Search Result

Search Results for " keap1-nrf2 "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T39514	Keap1-Nrf2-IN-3	Keap1-Nrf2-IN-3
	Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.
T11752	Keap1-Nrf2-IN-1	Keap1–Nrf2-IN-1	Src
	Keap1–Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1–Nrf2 IN-1 is a Kelch-like ECH-associated protein 1-nuclear fa...		Src
T12253	Nrf2-IN-1		Others , Nrf2
	Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).		Others , Nrf2
T8979	AEM1		Nrf2
	AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. AEM1 acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibit...		Nrf2
T16331	NK-252		Others , Nrf2
	NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.		Others , Nrf2
T4360	ML385		Others , Ferroptosis , Nrf2
	ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhibition of NRF2. ML385 also exhibits anti-tumor activity.		Others , Ferroptosis , Nrf2
T80522	Keap1-Nrf2 probe
	Keap1-Nrf2 probe [1] is a fluorescent molecule designed to target the interaction between the Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2).
T72760	Keap1-Nrf2-IN-6
	Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nM and a dissociation constant (Kd) of 68 nM.
T78697	Keap1-Nrf2-IN-15
	Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence re...
T74600	Keap1-Nrf2-IN-9
	Keap1-Nrf2-IN-9 (compound 11) is a potent inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI) with an IC50 value of 0.575 µM. It enhances the expression of Nrf2 target genes, including heme oxygenase 1 (Hmox1),...
T72706	Keap1-Nrf2-IN-13
	Keap1-Nrf2-IN-13 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI), exhibiting an IC50 value of 0.15 μM, indicative of its high efficacy. It binds strongly to the Keap1 protein by forming hydrogen...
T81984	Keap1-Nrf2-IN-10
	Keap1-Nrf2-IN-10 (compound 15) is a potent inducer of NQO1 and efficaciously mitigates oxidative stress in gamma-irradiated mice by reducing MDA and ROS levels, as well as NQO1 in the liver, which enhances the survival r...
T64218	Keap1-Nrf2-IN-1 TFA
	Keap1-Nrf2-IN-1 TFA (compound35) is a Keap1-Nrf2 protein-protein interaction inhibitor (IC50: 43 nM) that activates Nrf2-regulated cytoprotective responses. Keap1-Nrf2-IN-1 TFA antagonizes acetaminophen-induced liver inj...
T63294	Keap1-Nrf2-IN-5
	Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).
T63987	Keap1-Nrf2-IN-14
	Keap1-Nrf2-IN-14 is a KEAP1-NRF2 inhibitor that effectively disrupts the KEAP1-NRF2 interaction (IC50: 75 nM) with a Kd=24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of NRF2 target genes and is able to enhance...
T80260	Keap1-Nrf2-IN-16
	Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.
T64190	Keap1-Nrf2-IN-12
	eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.
T72687	Keap1-Nrf2-IN-11
	Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression...
T61773	Keap1-Nrf2-IN-4
	Keap1-Nrf2-IN-4, a powerful neddylation inhibitor, demonstrates significant anti-proliferation activity against MGC-803 cells (IC50 = 2.55 μM), effectively impeding their migration and inducing apoptosis. Additionally, i...
T1593	Ezetimibe	SCH 58235	Others , Nrf2 , NPC1L1 , Autophagy
	Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.		Others , Nrf2 , NPC1L1 , Autophagy
T5364	TBHQ	tert-Butylhydroquinone	Apoptosis , ERK , Others , Ferroptosis , Nrf2 , Autophagy
	TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.		Apoptosis , ERK , Others , Ferroptosis , Nrf2 , Autophagy
T13604	CDDO-dhTFEA		Others , NF-κB , Nrf2
	CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expressi...		Others , NF-κB , Nrf2
T6919	Omaveloxolone	RTA-408	Apoptosis , Others , Nrf2 , STING
	Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.		Apoptosis , Others , Nrf2 , STING
