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Search Results for " irak "

Targets

52

Compounds

2

Natural Products

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T7368 IRAK inhibitor 2 IRAK-IN-2 IRAK
IRAK inhibitor 2 (IRAK-IN-2) is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK-4) for the study of inflammation-related diseases.
T2457 IRAK-1-4 Inhibitor I IRAK-1/4 Inhibitor I,IRAK-1/4 Inhibitor IRAK
IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1.
T5110 IRAK inhibitor 6 IRAK
IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK-4, IC50: 160 nM).
T5094 IRAK inhibitor 1 IRAK , JNK
IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).
T9631 IRAK-4 protein kinase inhibitor 2 IRAK
IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM).
T11670 IRAK inhibitor 3 IRAK
IRAK inhibitor 3 is an interleukin-1 (IL-1) receptor-associated kinase (IRAK) modulator.
T11672 IRAK inhibitor 4 Others
IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 inhibitor.
T11671 IRAK inhibitor 4 trans SGLT
IRAK inhibitor 4 is a compound that functions as an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). It specifically targets and inhibits the activity of IRAK4. The (trans) form of IRAK inhibitor 4 refers...
T75136 IRAK degrader-1
IRAK degrader-1 (example I-3) is a potent IRAK degrader [1] .
T4140 IRAK4-IN-1 IRAK
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
T11673 IRAK4-IN-4 IRAK , cGAS
IRAK4-IN-4 inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor, has an IC50 of 2.8 nM.
T4299 AS-2444697 IRAK
AS-2444697 is an inhibitor of IRAK-4 (C50 = 21 nM). AS-2444697 exhibits renoprotective effects through anti-inflammatory action. AS-2444697 potently inhibits human and rat IRAK-4 activity.
T5354 IRAK4-IN-7 CA-4948 IRAK
IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.
TQ0167 Zimlovisertib PF-06650833,PF06650833 IRAK
Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) (IC50s: 0.2 and 2.4 nM in the cell and PBMC assay).
T9203 JH-X-119-01 IRAK
JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.
T60012 HS-243 IRAK , MAPK , CDK
HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
T11674 IRAK4-IN-6 Others
IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC 50 of 4 nM. IRAK4-IN-6 targetes MyD88 L265P mutant diffuse large B cell lymphoma [1].
T24174 IRAK4-IN-16
IRAK4-IN-16 (compound 4) is a potent inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with an IC 50 of 2.5 nM. IRAK4-IN-16 exhibits cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC...
T14367 AZ1495 IRAK , CDK , Haspin Kinase
AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffu...
T9027 CA-4948 Emavusertib IRAK , FLT
CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.
T13842 PROTAC IRAK4 degrader-1 Others
PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4).
T13843 PROTAC IRAK4 ligand-1 Others
PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4.
T39920 PROTAC IRAK4 degrader-3 PROTAC IRAK4 degrader-3
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.
T39902 PROTAC IRAK4 degrader-5 PROTAC IRAK4 degrader-5
PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader.
T39903 PROTAC IRAK4 degrader-6 PROTAC IRAK4 degrader-6
PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T40334 PROTAC IRAK3 degrade-1 PROTAC IRAK3 degrade-1
PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 ( IC 50 = 5 nM).
T39901 PROTAC IRAK4 degrader-4 PROTAC IRAK4 degrader-4
PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T62714 IRAK4-IN-20 BAY-1834845 IRAK
IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS).
T63388 IRAK4-IN-8 IRAK
IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor for the study of diseases associated with cancer and inflammation.
T63315 IRAK4-IN-19
