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Cat No. | Product Name | Synonyms | Targets |
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T21512 | MMP-2/MMP-9 Inhibitor I | MMP | |
MMP-2/MMP-9-IN-1 is a potent, highly selective and orally bioavailable inhibitor of type IV collagenases (MMP-9 and MMP-2) with an IC50 of 0.24 and 0.3 1 μM for MMP-9 and MMP-2, respectively. activity, which can be used ... | |||
T37048 | MMP-3 Inhibitor | MMP | |
MMP-3 Inhibitor is a peptide matrix metalloproteinase-3 (MMP-3) inhibitor with a Ki value of 95 nM.MMP-3 inhibitor has anticancer and antitumor activity. | |||
T36712 | BPHA | MMP-2/MMP-9 Inhibitor II | MMP |
BPHA (MMP-2/MMP-9 Inhibitor II) is a potent, selective and orally active inhibitor of MMP-2, MMP-9 and MMP-14 with IC50s of 12 nM, 16 nM and 17 nM, respectively.BPHA does not inhibit MMP-1, -3 and -7 (IC50s of 974, >1000... | |||
T8310 | MMP-9-IN-1 | MMP | |
MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9). | |||
T77617 | MMP-9-IN-6 | MMP | |
MMP-9-IN-6 is an MMP-9 inhibitor with an IC50 value of 50 μM and good anti-ulcer efficacy.MMP-9-IN-6 has potential anti-tumor activity and can be used to study tissue remodeling, wound repair and atherosclerosis. | |||
T78181 | MMP-7-IN-2 | MMP , Others | |
MMP-7-IN-2 acts as a selective and potent MMP7 inhibitor and can be used to study inflammatory responses and vascular-related diseases. | |||
T72069 | MMP-9-IN-7 | ||
Acetamide, N-[2-[(5-chloro-2 methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]-inhibits pro-matrix metalloproteinase activation and can be used to prevent, treat or ameliorate MMP9 and/or MMP13-mediated syndromes. | |||
T15055 | DB04760 | MMP-13 Inhibitor | MMP |
DB04760 is a highly selective, non-zinc-chelating inhibitor of MMP-13 (IC50: 8 nM). DB04760 obviously decreases paclitaxel neurotoxicity and has anticancer activity. | |||
T14322 | ARP-100 | MMP-2 Inhibitor III | MMP |
ARP-100 (MMP-2 Inhibitor III) is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with the S1' pocket of MMP-2 and exhibits anti-invasive properties in an in vitro invasion ... | |||
T37048L | MMP-3 Inhibitor acetate | MMP-3 Inhibitor acetate(158841-76-0 Free base) | MMP |
MMP-3 Inhibitor acetate is a cell-permeable and potent inhibitor of human MMP-3. | |||
T37172 | MMP-9/MMP-13 Inhibitor I | ||
MMP-9/MMP-13 Inhibitor I is a dual inhibitor of MMP-9 and MMP-13 with IC50 of both 0.9 nM. MMP-9/MMP-13 Inhibitor I is over 20 times more selective for MMP-9/MMP-13 than other MMPs. | |||
T60083 | MMP-12 Inhibitor | MMP12,MMP408 | MMP |
MMP-12 Inhibitor is a selective inhibitor of MMP-12 with IC50s of 2, 160, 320, and 22.3 nM for human, mouse, rat, and sheep MMP-12. | |||
T25825 | MMP-145 | ||
MMP-145 is used as a protease inhibitor. | |||
T37726 | MMP-9 Inhibitor I | ||
MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TAC... | |||
T36962 | MMP Inhibitor I (trifluoroacetate salt) | ||
MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively). It is selective for MMP-1, MMP-2, and MMP-3 over the proteases thermolysin, urea... | |||
T69666 | MMP-8 Inhibitor I | ||
MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. | |||
T76077 | MMP-13 Substrate | ||
MMP-13 Substrate, a compound utilized in osteoarthritis (OA) research [1], functions as a substrate for MMP-13. | |||
T16124 | MMP13-IN-3 | MMP | |
MMP13-IN-3 is >1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis. | |||
T63155 | MMP-9-IN-3 | ||
MMP-9-IN-3 is an MMP-9 inhibitor (IC50: 5.56 nM) that forms hydrogen bonds with MMP-9. MMP-9-IN-3 inhibits AKT activity (IC50: 2.11 nM). mmp-9-IN-3 is cytotoxic and induces apoptosis. mmp-9-IN-3 can be used to study canc... | |||
T63994 | MMP-9-IN-4 | ||
MMP-9-IN-4 is an inhibitor of MMP-9 and interacts with MMP-9 to form H-π with an IC50 value of 7.46 nM. MMP-9-IN-4 also inhibits AKT activity with an IC50 value of 8.82 nM. MMP-9-IN-4 induces apoptosis, shows cytotoxicit... | |||
T73175 | MMP-1-IN-1 | ||
MMP-1-IN-1 is a highly potent MMP-1 inhibitor with an IC 50 of 0.034 μM . | |||
T72719 | Tubulin/MMP-IN-2 | ||
Tubulin/MMP-IN-2, a dual inhibitor of tubulin and matrix metalloproteinases (MMPs), effectively inhibits tubulin polymerization and induces cell apoptosis. It demonstrates inhibitory activities against MMP-2, MMP-3, and ... | |||
T81778 | MMP-7-IN-3 | MMP | |
MMP-7-IN-3 is a potent, selective MMP-7 inhibitor that effectively suppresses the progression of kidney fibrosis in a mouse model with unilateral ureteral obstruction [1]. | |||
T72676 | Tubulin/MMP-IN-1 | ||
Tubulin/MMP-IN-1, a potent inhibitor of both tubulin and MMP, holds promise for cancer research. It effectively suppresses tubulin polymerization, induces G2/M phase cell cycle arrest, and promotes reactive oxidative str... | |||
T64083 | MMP-9-IN-5 | ||
MMP-9-IN-5 is an MMP-9 inhibitor with an IC50 value of 4.49 nM and is able to form hydrogen bonds with MMP-9. MMP-9-IN-5 also inhibits AKT activity with an IC50 value of 1.34 nM. MMP-9-IN-5 exhibits cytotoxicity, induces... | |||
T81777 | MMP-9-IN-8 | ||
MMP-9-IN-8 (Compound 3), an MMP-9 inhibitor, exhibits inhibitory activities of 42.16% at 10 μM and 58.28% at 50 μM. Additionally, MMP-9-IN-8 demonstrates anti-cancer properties, inducing apoptosis in MCF-7 cells with an ... | |||
T83759 | MMP-3 Fluorogenic Substrate TFA | Mca-RPKPVE-Nval-WR-K(Dnp)-NH2,Matrix Metalloproteinase-3 Fluorogenic Substrate,Stromelysin-1 Fluorogenic Substrate | |
MMP-3 Fluorogenic Substrate, a compound designed for matrix metalloproteinase-3 (MMP-3) activity quantification, releases 7-methoxycoumarin-4-acetyl (Mca) upon MMP-3 cleavage. Mca's fluorescence, with excitation and emis... | |||
T62555 | MMP-2/9-IN-1 | ||
MMP-2/9-IN-1 (Compound 4a) is a potent dual inhibitor of MMP-2 (IC50: 56 nM) and MMP-9 (IC50: 38 nM). leading to DNA fragmentation. | |||
T2009 | SB-3CT | MMP | |
SB-3CT is a potent and specific gelatinase inhibitor for MMP-2(Ki=13.9 nM) and MMP-9(Ki=600 nM). | |||
T5361 | T-26c | MMP | |
T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor (IC50: 6.75 pM). | |||
T22115 | SM-7368 | NF-κB | |
The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications. | |||
T16966 | S 3304 | MMP | |
S 3304 is a novel matrix metalloproteinases inhibitor which is specific for MMP-2 and MMP-9. | |||
T14978 | CL-82198 | MMP | |
CL-82198, a selective MMP-13 inhibitor, serves as a pharmacological intervention to halt the progression of osteoarthritis (OA). Its mechanism of action involves binding to the S1’ pocket of MMP-13, ensuring its selectiv... | |||
T4783 | JNJ0966 | MMP | |
JNJ0966 is a highly selective MMP-9 zymogen inhibitor (IC50: 440 nM). | |||
T5416 | T-5224 | MMP | |
T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. | |||
T6011 | Batimastat | BB94 | MMP |
Batimastat (BB94) (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor. Batimastat induces extracellular matrix degradation and inhibits angiogenesis, tumor growth and invasion, and metastasis. | |||
T5983 | O-Phenanthroline | 1,10-Phenanthroline | MMP , Others |
o-Phenanthroline (1,10-Phenanthroline) , a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells.o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene m... | |||
T1891 | NSC 405020 | MMP | |
NSC 405020 is a noncatalytic inhibitor of MT1-MMP. | |||
T8961 | GW280264X | Carbamic acid | MMP |
GW280264X (Carbamic acid) is an inhibitor of ADAM17 . | |||
T7522 | GI254023X | GI 254023X | MMP , Immunology/Inflammation related |
GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can remarkably inhibit the proliferation and induce the apoptosis... | |||
T2743 | Ilomastat | Galardin,GM6001 | MMP |
Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor. | |||
T4282 | S-methyl-KE-298 | MMP , Drug Metabolite | |
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. | |||
T6009 | TAPI1 | TAPI 1,TAPI,TAPI-1 | MMP |
TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors. | |||
T21806 | HNHA | HDAC | |
HNHA is an inhibitor of HDAC. | |||
T15574 | Incyclinide | COL-3,CMT-3 | MMP |
Incyclinide (COL-3) is a matrix metalloproteinase (MMP) inhibitor. Thereby causing extracellular matrix degradation, tumor growth and invasion, and inhibiting angiogenesis, and metastasis. | |||
T0407 | Edaravone | MCI-186 | Apoptosis , MMP , Free radical scavengers |
Edaravone (MCI-186)(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction. | |||
TP1015 | NFAT Inhibitor | VIVIT peptide | Others |
NFAT Inhibitor (VIVIT peptide) is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. | |||
T7459 | Abametapir | HA-44,BRN 0123183 | MMP , Others , Parasite |
Abametapir (BRN 0123183), a metalloproteinase inhibitor, is able to target metalloproteinases critical to egg hatching and louse development. | |||
T12082 | MMP3 inhibitor 1 | MMP | |
MMP3 inhibitor 1 is a potent and highly selective inhibitor of MMP-3 (IC50 of 1 nM). | |||
T6885 | Marimastat | BB2516,KB-R8898,TA2516 | MMP |
Marimastat (BB2516) (BB-2516) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor. MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM)and MMP-7 (IC50=13 nM). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3414 | Morroniside | Apoptosis , MMP , Pyroptosis | |
Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells, by inhib... | |||
T5S0045 | Isofraxidin | 6,8-Dimethoxyumbelliferone,Phytodolor | MMP , ERK , p38 MAPK , TLR , COX |
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote... | |||
T2993 | Cordycepin | 3'-Deoxyadenosine | MMP , TNF , Antibacterial , Antibiotic , Autophagy |
Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity. | |||
T4115 | Auraptene | 7-geranyloxycoumarin | MMP , BACE |
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits le... | |||
TN1879 | Lucideric acid A | Lucidenic acid A | MMP , p38 MAPK , JNK |
Lucideric acid A (Lucidenic acid A) is a modulator of JNK and p38 and enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK/MAPKs activation. | |||
T3860 | Isoliquiritin apioside | MMP , p38 MAPK , NF-κB | |
Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse... | |||
T8259 | Doxycycline monohydrate | MMP , Antibacterial , Antibiotic , Parasite | |
Doxycycline monohydrate is an inhibitor of metalloproteinase (MMP) | |||
T2967 | Stigmasterol | Stigmasterin,beta-Stigmasterol | MMP , Endogenous Metabolite |
Stigmasterol (Stigmasterin) is found in the fats and oils of soybean, calabar bean and rape seed, as well as several other vegetables, legumes, nuts, seeds, and unpasteurized milk. Stigmasterol has been focused on the ch... | |||
T6S0444 | Salvianolic acid A | Dan Phenolic Acid A | MMP |
Salvianolic acid A (Dan Phenolic Acid A) could protect the blood brain barrier through inhibition of matrix metallopeptidase 9 (MMP-9) and anti-inflammation. | |||
T2957 | Arctigenin | (-)-Arctigenin | Apoptosis , MMP , Influenza Virus , Autophagy |
(-)-Arctigenin ((-)-Arctigenin) is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD). Arctigenin is a lignan found in certain plan... | |||
T3767 | Polygalacic acid | Virgaureagenin G | MMP , AChR , AChE |
Polygalacic acid (Virgaureagenin G)(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline acetyltransferase (ChAT) activity, and eleva... | |||
T2980 | Chondroitin sulfate | Chonsurid,Chondroitin polysulfate | MMP , Others , Endogenous Metabolite , NO Synthase |
Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry condition | |||
T5S1026 | Apigenin-7-glucuronide | Apigenin 7-O-glucuronide | MMP |
Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP activities (IC50s: 12.87, 22.39, 1... | |||
T3S0640 | Triolein | Glycerol trioleate,Glycerine Trioleate | MMP , Others , Endogenous Metabolite |
Glyceryl Trioleate has been investigated for the treatment of Adrenoleukodystrophy. | |||
T2987 | (-)-Epigallocatechin | l-Epigallocatechin,Epigallocatechin,EGC | MMP , Autophagy |
(-)-Epigallocatechin, the predominant flavonoid in green tea, possesses the unique ability to attach to unfolded native polypeptides, thereby inhibiting their transformation into amyloid fibrils. | |||
T5680 | Aloin(mixture of A&B) | MMP , IL Receptor , Antibacterial , Antifungal | |
ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells. | |||
T2973 | Astragaloside IV | AST-IV,AS-IV | MMP , ERK , Estrogen/progestogen Receptor , JNK |
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cel... | |||
T6S2140 | β-Anhydroicaritin | Anhydroicaritin,Beta-Anhydroicaritin | MMP , Others , TNF , Interleukin |
1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical ... | |||
T2750 | Ginkgolide C | BN-52022 | MMP , Sirtuin , Endogenous Metabolite , AMPK |
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body. | |||
T3850 | Luteolin 7-O-glucuronide | Luteolin-7-glucuronide | MMP |
Luteolin 7-O-glucuronide (Luteolin-7-glucuronide) possesses antioxidant activities. | |||
T1687 | Doxycycline | Vibramycin,Doxiciclina,Doxytetracycline,Doxycyclinum | MMP , ribosome , Antibacterial , Antibiotic , Parasite |
Doxycycline (Doxiciclina) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline has antibacterial activity and antitumor activity. | |||
T4S21320 | ISOGINKGETIN | 4',4'''-Dimethylamentoflavone | MMP , Others |
1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti... | |||
T3813 | 20(R)-Ginsenoside Rh2 | (20R)Ginsenoside Rh2,Ginsenoside Rh2 | Apoptosis , MMP , HSV |
20(R)-Ginsenoside Rh2 (Ginsenoside Rh2) is a minor stereoisomer of ginsenoside Rh2, possesses matrix metalloproteinase inhibitory. | |||
T1687L | Doxycycline (hyclate) | Doxycycline hydrochloride hemiethanolate hemihydrate,WC2031,Doxycycline hyclate | MMP , ribosome , Antibacterial , Antibiotic |
Doxycycline hyclate (WC2031) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline hyclate has antibacterial activity and antitumor act... | |||
T1205 | Chloramphenicol | Chlornitromycin,Levomycetin,Chloromycetin | ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic |
Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis. | |||
T2769 | 3-Aminopropionitrile fumarate (2:1) | Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate | Others |
3-Aminopropionitrile fumarate (2:1) (β-Aminopropionitrile fumarate) is an organic compound and antirheumatic agent used in veterinary medicine. | |||
T6S0325 | Glycitein | Glycetein | Apoptosis , Others |
1. Gycitein has weak estrogenic activity. 2. Glycitein (Glycetein) inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. | |||
T3524 | Halofuginone hydrobromide | Tempostatin,RU-19110 (hydrobromide),Stenorol | Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce... | |||
TN6784 | Ethyl rosmarinate | Methyl rosmarinate | MMP , Tyrosinase , Glucosidase |
Methyl rosmarinate (Methyl rosmarinate) inhibit the activity of tyrosinase, α-glucosidase, and matrix metalloproteinase-1 (MMP-1). | |||
T7044 | Norepinephrine | Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol | MMP , Endogenous Metabolite , Adrenergic Receptor , Autophagy |
Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. It can up-regulate the expression of vascular endothelial growth factor, matrix metalloprotei... | |||
TN3016 | 4',6,7-Trimethoxyisoflavone | MMP | |
4',6,7-Trimethoxyisoflavone promotes wound healing through NOX2 induction, which leads to collective migration and MMP activation. | |||
T5S1262 | Methylophiopogonanone A | Others | |