TP2109	TAT 14		Nrf2
	Nrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-α expression in THP-1 cells.		Nrf2
T0153	Oltipraz	NSC 347901,RP 35972	HIF/HIF Prolyl-Hydroxylase , HIV Protease , Reverse Transcriptase , Nrf2 , HIF
	Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin...
TQ0120	CDDO-Im	RTA-403,CDDO-Imidazolide,TP-235	Others , Ferroptosis , Nrf2 , PPAR
	CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).		Others , Ferroptosis , Nrf2 , PPAR
T6165	Bardoxolone Methyl	RTA 402,CDDO Methyl ester,TP-155,NSC 713200	Apoptosis , IκB/IKK , Ferroptosis , Nrf2 , Autophagy
	Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-tumor and anti-inflammatory activities.		Apoptosis , IκB/IKK , Ferroptosis , Nrf2 , Autophagy
T11758L	KI696		Nrf2
	KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.		Nrf2
T28497	RA-839	RA 839,RA839	Nrf2
	RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.RA-839 inhibits the expression of inducible nitric oxi...		Nrf2
TP2109L	AT 14 acetate		Nrf2
	TAT 14 acetate, a 14-mer peptide, is an Nrf2 activator with anti-inflammatory properties. TAT 14 acetate increases Nrf2 protein levels due to targeting the Nrf2 binding site on Keap1, but has no effect on Nrf2 mRNA expre...		Nrf2
T12078	ML334	LH601A	Nrf2
	ML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proli...		Nrf2
T7374	2-HBA		Caspase , NADPH
	2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.		Caspase , NADPH
T40063	CBR-470-1		Nrf2
	CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protect...		Nrf2
T4580	4-Octyl itaconate		Nrf2
	4-Octyl Itaconate is a cell-permeable derivative of Itaconate, an anti-inflammatory metabolite. 4-Octyl Itaconate activates Nrf2 via alkylation of KEAP1 and also inhibits phosphorylation of STING. 4-Octyl Itaconate is an...		Nrf2
T27077	CPUY192018 Disodium	CPUY-192018,CPUY192018,CPUY192018disodium,CPUY192018 Na2,CPUY192018-disodium
	CPUY192018 Disodium is a potent inhibitor of the Keap1-Nrf2 PPI. The inhibition of the Keap1-Nrf2 PPI may be beneficial as a treatment for ulcerative colitis.
T22556	AI-3		Others
	Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor		Others
T78841	Nrf2-IN-3
	Nrf2-IN-3 (Compound R16), a Nrf2 inhibitor, binds to KEAP1 mutants (G333C mKEAP1) thereby restoring the impaired KEAP1/NRF2 interactions. This restoration sensitizes KEAP1-mutant cancer cells to chemotherapeutic agents, ...
T69401	MIND4-17
	MIND4-17, a potent NRF2 activator, covalently modifies the C151 residue of Keap1, disrupting the Keap1-Nrf2 association. This action leads to the stabilization and nuclear translocation of the Nrf2 protein, consequently ...
T75914	TAT-14 TFA
	TAT-14 TFA is a 14-mer peptide functioning as an Nrf2 activator possessing anti-inflammatory properties. It does not alter Nrf2 mRNA expression but elevates Nrf2 protein levels by targeting the Nrf2 binding site on Keap1...
T79698	S217879
	S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway. This compound is applicable in research on non-alcoholic steatohepati...
T36614	DL-Sulforaphane N-acetyl-L-cysteine
	Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressor...
T61688	Nrf2 activator-2
	Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 μM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 acti...
T68790	Shinorine
	Shinorine, a mycosporine-like amino acid (MAA), is a small molecule sunscreen produced in some bacteria. Shinorine ameliorates chromium induced toxicity in zebrafish hepatocytes through the facultative activation of Nrf...
T64214	NXPZ-2
	NXPZ-2 is an orally active Keap1-Nrf2protein-protein interaction (PPI) inhibitor (Ki: 95 nM, EC50: 120 and 170 nM). NXPZ-2 dose-dependently attenuates Aβ[1-42]-induced cognitive disturbances, enhances neuronal number and...

