52
2
5
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7368 | IRAK inhibitor 2 | IRAK-IN-2 | IRAK |
IRAK inhibitor 2 (IRAK-IN-2) is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK-4) for the study of inflammation-related diseases. | |||
T2457 | IRAK-1-4 Inhibitor I | IRAK-1/4 Inhibitor I,IRAK-1/4 Inhibitor | IRAK |
IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1. | |||
T5110 | IRAK inhibitor 6 | IRAK | |
IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK-4, IC50: 160 nM). | |||
T5094 | IRAK inhibitor 1 | IRAK , JNK | |
IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM). | |||
T9631 | IRAK-4 protein kinase inhibitor 2 | IRAK | |
IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM). | |||
T11670 | IRAK inhibitor 3 | IRAK | |
IRAK inhibitor 3 is an interleukin-1 (IL-1) receptor-associated kinase (IRAK) modulator. | |||
T11672 | IRAK inhibitor 4 | Others | |
IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 inhibitor. | |||
T11671 | IRAK inhibitor 4 trans | SGLT | |
IRAK inhibitor 4 is a compound that functions as an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). It specifically targets and inhibits the activity of IRAK4. The (trans) form of IRAK inhibitor 4 refers... | |||
T75136 | IRAK degrader-1 | ||
IRAK degrader-1 (example I-3) is a potent IRAK degrader [1] . | |||
T4140 | IRAK4-IN-1 | IRAK | |
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. | |||
T11673 | IRAK4-IN-4 | IRAK , cGAS | |
IRAK4-IN-4 inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor, has an IC50 of 2.8 nM. | |||
T4299 | AS-2444697 | IRAK | |
AS-2444697 is an inhibitor of IRAK-4 (C50 = 21 nM). AS-2444697 exhibits renoprotective effects through anti-inflammatory action. AS-2444697 potently inhibits human and rat IRAK-4 activity. | |||
T5354 | IRAK4-IN-7 | CA-4948 | IRAK |
IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model. | |||
TQ0167 | Zimlovisertib | PF-06650833,PF06650833 | IRAK |
Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) (IC50s: 0.2 and 2.4 nM in the cell and PBMC assay). | |||
T9203 | JH-X-119-01 | IRAK | |
JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1. | |||
T60012 | HS-243 | IRAK , MAPK , CDK | |
HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity. | |||
T11674 | IRAK4-IN-6 | Others | |
IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC 50 of 4 nM. IRAK4-IN-6 targetes MyD88 L265P mutant diffuse large B cell lymphoma [1]. | |||
T24174 | IRAK4-IN-16 | ||
IRAK4-IN-16 (compound 4) is a potent inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with an IC 50 of 2.5 nM. IRAK4-IN-16 exhibits cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC... | |||
T14367 | AZ1495 | IRAK , CDK , Haspin Kinase | |
AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffu... | |||
T9027 | CA-4948 | Emavusertib | IRAK , FLT |
CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity. | |||
T13842 | PROTAC IRAK4 degrader-1 | Others | |
PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T13843 | PROTAC IRAK4 ligand-1 | Others | |
PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4. | |||
T39920 | PROTAC IRAK4 degrader-3 | PROTAC IRAK4 degrader-3 | |
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau. | |||
T39902 | PROTAC IRAK4 degrader-5 | PROTAC IRAK4 degrader-5 | |
PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader. | |||
T39903 | PROTAC IRAK4 degrader-6 | PROTAC IRAK4 degrader-6 | |
PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T40334 | PROTAC IRAK3 degrade-1 | PROTAC IRAK3 degrade-1 | |
PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 ( IC 50 = 5 nM). | |||
T39901 | PROTAC IRAK4 degrader-4 | PROTAC IRAK4 degrader-4 | |
PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T62714 | IRAK4-IN-20 | BAY-1834845 | IRAK |
IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS). | |||
T63388 | IRAK4-IN-8 | IRAK | |
IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor for the study of diseases associated with cancer and inflammation. | |||
T63315 | IRAK4-IN-19 | ||
IRAK4-IN-19 is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK4) (IC50: 4.3 nM).IRAK4-IN-19 inhibits LPS-induced IL23 production in THP and DC cells and suppresses the development of arthritis in a... | |||
T62989 | IRAK4-IN-12 | ||
IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM). | |||
T63262 | IRAK4-IN-15 | ||
IRAK4-IN-15 is a selective and potent IRAK4 inhibitor (IC50: 0.002 μM) with good human PK prediction and low intrinsic clearance.IRAK4-IN-15 in combination with Acalabrutinib exhibited potent synergistic in vitro activit... | |||
