Search Result

Search Results for " jak2 "

Targets

158

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T40443	JAK2-IN-6	JAK2-IN-6	JAK
	JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 μg/mL). Jak2-in-6 inhibits the activity of JAK2 enzymes by interfering with Jak2-related signaling pathway...		JAK
T35900	JAK2-IN-7	JAK2-IN-7	JAK
	JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and select...		JAK
T3042	JAK2 Inhibitor V	JAK2 Inhibitor V Z3,Z3	JAK
	JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.		JAK
T8742	G5-7	JAK2 inhibitor G5-7	Apoptosis , JAK
	JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) is an orally active JAK2 inhibitor, selectively inhibits JAK2–mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 has the potential for g...		Apoptosis , JAK
T71193	Jak2-IN-7j
	Jak2-IN-7j is a selective Jak2 inhibitor which demonstrates a time-dependent knock-down of pSTAT5, which is a downstream target of Jak2.
T11708	JAK2-IN-4		JAK
	JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.		JAK
T19017	JAK2 JH2 Tracer		Others
	JAK2 JH2 Tracer is a fluorescent probe for the JAK2 JH2 domain (Kd: 0.2 μM).		Others
T11707	JAK2/FLT3-IN-1		JNK
	JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, F...		JNK
T79581	JAK2-IN-9		JAK
	Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM. It effectively inhibits the phosphorylation of JAK2, STAT3, and STAT5, possesses metabolic stabilities, and induces apoptosis. This com...		JAK
T64227	JAK2 JH2 binder-1
	JAK2 JH2 binder-1 is a potent and selective JAK2 JH2 binder (Ki: 37.1 nM). JAK2 JH2 binder-1 has the potential to be used in the study of various myeloproliferative neoplasms.
T63146	JAK2/TYK2-IN-1
	JAK2/TYK2-IN-2 is a potent and selective inhibitor of TYK2 (IC50: 9 nM) and JAK2 (IC50: 157 nM) with anti-inflammatory effects.
T80921	Tubulin/JAK2-IN-1
	Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant antiproliferative effects against cancer cells [1].
T72754	JAK2/STAT3-IN-1
	JAK2/STAT3-IN-1 -10a) is a potent inhibitor of GP130, exhibiting an IC50 value of 3.04 µM and demonstrating anti-tumor activity.
T64104	JAK2/FLT3-IN-1 TFA
	JAK2/FLT3-IN-1 (TFA) is an orally active dual inhibitor of JAK2/FLT3 that exhibits anticancer effects, acting on JAK2 (IC50: 0.7 nM), FLT3 (IC50: 4 nM), JAK1 (IC50: 26 nM) and JAK3 (IC50: 39 nM).
T62317	α7 nAchR-JAK2-STAT3 agonist 1
	α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β...
TP1269	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)	Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9
	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.
T3133	YM-90709	YM90709,YM 90709	IL Receptor , Interleukin
	YM-90709 is a new-type antagonist inhibiting the binding of interleukin-5 to the interleukin-5 receptor.		IL Receptor , Interleukin
T12266	Ilginatinib	NS-018	Tyrosine Kinases , JAK
	Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.		Tyrosine Kinases , JAK
T71191	Covidcil-19
	Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency i...
T12266L2	Ilginatinib hydrochloride	NS-018 hydrochloride	Tyrosine Kinases , JAK
	Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.		Tyrosine Kinases , JAK
T12266L	Ilginatinib maleate	NS-018 maleate	Tyrosine Kinases , JAK
	Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.		Tyrosine Kinases , JAK
T22338	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	GDC046	Others , JAK
	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.		Others , JAK
T1995	Fedratinib	TG-101348,SAR 302503	Apoptosis , FLT , c-RET , JAK
	Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.		Apoptosis , FLT , c-RET , JAK
T38436	JAK-2/3-IN-1
	JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms. It exhibits remarkable potency, with Ki values below 250 nM for both isoforms.
T9251	Fedratinib hydrochloride hydrate	TG-101348 hydrochloride hydrate,SAR 302503 hydrochloride hydrate	Apoptosis , JAK
	Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.		Apoptosis , JAK
T21503	(E/Z)-Zotiraciclib	(E/Z)-TG02,(E/Z)-SB1317	FLT , JAK , CDK
	(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.		FLT , JAK , CDK
T5049	NVP-BSK805	NVP-BSK805 2HCl,BSK 805	Tyrosine Kinases , JAK
	NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.		Tyrosine Kinases , JAK
T20742	TG-89		FLT , c-RET , JAK
	TG-89 is an inhibitor of JAK2, JAK3, RET and FLT3, and has an IC50 value of 11.2 μM against JAK2, showing anticancer activity in the treatment of ovarian and cervical cancer.		FLT , c-RET , JAK
T3072	XL019		Apoptosis , FLT , JAK , PDGFR
	XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.		Apoptosis , FLT , JAK , PDGFR
T6309	AZ960	AZ 960	Apoptosis , Virus Protease , JAK , Parasite
	AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).		Apoptosis , Virus Protease , JAK , Parasite
T3065	TG101209		Apoptosis , FLT , c-RET , JAK , Autophagy
	TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.		Apoptosis , FLT , c-RET , JAK , Autophagy
T6122	CEP-33779	CEP33779	JAK
	CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.		JAK
T6838	FLLL32		Apoptosis , JAK , STAT
	FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).		Apoptosis , JAK , STAT
T2360	Baricitinib phosphate	Baricitinib Phosphate,LY3009104,INCB-028050 phosphate,LY-3009104 phosphate,INCB028050	Tyrosine Kinases , JAK
	Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.		Tyrosine Kinases , JAK
T2638	Gandotinib	LY2784544	VEGFR , FGFR , FLT , JAK
	LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3.		VEGFR , FGFR , FLT , JAK
T2156	WP1066		Apoptosis , JAK , STAT
	WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has been used in trials studying the treatment of Melanoma, Bra...		Apoptosis , JAK , STAT
T6294	NVP-BSK805 2HCl (1092499-93-8(free base))	NVP-BSK805 dihydrochloride,BSK 805,NVP-BSK805 (dihydrochloride)	Tyrosine Kinases , JAK
	NVP-BSK805 2HCl (1092499-93-8(free base)) (BSK 805)(IC50=0.5 nM), a specific and effective ATP-competitive JAK2 inhibitor, is more than 20-fold specificity over JAK1, JAK3 and TYK2.		Tyrosine Kinases , JAK
T4227	SB1317 hydrochloride (1204918-72-8(free base))	TG-02 hydrochloride	FLT , JAK , CDK
	SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).		FLT , JAK , CDK
T3069	AZD-1480		JAK
	AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies...		JAK
T61494	JAK-IN-21		Tyrosine Kinases , JAK
	JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.		Tyrosine Kinases , JAK
T3068	AT9283	J-504568	Apoptosis , FLT , JAK , Bcr-Abl , Aurora Kinase , Autophagy
	AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).
T1929	Filgotinib	GLPG0634	Tyrosine Kinases , JAK
	Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.		Tyrosine Kinases , JAK
TQ0010	Brepocitinib	PF-06700841	Tyrosine Kinases , JAK
	Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).		Tyrosine Kinases , JAK
T17019	TCS 21311	NIBR3049	GSK-3 , JAK , PKC
	TCS 21311 (NIBR3049) is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively). It displays >100-fold selectivity over JAK1, JAK...		GSK-3 , JAK , PKC
T20743	TG-46	TG46,TG 46	FLT , JAK
	TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.		FLT , JAK
T3080	Pyridone 6	Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I	Tyrosine Kinases , JAK
	Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM...		Tyrosine Kinases , JAK
T8719	SC99		Apoptosis , JAK , STAT
	SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti...		Apoptosis , JAK , STAT
T15769	LMT-28		IL Receptor
	LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2.		IL Receptor
T6020	Pacritinib	SB1518	FLT , Tyrosine Kinases , JAK
	Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).		FLT , Tyrosine Kinases , JAK
T6217	LFM-A13		PLK , JAK , BTK
	LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.		PLK , JAK , BTK

Compounds

Synonym: JAK2 Inhibitor V Z3,Z3

Target: JAK

G5-7

T8742

Synonym: JAK2 inhibitor G5-7

Target: Apoptosis, JAK

α7 nAchR-JAK2-STAT3 agonist 1

T62317

Synonym:

Target:

Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)

TP1269

Synonym: Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9

Target:

YM-90709

T3133

Synonym: YM90709,YM 90709

Target: IL Receptor, Interleukin

Ilginatinib

T12266

Synonym: NS-018

Target: Tyrosine Kinases, JAK

Ilginatinib hydrochloride

T12266L2

Synonym: NS-018 hydrochloride

Target: Tyrosine Kinases, JAK

Ilginatinib maleate

T12266L

Synonym: NS-018 maleate

Target: Tyrosine Kinases, JAK

2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

T22338

Synonym: GDC046

Target: Others, JAK

Fedratinib

T1995

Synonym: TG-101348,SAR 302503

Target: Apoptosis, FLT, c-RET, JAK

Fedratinib hydrochloride hydrate

T9251

Synonym: TG-101348 hydrochloride hydrate,SAR 302503 hydrochloride hydrate

Target: Apoptosis, JAK

(E/Z)-Zotiraciclib

T21503

Synonym: (E/Z)-TG02,(E/Z)-SB1317

Target: FLT, JAK, CDK

NVP-BSK805

T5049

Synonym: NVP-BSK805 2HCl,BSK 805

Target: Tyrosine Kinases, JAK

TG-89

T20742

Synonym:

Target: FLT, c-RET, JAK

XL019

T3072

Synonym:

Target: Apoptosis, FLT, JAK, PDGFR

AZ960

T6309

Synonym: AZ 960

Target: Apoptosis, Virus Protease, JAK, Parasite

TG101209

T3065

Synonym:

Target: Apoptosis, FLT, c-RET, JAK, Autophagy

Target: Apoptosis, JAK, STAT

Baricitinib phosphate

T2360

Synonym: Baricitinib Phosphate,LY3009104,INCB-028050 phosphate,LY-3009104 phosphate,INCB028050

Target: Tyrosine Kinases, JAK

Gandotinib

T2638

Synonym: LY2784544

Target: VEGFR, FGFR, FLT, JAK

WP1066

T2156

Synonym:

Target: Apoptosis, JAK, STAT

NVP-BSK805 2HCl (1092499-93-8(free base))

T6294

Synonym: NVP-BSK805 dihydrochloride,BSK 805,NVP-BSK805 (dihydrochloride)

Target: Tyrosine Kinases, JAK

SB1317 hydrochloride (1204918-72-8(free base))

T4227

Synonym: TG-02 hydrochloride

Target: FLT, JAK, CDK

Target: Tyrosine Kinases, JAK

AT9283

T3068

Synonym: J-504568

Target: Apoptosis, FLT, JAK, Bcr-Abl, Aurora Kinase, Autophagy

Filgotinib

T1929

Synonym: GLPG0634

Target: Tyrosine Kinases, JAK

Brepocitinib

TQ0010

Synonym: PF-06700841

Target: Tyrosine Kinases, JAK

TCS 21311

T17019

Synonym: NIBR3049

Target: GSK-3, JAK, PKC

Synonym: Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I

Target: Tyrosine Kinases, JAK

SC99

T8719

Synonym:

Target: Apoptosis, JAK, STAT

Target: FLT, Tyrosine Kinases, JAK

LFM-A13

T6217

Synonym:

Target: PLK, JAK, BTK

Cat No.	Product Name	Synonyms	Targets
T2S1975	Ponicidin	Rubescensine B	Apoptosis , JAK , STAT
	Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens. Ponicidin exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicidin induces apoptosis of gastric carcinoma ...		Apoptosis , JAK , STAT
TQ0196	Cucurbitacin I	NSC-521777,JSI-124,Elatericin B	JAK , STAT
	Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.		JAK , STAT
TJS1779	Protosappanin A	PTA	NADPH-oxidase , IL Receptor , IκB/IKK , TNF , NF-κB , TLR , ROS , COX , HIV Protease , JAK , NO Synthase , STAT
	Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory ...
T3398	Icaritin	Anhydroicaritin,Cycloicaritin	Apoptosis , JAK , STAT , Autophagy
	Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Ica...		Apoptosis , JAK , STAT , Autophagy
T5S0734	Desmethoxyyangonin	Desmethoxy yangonin,Demethoxyyangonin,5,6-Dehydrokavain	Others , Monoamine Oxidase
	1. Desmethoxyyangonin (5,6-Dehydrokavain) protects LPS or LPS/D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways. 2. The induction of CYP3A23 by dihydr...		Others , Monoamine Oxidase
T3805	Prim-O-glucosylcimifugin	Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside	TNF , COX , JAK , NO Synthase
	Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.		TNF , COX , JAK , NO Synthase
T3S1471	Cucurbitacin IIA	Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis , Survivin
	1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a ...		Apoptosis , Survivin
T3673	Mollugin	Rubimaillin	HER , JAK
	Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr...		HER , JAK
T5S0167	Atractylenolide I		IL Receptor , TNF , TLR , JAK , STAT
	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide...		IL Receptor , TNF , TLR , JAK , STAT
T4S1499	Ginsenoside Rk1		Apoptosis , Others , NF-κB , PI3K , JAK
	Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside Rk1 has an anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB. It also h...		Apoptosis , Others , NF-κB , PI3K , JAK
TN3541	Broussonin E		ERK , p38 MAPK , TNF , JAK , STAT
	Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway, and can be further developed as a promising drug for the...		ERK , p38 MAPK , TNF , JAK , STAT

Natural Products

Ponicidin

T2S1975

Synonym: Rubescensine B

Target: Apoptosis, JAK, STAT

Cucurbitacin I

TQ0196

Synonym: NSC-521777,JSI-124,Elatericin B

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Icaritin

T3398

Synonym: Anhydroicaritin,Cycloicaritin

Target: Apoptosis, JAK, STAT, Autophagy

Desmethoxyyangonin

T5S0734

Synonym: Desmethoxy yangonin,Demethoxyyangonin,5,6-Dehydrokavain

Target: Others, Monoamine Oxidase

Prim-O-glucosylcimifugin

T3805

Synonym: Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside

Target: TNF, COX, JAK, NO Synthase

Cucurbitacin IIA

T3S1471

Synonym: Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA

Target: Apoptosis, Survivin

Target: IL Receptor, TNF, TLR, JAK, STAT

Ginsenoside Rk1

T4S1499

Synonym:

Target: Apoptosis, Others, NF-κB, PI3K, JAK

Broussonin E

TN3541

Synonym:

Target: ERK, p38 MAPK, TNF, JAK, STAT

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02274	JAK2 Protein, Human, Recombinant (His)	Human	E. coli
	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cyto...
TMPY-02333	ULBP-2 Protein, Human, Recombinant (His)	Human	HEK293
	NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is e...
TMPY-05592	ULBP-2 Protein, Human, Recombinant(aa 1-217, His&AVI),Biotinylated	Human	HEK293
	NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is e...
TMPY-04125	PTP1B Protein, Human, Recombinant (His)	Human	E. coli
	PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly c...
TMPY-01767	IL-12RB2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interleukin-12 receptor subunit beta-2 (IL12RB2), also known as IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, and IL-12RB2, is a type I transmembrane protein identified as a subunit of the interleu...
TMPY-01053	Prolactin Receptor Protein, Human, Recombinant (His)	Human	HEK293
	Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective recept...
TMPY-01725	Leptin Receptor Protein, Human, Recombinant (His)	Human	HEK293
	Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-spe...
TMPY-05636	G-CSF Protein, Mouse, Recombinant	Mouse	HEK293
	Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial...
TMPY-04829	G-CSF Protein, Human, Recombinant	Human	HEK293
	Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial...
TMPH-03287	EPOR Protein, Rat, Recombinant (His & SUMO)	Rat	E. coli
	Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also ...
TMPH-03111	Erythropoietin Protein, Pig, Recombinant (B2M & His)	Sus scrofa (Pig)	E. coli
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activa...
TMPH-02427	Erythropoietin Protein, Cynomolgus, Recombinant (His & SUMO)	Cynomolgus	E. coli
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activa...
TMPH-00828	Erythropoietin Protein, Horse, Recombinant (His & SUMO)	Horse	E. coli
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activa...
TMPH-00827	Erythropoietin Protein, Horse, Recombinant (hFc)	Horse	HEK293
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activa...
TMPH-02426	Erythropoietin Protein, Cynomolgus, Recombinant (His & Myc)	Cynomolgus	HEK293
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activa...
TMPH-03110	Erythropoietin Protein, Pig, Recombinant (His)	Sus scrofa (Pig)	Yeast
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activa...
TMPH-02440	GHR Protein, Rhesus macaque, Recombinant (His)	Rhesus	E. coli
	Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormon...
TMPK-00136	ULBP-2 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, E...
TMPH-01558	IL12RB2 Protein, Human, Recombinant (His)	Human	Yeast
	Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenoty...
TMPH-03112	GHR Protein, Pig, Recombinant (His)	Sus scrofa (Pig)	E. coli
	Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormon...
TMPH-03204	GHR Protein, Rabbit, Recombinant (His & Myc)	Rabbit	in vitro E. coli expression system
	Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormon...
TMPJ-00398	IL-12RB2 Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits tha...
TMPY-04817	Syntenin Protein, Human, Recombinant (His)	Human	E. coli
	Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma. IL-6 promot...
TMPY-02194	SOCS3 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, plac...
TMPY-03125	SHP-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric ac...
TMPY-02334	ULBP-2 Protein, Human, Recombinant (hFc)	Human	HEK293
	NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is e...
TMPH-02156	SOCS1 Protein, Human, Recombinant (His)	Human	Yeast
	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through ...
TMPH-02919	SOCS1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through ...
TMPH-02155	SOCS1 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through ...
TMPH-01778	TYK2 Protein, Human, Recombinant (His)	Human	Baculovirus
	Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous cytokines and interferons signalin...
TMPH-01777	TYK2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous cytokines and interferons signalin...
TMPJ-00346	PRLR Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	The prolactin receptor (PRLR) is a member of the class I cytokine/lactogen receptor family which mediates the diverse cellular actions of prolactin in several tissues. PRLRs are expressed in normal and neoplastic human b...
TMPJ-00347	PRLR Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	The prolactin receptor (PRLR) is a member of the class I cytokine/lactogen receptor family which mediates the diverse cellular actions of prolactin in several tissues. PRLRs are expressed in normal and neoplastic human b...
TMPY-02122	IFNGR2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disea...
TMPY-06428	IL-12RB2 Protein, Cynomolgus, Recombinant (mFc)	Cynomolgus	HEK293
	Interleukin-12 receptor subunit beta-2 (IL12RB2), also known as IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, and IL-12RB2, is a type I transmembrane protein identified as a subunit of the interleu...
TMPY-01566	Prolactin Receptor Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293
	Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective recept...
TMPY-02984	Prolactin Receptor Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective recept...
TMPY-02434	Prolactin Receptor Protein, Rat, Recombinant (His)	Rat	HEK293
	Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective recept...
TMPJ-00047	IL-31 Protein, Human, Recombinant	Human	E. coli
	Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes...
TMPY-01448	GHR/Growth Hormone R Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I membrane protein which belongs to thetype I cytokine receptor family and type 1 subfamily. GHR contains onefibronectin type-III domai...
TMPY-00977	GHR/Growth Hormone R Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293
	Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I membrane protein which belongs to thetype I cytokine receptor family and type 1 subfamily. GHR contains onefibronectin type-III domai...
TMPY-02007	GHR/Growth Hormone R Protein, Rat, Recombinant (His)	Rat	HEK293
	Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I membrane protein which belongs to thetype I cytokine receptor family and type 1 subfamily. GHR contains onefibronectin type-III domai...
TMPH-03494	IFN gamma Protein, Sheep, Recombinant (E. coli, His)	Sheep	E. coli
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPY-04281	GHR/Growth Hormone R Protein, Rat, Recombinant (hFc)	Rat	HEK293
	Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I membrane protein which belongs to thetype I cytokine receptor family and type 1 subfamily. GHR contains onefibronectin type-III domai...
TMPH-03495	IFN gamma Protein, Sheep, Recombinant (His)	Sheep	Yeast
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPH-00775	IFN gamma Protein, Goat, Recombinant (His & Myc)	Goat	E. coli
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPY-00874	Leptin Receptor Protein, Human, Recombinant (His & hFc)	Human	HEK293
	Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-spe...
TMPY-00813	G-CSF Protein, Human, Recombinant (hFc)	Human	HEK293
	Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial...

JAK2 Protein, Human, Recombinant (His)

TMPH-02274

Species: Human

Expression System: E. coli

ULBP-2 Protein, Human, Recombinant (His)

TMPY-02333

Species: Human

Expression System: HEK293

ULBP-2 Protein, Human, Recombinant(aa 1-217, His&AVI),Biotinylated

TMPY-05592

Species: Human

Expression System: HEK293

PTP1B Protein, Human, Recombinant (His)

TMPY-04125

Species: Human

Expression System: E. coli

IL-12RB2 Protein, Mouse, Recombinant (His)

TMPY-01767

Species: Mouse

Expression System: HEK293

Prolactin Receptor Protein, Human, Recombinant (His)

TMPY-01053

Species: Human

Expression System: HEK293

Leptin Receptor Protein, Human, Recombinant (His)

TMPY-01725

Species: Human

Expression System: HEK293

G-CSF Protein, Mouse, Recombinant

TMPY-05636

Species: Mouse

Expression System: HEK293

G-CSF Protein, Human, Recombinant

TMPY-04829

Species: Human

Expression System: HEK293

EPOR Protein, Rat, Recombinant (His & SUMO)

TMPH-03287

Species: Rat

Expression System: E. coli

Erythropoietin Protein, Pig, Recombinant (B2M & His)

TMPH-03111

Species: Sus scrofa (Pig)

Expression System: E. coli

Erythropoietin Protein, Cynomolgus, Recombinant (His & SUMO)

TMPH-02427

Species: Cynomolgus

Expression System: E. coli

Erythropoietin Protein, Horse, Recombinant (His & SUMO)

TMPH-00828

Species: Horse

Expression System: E. coli

Erythropoietin Protein, Horse, Recombinant (hFc)

TMPH-00827

Species: Horse

Expression System: HEK293

Erythropoietin Protein, Cynomolgus, Recombinant (His & Myc)

TMPH-02426

Species: Cynomolgus

Expression System: HEK293

Erythropoietin Protein, Pig, Recombinant (His)

TMPH-03110

Species: Sus scrofa (Pig)

Expression System: Yeast

GHR Protein, Rhesus macaque, Recombinant (His)

TMPH-02440

Species: Rhesus

Expression System: E. coli

ULBP-2 Protein, Human, Recombinant (His & Avi)

TMPK-00136

Species: Human

Expression System: HEK293

IL12RB2 Protein, Human, Recombinant (His)

TMPH-01558

Species: Human

Expression System: Yeast

GHR Protein, Pig, Recombinant (His)

TMPH-03112

Species: Sus scrofa (Pig)