1. Methylophiopogonanone A has anti-inflammatory and anti-oxidative properties. 2. Methylophiopogonanone A has therapeutic potential against cerebral I/R injury through its ability to attenuate BBB disruption by regulati... | |||
T3729 | Ethyl gallate | Nipagallin A,Phyllemblin,gallic acid ethyl ester | MMP , NF-κB , Akt , Antibacterial |
Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhib... | |||
T5740 | 25(R,S)-Ruscogenin | (25RS)-Ruscogenin | Others , HIF |
25(R,S)-Ruscogenin is a natual product. | |||
TN4234 | Hydrangenol | NOS , NF-κB , Nrf2 , NO Synthase , Antifection , Autophagy | |
Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can reduce MMP and inflammatory cytokine expression and increa... | |||
TN1928 | Methyl rosmarinate | MMP , Anti-infection , Tyrosinase | |
Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase.Methyl rosmarinate shows antioxidative, and antifungal activities. It has... | |||
T4034 | Solamargine | Solamargin,δ-Solanigrine | Apoptosis , p38 MAPK , P-gp , STAT |
Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cel... | |||
T5S2059 | Glaucine | Calcium Channel , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , PDE | |
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h... | |||
T4S0181 | Hinokiflavone | MMP , BCL , E1/E2/E3 Enzyme | |
Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO... | |||
T3895 | Polyphyllin I | Apoptosis , Akt , JNK , PDK , mTOR , Autophagy | |
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha... | |||
T3S1641 | Esculentoside H | TNF , NF-κB , JNK | |
Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release. | |||
T5S0053 | Coptisine | Coptisin | Indoleamine 2,3-Dioxygenase (IDO) |
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ... | |||
T6S1699 | Shogaol | [6]-Shogaol,6-Shogaol | Lipoxygenase , Autophagy |
1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the f... | |||
T72730 | D-Isofloridoside | ||
D-Isofloridoside, a polysaccharide precursor, exhibits free radical scavenging activity and inhibits both ROS expression and the enzymes MMP-2 and MMP-9. | |||
TN4978 | Scutellarein-7-O-glucoside | MMP | |
Scutellarein-7-O-glucoside inhibites MMP-2 activity. | |||
T14121 | Actinonin | (-)-Actinonin | Aminopeptidase |
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin ... | |||
TN1881 | Lucidenic acid C | MMP | |
Lucidenic acid C has anti-invasive effect, it shows significant inhibitory effects on PMA-induced MMP-9 activity and invasion of HepG(2 )cells. | |||
TN2697 | 2,3-Dihydrohinokiflavone | MMP , Parasite , Antifection | |
2,3-Dihydrohinokiflavone is a suppressor of matrix metalloproteinases (MMP) gene expression and shows strong activity against Leishmania with an IC50 of 1.6 μM. | |||
TN3691 | Communic acid | MMP , MAPK , Akt , PI3K , DNA/RNA Synthesis , Antifection | |
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic ingredients, as they suppress UVB-induced MMP-1 expression... | |||
TN1832 | Kanzonol C | Others , NF-κB , Tyrosinase | |
Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it shows the inhibition of matrix metalloproteinase (MMP)-2 secre... | |||
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Cat No. | Product Name | Species | Expression System |
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TMPY-01919 | MMP-9 Protein, Mouse, Recombinant | Mouse | HEK293 |
Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogen... | |||
TMPY-01477 | MMP-2 Protein, Human, Recombinant | Human | HEK293 |
Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is de... | |||
TMPY-01248 | MMP-9 Protein, Human, Recombinant | Human | HEK293 |
Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogen... | |||
TMPY-01884 | MMP-8 Protein, Human, Recombinant | Human | HEK293 |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ... | |||
