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Cat No. | Product Name | Synonyms | Targets |
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T77353 | MyD88-IN-1 | IL Receptor , NF-κB , TLR , MyD88 | |
MyD88-IN-1 is a potent MyD88 inhibitor MyD88-IN-1 has anti-inflammatory activity and inhibits downstream inflammatory signaling pathways, including the NF-κB pathway, of members of the Toll-like receptor (TLR) and interl... | |||
T9765 | TJ-M2010-5 | MyD88 | |
TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain to interfere with its homodimerization and suppress MyD88 signaling. TJ-M2010-5 can be used in myocardial ischemia/reperfusion injury studies. | |||
T13932 | TLR1 | Others , MyD88 | |
TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses. | |||
T9203 | JH-X-119-01 | IRAK | |
JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1. | |||
T9027 | CA-4948 | Emavusertib | IRAK , FLT |
CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity. | |||
TQ0181 | Resatorvid | CLI-095,TAK-242 | TNF , TLR , Autophagy , Interleukin |
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid binds directly to Cys747 and prevents TLR4 from binding to TIRAP, thereby blocking downstream signaling. Resatorvid has antitumor a... | |||
T13063 | T6167923 | MyD88 | |
T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6... | |||
T27034 | CL075 | 3M002,CL-075 | NF-κB , TLR , MyD88 |
CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to elicit the production of inflammatory cytokines and type I i... | |||
T41142 | EM 163 | IL Receptor , p38 MAPK , MyD88 | |
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interacti... | |||
T69722 | TSI-13-48 | ||
TSI-13-48 is a MyD88 inhibitor. | |||
T69719 | TSI-13-57 | ||
TSI-13-57 is a MyD88 inhibitor. | |||
T68261 | T5996207 | ||
T5996207 is a inhibitor of MyD88-dependent signaling pathways | |||
T75223 | RDR 02308 | ||
RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase [1] . | |||
T69733 | LM9 | ||
LM9 is a MyD88 inhibitor which prevents atherosclerosis by regulating inflammatory responses and oxidative stress in macrophages. | |||
T16937 | ST 2825 | Others | |
ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 inhibition of IL-1β-mediated activation of NF-κB transcriptional activity. | |||
T61734 | IRAK4-IN-9 | ||
IRAK4-IN-9 (compound 73) is a highly potent inhibitor of IRAK4, displaying an impressive IC50 value of 1.5 nM. By blocking MyD88-dependent signaling, IRAK4-IN-9 exhibits promising potential for the investigation of infla... | |||
T11674 | IRAK4-IN-6 | Others | |
IRAK4-IN-6 is a selective and orally efficacious inhibitor of IRAK4, demonstrating an IC50 value of 4 nM. This compound specifically targets MyD88 L265P mutant diffuse large B-cell lymphoma [1]. | |||
T61931 | IRAK4-IN-10 | ||
IRAK4-IN-10 (compound 75) is an effective IRAK4 inhibitor (IC50 is 1.5 nM), which can block the MyD88-dependent signal pathway. IRAK4-IN-10 has research potential in inflammatory diseases, autoimmune diseases and cancer. | |||
T63262 | IRAK4-IN-15 | ||
IRAK4-IN-15 is a selective and potent IRAK4 inhibitor (IC50: 0.002 μM) with good human PK prediction and low intrinsic clearance.IRAK4-IN-15 in combination with Acalabrutinib exhibited potent synergistic in vitro activit... | |||
T70145 | LYRM03 | ||
LYRM03 is an aminopeptidase inhibitor. LYRM03 is also an ubenimex derivative. LYRM03 attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway. LYRM03 effectively attenuates LPS-induced A... | |||
T70595 | Artemisinin B | ||
Artemisinin B is a drug which may improve spatial memory in dementia patients and alter the levels of inflammatory cytokines in the hippocampus and the cortex. Artemisinin B may inhibit neuroinflammation and exert neurop... | |||
T74664 | KTX-582 | ||
KTX-582 is a potent IRAK4 degrader, exhibiting DC50 values of 4 nM for IRAK4 and 5 nM for Ikaros. It efficiently induces apoptosis in MYD88 MT DLBCL and has demonstrated effectiveness in inducing in vivo tumor regression... | |||
T79485 | IRAK4-IN-27 | IRAK | |
IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) c... | |||
T63278 | IRAK4-IN-14 | ||
IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect. |
Cat No. | Product Name | Synonyms | Targets |
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T3898 | Schaftoside | APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside | Dynamin , Antioxidant , TLR , MyD88 , Mitochondrial Metabolism , Autophagy |
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity. | |||
T5S0167 | Atractylenolide I | IL Receptor , TNF , TLR , JAK , STAT | |
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide... | |||
T27191 | D-Mannuronic Acid | ||
D-Mannuronic Acid is a blocker of the TLR2 and TLR4 downstream signaling pathway. D-Mannuronic Acid effectively inhibits mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01723 | MYD88 Protein, Human, Recombinant (His) | Human | E. coli |
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the in... | |||
TMPY-02794 | TLR2 Protein, Human, Recombinant (aa 1-587, His) | Human | Baculovirus-Insect Cells |
TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge... | |||
TMPY-02904 | TLR4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans... | |||
TMPY-05593 | IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ... | |||
TMPY-04580 | IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ... | |||
TMPY-05840 | IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ... | |||
TMPH-02937 | TLR11 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. | |||
TMPH-01740 | SARM1 Protein, Human, Recombinant (His & Myc) | Human | Baculovirus |
NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promotin... | |||
TMPH-01741 | SARM1 Protein, Human, Recombinant (His & KSI) | Human | E. coli |
NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promotin... | |||
TMPJ-01347 | IL-1RAP/IL-1RAcP Protein, Human, Recombinant (aa 21-356, His) | Human | Human Cells |
Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in sign... | |||
TMPH-02211 | TLR7 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine... | |||
TMPH-02938 | TLR7 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine... | |||
TMPJ-01346 | IL-1RAP/IL-1RAcP Protein, Human, Recombinant (hFc & His) | Human | Human Cells |
Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in sign... | |||
TMPH-02212 | TLR8 Protein, Human, Recombinant (His) | Human | Yeast |
Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially proc... | |||
TMPH-03267 | CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO) | Rat | E. coli |
Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which... | |||
TMPY-03042 | TLR2 Protein, Rat, Recombinant (His) | Rat | Baculovirus-Insect Cells |
TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge... | |||
TMPY-01251 | IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His) | Human | HEK293 |
Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ... | |||
TMPY-02930 | TLR2 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge... | |||
TMPY-05392 | IL-1RAP/IL-1RAcP Protein, Human, Recombinant (hFc) | Human | HEK293 |
Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ... | |||
TMPY-05839 | IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ... | |||
TMPY-04579 | IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ... | |||
TMPH-01788 | NFE2L2 Protein, Human, Recombinant (His) | Human | E. coli |
Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzyme... |