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Search Result

Search Results for " mc1r "

Targets

Melanocortin Receptor

16

Compounds

1

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T7589 Afamelanotide acetate afamelanotide Melanocortin Receptor
Afamelanotide acetate is a synthetic α-melanocyte stimulating hormone analogue and first-in-class melanocortin-1 receptor agonist, used to for Erythropoietic Protoporphyria.
TP1097 Melanotan I [Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I Others
Melanotan I is a non-specific melanocortin receptor (MCR) agonist, an α-melanocyte-stimulating hormone (α-MSH) analog, which is injected subcutaneously to increase the amount of melanin in the skin Melanotan I is used as...
T76670 HMC1R agonist 1
hMC1R agonist 1, with an EC 50 of 3 nM, exhibits at least 300-fold higher selectivity for hMC1R compared to hMC3R (EC 50 >902 nM), hMC4R (EC 50 >915 nM), and hMC5R (EC 50 >1000 nM). This compound demonstrates potential f...
T5464 JNJ-10229570 JNJ10229570,UNII-N9IX402L35,JNJ 10229570 Melanocortin Receptor
JNJ-10229570 (UNII-N9IX402L35) is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids.
T25310 Dersimelagon MT-7117 Melanocortin Receptor
Dersimelagon (MT-7117) is an orally active, selective agonist for the melanocortin 1 receptor (MC1R), demonstrating EC50 values of 8.16 nM (h), 3.91 nM (cm), 1.14 nM (m), and 0.251 nM (r) across species such as human, cy...
TP1011L ACTH (1-17) acetate Melanocortin Receptor
ACTH (1-17) acetate is a potent agonist at the human melanocortin 1 (MC1) receptor with high affinity(Ki = 0.21 nM).
T70720 CD08108
CD08108 is a MC1R agonist.
T69607 Dersimelagon phosphate
Dersimelagon phosphate is a selective melanocortin-1 receptor (MC1R) agonist that increases skin melanin without sun exposure and is being developed to increase light tolerance in EPP/XLP patients.
TP2154 RO27-3225 TFA (274682-89-2 free base) RO27-3225 TFA Others
RO27-3225 TFA is a potent and selective agonist of melanocortin 4 receptor (MC4R; EC50: 1 nM and 8 nM for MC4R and MC1R) with neuroprotective and anti-inflammatory effects. RO27-3225 TFA shows ~30-fold selectivity for MC...
T76072 CCZ01048
CCZ01048, an analogue of α-melanocyte-stimulating hormone (α-MSH), demonstrates a high binding affinity for the melanocortin 1 receptor (MC1R), with a Ki of 0.31 nM. It rapidly internalizes into B16F10 melanoma cells and...
T76072L CCZ01048 TFA
CCZ01048 TFA, an α-MSH analogue, demonstrates a strong binding affinity for the melanocortin 1 receptor (MC1R), displaying a K i value of 0.31 nM. It exhibits rapid internalization into B16F10 melanoma cells and maintain...
T75715 Nonapeptide-1 acetate salt
Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, functions as a selective and competitive antagonist of the melanocortin 1 receptor (MC1R) with a binding affinity (K i) of 40 nM. It effectively inhibits α...
T71559 Melanotan II acetate
Melanotan II acetate is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R. It has been shown to improve recovery of sciatic nerve function after mechanical injury and increase cisplatin-induced decreases...
T12882L Setmelanotide Acetate(920014-72-8 free base) RM-493 Acetate,IRC-022493 Acetate,BIM-22493 Acetate Melanocortin Receptor
Setmelanotide Acetate(920014-72-8 free base) (RM-493 Acetate) is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM and 0.28 nM, respectively).
T10568 BMS-470539 dihydrochloride Others
BMS-470539 dihydrochloride is a highly potent and selective agonist of the melanocortin-1 receptor (MC-1R; IC50: 120 nM; EC50: 28 nM) with anti-inflammatory properties. It does not activate MC-3R and is a very weak parti...
T12882 Setmelanotide BIM-22493,IRC-022493,RM-493 Melanocortin Receptor
Setmelanotide (BIM-22493) is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM and 0.28 nM, respectively).
Cat No. Product Name Synonyms Targets
TMA0003 Trans-caffeic acid cAMP , Tyrosinase
Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyr...

Natural Products

Trans-caffeic acid
TMA0003
Synonym:
Target: cAMP, Tyrosinase

Recombinant Proteins

Species：
Bovine (1)
Expression System：
Baculovirus (1)
Tag：
N-terminal 10xHis-tagged (1)
Cat No. Product Name Species Expression System
TMPH-00221 Agouti-signaling Protein, Bovine, Recombinant (His) Bovine Baculovirus
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) an...
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