TMPY-00888 | MMP-9 Protein, Human, Recombinant (His) | Human | HEK293 |
Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogen... | |||
TMPY-02869 | MMP-12 Protein, Human, Recombinant (catalytic domain) | Human | E. coli |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ... | |||
TMPY-02290 | MMP-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is de... | |||
TMPK-00503 | MMP-9 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demon... | |||
TMPK-00367 | MMP-9 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demon... | |||
TMPJ-00942 | MMP-12 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Matrix metalloproteinase-12(MMP12) is a secreted protein.It contains 4 hemopexin repeats and belongs to the peptidase M10A family. MMP12 may be involved in tissue injury and remodeling and have significant elastolytic ac... | |||
TMPY-01377 | MMP-8 Protein, Human, Recombinant (His) | Human | HEK293 |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ... | |||
TMPH-00010 | MMP-14 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tiss... | |||
TMPY-02689 | MMP-3 Protein, Human, Recombinant | Human | E. coli |
Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular... | |||
TMPK-00368 | MMP-9 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demon... | |||
TMPJ-00447 | MMP-3 Protein, Human, Recombinant (His) | Human | Human Cells |
MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue rem... | |||
TMPJ-00957 | MMP-9 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-9 (gelatinase B) can degrade a broad range of s... | |||
TMPJ-00362 | MMP-2 Protein, Human, Recombinant (His) | Human | Human Cells |
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. Matrix metallo... | |||
TMPY-04100 | MMP-26 Protein, Human, Recombinant | Human | E. coli |
MMP26 (Matrix Metallopeptidase 26) is a Protein Coding gene. MMP26 is a member of matrix metalloproteinases (MMPs) and has been reported to be highly expressed in many cancers. The protein differs from most MMP family me... | |||
TMPY-02965 | MMP-19 Protein, Human, Recombinant | Human | E. coli |
MMP19, also known as RASI-1, is a member of the peptidase M1A family. It contains 4 hemopexin-like domains and is expressed in the mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate... | |||
TMPK-01286 | MMP-8 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Alteration of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) expression has been studied for various cardiac diseases, including dilated cardiomyopathy (DCM), with the significance o... | |||
TMPY-01844 | MMP-8 Protein, Mouse, Recombinant | Mouse | HEK293 |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ... | |||
TMPY-00886 | MMP-1 Protein, Human, Recombinant (His) | Human | HEK293 |
MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the ma... | |||
TMPH-03331 | MMP-7 Protein, Rat, Recombinant (GST) | Rat | E. coli |
MMP-7 Protein, Rat, Recombinant (GST) is expressed in E. coli. | |||
TMPY-00520 | MMP-8 Protein, Mouse, Recombinant (His) | Mouse | CHO |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ... | |||
TMPY-02054 | MMP-9 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogen... | |||
TMPH-02915 | MMP-3 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. | |||
TMPH-01633 | MMP-12 Protein, Human, Recombinant (His) | Human | E. coli |
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are prefer... | |||
TMPH-01644 | MMP-7 Protein, Human, Recombinant (GST) | Human | E. coli |
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. | |||
TMPH-02146 | MMP-10 Protein, Human, Recombinant (His) | Human | E. coli |
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase. | |||
TMPH-02594 | MMP-13 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the hig... | |||
TMPH-01124 | MMP-13 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
