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Search Results for " il-1β "

Targets

138

Compounds

29

Natural Products

30

Recombinant Proteins

2

Libraries

Cat No. Product Name Synonyms Targets
T8477 IQ-3 JNK
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α an...
T21629 Loxapine Dopamine Receptor , 5-HT Receptor
Loxapine is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent,used primarily in the treatment of schizophrenia. The drug is a member of the dibenzoxazepine class ...
T8692 (Rac)-Benpyrine TNF
(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.
T8381 Amodiaquine Others , Histone Methyltransferase , Parasite
Amodiaquine is a synthetic aminoquinoline, used to treat malaria.
T8828 CP 424174 IL Receptor
CP 424174 is an inhibitor of IL- post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.
T8553 BC-1471 Others
BC-1471 is a STAM-binding protein (STAMBP) deubiquitinase inhibitor. BC-1471 inhibits inflammasome activity of NALP7 (NACHT, LRR and PYD domains-containing protein 7) [1].
T74819 IL--IN-1
IL--IN-1, cannabidiol derivative, is a potent IL- inhibitor. IL--IN-1 has anti-inflammatory and pain-resolving properties [1] .
T78707 IL--IN-2
IL--IN-2, a cannabigerol derivative, serves as a potent inhibitor of IL-, exhibiting anti-inflammatory and pain-resolving properties [1].
T6927 Pamapimod R1503,Ro4402257 p38 MAPK , Autophagy
Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectiv...
T27695 JTE-607 JTE-607 dihydrochloride,JTE-607 HCl Cysteine Protease
JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
T41302 Itaconate-alkyne ITalk Others
Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of itaconate in inflammatory macrophages and enables biochemical evaluation and proteomic analysis of its dire...
T1412 Loxapine succinate Daxolin,Loxapac,Cloxazepin,Loxapine succinate salt Dopamine Receptor , 5-HT Receptor
Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia.
T22698 TLR3-IN-1 CU CPT 4a TLR
TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL- in whole cell...
T0089 Cetirizine dihydrochloride P071,UCB P071,Cetirizine DiHCl Histamine Receptor
Cetirizine dihydrochloride (UCB P071) is an effective second-generation histamine H1 antagonist that is potent in the therapy of allergic rhinitis, confirmed urticaria, and pollen-induced asthma. Unlike other conventiona...
T0381 Amodiaquine dihydrochloride dihydrate Amodiaquine hydrochloride,Amodiaquin dihydrochloride dihydrate Histone Methyltransferase , Parasite , Histamine Receptor
Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.
T3147 Pyrrolidinedithiocarbamate ammonium PDTC,Pyrrolidinedithiocarbamate,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate NF-κB
Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
T7162 R1487 Hydrochloride R1487 (Hydrochloride) p38 MAPK , Autophagy
R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.
T73695 Canakinumab ACZ 885,Ilaris IL Receptor
Canakinumab (ACZ885) is a recombinant human IL--targeting monoclonal antibody.Canakinumab has been shown to inhibit human and chorioallantoic monkey IL-, with IC50 values of 43.6 and 40.8 pM, respectively.Canakinumab...
T4450 GIBH-130 IL Receptor , TNF , Interleukin
GIBH-130 markedly inhibits the IL- secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
T36347 Ac-YVAD-CMK Caspase-1 Inhibitor II,Ac-Tyr-Val-Ala-Asp-chloromethylketone,Ac-Tyr-Val-Ala-Asp-CMK IL Receptor , Caspase , Immunology/Inflammation related , Pyroptosis
Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL- and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
T13375 YQ128 IL Receptor , NOD-like Receptor (NLR) , NOD , Interleukin
YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.
T67924 ABzOH
ABzOH is a benzoic acid derivative, similar in structure to non-steroidal anti-inflammatory drugs such as aspirin, with anti-inflammatory, anti-tumor and anti-proliferative effects. ABzOH can not only inhibit the express...
T11742 K-7174 IL Receptor , TNF
K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL- or TNF-α.
T61392 NLRP3-IN-10 ZVN26391 NOD
NLRP3-IN-10 (ZVN26391) is a potent NLRP3 inhibitor. NLRP3-IN-10 inhibits IL- release with an IC50 value of 251.1 nM. NLRP3-IN-10 attenuates ASC speck formation, leading to suppress activation of NLRP3 inflammasome.