Compounds

Keap1-Nrf2-IN-3

T39514

Synonym: Keap1-Nrf2-IN-3

Target:

Keap1-Nrf2-IN-1

T11752

Synonym: Keap1–Nrf2-IN-1

Target: Others, Nrf2

Target: Others, Nrf2

ML385

T4360

Synonym:

Target: Others, Ferroptosis, Nrf2

Keap1-Nrf2-IN-1 TFA

Target: Others, Nrf2, NPC1L1, Autophagy

TBHQ

T5364

Synonym: tert-Butylhydroquinone

Target: Apoptosis, ERK, Others, Ferroptosis, Nrf2, Autophagy

CDDO-dhTFEA

T13604

Synonym:

Target: Others, NF-κB, Nrf2

Omaveloxolone

T6919

Synonym: RTA-408

Target: Apoptosis, Others, Nrf2, STING

Synonym: NSC 347901,RP 35972

Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF

CDDO-Im

TQ0120

Synonym: RTA-403,CDDO-Imidazolide,TP-235

Target: Others, Ferroptosis, Nrf2, PPAR

Bardoxolone Methyl

T6165

Synonym: RTA 402,CDDO Methyl ester,TP-155,NSC 713200

Target: Apoptosis, IκB/IKK, Ferroptosis, Nrf2, Autophagy

Synonym: RA 839,RA839

Target: Caspase, NADPH

Synonym: CPUY-192018,CPUY192018,CPUY192018disodium,CPUY192018 Na2,CPUY192018-disodium