T79097 | PROTAC IRAK4 degrader-8 | IRAK | |
PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1]. | |||
T79447 | IRAK4-IN-25 | IRAK | |
IRAK4-IN-25 (compound 38), a potent oral IRAK4 inhibitor (IC50 = 7.3 nM) with low clearance (Cl = 12 mL/min/kg), effectively suppresses pro-inflammatory cytokine production and demonstrates favorable in vitro safety and ... | |||
T78744 | IRAK4-IN-24 | IRAK | |
IRAK4-IN-24 (compound 16), a potent IRAK4 inhibitor, exhibits high clearance (Cl) and low oral bioavailability. It is utilized in research pertaining to inflammatory and autoimmune disorders. | |||
T63278 | IRAK4-IN-14 | ||
IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect. | |||
T74062 | PROTAC IRAK4 degrader-2 | ||
PROTAC IRAK4 degrader-2 (Compound 9) is a PROTAC-based IRAK4 degrader that affords potent IRAK4 degradation with a DC 50 in peripheral blood mononuclear cells (PBMCs) cells of 151 nM. PROTAC IRAK4 degrader-2 induce a red... | |||
T63559 | IRAK4-IN-22 | ||
IRAK4-IN-22 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 3 nM) and TAK1 (IC50: 17 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.10 μM. IRAK4-IN... | |||
T61931 | IRAK4-IN-10 | ||
IRAK4-IN-10 (compound 75) is an effective IRAK4 inhibitor (IC50 is 1.5 nM), which can block the MyD88-dependent signal pathway. IRAK4-IN-10 has research potential in inflammatory diseases, autoimmune diseases and cancer. | |||
T62950 | IRAK4-IN-18 | ||
IRAK4-IN-18 is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK4) (IC50: 15 nM). IRAK4-IN-18 inhibits LPS-induced IL23 production in THP and DC cells and blocks the development of arthritis in rats,... | |||
T61767 | IRAK4-IN-17 | ||
IRAK4-IN-17 (Compound 5) is a highly potent inhibitor of IRAK4, exhibiting an impressive IC50 value of 1.3 nM [1]. This compound is particularly valuable for research focused on large B-cell lymphoma (DLBCL) [1]. | |||
T74411 | PROTAC IRAK4 degrader-7 | ||
PROTAC IRAK4 degrader-7 (Compound I-417) is an orally active PROTAC IRAK4 degrader with antitumor activities [1] . | |||
T79485 | IRAK4-IN-27 | IRAK | |
IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) c... | |||
T81378 | PROTAC IRAK4 ligand-3 | PROTACs | |
PROTAC IRAK4 Ligand-3 serves as a ligand for PROTAC IRAK4 Degrader-7 and is utilized in cancer research [1]. | |||
T60899 | IRAK4-IN-11 | ||
IRAK4-IN-11 (compound 6) is a potent inhibitor of IRAK4 with an IC 50 of 0.008 μM. IRAK4-IN-11 exhibits cell pIRAK4 potencies with an IC 50 of 0.19 μM [1]. | |||
T61734 | IRAK4-IN-9 | ||
IRAK4-IN-9 (compound 73) is a highly potent inhibitor of IRAK4, displaying an impressive IC50 value of 1.5 nM. By blocking MyD88-dependent signaling, IRAK4-IN-9 exhibits promising potential for the investigation of infla... | |||
T79448 | IRAK4-IN-26 | IRAK | |
IRAK4-IN-26 (Compound 21), an IRAK4 inhibitor with an IC50 of 6.2 nM, exhibits an oral bioavailability of 21%. It is utilized for the study of inflammatory and autoimmune disorders [1]. | |||
T77931 | PROTAC IRAK3 degrade-1 formic | PROTACs | |
PROTAC IRAK3 Degrade-1 (Compound 23) is a selective and potent IRAK3 degrader, demonstrating an IC50 value of 5 nM [1]. | |||
T79337 | IRAK4-IN-28 | IRAK | |
IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme. It is utilized for research purposes in the study of inflammation an... | |||
T63558 | IRAK4-IN-21 | ||
IRAK4-IN-21 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 5 nM) and TAK1 (IC50: 56 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.17 μM. can be ... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2822 | Ginsenoside Rb1 | Gypenoside Ⅲ,Gypenoside III | ATPase , Mitophagy , IRAK , NF-κB , Autophagy , HSV |
Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors. | |||
T4700 | 1,3,5-Trihydroxy-4-prenylxanthone | ||
1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylch... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04483 | IRAK4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4... | |||
TMPH-02738 | IRAK3 Protein, Mouse, Recombinant (His & Myc) | Mouse | Baculovirus |
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | |||
TMPH-02739 | IRAK3 Protein, Mouse, Recombinant (E. coli, His & Myc) | Mouse | E. coli |
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | |||
TMPH-01149 | Human coronavirus HKU1 (isolate N1) Spike glycoprotein (His & Myc) | HCoV-HKU1 | E. coli |
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me... | |||
TMPH-01148 | Human coronavirus HKU1 (isolate N1) Protein I (His) | HCoV-HKU1 | E. coli |
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me... |