T3701 MCC950 CP-456773 NOD
CP-456773 (MCC950 (CP-456773) and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL- secretion and caspase 1 processing. MCC950 blocked canonical and...
T8706 STAMBP-IN-1 Others
STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL- release after TLR agonism.
T21738 PF-9184 Prostaglandin Receptor
PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), IC50 =16.5 nM. PF-9184 inhibits IL--induced PGE2 synthesis in vitro.
T28958 TG6-129 TG6 129 Prostaglandin Receptor
TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-, IL-6, IL-12, IL-23 and...
T9645 CU-115 N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide TLR
CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL- activated by R-848 in THP-1 cells.
T79906 ADS032 BT-032 NOD
ADS032 (BT-032) is an NLRP1 and NLRP3 inhibitor with anti-inflammatory activity,, inhibits the activation of NLRP1 and NLRP3, inhibits Nigericin-induced IL- production, and can be used to study respiratory inflammation...
T77675 TNKS-2-IN-1 PARP , Wnt/beta-catenin , Antibiotic
TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity against E. coli and S. aureus.TNKS-2-IN-1 inhibits the releas...
T5821 BC-1215 Others , Ligand for E3 Ligase
BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL- release).
T77579 JC2-11 IL Receptor , Dehydrogenase , ROS , Caspase , NOD-like Receptor (NLR) , AIM2
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen sp...
T76711 Golimumab MK-8259,SCH 900259,CNTO-148 TNF
Golimumab (CNTO-148) is a potent humanized anti-TNFα IgG1κ monoclonal antibody.Golimumab has anti-inflammatory and anticancer activity, inhibits the production of IL-6 and IL-, and induces apoptosis.Golimumab can be us...
T13063 T6167923 MyD88
T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB dri...
T6090 Belnacasan VX-765 Caspase
Belnacasan (VX-765) is an orally active IL-converting enzyme/caspase-1 inhibitor.
TP2015L HS 014 acetate(207678-81-7 free base) Melanocortin Receptor
HS 014 acetate is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and no...
T1813 VGX-1027 VGX1027,VGX 1027,GIT 27 IL Receptor , TNF , Interleukin
VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.
T41142 EM 163 IL Receptor , p38 MAPK , MyD88
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interacti...
T5416 T-5224 MMP
T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors.
T38361 GSK717 IL Receptor , NOD
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretio...
T16570 Pralnacasan VX-740,HMR 3480 Others
Pralnacasan inhibits proinflammatory cytokines IL-18, IL- , and IFN-γ. Pralnacasan is an effective, non-peptide, and orally active interleukin- converting enzyme inhibitor (Ki: 1.4 nM). Pralnacasan has the potential ...
T36534 SDZ 224-015 SDZ 224015 IL Receptor , Caspase
SDZ 224-015 is an orally active inhibitor of interleukin- (IL-) converting enzyme and caspase-1.SDZ 224-015 exhibits anti-COVID-19 and anti-inflammatory activity, and reduces carrageenan gum-induced paw edema in rats...
T75113 GLPG2534 GLPG-2534 IRAK
GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 inhibits human and mouse IRAK4 and could be used to study psoriasis and atopic dermatitis.
T76731 Gevokizumab
Gevokizumab is a potent anti- IL- antibody, negatively modulates IL- signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of IL- for the IL-1 receptor type I (IL-1RI) si...
T69745 GDC-2394
GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits IL- with IC 50 s of 0.4 μM (human IL-) and 0.1 μM (mouse IL-). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLR...
T77077 Lutikizumab
Lutikizumab (ABT-981) is an anti- IL-1α and IL- dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-. Lutikizumab can be used for the research of osteoarthritis [1] .
T26626 AN3485 Hydrochloride
AN3485 Hydrochloride inhibits TLR2-, TLR3-, TLR4- and TLR5-mediated TNF-α, IL- and IL-6.
T78073 HP210 Glucocorticoid Receptor
HP210, a selective glucocorticoid receptor modulator (SGRM), can suppress IL- and IL-6 mRNA expression, suggesting its utility in investigating inflammation-related diseases [1].
T16937 ST 2825 Others
ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 inhibition of IL--mediated activation of NF-κB transcriptional activity.