DL-Sulforaphane N-acetyl-L-cysteine

Cat No.	Product Name	Synonyms	Targets
T21065	Artemisitene		Others
	Artemisitene is the oxidized form of Artemisinin and is an antimalarial agent. Artemisinin precursors are the important basic substances for biosynthesis of Artemisinin, including Artemisinin B, Artemisitene, Artemisini...		Others
T6S1302	Carnosol		Nrf2 , Endogenous Metabolite , S6 Kinase
	Carnosol is an Nrf2 activator, increasing Nrf2 levels and promoting heme oxygenase 1 (HMOX1) expression. It is a ribosomal S6 kinase (RSK2) inhibitor and can be used in gastric cancer-related research with an IC50 value ...		Nrf2 , Endogenous Metabolite , S6 Kinase
T3849	Kinsenoside	(+)-Kinsenoside	Apoptosis , Nrf2
	Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function, it cou...		Apoptosis , Nrf2
TQ0207	Sulforaphane		Apoptosis , Nrf2 , HDAC
	Sulforaphane is derived from the consumption of cruciferous vegetables, such as broccoli. It has shown anticancer and cardioprotective activities.		Apoptosis , Nrf2 , HDAC
TN1621	Eriodictyol-7-O-glucoside		Nrf2
	Eriodictyol-7-O-glucoside is an Nrf2 activator conferring protection against Cisplatin-induced toxicity. Eriodictyol-7-O-glucoside is a flavonoid and a free radical scavenger with antioxidant activity in pistachio skin.		Nrf2
T6S2356	Corynoline	(+)-Corynoline	Nrf2 , AChE
	1. Corynoline ((+)-Corynoline) is an acetylcholinesterase inhibitor.		Nrf2 , AChE
TN1674	Garcinone D		Reactive Oxygen Species , Nrf2 , STAT
	Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 acti...		Reactive Oxygen Species , Nrf2 , STAT
T6S0232	Eriodictyol	Huazhongilexone	Influenza Virus , DNA/RNA Synthesis , Nrf2 , Endogenous Metabolite
	1. Eriodictyol (Huazhongilexone) is a flavonoid with anti-inflammatory and antioxidant activities. 2. Eriodictyol may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance. 3....
TQ0211	Brusatol	(+)-Brusatol,NSC 172924	Others , Ferroptosis , Nrf2
	Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.		Others , Ferroptosis , Nrf2
T3012	Mangiferin	Alpizarin,Chinomin,Hedysarid	Apoptosis , Others , NF-κB , Nrf2
	Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.		Apoptosis , Others , NF-κB , Nrf2
T1027	Luteolin	Luteolol,Flacitran,Digitoflavone,Luteoline	Apoptosis , Nrf2 , Endogenous Metabolite , PDE , Autophagy
	Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor. Luteolin has a wide range of biological activities including antitumor, antioxidant, anti-inflammatory, antim...
T0973	Pyridoxine	Pyridoxol,Vitamin B6,Gravidox	PLK , Nrf2 , Endogenous Metabolite
	Pyridoxine (Vitamin B6) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical research...		PLK , Nrf2 , Endogenous Metabolite
T2915	Bardoxolone	RTA 401,CDDO	Others , Nrf2
	Bardoxolone (CDDO) is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By supp...		Others , Nrf2
TN6339	(R)-5-Hydroxy-1,7-diphenylheptan-3-one	(5R)-Dihydroyashabushiketol	Others
	(R)-5-Hydroxy-1,7-diphenylheptan-3-one ((5R)-Dihydroyashabushiketol) is extracted from the rhizomes of Alpinia officinarum, a Chinese medicinal herb. (R)-5-Hydroxy-1,7-diphenylheptan-3-one inhibits melanogenesis in theop...		Others
T3227	Danshensu	Salvianic acid A,Dan shen suan A	Apoptosis , Nrf2 , Autophagy
	Danshensu (Dan shen suan A) is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.		Apoptosis , Nrf2 , Autophagy
T0492	Dimethyl fumarate	DMF	Reactive Oxygen Species , HIV Protease , Nrf2 , Endogenous Metabolite , Autophagy
	Dimethyl fumarate (DMF), a fumarate derivative, is used as antiinflammatory and immunomodulatory agent.
TN6711	Toralactone		Others , Nrf2
	Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism		Others , Nrf2
T1558	Resveratrol	trans-Resveratrol,SRT 501	Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal
	Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop...
T3743	4-hydroxyphenylacetic acid	p-Hydroxyphenylacetic acid,parahydroxy phenylacetate	Antioxidant , Nrf2 , Endogenous Metabolite
	4-hydroxyphenylacetic acid (parahydroxy phenylacetate) is a major microbiota-derived metabolite of polyphenols. 4-hydroxyphenylacetic acid(p-Hydroxyphenylacetic acid) is involved in the antioxidative action. 4-hydroxyphe...		Antioxidant , Nrf2 , Endogenous Metabolite
T1516	Curcumin	Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow	Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy
	Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant...
T0973L	Pyridoxine hydrochloride	Pyridoxine HCl,Pyridoxol (hydrochloride),Vitamin B6 (hydrochloride),Vitamin B6	Nrf2 , Endogenous Metabolite
	Pyridoxine hydrochloride (Vitamin B6) is the 4-methanol form of vitaminB6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingo...		Nrf2 , Endogenous Metabolite
T2794	Astilbin	Neoastilbin,Taxifolin 3-O-rhamnoside,Isoastilbin,Taxifolin 3-rhamnoside,Neoisoastilbin	TNF , NF-κB , Nrf2
	Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.		TNF , NF-κB , Nrf2
T1368	Methyl 3,4-dihydroxybenzoate	3,4-Dihydroxybenzoic acid methyl ester,Methyl protocatechuate,Protocatechuic acid methyl ester	Apoptosis , Antioxidant , Nrf2
	Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect.		Apoptosis , Antioxidant , Nrf2
T8281	(R)-Sulforaphane	L-Sulforaphane	Nrf2
	(R)-Sulforaphane (L-Sulforaphane) is a potent inducer of the Keap1/Nrf2/ARE pathway.		Nrf2
TN6750	2-tert-Butyl-1,4-benzoquinone		Nrf2
	2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its negative regulator Keap1 in RAW264.7 cells.		Nrf2
TN1058	Pelargonidin chloride		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
T6S0525	Farrerol		ERK , p38 MAPK , Akt
	1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection and could be useful in protection against bovine mastitis. 3....		ERK , p38 MAPK , Akt
T73205	Praelolide
	Praelolide, a potent Nrf2 activator, disrupts Keap1-Nrf2 protein-protein interactions through noncovalent binding to Keap1, inhibiting osteoclastogenesis and the production of reactive oxygen species (ROS). With its pote...
T75485	Dehydrobruceine B
	Dehydrobruceine B, a quassinoid isolated from Brucea javanica, demonstrates a synergistic effect with Cisplatin in inducing apoptosis through the mitochondrial pathway. It enhances the expression of apoptosis-inducing fa...
TN3806	Dehydroglyasperin C		ERK , IκB/IKK , p38 MAPK , TNF , NF-κB , Akt , COX , PI3K , NADPH , DNA/RNA Synthesis , Nrf2 , JNK , Autophagy
	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protectiv...

