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Search Result

Search Results for " mth1 "

Targets

MTH1 MTH1

18

Compounds

1

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T12122 MTH1-IN-2 MTH1
MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.
T2069 TH287 TH287 hydrochloride DNA/RNA Synthesis , MTH1
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
T2069L TH287 hydrochloride DNA/RNA Synthesis , MTH1
TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
T2037 TH588 DNA/RNA Synthesis , MTH1
TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.
T6357 (S)-crizotinib ent-crizotinib Apoptosis , DNA/RNA Synthesis , MTH1
(S)-crizotinib (ent-crizotinib) （IC50 of 72 nM）, an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.
T14509 BAY-707 Others
BAY-707, a highly potent and selective substrate-competitive inhibitor of MTH1 (NUDT1) with an IC50 of 2.3 nM, is well-tolerated in mice and exhibits a favorable pharmacokinetic (PK) profile compared to other MTH1 compou...
T70091 IACS-4759
IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.
T35475 ATAG 4531
Degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide . Induces highly potent and selective degradation of fusion pro...
T69776 BAY-707 acetate
BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1. Despite superior cellular target engagement and pharmacokinetic properties, inhibition of MTH1 with BAY-707 resulted in a clear lack of i...
T24875 TH086 TH 086,TH-086
TH086 is a MTH1 inhibitor.
T28192 NPD7155 NPD-7155,NPD 7155
NPD7155 is a competitive inhibitor of MTH1.
T28194 NPD9948 NPD-9948,NPD 9948
NPD9948 is a competitive inhibitor of MTH1.
T39785 TH5427 hydrochloride
TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibi...
T35474 ATAG 2139
Degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide . Induces highly potent and selective degradation of fusion pro...
T60984 TH588 hydrochloride
TH588 hydrochloride is first-in-class inhibitor of nudix hydrolase family that selectively and effectively bind and inhibit the MTH1 with IC50 value of 5 nM.
T10850 CMP-5 Others
CMP-5 is an effective and selective small-molecule inhibitor of PRMT5. CMP-5 blocks EBV-driven B lymphocyte transformation and survival, but does not show this activity against PRMT1, PRMT4 and PRMT7 enzymes. During hist...
T83818 Isoguanosine-5'-O-triphosphate sodium 2-Hydroxyadenosine 5’-triphosphate,2-hydroxy ATP,isoGTP
Isoguanosine-5'-O-triphosphate, an isomer of guanosine 5'-triphosphate (GTP) and a phosphorylated derivative of crotonoside, does not promote microtubule assembly like GTP. At a concentration of 2 mM, it hampers transcri...
T19243 CMP-5 hydrochloride Others
CMP-5 hydrochloride is a potent and selective PRMT5 inhibitor, while displays no activity against PRMT1/4/7 enzymes. It selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations.
Cat No. Product Name Synonyms Targets
T2S1635 3-Isomangostin MTH1
3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has free radical scavenging activity; it shows antiplasmodial ac...

Natural Products

3-Isomangostin
T2S1635
Synonym:
Target: MTH1

Recombinant Proteins

Species：
Human (1)
Expression System：
E. coli (1)
Tag：
His (1)
Cat No. Product Name Species Expression System
TMPY-00116 MTH1 Protein, Human, Recombinant (His) Human E. coli
NUDT1 (Nudix Hydrolase 1) is a Protein Coding gene. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates to monophosphates, thereby preventing misincorporation. The NUDT1...
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