Compounds

IQ-3
T8477
Synonym:
Target: JNK
Loxapine
T21629
Synonym:
Target: Dopamine Receptor, 5-HT Receptor
(Rac)-Benpyrine
T8692
Synonym:
Target: TNF
Amodiaquine
T8381
Synonym:
Target: Others, Histone Methyltransferase, Parasite
CP 424174
T8828
Synonym:
Target: IL Receptor
BC-1471
T8553
Synonym:
Target: Others
IL--IN-1
T74819
Synonym:
Target:
IL--IN-2
T78707
Synonym:
Target:
Pamapimod
T6927
Synonym: R1503,Ro4402257
Target: p38 MAPK, Autophagy
JTE-607
T27695
Synonym: JTE-607 dihydrochloride,JTE-607 HCl
Target: Cysteine Protease
Itaconate-alkyne
T41302
Synonym: ITalk
Target: Others
Loxapine succinate
T1412
Synonym: Daxolin,Loxapac,Cloxazepin,Loxapine succinate salt
Target: Dopamine Receptor, 5-HT Receptor
TLR3-IN-1
T22698
Synonym: CU CPT 4a
Target: TLR
Cetirizine dihydrochloride
T0089
Synonym: P071,UCB P071,Cetirizine DiHCl
Target: Histamine Receptor
Amodiaquine dihydrochloride dihydrate
T0381
Synonym: Amodiaquine hydrochloride,Amodiaquin dihydrochloride dihydrate
Target: Histone Methyltransferase, Parasite, Histamine Receptor
Pyrrolidinedithiocarbamate ammonium
T3147
Synonym: PDTC,Pyrrolidinedithiocarbamate,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate
Target: NF-κB
R1487 Hydrochloride
T7162
Synonym: R1487 (Hydrochloride)
Target: p38 MAPK, Autophagy
Canakinumab
T73695
Synonym: ACZ 885,Ilaris
Target: IL Receptor
GIBH-130
T4450
Synonym:
Target: IL Receptor, TNF, Interleukin
Ac-YVAD-CMK
T36347
Synonym: Caspase-1 Inhibitor II,Ac-Tyr-Val-Ala-Asp-chloromethylketone,Ac-Tyr-Val-Ala-Asp-CMK
Target: IL Receptor, Caspase, Immunology/Inflammation related, Pyroptosis
YQ128
T13375
Synonym:
Target: IL Receptor, NOD-like Receptor (NLR), NOD, Interleukin
ABzOH
T67924
Synonym:
Target:
K-7174
T11742
Synonym:
Target: IL Receptor, TNF
NLRP3-IN-10
T61392
Synonym: ZVN26391
Target: NOD
MCC950
T3701
Synonym: CP-456773
Target: NOD
STAMBP-IN-1
T8706
Synonym:
Target: Others
PF-9184
T21738
Synonym:
Target: Prostaglandin Receptor
TG6-129
T28958
Synonym: TG6 129
Target: Prostaglandin Receptor
CU-115
T9645
Synonym: N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide
Target: TLR
ADS032
T79906
Synonym: BT-032
Target: NOD
TNKS-2-IN-1
T77675
Synonym:
Target: PARP, Wnt/beta-catenin, Antibiotic
BC-1215
T5821
Synonym:
Target: Others, Ligand for E3 Ligase
JC2-11
T77579
Synonym:
Target: IL Receptor, Dehydrogenase, ROS, Caspase, NOD-like Receptor (NLR), AIM2
Golimumab
T76711
Synonym: MK-8259,SCH 900259,CNTO-148
Target: TNF
T6167923
T13063
Synonym:
Target: MyD88
Belnacasan
T6090
Synonym: VX-765
Target: Caspase
HS 014 acetate(207678-81-7 free base)
TP2015L
Synonym:
Target: Melanocortin Receptor
VGX-1027
T1813
Synonym: VGX1027,VGX 1027,GIT 27
Target: IL Receptor, TNF, Interleukin
EM 163
T41142
Synonym:
Target: IL Receptor, p38 MAPK, MyD88
T-5224
T5416
Synonym:
Target: MMP
GSK717
T38361
Synonym:
Target: IL Receptor, NOD
Pralnacasan
T16570
Synonym: VX-740,HMR 3480
Target: Others
SDZ 224-015
T36534
Synonym: SDZ 224015
Target: IL Receptor, Caspase
GLPG2534
T75113
Synonym: GLPG-2534
Target: IRAK
Gevokizumab
T76731
Synonym:
Target:
GDC-2394
T69745
Synonym:
Target:
Lutikizumab
T77077
Synonym:
Target:
AN3485 Hydrochloride
T26626
Synonym:
Target:
HP210
T78073
Synonym:
Target: Glucocorticoid Receptor
ST 2825
T16937
Synonym:
Target: Others
1 2 3
Cat No. Product Name Synonyms Targets
TN6722 Terminolic acid 2α,6β,23-trihydroxyl oleanolic acid Antibacterial
Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL- and ...
T9352 Hydrocotarnine Others
hydrocotarnine is an inhibitor of Cbl.
T2893 Muscone 3-Methylcyclopentadecanone,Methylexaltone MMP , TNF , NF-κB , NOD-like Receptor (NLR) , P-gp , Interleukin
Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
T5779 MOSLOFLAVONE IL Receptor , Virus Protease , TNF , Antibacterial
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL- with IC50 values of 0.71 μM and 7.8 μM, respectively.
TN1520 Isoforskolin Coleonol B IL Receptor , TNF
Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used in studies about the treatment of Lyme arthritis.