IRAK4-IN-19 is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK4) (IC50: 4.3 nM).IRAK4-IN-19 inhibits LPS-induced IL23 production in THP and DC cells and suppresses the development of arthritis in a...
T62989 IRAK4-IN-12
IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).
T63262 IRAK4-IN-15
IRAK4-IN-15 is a selective and potent IRAK4 inhibitor (IC50: 0.002 μM) with good human PK prediction and low intrinsic clearance.IRAK4-IN-15 in combination with Acalabrutinib exhibited potent synergistic in vitro activit...
T79097 PROTAC IRAK4 degrader-8 IRAK
PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1].
T79447 IRAK4-IN-25 IRAK
IRAK4-IN-25 (compound 38), a potent oral IRAK4 inhibitor (IC50 = 7.3 nM) with low clearance (Cl = 12 mL/min/kg), effectively suppresses pro-inflammatory cytokine production and demonstrates favorable in vitro safety and ...
T78744 IRAK4-IN-24 IRAK
IRAK4-IN-24 (compound 16), a potent IRAK4 inhibitor, exhibits high clearance (Cl) and low oral bioavailability. It is utilized in research pertaining to inflammatory and autoimmune disorders.
T63278 IRAK4-IN-14
IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.
T74062 PROTAC IRAK4 degrader-2
PROTAC IRAK4 degrader-2 (Compound 9) is a PROTAC-based IRAK4 degrader that affords potent IRAK4 degradation with a DC 50 in peripheral blood mononuclear cells (PBMCs) cells of 151 nM. PROTAC IRAK4 degrader-2 induce a red...
T63559 IRAK4-IN-22
IRAK4-IN-22 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 3 nM) and TAK1 (IC50: 17 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.10 μM. IRAK4-IN...
T61931 IRAK4-IN-10
IRAK4-IN-10 (compound 75) is an effective IRAK4 inhibitor (IC50 is 1.5 nM), which can block the MyD88-dependent signal pathway. IRAK4-IN-10 has research potential in inflammatory diseases, autoimmune diseases and cancer.
T62950 IRAK4-IN-18
IRAK4-IN-18 is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK4) (IC50: 15 nM). IRAK4-IN-18 inhibits LPS-induced IL23 production in THP and DC cells and blocks the development of arthritis in rats,...
T61767 IRAK4-IN-17
IRAK4-IN-17 (Compound 5) is a highly potent inhibitor of IRAK4, exhibiting an impressive IC50 value of 1.3 nM [1]. This compound is particularly valuable for research focused on large B-cell lymphoma (DLBCL) [1].
T74411 PROTAC IRAK4 degrader-7
PROTAC IRAK4 degrader-7 (Compound I-417) is an orally active PROTAC IRAK4 degrader with antitumor activities [1] .
T79485 IRAK4-IN-27 IRAK
IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) c...
T81378 PROTAC IRAK4 ligand-3 PROTACs
PROTAC IRAK4 Ligand-3 serves as a ligand for PROTAC IRAK4 Degrader-7 and is utilized in cancer research [1].
T60899 IRAK4-IN-11
IRAK4-IN-11 (compound 6) is a potent inhibitor of IRAK4 with an IC 50 of 0.008 μM. IRAK4-IN-11 exhibits cell pIRAK4 potencies with an IC 50 of 0.19 μM [1].
T61734 IRAK4-IN-9
IRAK4-IN-9 (compound 73) is a highly potent inhibitor of IRAK4, displaying an impressive IC50 value of 1.5 nM. By blocking MyD88-dependent signaling, IRAK4-IN-9 exhibits promising potential for the investigation of infla...
T79448 IRAK4-IN-26 IRAK
IRAK4-IN-26 (Compound 21), an IRAK4 inhibitor with an IC50 of 6.2 nM, exhibits an oral bioavailability of 21%. It is utilized for the study of inflammatory and autoimmune disorders [1].
T77931 PROTAC IRAK3 degrade-1 formic PROTACs
PROTAC IRAK3 Degrade-1 (Compound 23) is a selective and potent IRAK3 degrader, demonstrating an IC50 value of 5 nM [1].
T79337 IRAK4-IN-28 IRAK
IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme. It is utilized for research purposes in the study of inflammation an...
T63558 IRAK4-IN-21
IRAK4-IN-21 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 5 nM) and TAK1 (IC50: 56 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.17 μM. can be ...

Compounds

IRAK inhibitor 2
T7368
Synonym: IRAK-IN-2
Target: IRAK
IRAK-1-4 Inhibitor I
T2457
Synonym: IRAK-1/4 Inhibitor I,IRAK-1/4 Inhibitor
Target: IRAK
IRAK inhibitor 6
T5110
Synonym:
Target: IRAK
IRAK inhibitor 1
T5094
Synonym:
Target: IRAK, JNK
IRAK-4 protein kinase inhibitor 2
T9631
Synonym:
Target: IRAK
IRAK inhibitor 3
T11670
Synonym:
Target: IRAK
IRAK inhibitor 4
T11672
Synonym:
Target: Others
IRAK inhibitor 4 trans
T11671
Synonym:
Target: SGLT
IRAK degrader-1
T75136
Synonym:
Target:
IRAK4-IN-1
T4140
Synonym:
Target: IRAK
IRAK4-IN-4
T11673
Synonym:
Target: IRAK, cGAS
AS-2444697
T4299
Synonym:
Target: IRAK
IRAK4-IN-7
T5354
Synonym: CA-4948
Target: IRAK
Zimlovisertib
TQ0167
Synonym: PF-06650833,PF06650833
Target: IRAK
JH-X-119-01
T9203
Synonym:
Target: IRAK
HS-243
T60012
Synonym:
Target: IRAK, MAPK, CDK
IRAK4-IN-6
T11674
Synonym:
Target: Others
IRAK4-IN-16
T24174
Synonym:
Target:
AZ1495
T14367
Synonym:
Target: IRAK, CDK, Haspin Kinase
CA-4948
T9027
Synonym: Emavusertib
Target: IRAK, FLT
PROTAC IRAK4 degrader-1
T13842
Synonym:
Target: Others
PROTAC IRAK4 ligand-1
T13843
Synonym:
Target: Others
PROTAC IRAK4 degrader-3
T39920
Synonym: PROTAC IRAK4 degrader-3
Target:
PROTAC IRAK4 degrader-5
T39902
Synonym: PROTAC IRAK4 degrader-5
Target:
PROTAC IRAK4 degrader-6
T39903
Synonym: PROTAC IRAK4 degrader-6
Target:
PROTAC IRAK3 degrade-1
T40334
Synonym: PROTAC IRAK3 degrade-1
Target:
PROTAC IRAK4 degrader-4
T39901
Synonym: PROTAC IRAK4 degrader-4
Target:
IRAK4-IN-20
T62714
Synonym: BAY-1834845
Target: IRAK
IRAK4-IN-8
T63388
Synonym:
Target: IRAK
IRAK4-IN-19
T63315
Synonym:
Target:
IRAK4-IN-12
T62989
Synonym:
Target:
IRAK4-IN-15
T63262
Synonym:
Target:
PROTAC IRAK4 degrader-8
T79097
Synonym:
Target: IRAK
IRAK4-IN-25
T79447
Synonym:
Target: IRAK
IRAK4-IN-24
T78744
Synonym:
Target: IRAK
IRAK4-IN-14
T63278
Synonym:
Target:
PROTAC IRAK4 degrader-2
T74062
Synonym:
Target:
IRAK4-IN-22
T63559
Synonym:
Target:
IRAK4-IN-10
T61931
Synonym:
Target:
IRAK4-IN-18
T62950
Synonym:
Target:
IRAK4-IN-17
T61767
Synonym:
Target:
PROTAC IRAK4 degrader-7
T74411
Synonym:
Target:
IRAK4-IN-27
T79485
Synonym:
Target: IRAK
PROTAC IRAK4 ligand-3
T81378
Synonym:
Target: PROTACs
IRAK4-IN-11
T60899
Synonym:
Target:
IRAK4-IN-9
T61734
Synonym:
Target:
IRAK4-IN-26
T79448
Synonym:
Target: IRAK
PROTAC IRAK3 degrade-1 formic
T77931
Synonym:
Target: PROTACs
IRAK4-IN-28
T79337
Synonym:
Target: IRAK
IRAK4-IN-21
T63558
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T2822 Ginsenoside Rb1 Gypenoside Ⅲ,Gypenoside III ATPase , Mitophagy , IRAK , NF-κB , Autophagy , HSV
Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
T4700 1,3,5-Trihydroxy-4-prenylxanthone
1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylch...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04483 IRAK4 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4...
TMPH-02738 IRAK3 Protein, Mouse, Recombinant (His & Myc) Mouse Baculovirus
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
TMPH-02739 IRAK3 Protein, Mouse, Recombinant (E. coli, His & Myc) Mouse E. coli
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
TMPH-01149 Human coronavirus HKU1 (isolate N1) Spike glycoprotein (His & Myc) HCoV-HKU1 E. coli
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me...
TMPH-01148 Human coronavirus HKU1 (isolate N1) Protein I (His) HCoV-HKU1 E. coli
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me...
TargetMol