MMP-13 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-02145 | MMP-3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. | |||
TMPH-02780 | MMP-24 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
MMP-24 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPY-06314 | MMP-10 Protein, Human, Recombinant (HEK293, His) | Human | HEK293 |
MMP-10 Protein, Human, Recombinant (HEK293, His) is expressed in HEK293 with His tag. The predicted molecular weight is 44.38 kDa. Accession number: P09238 | |||
TMPH-01646 | MMP-20 Protein, Human, Recombinant (His & Myc) | Human | Baculovirus |
Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play... | |||
TMPH-01647 | MMP-20 Protein, Human, Recombinant (E. coli, His & Myc) | Human | E. coli |
Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play... | |||
TMPJ-00159 | EMMPRIN/CD147 Protein, Human, Recombinant (Avi & His), Biotinylated | Human | Human Cells |
Basigin/CD147 is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermato... | |||
TMPY-00685 | EMMPRIN/CD147 Protein, Human, Recombinant | Human | HEK293 |
CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence var... | |||
TMPY-00684 | EMMPRIN/CD147 Protein, Human, Recombinant (hFc) | Human | HEK293 |
CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence var... | |||
TMPY-01316 | EMMPRIN/CD147 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence var... | |||
TMPY-01315 | EMMPRIN/CD147 Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 |
CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence var... | |||
TMPY-06019 | EMMPRIN/CD147 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence var... | |||
TMPK-01334 | EMMPRIN/CD147 Protein, Canine, Recombinant (His) | Canine | HEK293 |
CD147, also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or basigin, is expressed in a variety of cell types. It is involved in the regulation of extracellular matrix (ECM) remodeling during physiolo... | |||
TMPJ-00160 | EMMPRIN/CD147 Protein, Human, Recombinant (His) | Human | Human Cells |
Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) belongs to the immunoglobulin superfamily, which has the homology to both the immunoglobulin V domain and MHC class II antigen β-chain. EMMPRIN is a transmembrane ... | |||
TMPY-01107 | TIMP-1 Protein, Human, Recombinant | Human | HEK293 |
TIMP metallopeptidase inhibitor 1, also known as TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating activity, TPA-S1TPA-induced proteinTissue inhibitor of metalloproteinases 1, is a natural inhibi... | |||
TMPY-05717 | Integrin alpha V beta 8 Protein, Human, Recombinant (His) | Human | HEK293 |
Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cyto... | |||
TMPY-01289 | DDR1 Protein, Human, Recombinant (His) | Human | HEK293 |
Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracell... | |||
TMPH-01665 | TIMP3 Protein, Human, Recombinant (His) | Human | E. coli |
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to ac... | |||
TMPJ-01289 | TIMP-4 Protein, Human, Recombinant (His) | Human | Human Cells |
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene, belongs to the protease inhibitor I35 (TIMP) family. The protein complexes with metalloproteinases (such as collagenases) and irreve... | |||
TMPY-01485 | TIMP-1 Protein, Mouse, Recombinant | Mouse | HEK293 |
TIMP metallopeptidase inhibitor 1, also known as TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating activity, TPA-S1TPA-induced proteinTissue inhibitor of metalloproteinases 1, is a natural inhibi... | |||
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Cat No. | Product Name | ||
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L9810 | Anti-Fibrosis Compound Library | 1180 compounds | |
A unique collection of 1180 potential anti-fibrosis compounds, can be used in HTS and HCS; |