TC0036 Compound Lup-20(29)-en-3-yl acetate IL Receptor , VEGFR , Others , TNF , COX
Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-, MCP-1, COX-2, VEGF and granzyme B.
T2856 (-)-Epicatechin L-Epicatechin,Epicatechin,(-)-Epicatechol Ferroptosis , COX , Endogenous Metabolite
(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL--induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.
T5680 Aloin(mixture of A&B) MMP , IL Receptor , Antibacterial , Antifungal
ALOIN Inhibits Interleukin (IL)--Stimulated IL-8 Production in KB Cells.
T2720 Ginsenoside Rc Panaxoside Rc Others , TNF , GABA Receptor , Interleukin
Ginsenoside Rc (Panaxoside Rc) is one of the ginsenosides from Panax ginseng, inhibits the expression of TNF-α and IL-.
T2S0843 Negletein 7-O-Methylbaicalein,Baicalein-7-methylether IL Receptor , TNF , NOS , Interleukin
1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n...
TN5171 Tricetin Apoptosis , Others , Nrf2
Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...
T6S1597 Mulberroside A TNF , Tyrosinase , Interleukin
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of...
T2S0342 Armillarisin A Others , Interleukin
Armillarisin A enhancing the role of macrophages, inhibiting bacteria growth, improving the protein metabolism, and regulating liver function.
T6S1579 Monotropein Monotropeine Others
1. Monotropein (Monotropeine) has antinociceptive action. 2. Monotropein has anti-apoptosis and anti-catabolic activity in chondrocytes. 3. Monotropein has anti-inflammatory action by inhibition of the expressions of inf...
T6S0139 Neobavaisoflavone Apoptosis , DNA/RNA Synthesis
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si...
T2932 Ginsenoside Rh1 Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1 IL Receptor , TNF , Endogenous Metabolite , PPAR , Interleukin
Ginsenoside Rh1 (Sanchinoside B2) , one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
T2768 Saikosaponin A NF-κB , Antibacterial , Liver X Receptor
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath...
T3887 Rosarin Others
Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice .
T6S1538 Neochlorogenic acid trans-5-O-Caffeoylquinic acid,Neochlorogenate,5-O-Caffeoylquinic acid TNF , NF-κB , COX , Antibacterial , Interleukin
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.
T2993 Cordycepin 3'-Deoxyadenosine MMP , TNF , Antibacterial , Antibiotic , Autophagy
Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity.
T6S0077 Byakangelicol COX
1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr...
T3803 Specnuezhenide Nuzhenide,Nuezhenide Others , NF-κB , Wnt/beta-catenin
Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect t...
T26545 Acanthoic acid NP1302,NP 1302: NP-1302
Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum with anti-inflammatory activities. Acanthoic acid downregulates LPS-induced IL-, IL-6 and TNF-α production in BALF, attenuates lung histopat...
T79970 Taxamairin B
Taxamairin B is a potent anti-inflammatory compound that inhibits the expression of proinflammatory cytokines (TNF-α, IL-, and IL-6) and reduces the production of NO and ROS in LPS-induced RAW264.7 cells. Furthermore, ...
T38838 QS-21 Stimulon,QS-21
QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, Q...
TN6445 Cyclo(Gly-L-Pro)
Cyclo(Gly-(L)-Pro) shows immunostimulatory properties. Cyclo(Gly-l-Pro) exhibits potent inhibition of TNF-α release with the IC50 values of 4.5 ug/mL, respectively, it also exhibits significant diminution of IL- and IL...
TN4879 Questinol IL Receptor , TNF , COX , Prostaglandin Receptor
Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit the production of pro-inflammatory cytokines, including TNF-α...
TN5238 Viscidulin II IL Receptor , TNF
Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL- production in THP-1 cells, concomitant intradermal injection of ...
T79992 Sarglaroids F Caspase
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL- secretion by modulating K+ efflux and diminishing Caspase-1(P20) concentrations. Additional...

