il-1β — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8477	IQ-3		JNK
	IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α an...		JNK
T21629	Loxapine		Dopamine Receptor , 5-HT Receptor
	Loxapine is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent,used primarily in the treatment of schizophrenia. The drug is a member of the dibenzoxazepine class ...		Dopamine Receptor , 5-HT Receptor
T8692	(Rac)-Benpyrine		TNF
	(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.		TNF
T8381	Amodiaquine		Others , Histone Methyltransferase , Parasite
	Amodiaquine is a synthetic aminoquinoline, used to treat malaria.		Others , Histone Methyltransferase , Parasite
T8828	CP 424174		IL Receptor
	CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.		IL Receptor
T8553	BC-1471		Others
	BC-1471 is a STAM-binding protein (STAMBP) deubiquitinase inhibitor. BC-1471 inhibits inflammasome activity of NALP7 (NACHT, LRR and PYD domains-containing protein 7) [1].		Others
T78707	IL-1β-IN-2
	IL-1β-IN-2, a cannabigerol derivative, serves as a potent inhibitor of IL-1β, exhibiting anti-inflammatory and pain-resolving properties [1].
T74819	IL-1β-IN-1
	IL-1β-IN-1, a cannabidiol derivative, acts as a potent inhibitor of IL-1β, exhibiting significant anti-inflammatory and pain relief properties [1].
TN6722	Terminolic acid	2α,6β,23-trihydroxyl oleanolic acid	Antibacterial
	Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and ...		Antibacterial
T6927	Pamapimod	R1503,Ro4402257	p38 MAPK , Autophagy
	Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectiv...		p38 MAPK , Autophagy
T27695	JTE-607	JTE-607 dihydrochloride,JTE-607 HCl	Cysteine Protease
	JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.		Cysteine Protease
T9352	Hydrocotarnine		Others
	hydrocotarnine is an inhibitor of Cbl.		Others
T41302	Itaconate-alkyne	ITalk	Others
	Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of itaconate in inflammatory macrophages and enables biochemical evaluation and proteomic analysis of its dire...		Others
T2893	Muscone	3-Methylcyclopentadecanone,Methylexaltone	MMP , TNF , NF-κB , NOD-like Receptor (NLR) , P-gp , Interleukin
	Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
T1412	Loxapine succinate	Daxolin,Loxapac,Cloxazepin,Loxapine succinate salt	Dopamine Receptor , 5-HT Receptor
	Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia.		Dopamine Receptor , 5-HT Receptor
T22698	TLR3-IN-1	CU CPT 4a	TLR
	TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cell...		TLR
T0089	Cetirizine dihydrochloride	P071,UCB P071,Cetirizine DiHCl	Histamine Receptor
	Cetirizine dihydrochloride (UCB P071) is an effective second-generation histamine H1 antagonist that is potent in the therapy of allergic rhinitis, confirmed urticaria, and pollen-induced asthma. Unlike other conventiona...		Histamine Receptor
T0381	Amodiaquine dihydrochloride dihydrate	Amodiaquine hydrochloride,Amodiaquin dihydrochloride dihydrate	Histone Methyltransferase , Parasite , Histamine Receptor
	Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.		Histone Methyltransferase , Parasite , Histamine Receptor
T3147	Pyrrolidinedithiocarbamate ammonium	PDTC,Pyrrolidinedithiocarbamate,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate	NF-κB
	Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.		NF-κB
T7162	R1487 Hydrochloride	R1487 (Hydrochloride)	p38 MAPK , Autophagy
	R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.		p38 MAPK , Autophagy