Expression System: E. coli

GHR Protein, Rabbit, Recombinant (His & Myc)

TMPH-03204

Species: Rabbit

Expression System: in vitro E. coli expression system

IL-12RB2 Protein, Mouse, Recombinant (hFc)

TMPJ-00398

Species: Mouse

Expression System: Human Cells

Syntenin Protein, Human, Recombinant (His)

TMPY-04817

Species: Human

Expression System: E. coli

SOCS3 Protein, Human, Recombinant (His & Trx)

TMPY-02194

Species: Human

Expression System: E. coli

SHP-2 Protein, Mouse, Recombinant (His)

TMPY-03125

Species: Mouse

Expression System: HEK293

ULBP-2 Protein, Human, Recombinant (hFc)

TMPY-02334

Species: Human

Expression System: HEK293

SOCS1 Protein, Human, Recombinant (His)

TMPH-02156

Species: Human

Expression System: Yeast

SOCS1 Protein, Mouse, Recombinant (His & Myc)

TMPH-02919

Species: Mouse

Expression System: E. coli

SOCS1 Protein, Human, Recombinant (E. coli, His)

TMPH-02155

Species: Human

Expression System: E. coli

TYK2 Protein, Human, Recombinant (His)

TMPH-01778

Species: Human

Expression System: Baculovirus

TYK2 Protein, Human, Recombinant (E. coli, His)

TMPH-01777

Species: Human

Expression System: E. coli

PRLR Protein, Mouse, Recombinant (hFc)

TMPJ-00346

Species: Mouse

Expression System: Human Cells

PRLR Protein, Mouse, Recombinant (His)

TMPJ-00347

Species: Mouse

Expression System: Human Cells

IFNGR2 Protein, Mouse, Recombinant (His)

TMPY-02122

Species: Mouse

Expression System: HEK293

IL-12RB2 Protein, Cynomolgus, Recombinant (mFc)

TMPY-06428

Species: Cynomolgus

Expression System: HEK293

Prolactin Receptor Protein, Mouse, Recombinant (His & hFc)

TMPY-01566

Species: Mouse

Expression System: HEK293

Prolactin Receptor Protein, Mouse, Recombinant (His)

TMPY-02984

Species: Mouse

Expression System: HEK293

Prolactin Receptor Protein, Rat, Recombinant (His)

TMPY-02434

Species: Rat

Expression System: HEK293

IL-31 Protein, Human, Recombinant

TMPJ-00047

Species: Human

Expression System: E. coli

GHR/Growth Hormone R Protein, Mouse, Recombinant (His)

TMPY-01448

Species: Mouse

Expression System: HEK293

GHR/Growth Hormone R Protein, Mouse, Recombinant (His & hFc)

TMPY-00977

Species: Mouse

Expression System: HEK293

GHR/Growth Hormone R Protein, Rat, Recombinant (His)

TMPY-02007

Species: Rat

Expression System: HEK293

IFN gamma Protein, Sheep, Recombinant (E. coli, His)

TMPH-03494

Species: Sheep

Expression System: E. coli

GHR/Growth Hormone R Protein, Rat, Recombinant (hFc)

TMPY-04281

Species: Rat

Expression System: HEK293

IFN gamma Protein, Sheep, Recombinant (His)

TMPH-03495

Species: Sheep

Expression System: Yeast

IFN gamma Protein, Goat, Recombinant (His & Myc)

TMPH-00775

Species: Goat

Expression System: E. coli

Leptin Receptor Protein, Human, Recombinant (His & hFc)

TMPY-00874

Species: Human

Expression System: HEK293

G-CSF Protein, Human, Recombinant (hFc)

TMPY-00813

Species: Human

Expression System: HEK293

Cat No.	Product Name
L3700	JAK-STAT Compound Library		256 compounds
	A unique collection of 256 JAK/STAT signaling targeted compounds for high throughput and high content screening;

Libraries

JAK-STAT Compound Library

L3700

Compounds: 256