Natural Products

Terminolic acid
TN6722
Synonym: 2α,6β,23-trihydroxyl oleanolic acid
Target: Antibacterial
hydrocotarnine
T9352
Synonym:
Target: Others
Muscone
T2893
Synonym: 3-Methylcyclopentadecanone,Methylexaltone
Target: MMP, TNF, NF-κB, NOD-like Receptor (NLR), P-gp, Interleukin
MOSLOFLAVONE
T5779
Synonym:
Target: IL Receptor, Virus Protease, TNF, Antibacterial
Isoforskolin
TN1520
Synonym: Coleonol B
Target: IL Receptor, TNF
Compound Lup-20(29)-en-3-yl acetate
TC0036
Synonym:
Target: IL Receptor, VEGFR, Others, TNF, COX
(-)-Epicatechin
T2856
Synonym: L-Epicatechin,Epicatechin,(-)-Epicatechol
Target: Ferroptosis, COX, Endogenous Metabolite
Aloin(mixture of A&B)
T5680
Synonym:
Target: MMP, IL Receptor, Antibacterial, Antifungal
Ginsenoside Rc
T2720
Synonym: Panaxoside Rc
Target: Others, TNF, GABA Receptor, Interleukin
Negletein
T2S0843
Synonym: 7-O-Methylbaicalein,Baicalein-7-methylether
Target: IL Receptor, TNF, NOS, Interleukin
Tricetin
TN5171
Synonym:
Target: Apoptosis, Others, Nrf2
Mulberroside A
T6S1597
Synonym:
Target: TNF, Tyrosinase, Interleukin
Armillarisin A
T2S0342
Synonym:
Target: Others, Interleukin
Monotropein
T6S1579
Synonym: Monotropeine
Target: Others
Neobavaisoflavone
T6S0139
Synonym:
Target: Apoptosis, DNA/RNA Synthesis
Ginsenoside Rh1
T2932
Synonym: Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1
Target: IL Receptor, TNF, Endogenous Metabolite, PPAR, Interleukin
Saikosaponin A
T2768
Synonym:
Target: NF-κB, Antibacterial, Liver X Receptor
Rosarin
T3887
Synonym:
Target: Others
Neochlorogenic acid
T6S1538
Synonym: trans-5-O-Caffeoylquinic acid,Neochlorogenate,5-O-Caffeoylquinic acid
Target: TNF, NF-κB, COX, Antibacterial, Interleukin
Cordycepin
T2993
Synonym: 3'-Deoxyadenosine
Target: MMP, TNF, Antibacterial, Antibiotic, Autophagy
Byakangelicol
T6S0077
Synonym:
Target: COX
Specnuezhenide
T3803
Synonym: Nuzhenide,Nuezhenide
Target: Others, NF-κB, Wnt/beta-catenin
Acanthoic acid
T26545
Synonym: NP1302,NP 1302: NP-1302
Target:
Taxamairin B
T79970
Synonym:
Target:
QS-21
T38838
Synonym: Stimulon,QS-21
Target:
Cyclo(Gly-L-Pro)
TN6445
Synonym:
Target:
Questinol
TN4879
Synonym:
Target: IL Receptor, TNF, COX, Prostaglandin Receptor
Viscidulin II
TN5238
Synonym:
Target: IL Receptor, TNF
Sarglaroids F
T79992
Synonym:
Target: Caspase

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02134 IL-1 beta/IL-1F2 Protein, Mouse, Recombinant Mouse E. coli
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair ...
TMPK-00515 IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His) Cynomolgus E. coli
Interleukin-1 beta (IL-) is induced by inflammatory signals in a broad number of immune cell types. IL- (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1...
TMPK-00162 IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated Human E. coli
Interleukin-1 beta (IL-) is induced by inflammatory signals in a broad number of immune cell types. IL- (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1...
TMPK-00161 IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi) Human E. coli
Interleukin-1 beta (IL-) is induced by inflammatory signals in a broad number of immune cell types. IL- (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1...
TMPJ-00968 NAMPT Protein, Human, Recombinant (His) Human E. coli
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular e...
TMPY-01047 IL-1R1 Protein, Human, Recombinant (hFc) Human HEK293
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro...
TMPY-01928 IL-18 Protein, Rhesus, Recombinant (His) Rhesus E. coli
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-g...
TMPY-03273 IL-18 Protein, Mouse, Recombinant Mouse E. coli
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-g...
TMPY-00277 IL-18 Protein, Human, Recombinant Human E. coli
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-g...
TMPY-01774 TREM-1 Protein, Human, Recombinant (His) Human HEK293
TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growi...
TMPY-05053 ANGPTL2 Protein, Human, Recombinant (His) Human HEK293
The angiopoietin-like protein (ANGPTL) family is homologous to angiopoietins but does not bind to the Tie2 receptor. The function of ANGPTLs has been elucidated largely in the context of angiogenesis and lipid metabolism...
TMPK-00920 IL-1 alpha/IL-1A Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL- were the first members of the IL-1 family to be described, and b...
TMPK-01029 IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (aa 21-367, His) Mouse HEK293
Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disea...
TMPY-02341 IL-1R1 Protein, Mouse, Recombinant (His) Mouse HEK293
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro...
TMPY-03426 IL-1R1 Protein, Human, Recombinant Human HEK293
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro...
TMPY-02142 IL-1R1 Protein, Rat, Recombinant (His & mFc) Rat HEK293
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro...
TMPY-02059 IL-1R1 Protein, Rat, Recombinant (His) Rat HEK293
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro...
TMPY-03688 IL-1R1 Protein, Cynomolgus, Recombinant (hFc) Cynomolgus HEK293
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro...
TMPY-03744 IL-1R1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro...
TMPY-02729 IL-1R1 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro...
TMPY-01048 IL-1R1 Protein, Human, Recombinant (His) Human HEK293
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro...
TMPY-02549 GBP1 Protein, Human, Recombinant (His) Human HEK293
Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 ex...
TMPY-03381 IL-18 Protein, Human, Recombinant (GST) Human E. coli
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-g...
TMPY-04275 IL-36RN/IL-1F5 Protein, Mouse, Recombinant Mouse E. coli
Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-ka...
TMPY-00847 IL-36RN/IL-1F5 Protein, Human, Recombinant Human E. coli
Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-ka...
TMPY-05528 Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated Human E. coli
Apolipoprotein E (ApoE) is a 34.2 kDa glycosylated protein with 299 amino acid residues. There are three isoforms in human (apoE2, apoE3, and apoE4) due to different amino acid residues at positions 112 and 158. ApoE is ...
TMPY-00943 TREM-1 Protein, Human, Recombinant (His & hFc) Human HEK293
TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growi...
TMPY-06527 TREM-1 Protein, Mouse, Recombinant (His) Mouse HEK293
TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growi...
TMPY-05297 Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx) Human E. coli
Apolipoprotein E (ApoE) is a 34.2 kDa glycosylated protein with 299 amino acid residues. There are three isoforms in human (apoE2, apoE3, and apoE4) due to different amino acid residues at positions 112 and 158. ApoE is ...
TMPY-03998 ANGPTL2 Protein, Mouse, Recombinant (hFc) Mouse HEK293
The angiopoietin-like protein (ANGPTL) family is homologous to angiopoietins but does not bind to the Tie2 receptor. The function of ANGPTLs has been elucidated largely in the context of angiogenesis and lipid metabolism...
IL-1 beta/IL-1F2 Protein, Mouse, Recombinant
TMPY-02134
Species: Mouse
Expression System: E. coli
IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His)
TMPK-00515
Species: Cynomolgus
Expression System: E. coli
IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00162
Species: Human
Expression System: E. coli
IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi)
TMPK-00161
Species: Human
Expression System: E. coli
NAMPT Protein, Human, Recombinant (His)
TMPJ-00968
Species: Human
Expression System: E. coli
IL-1R1 Protein, Human, Recombinant (hFc)
TMPY-01047
Species: Human
Expression System: HEK293
IL-18 Protein, Rhesus, Recombinant (His)
TMPY-01928
Species: Rhesus
Expression System: E. coli
IL-18 Protein, Mouse, Recombinant
TMPY-03273
Species: Mouse
Expression System: E. coli
IL-18 Protein, Human, Recombinant
TMPY-00277
Species: Human
Expression System: E. coli
TREM-1 Protein, Human, Recombinant (His)
TMPY-01774
Species: Human
Expression System: HEK293
ANGPTL2 Protein, Human, Recombinant (His)
TMPY-05053
Species: Human
Expression System: HEK293
IL-1 alpha/IL-1A Protein, Cynomolgus, Recombinant (His)
TMPK-00920
Species: Cynomolgus
Expression System: HEK293
IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (aa 21-367, His)
TMPK-01029
Species: Mouse
Expression System: HEK293
IL-1R1 Protein, Mouse, Recombinant (His)
TMPY-02341
Species: Mouse
Expression System: HEK293
IL-1R1 Protein, Human, Recombinant
TMPY-03426
Species: Human
Expression System: HEK293
IL-1R1 Protein, Rat, Recombinant (His & mFc)
TMPY-02142
Species: Rat
Expression System: HEK293
IL-1R1 Protein, Rat, Recombinant (His)
TMPY-02059
Species: Rat
Expression System: HEK293
IL-1R1 Protein, Cynomolgus, Recombinant (hFc)
TMPY-03688
Species: Cynomolgus
Expression System: HEK293
IL-1R1 Protein, Cynomolgus, Recombinant (His)
TMPY-03744
Species: Cynomolgus
Expression System: HEK293
IL-1R1 Protein, Mouse, Recombinant (hFc)
TMPY-02729
Species: Mouse
Expression System: HEK293
IL-1R1 Protein, Human, Recombinant (His)
TMPY-01048
Species: Human
Expression System: HEK293
GBP1 Protein, Human, Recombinant (His)
TMPY-02549
Species: Human
Expression System: HEK293
IL-18 Protein, Human, Recombinant (GST)
TMPY-03381
Species: Human
Expression System: E. coli
IL-36RN/IL-1F5 Protein, Mouse, Recombinant
TMPY-04275
Species: Mouse
Expression System: E. coli
IL-36RN/IL-1F5 Protein, Human, Recombinant
TMPY-00847
Species: Human
Expression System: E. coli
Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated
TMPY-05528
Species: Human
Expression System: E. coli
TREM-1 Protein, Human, Recombinant (His & hFc)
TMPY-00943
Species: Human
Expression System: HEK293
TREM-1 Protein, Mouse, Recombinant (His)
TMPY-06527
Species: Mouse
Expression System: HEK293
Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx)
TMPY-05297
Species: Human
Expression System: E. coli
ANGPTL2 Protein, Mouse, Recombinant (hFc)
TMPY-03998
Species: Mouse
Expression System: HEK293
Cat No. Product Name
L8720 Pyroptosis Compound Library

1077 compounds
1077 types of active small molecules associated with pyroptosis for high-throughput and high-content screening.
L3800 NF-κB Signaling Compound Library

740 compounds
A unique collection of 740 compounds targeting NF-κB signaling for high throughput screening and high content screening;
TargetMol