAPK , MyD88
	EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interacti...		IL Receptor , p38 MAPK , MyD88
T69722	TSI-13-48
	TSI-13-48 is a MyD88 inhibitor.
T69719	TSI-13-57
	TSI-13-57 is a MyD88 inhibitor.
T68261	T5996207
	T5996207 is a inhibitor of MyD88-dependent signaling pathways
T75223	RDR 02308
	RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase [1] .
T69733	LM9
	LM9 is a MyD88 inhibitor which prevents atherosclerosis by regulating inflammatory responses and oxidative stress in macrophages.
T16937	ST 2825		Others
	ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 inhibition of IL-1β-mediated activation of NF-κB transcriptional activity.		Others
T61734	IRAK4-IN-9
	IRAK4-IN-9 (compound 73) is a highly potent inhibitor of IRAK4, displaying an impressive IC50 value of 1.5 nM. By blocking MyD88-dependent signaling, IRAK4-IN-9 exhibits promising potential for the investigation of infla...
T11674	IRAK4-IN-6		Others
	IRAK4-IN-6 is a selective and orally efficacious inhibitor of IRAK4, demonstrating an IC50 value of 4 nM. This compound specifically targets MyD88 L265P mutant diffuse large B-cell lymphoma [1].		Others
T61931	IRAK4-IN-10
	IRAK4-IN-10 (compound 75) is an effective IRAK4 inhibitor (IC50 is 1.5 nM), which can block the MyD88-dependent signal pathway. IRAK4-IN-10 has research potential in inflammatory diseases, autoimmune diseases and cancer.
T63262	IRAK4-IN-15
	IRAK4-IN-15 is a selective and potent IRAK4 inhibitor (IC50: 0.002 μM) with good human PK prediction and low intrinsic clearance.IRAK4-IN-15 in combination with Acalabrutinib exhibited potent synergistic in vitro activit...
T70145	LYRM03
	LYRM03 is an aminopeptidase inhibitor. LYRM03 is also an ubenimex derivative. LYRM03 attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway. LYRM03 effectively attenuates LPS-induced A...
T70595	Artemisinin B
	Artemisinin B is a drug which may improve spatial memory in dementia patients and alter the levels of inflammatory cytokines in the hippocampus and the cortex. Artemisinin B may inhibit neuroinflammation and exert neurop...
T74664	KTX-582
	KTX-582 is a potent IRAK4 degrader, exhibiting DC50 values of 4 nM for IRAK4 and 5 nM for Ikaros. It efficiently induces apoptosis in MYD88 MT DLBCL and has demonstrated effectiveness in inducing in vivo tumor regression...
T79485	IRAK4-IN-27		IRAK
	IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) c...		IRAK
T63278	IRAK4-IN-14
	IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.

Compounds

MyD88-IN-1

T77353

Synonym:

Target: IL Receptor, NF-κB, TLR, MyD88

Target: Others, MyD88

Synonym: CLI-095,TAK-242

Target: TNF, TLR, Autophagy, Interleukin

Synonym: 3M002,CL-075

Target: NF-κB, TLR, MyD88

EM 163

T41142

Synonym:

Target: IL Receptor, p38 MAPK, MyD88

Cat No.	Product Name	Synonyms	Targets
T3898	Schaftoside	APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside	Dynamin , Antioxidant , TLR , MyD88 , Mitochondrial Metabolism , Autophagy
	Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
T5S0167	Atractylenolide I		IL Receptor , TNF , TLR , JAK , STAT
	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide...		IL Receptor , TNF , TLR , JAK , STAT
T27191	D-Mannuronic Acid
	D-Mannuronic Acid is a blocker of the TLR2 and TLR4 downstream signaling pathway. D-Mannuronic Acid effectively inhibits mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB.

Natural Products

Schaftoside

T3898

Synonym: APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside

Target: Dynamin, Antioxidant, TLR, MyD88, Mitochondrial Metabolism, Autophagy

Atractylenolide I

T5S0167

Synonym:

Target: IL Receptor, TNF, TLR, JAK, STAT

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01723	MYD88 Protein, Human, Recombinant (His)	Human	E. coli
	Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the in...
TMPY-02794	TLR2 Protein, Human, Recombinant (aa 1-587, His)	Human	Baculovirus-Insect Cells
	TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge...
TMPY-02904	TLR4 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans...
TMPY-05593	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ...
TMPY-04580	IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ...
TMPY-05840	IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ...
TMPH-02937	TLR11 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
TMPH-01740	SARM1 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promotin...
TMPH-01741	SARM1 Protein, Human, Recombinant (His & KSI)	Human	E. coli
	NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promotin...
TMPJ-01347	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (aa 21-356, His)	Human	Human Cells
	Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in sign...
TMPH-02211	TLR7 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine...
TMPH-02938	TLR7 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine...
TMPJ-01346	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (hFc & His)	Human	Human Cells
	Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in sign...
TMPH-02212	TLR8 Protein, Human, Recombinant (His)	Human	Yeast
	Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially proc...
TMPH-03267	CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)	Rat	E. coli
	Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which...
TMPY-03042	TLR2 Protein, Rat, Recombinant (His)	Rat	Baculovirus-Insect Cells
	TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge...
TMPY-01251	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ...
TMPY-02930	TLR2 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge...
TMPY-05392	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (hFc)	Human	HEK293
	Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ...
TMPY-05839	IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ...
TMPY-04579	IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ...
TMPH-01788	NFE2L2 Protein, Human, Recombinant (His)	Human	E. coli
	Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzyme...