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Search Results for " metastasis "

Targets

150

Compounds

24

Natural Products

314

Recombinant Proteins

7

Libraries

Cat No. Product Name Synonyms Targets
T6347 Ki16198 LPA Receptor , LPL Receptor
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activ...
T12580 PTUPB COX , Epoxide Hydrolase
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
T22336 Galloflavin Dehydrogenase
Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticancer agent.
T9107 NP-G2-044 Others
NP-G2-044 is an orally active fascin inhibitor, with an IC50 of ~2 μM. It blocks tumor metastasis and increases antitumor immune response.
T4033 MSX-130 MSX 130 CXCR
MSX-130 is CXCR4 Antagonist.
T10425 AZ084 CCR
AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
T9963 MPT0B390 HDAC
MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.
T4032 MSX-127 MSX 127 CXCR
MSX-127 elicites positive response in peptide CXCR4.
T10297L AMG 487 CXCR
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
T2014 CCG-1423 CCG1423 LRRK2 , Rho , Ras
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
T4306 CCG-203971 CCG203971 Rho , Ras
CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This compound also inhibits PC-3 cell migration (IC50: 4.2 μM),...
T8310 MMP-9-IN-1 MMP
MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).
T1921 Alpelisib BYL-719 PI3K
Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity. Alpelisib inhibits PI3Kβ/γ/δ with low activity (IC50=250/290/1200 nM). Alpelisib has antitumor activity and is targeted to P...
T5465 PF-5274857 PF-5274857 freebase Smo
PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor t...
T27730 KGP94 KGP-94,KGP 94 Cysteine Protease
KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).
T36758 CAIX Inhibitor S4 S4 Carbonic Anhydrase
CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.
T0939 Phenytoin Diphenylhydantoin,5,5-Diphenylhydantoin Virus Protease , Sodium Channel
Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cor...
T9236 WSB1 Degrader 1 Others , E1/E2/E3 Enzyme
WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.
T7764 CCG-222740 ROCK , Rho , Ras
CCG-222740 is an inhibitor of Rho/MRTF pathway
T41003 KG5 Raf , FLT , PDGFR , c-Kit
KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibits FLT3, KIT, and c-Raf with anticancer and antiangiogenic activities.
T0008 Phenytoin sodium 5,5-Diphenylhydantoin sodium salt,Diphantoine,Dilantin sodium,Diphenylhydantoin Sodium Virus Protease , Sodium Channel
Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .
T5007 Benproperine phosphate Blascorid,Pirexyl phosphate Others , Microtubule Associated
Benproperine phosphate (Pirexyl phosphate) is a cough suppressant.
T25492 Hepln-13 Hepln 13,Hepln13 c-Met/HGFR
Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.
T24642 YH-306 YH306,TRV055 acetate (25849-90-5 Free base) MMP , MMP , FAK , Rho , PI3K , Src
YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
TQ0290 ONO-AE3-208 AE 3-208 Prostaglandin Receptor
ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
T15574 Incyclinide COL-3,CMT-3 MMP
Incyclinide (COL-3) is a matrix metalloproteinase (MMP) inhibitor. Thereby causing extracellular matrix degradation, tumor growth and invasion, and inhibiting angiogenesis, and metastasis.
T12493 PK68 Others , RIP kinase
PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of inflammatory disorders and cancer metastasis.
T28212 NSC668394 NSC-668394,NSC 668394 PKC
NSC668394 is a potent small molecule ezrin (Thr567) phosphorylation inhibitor.NSC668394 has potential antitumor activity by inhibiting ezrin T567 phosphorylation and increasing Ca2+-dependent ezrin cleavage.NSC668394 can...
T20626 Esomeprazole Proton pump , Cysteine Protease
Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).
T27613 InS3-54-A26 STAT
inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.
T11947 MARK4 inhibitor 1 Apoptosis , Others , AMPK
MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM.
T3710 XMD16-5 Tyrosinase , PPAR
XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted metastasis in a mouse model of breast Y. TNK2 signaling is d...
TP1472 Tyroserleutide Others
Tyroserleutide (YSL), isolated from the degradation products of porcine spleen, is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo.Tyroserleutide inhibits the growth and metastasis of h...
T9205 NCGC00378430 Phosphatase , Others
NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
T9732 VY-3-135 Fatty Acid Synthase
VY-3-135 is a metastasis inhibitor and an acetyl-CoA synthetase 2 (ACSS2) modulator.
T6011 Batimastat BB94 MMP
Batimastat (BB94) (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor. Batimastat induces extracellular matrix degradation and inhibits angiogenesis, tumor growth and invasion, and metastasis.
T12731 RIPK1-IN-7 RIP kinase
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
T14496 BAMB-4 ITPKA-IN-C14 Others
BAMB-4 (ITPKA-IN-C14) is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA). It acts by suppressing the metastasis-promoting effect of ITPKA in lung tumor cells(with IC50 of 37 μM in...
T41094 Wnt/β-catenin agonist 2 GSK-3 , Wnt/beta-catenin
Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer inva...
T27371 FR-167356 FR167356,FR 167356 ATPase
FR-167356 is a specific inhibitor of a3 isoform vacuolar type H⁺-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces b...
T26629 Angstrom6 A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide PAI-1
Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and abrogates the downstream effects.Angstrom6 has antitumor a...
T12006 Metarrestin ML246 DNA/RNA Synthesis
Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (...
T15367 Gadoxetate Disodium Gd-EOB-DTPA Disodium,ZK 139834 Others
Gadoxetate Disodium is used to evaluate focal liver lesions, such as hepatocellular carcinoma or liver metastasis on T1-weighted imaging. It is a contrast agent in magnetic resonance imaging (MRI) of the hepatobiliary sy...
T16549 PKI-166 VEGFR
PKI-166 is an oral inhibitor of EGF-R tyrosine kinase (IC50:0.7 nM) that is both effective and selective. PKI-166 can effectively inhibit the growth and metastasis of various human cancer cells including pancreatic cance...
T10904 CWP232228 Wnt/beta-catenin
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting t...
T8436 Minodronic acid Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-,ONO-5920,YM-529 Apoptosis , P2X Receptor
Minodronic acid(YM-529) is a P2X2/3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducing apoptosis. Minodronic acid has been shown to inhibit the ...
T29231 ZLD1039 ZLD-1039,ZLD 1039 Histone Methyltransferase
ZLD1039 is a potent, orally bioavailable EZH2 (Enhancer of Zeste Homolog 2) inhibitor with high selectivity. It demonstrates strong, concentration-dependent inhibition of both wild-type and mutant (Y641F and A677G) PRC2 ...
T77059 Leronlimab PRO 140 CCR
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. leronlimumab has both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronl...
T15646 KBU2046 Others
KBU2046 is an orally administered compound that inhibits cell motility and invasion, effectively suppressing cancer metastasis and extending lifespan. This compound uniquely targets and binds to chaperone heterocomplexes...
T38752 EW-7195 ALK , TGF-beta/Smad
EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-i...

Compounds

Ki16198
T6347
Synonym:
Target: LPA Receptor, LPL Receptor
PTUPB
T12580
Synonym:
Target: COX, Epoxide Hydrolase
Galloflavin
T22336
Synonym:
Target: Dehydrogenase
NP-G2-044
T9107
Synonym:
Target: Others
MSX-130
T4033
Synonym: MSX 130
Target: CXCR
AZ084
T10425
Synonym:
Target: CCR
MPT0B390
T9963
Synonym:
Target: HDAC
MSX-127
T4032
Synonym: MSX 127
Target: CXCR
AMG 487
T10297L
Synonym:
Target: CXCR
CCG-1423
T2014
Synonym: CCG1423
Target: LRRK2, Rho, Ras
CCG-203971
T4306
Synonym: CCG203971
Target: Rho, Ras
MMP-9-IN-1
T8310
Synonym:
Target: MMP
Alpelisib
T1921
Synonym: BYL-719
Target: PI3K
PF-5274857
T5465
Synonym: PF-5274857 freebase
Target: Smo
KGP94
T27730
Synonym: KGP-94,KGP 94
Target: Cysteine Protease
CAIX Inhibitor S4
T36758
Synonym: S4
Target: Carbonic Anhydrase
Phenytoin
T0939
Synonym: Diphenylhydantoin,5,5-Diphenylhydantoin
Target: Virus Protease, Sodium Channel
WSB1 Degrader 1
T9236
Synonym:
Target: Others, E1/E2/E3 Enzyme
CCG-222740
T7764
Synonym:
Target: ROCK, Rho, Ras
KG5
T41003
Synonym:
Target: Raf, FLT, PDGFR, c-Kit
Phenytoin sodium
T0008
Synonym: 5,5-Diphenylhydantoin sodium salt,Diphantoine,Dilantin sodium,Diphenylhydantoin Sodium
Target: Virus Protease, Sodium Channel
Benproperine phosphate
T5007
Synonym: Blascorid,Pirexyl phosphate
Target: Others, Microtubule Associated
Hepln-13
T25492
Synonym: Hepln 13,Hepln13
Target: c-Met/HGFR
YH-306
T24642
Synonym: YH306,TRV055 acetate (25849-90-5 Free base)
Target: MMP, MMP, FAK, Rho, PI3K, Src
ONO-AE3-208
TQ0290
Synonym: AE 3-208
Target: Prostaglandin Receptor
Incyclinide
T15574
Synonym: COL-3,CMT-3
Target: MMP
PK68
T12493
Synonym:
Target: Others, RIP kinase
NSC668394
T28212
Synonym: NSC-668394,NSC 668394
Target: PKC
Esomeprazole
T20626
Synonym:
Target: Proton pump, Cysteine Protease
inS3-54-A26
T27613
Synonym:
Target: STAT
MARK4 inhibitor 1
T11947
Synonym:
Target: Apoptosis, Others, AMPK
XMD16-5
T3710
Synonym:
Target: Tyrosinase, PPAR
Tyroserleutide
TP1472
Synonym:
Target: Others
NCGC00378430
T9205
Synonym:
Target: Phosphatase, Others
VY-3-135
T9732
Synonym:
Target: Fatty Acid Synthase
Batimastat
T6011
Synonym: BB94
Target: MMP
RIPK1-IN-7
T12731
Synonym:
Target: RIP kinase
BAMB-4
T14496
Synonym: ITPKA-IN-C14
Target: Others
Wnt/β-catenin agonist 2
T41094
Synonym:
Target: GSK-3, Wnt/beta-catenin
FR-167356
T27371
Synonym: FR167356,FR 167356
Target: ATPase
Angstrom6
T26629
Synonym: A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide
Target: PAI-1
Metarrestin
T12006
Synonym: ML246
Target: DNA/RNA Synthesis
Gadoxetate Disodium
T15367
Synonym: Gd-EOB-DTPA Disodium,ZK 139834
Target: Others
PKI-166
T16549
Synonym:
Target: VEGFR
CWP232228
T10904
Synonym:
Target: Wnt/beta-catenin
Minodronic acid
T8436
Synonym: Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-,ONO-5920,YM-529
Target: Apoptosis, P2X Receptor
ZLD1039
T29231
Synonym: ZLD-1039,ZLD 1039
Target: Histone Methyltransferase
Leronlimab
T77059
Synonym: PRO 140
Target: CCR
KBU2046
T15646
Synonym:
Target: Others
EW-7195
T38752
Synonym:
Target: ALK, TGF-beta/Smad
1 2 3
Cat No. Product Name Synonyms Targets
TN1046 Murrayone Others
Murrayone, a coumarin-containing compound derived from M. paniculata, stands out as the most bioactive substance within this species, primarily due to its unique pharmacological attributes that notably suppress cancer me...
T3862 Irigenin NF-κB , Integrin
Irigenin has antifungal activity.
T2786 Oxysophocarpine Prostaglandin Receptor
Oxysophocarpine is extracted from Sophra flavescens Ait.
T3860 Isoliquiritin apioside MMP , p38 MAPK , NF-κB
Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse...
T4S0969 Obtusifolin Antioxidant , NF-κB
1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...
T1181 Gefitinib ZD1839 EGFR , Tyrosine Kinases , Autophagy
Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell...
T2982 Xanthone Genicide,Xanthenone,Benzophenone oxide Apoptosis , Others , Influenza Virus , Antibacterial , Antifungal
Xanthone (Xanthenone) is currently used as ovicide for codling moth eggs and as a larvicide.
T8169 Decursinol Others
Decursinol is isolated from the roots of Angelica Gigas with an antinociceptive effect. It also has anti-tumor and anti-metastasis activity.
T4S1383 Escin IA Aescin IA,Escin IA;Aescin IA,Escin IA HIV Protease
Escin IA (Escin IA;Aescin IA) is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved ...
T75643 Isoxanthohumol HSV
Isoxanthohumol is a prenylated flavonoid derived from hops and beer with antiproliferative activity against several human cancer cell lines.Isoxanthohumol inhibits the metastasis or invasion of lung metastases of tumor c...
T4S1050 Pristimerin Celastrol methyl ester NF-κB , Antibacterial
1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell...
T3402 20(S)-Ginsenoside Rg3 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3 EGFR , Beta Amyloid , Potassium Channel , NF-κB , COX , Sodium Channel , Endogenous Metabolite
20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial c...
T3403 Glabridin Q-100692,KB-289522,LS-176045 Reactive Oxygen Species , Tyrosinase , GABA Receptor , Antibacterial , PPAR
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on...
T5S0055 Chelidonine Helidonine,Khelidonin,Stylophorin Apoptosis , Others , Influenza Virus
1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model ...
T6S1699 Shogaol [6]-Shogaol,6-Shogaol Lipoxygenase , Autophagy
1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the f...
T23773 Barbigerone Barubigeron
Barbigerone is a tumor angiogenesis, growth, and metastasis inhibitor in melanoma.
TN4166 Griffipavixanthone ERK , Raf , ROS , MEK , Caspase
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS productio...
TN5901 Cudratricusxanthone A
Cudratricusxanthone A has potent anti-proliferative, antioxidative, and monoamine oxidase inhibitory effects, it also possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to in...
T71471 Chrysotobibenzyl
Chrysotobibenzyl, a bibenzyl found in the stem of Dendrobium pulchellum, may facilitate anoikis--a form of programmed cell death that occurs in anchorage-dependent cells when they detach from the surrounding extracellula...
TN3587 Capillarisin MMP , ERK , IL Receptor , BCL , VEGFR , TNF , NOS , NF-κB , TLR , MAPK , COX , DNA/RNA Synthesis , Prostaglandin Receptor , JNK , STAT
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by ...
T19978 Puromycin NSC 3055,NSC3055,Puromycine,NSC-3055 Antibiotic
Puromycin (NSC-3055) is an antibiotic protein synthesis inhibitor. It inhibits protein synthesis by binding to RNA. It also serves as an anticancer drug by suppressing the growth and metastasis in esophagus cancer cells ...
TN4300 Isojacareubin MAPK , PKC , Antifection
Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the standard drug amoxicillin. Isojacareubin is a potent inhibitor of...
T3229 Cytochalasin D ATPase , p38 MAPK , Calcium Channel , Akt , PI3K
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head dec...
T35624 Ajoene
Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs =...

Natural Products

Murrayone
TN1046
Synonym:
Target: Others
Irigenin
T3862
Synonym:
Target: NF-κB, Integrin
Oxysophocarpine
T2786
Synonym:
Target: Prostaglandin Receptor
Isoliquiritin apioside
T3860
Synonym:
Target: MMP, p38 MAPK, NF-κB
Obtusifolin
T4S0969
Synonym:
Target: Antioxidant, NF-κB
Gefitinib
T1181
Synonym: ZD1839
Target: EGFR, Tyrosine Kinases, Autophagy
Xanthone
T2982
Synonym: Genicide,Xanthenone,Benzophenone oxide
Target: Apoptosis, Others, Influenza Virus, Antibacterial, Antifungal
Decursinol
T8169
Synonym:
Target: Others
Escin IA
T4S1383
Synonym: Aescin IA,Escin IA;Aescin IA,Escin IA
Target: HIV Protease
Isoxanthohumol
T75643
Synonym:
Target: HSV
Pristimerin
T4S1050
Synonym: Celastrol methyl ester
Target: NF-κB, Antibacterial
20(S)-Ginsenoside Rg3
T3402
Synonym: 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3
Target: EGFR, Beta Amyloid, Potassium Channel, NF-κB, COX, Sodium Channel, Endogenous Metabolite
Glabridin
T3403
Synonym: Q-100692,KB-289522,LS-176045
Target: Reactive Oxygen Species, Tyrosinase, GABA Receptor, Antibacterial, PPAR
Chelidonine
T5S0055
Synonym: Helidonine,Khelidonin,Stylophorin
Target: Apoptosis, Others, Influenza Virus
Shogaol
T6S1699
Synonym: [6]-Shogaol,6-Shogaol
Target: Lipoxygenase, Autophagy
Barbigerone
T23773
Synonym: Barubigeron
Target:
Griffipavixanthone
TN4166
Synonym:
Target: ERK, Raf, ROS, MEK, Caspase
Cudratricusxanthone A
TN5901
Synonym:
Target:
Chrysotobibenzyl
T71471
Synonym:
Target:
Capillarisin
TN3587
Synonym:
Target: MMP, ERK, IL Receptor, BCL, VEGFR, TNF, NOS, NF-κB, TLR, MAPK, COX, DNA/RNA Synthesis, Prostaglandin Receptor, JNK, STAT
Puromycin
T19978
Synonym: NSC 3055,NSC3055,Puromycine,NSC-3055
Target: Antibiotic
Isojacareubin
TN4300
Synonym:
Target: MAPK, PKC, Antifection
Cytochalasin D
T3229
Synonym:
Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K
Ajoene
T35624
Synonym:
Target:

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02384 MTSS1 Protein, Human, Recombinant (aa1-250, His & MBP) Human E. coli
MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expr...
TMPJ-00708 CST7 Protein, Mouse, Recombinant (His) Mouse Human Cells
Mouse Cystatin F belongs to cystatin superfamily, which encompasses proteins that contain multiple cystatin-like sequences. It has been shown that Cystatin F is selectively expressed by hematopoietic cells and may be a b...
TMPJ-00025 CST7 Protein, Human, Recombinant (His) Human Human Cells
CST7 is a secreted protein and primarily expressed in peripheral blood cells and spleen.It is belongs to the cystatin family. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. S...
TMPY-01884 MMP-8 Protein, Human, Recombinant Human HEK293
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ...
TMPY-01477 MMP-2 Protein, Human, Recombinant Human HEK293
Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is de...
TMPY-02030 CD82 Protein, Human, Recombinant (His) Human HEK293
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetras...
TMPY-05850 CEACAM6 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It ...
TMPY-00971 CEACAM6 Protein, Human, Recombinant (His) Human HEK293
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It ...
TMPY-02141 UPAR/PLAUR Protein, Human, Recombinant (His) Human HEK293
Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and ...
TMPY-01601 AXL Protein, Human, Recombinant (His) Human HEK293
Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-01257 UPAR/PLAUR Protein, Mouse, Recombinant (His) Mouse HEK293
Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and ...
TMPH-00010 MMP-14 Protein, Human, Recombinant (His & SUMO) Human E. coli
MMP14 was first described by Sato et al. as a transmembrane protein which activates pro-MMP2 to induce tumor cell invasion. Most MMPs are secreted as inactive pro-proteinases that are activated by proteolytic cleavage. A...
TMPY-01030 TFPI Protein, Human, Recombinant (His) Human HEK293
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. Wit...
TMPY-05094 Tissue Factor Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-02530 Tissue Factor Protein, Human, Recombinant (His) Human HEK293
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-02312 CSF3R/G-CSFR Protein, Human, Recombinant (His) Human HEK293
Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regula...
TMPY-00476 ITGB1 Protein, Human, Recombinant (His) Human HEK293
ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. This gene encodes a beta subunit, which is a type 1 transmembrane protein of the integrin beta chain family. ITGB1 is a heterodimeric cell-surface receptor involv...
TMPY-01253 LAMP1 Protein, Human, Recombinant (His) Human HEK293
Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein that belongs to the LAMP family. CD107a is expressed largely in t...
TMPY-00665 Aminopeptidase N/CD13 Protein, Human, Recombinant (I603M, His) Human HEK293
Aminopeptidase N (ANPEP or APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. It belongs to the peptidase M1 fam...
TMPY-03564 TSPAN8 Protein, Human, Recombinant (His) Human HEK293
Tetraspanin 8 (TSPAN8) as an important modulator of melanoma invasiveness, and several of its transcriptional regulators, which affect TSPAN8 expression during melanoma progression toward an invasive stage. p53 as a nega...
TMPY-03014 Osteoactivin/GPNMB Protein, Mouse, Recombinant (His) Mouse HEK293
GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteocla...
TMPY-01859 LYPD3 Protein, Human, Recombinant (His) Human HEK293
Ly6 / PLAUR domain-containing protein 3, also known as GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4, and LYPD3, is a cell membrane protein that contains two UPAR/Ly6 ...
TMPY-00566 CCL18 Protein, Human, Recombinant (His) Human Yeast
CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its...
TMPY-00463 ENPP2 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen...
TMPY-02778 ENPP2 Protein, Human, Recombinant (His) Human HEK293
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen...
TMPY-04123 CEACAM1 Protein, Human, Recombinant (His & hFc) Human HEK293
The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and diffe...
TMPY-02033 CD44 Protein, Human, Recombinant (His) Human HEK293
CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The m...
TMPY-02028 RON/CD136 Protein, Human, Recombinant (His) Human HEK293
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. ...
TMPY-01139 PDGFRA Protein, Human, Recombinant (His) Human HEK293
PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfami...
TMPY-05435 ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc) Human HEK293
The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In dis...
TMPY-00892 Neuropilin-2 Protein, Human, Recombinant (His) Human HEK293
Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation fac...
TMPY-03763 Neuropilin-2 Protein, Human, Recombinant (hFc) Human HEK293
Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation fac...
TMPY-03235 BST2 Protein, Human, Recombinant (His) Human HEK293
BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demons...
TMPY-05047 CD44 Protein, Mouse, Recombinant (His) Mouse HEK293
CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The m...
TMPY-00876 Legumain Protein, Mouse, Recombinant (His) Mouse HEK293
The Mammalian Legumain, also known as LGMN, also called asparaginyl endopeptidase (AEP), is a cysteine protease belonging to peptidase family C13 with strict specificity for hydrolysis of asparaginyl bonds. Known previou...
TMPY-01288 Osteopontin Protein, Human, Recombinant (His) Human HEK293
Osteopontin, also known as Secreted phosphoprotein 1, Bone sialoprotein 1, BSP-1, OPN, and SPP1, is a member of the osteopontin family and a SIBLING glycoprotein. Osteopontin has been classified as T-helper 1 cytokine an...
TMPY-06988 Osteopontin Protein, Human, Recombinant (aa 17-166, His) Human HEK293
Osteopontin, also known as Secreted phosphoprotein 1, Bone sialoprotein 1, BSP-1, OPN, and SPP1, is a member of the osteopontin family and a SIBLING glycoprotein. Osteopontin has been classified as T-helper 1 cytokine an...
TMPY-01356 S100A8 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation....
TMPY-00871 LAYN Protein, Human, Recombinant (hFc) Human HEK293
Layilin recently characterized as a 55 kDa transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions bet...
TMPY-00720 Contactin 1 Protein, Human, Recombinant (His) Human HEK293
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3...
TMPY-02591 SDF-1 Protein, Human, Recombinant Human E. coli
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-01167 E-Selectin/CD62E Protein, Human, Recombinant (His) Human HEK293
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involv...
TMPY-02820 SDF-1 Protein, Human, Recombinant (isoform a) Human E. coli
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-00834 IGF1R/CD221 Protein, Human, Recombinant (His) Human HEK293
The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide...
TMPY-00904 Urokinase/uPA Protein, Human, Recombinant (His) Human HEK293
Plasminogen activator, urokinase, also known as PLAU and uPA, is a serine protease which converts plasminogen to plasmin, a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in compl...
TMPY-00740 SDF-1 Protein, Human, Recombinant (hFc) Human HEK293
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-00472 IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99) Human E. coli
Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proang...
TMPY-04726 IL-8/CXCL8 Protein, Human, Recombinant (His) Human Yeast
Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proang...
TMPY-00754 IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99) Human HEK293
Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proang...
TMPY-05337 CXCL16 Protein, Human, Recombinant (His) Human HEK293
C-X-C motif chemokine 16, also known as Small-inducible cytokine B16, SR-PSOX, and CXCL16, is a single-pass type I membrane protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL16 exists in transmemb...
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MTSS1 Protein, Human, Recombinant (aa1-250, His & MBP)
TMPY-02384
Species: Human
Expression System: E. coli
CST7 Protein, Mouse, Recombinant (His)
TMPJ-00708
Species: Mouse
Expression System: Human Cells
CST7 Protein, Human, Recombinant (His)
TMPJ-00025
Species: Human
Expression System: Human Cells
MMP-8 Protein, Human, Recombinant
TMPY-01884
Species: Human
Expression System: HEK293
MMP-2 Protein, Human, Recombinant
TMPY-01477
Species: Human
Expression System: HEK293
CD82 Protein, Human, Recombinant (His)
TMPY-02030
Species: Human
Expression System: HEK293
CEACAM6 Protein, Cynomolgus, Recombinant (His)
TMPY-05850
Species: Cynomolgus
Expression System: HEK293
CEACAM6 Protein, Human, Recombinant (His)
TMPY-00971
Species: Human
Expression System: HEK293
uPAR/PLAUR Protein, Human, Recombinant (His)
TMPY-02141
Species: Human
Expression System: HEK293
AXL Protein, Human, Recombinant (His)
TMPY-01601
Species: Human
Expression System: HEK293
uPAR/PLAUR Protein, Mouse, Recombinant (His)
TMPY-01257
Species: Mouse
Expression System: HEK293
MMP-14 Protein, Human, Recombinant (His & SUMO)
TMPH-00010
Species: Human
Expression System: E. coli
TFPI Protein, Human, Recombinant (His)
TMPY-01030
Species: Human
Expression System: HEK293
Tissue Factor Protein, Cynomolgus, Recombinant (His)
TMPY-05094
Species: Cynomolgus
Expression System: HEK293
Tissue Factor Protein, Human, Recombinant (His)
TMPY-02530
Species: Human
Expression System: HEK293
CSF3R/G-CSFR Protein, Human, Recombinant (His)
TMPY-02312
Species: Human
Expression System: HEK293
ITGB1 Protein, Human, Recombinant (His)
TMPY-00476
Species: Human
Expression System: HEK293
LAMP1 Protein, Human, Recombinant (His)
TMPY-01253
Species: Human
Expression System: HEK293
Aminopeptidase N/CD13 Protein, Human, Recombinant (I603M, His)
TMPY-00665
Species: Human
Expression System: HEK293
TSPAN8 Protein, Human, Recombinant (His)
TMPY-03564
Species: Human
Expression System: HEK293
Osteoactivin/GPNMB Protein, Mouse, Recombinant (His)
TMPY-03014
Species: Mouse
Expression System: HEK293
LYPD3 Protein, Human, Recombinant (His)
TMPY-01859
Species: Human
Expression System: HEK293
CCL18 Protein, Human, Recombinant (His)
TMPY-00566
Species: Human
Expression System: Yeast
ENPP2 Protein, Cynomolgus, Recombinant (His)
TMPY-00463
Species: Cynomolgus
Expression System: HEK293
ENPP2 Protein, Human, Recombinant (His)
TMPY-02778
Species: Human
Expression System: HEK293
CEACAM1 Protein, Human, Recombinant (His & hFc)
TMPY-04123
Species: Human
Expression System: HEK293
CD44 Protein, Human, Recombinant (His)
TMPY-02033
Species: Human
Expression System: HEK293
RON/CD136 Protein, Human, Recombinant (His)
TMPY-02028
Species: Human
Expression System: HEK293
PDGFRA Protein, Human, Recombinant (His)
TMPY-01139
Species: Human
Expression System: HEK293
ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc)
TMPY-05435
Species: Human
Expression System: HEK293
Neuropilin-2 Protein, Human, Recombinant (His)
TMPY-00892
Species: Human
Expression System: HEK293
Neuropilin-2 Protein, Human, Recombinant (hFc)
TMPY-03763
Species: Human
Expression System: HEK293
BST2 Protein, Human, Recombinant (His)
TMPY-03235
Species: Human
Expression System: HEK293
CD44 Protein, Mouse, Recombinant (His)
TMPY-05047
Species: Mouse
Expression System: HEK293
Legumain Protein, Mouse, Recombinant (His)
TMPY-00876
Species: Mouse
Expression System: HEK293
Osteopontin Protein, Human, Recombinant (His)
TMPY-01288
Species: Human
Expression System: HEK293
Osteopontin Protein, Human, Recombinant (aa 17-166, His)
TMPY-06988
Species: Human
Expression System: HEK293
S100A8 Protein, Human, Recombinant (His)
TMPY-01356
Species: Human
Expression System: Baculovirus-Insect Cells
LAYN Protein, Human, Recombinant (hFc)
TMPY-00871
Species: Human
Expression System: HEK293
Contactin 1 Protein, Human, Recombinant (His)
TMPY-00720
Species: Human
Expression System: HEK293
SDF-1 Protein, Human, Recombinant
TMPY-02591
Species: Human
Expression System: E. coli
E-Selectin/CD62E Protein, Human, Recombinant (His)
TMPY-01167
Species: Human
Expression System: HEK293
SDF-1 Protein, Human, Recombinant (isoform a)
TMPY-02820
Species: Human
Expression System: E. coli
IGF1R/CD221 Protein, Human, Recombinant (His)
TMPY-00834
Species: Human
Expression System: HEK293
Urokinase/uPA Protein, Human, Recombinant (His)
TMPY-00904
Species: Human
Expression System: HEK293
SDF-1 Protein, Human, Recombinant (hFc)
TMPY-00740
Species: Human
Expression System: HEK293
IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99)
TMPY-00472
Species: Human
Expression System: E. coli
IL-8/CXCL8 Protein, Human, Recombinant (His)
TMPY-04726
Species: Human
Expression System: Yeast
IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99)
TMPY-00754
Species: Human
Expression System: HEK293
CXCL16 Protein, Human, Recombinant (His)
TMPY-05337
Species: Human
Expression System: HEK293
Cat No. Product Name
L2151 Chemotherapy Drug Library

51 compounds
51 Chemotherapeutic drugs that can be used for high-throughput and high-content screening.
L2200 Tyrosine Kinase Inhibitor Library

1033 compounds
A unique collection of 1033 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
L2100 Anti-Cancer Compound Library

7360 compounds
A unique collection of 7360 compounds with anti-cancer activity for high throughput screening (HTS) and high content screening (HCS);
L4800 Angiogenesis related Compound Library

1370 compounds
A unique collection of 1370 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high throughput screening (HTS) and high content screening (HCS);
L9420 Exosome Compound Library

80 compounds
80 exosome-related compounds that can be used for high-throughput and high-content screening.
L7600 Chemokine Inhibitor Library

59 compounds
A unique collection of 59 chemokines or chemokine receptors targeted compounds for high throughput and high content screening;
L8500 HIF-1 Signaling Pathway Compound Library

1352 compounds
A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies;
TargetMol