Natural Products

Target: Nrf2, Endogenous Metabolite, S6 Kinase

Kinsenoside

T3849

Synonym: (+)-Kinsenoside

Target: Apoptosis, Nrf2

Sulforaphane

TQ0207

Synonym:

Target: Apoptosis, Nrf2, HDAC

Eriodictyol-7-O-glucoside

Synonym: (+)-Corynoline

Target: Reactive Oxygen Species, Nrf2, STAT

Eriodictyol

T6S0232

Synonym: Huazhongilexone

Target: Influenza Virus, DNA/RNA Synthesis, Nrf2, Endogenous Metabolite

Brusatol

TQ0211

Synonym: (+)-Brusatol,NSC 172924

Target: Others, Ferroptosis, Nrf2

Mangiferin

T3012

Synonym: Alpizarin,Chinomin,Hedysarid

Target: Apoptosis, Others, NF-κB, Nrf2

Luteolin

T1027

Synonym: Luteolol,Flacitran,Digitoflavone,Luteoline

Target: Apoptosis, Nrf2, Endogenous Metabolite, PDE, Autophagy

Pyridoxine

T0973

Synonym: Pyridoxol,Vitamin B6,Gravidox

Target: PLK, Nrf2, Endogenous Metabolite

Bardoxolone

T2915

Synonym: RTA 401,CDDO

Target: Others, Nrf2

(R)-5-Hydroxy-1,7-diphenylheptan-3-one

TN6339

Synonym: (5R)-Dihydroyashabushiketol

Target: Others

Danshensu

T3227

Synonym: Salvianic acid A,Dan shen suan A

Target: Apoptosis, Nrf2, Autophagy

Dimethyl fumarate

T0492

Synonym: DMF

Target: Reactive Oxygen Species, HIV Protease, Nrf2, Endogenous Metabolite, Autophagy

toralactone

TN6711

Synonym:

Target: Others, Nrf2

Resveratrol

T1558

Synonym: trans-Resveratrol,SRT 501

Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal

4-hydroxyphenylacetic acid

T3743

Synonym: p-Hydroxyphenylacetic acid,parahydroxy phenylacetate

Target: Antioxidant, Nrf2, Endogenous Metabolite

Curcumin

T1516

Synonym: Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow

Target: Mitophagy, Epigenetic Reader Domain, Ferroptosis, Influenza Virus, Nrf2, Histone Acetyltransferase, HDAC, Autophagy

Pyridoxine hydrochloride

T0973L

Synonym: Pyridoxine HCl,Pyridoxol (hydrochloride),Vitamin B6 (hydrochloride),Vitamin B6

Target: Nrf2, Endogenous Metabolite

Astilbin

T2794

Synonym: Neoastilbin,Taxifolin 3-O-rhamnoside,Isoastilbin,Taxifolin 3-rhamnoside,Neoisoastilbin

Target: TNF, NF-κB, Nrf2

Methyl 3,4-dihydroxybenzoate

T1368

Synonym: 3,4-Dihydroxybenzoic acid methyl ester,Methyl protocatechuate,Protocatechuic acid methyl ester

Target: Apoptosis, Antioxidant, Nrf2

(R)-Sulforaphane

T8281

Synonym: L-Sulforaphane

Target: Nrf2

2-tert-Butyl-1,4-benzoquinone

TN6750

Synonym:

Target: Nrf2

Pelargonidin chloride

TN1058

Synonym:

Target: NOS, Reactive Oxygen Species, Nrf2, NO Synthase

Tricetin

TN5171

Synonym:

Target: Apoptosis, Others, Nrf2

Farrerol

T6S0525

Synonym:

Target: ERK, p38 MAPK, Akt

Target: ERK, IκB/IKK, p38 MAPK, TNF, NF-κB, Akt, COX, PI3K, NADPH, DNA/RNA Synthesis, Nrf2, JNK, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03888	KEAP1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-02101	KEAP1 Protein, Human, Recombinant (His & GST & Avi)	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-03432	KEAP1 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPH-01788	NFE2L2 Protein, Human, Recombinant (His)	Human	E. coli
	Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzyme...

KEAP1 Protein, Human, Recombinant (His & GST)

TMPY-03888

Species: Human

Expression System: Baculovirus-Insect Cells

KEAP1 Protein, Human, Recombinant (His & GST & Avi)

TMPY-02101

Species: Human

Expression System: Baculovirus-Insect Cells

KEAP1 Protein, Human, Recombinant

TMPY-03432

Species: Human

Expression System: Baculovirus-Insect Cells

NFE2L2 Protein, Human, Recombinant (His)

TMPH-01788

Species: Human

Expression System: E. coli