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Search Results for " hexokinase "

Targets

16

Compounds

6

Natural Products

6

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T69625 Benitrobenrazide Hexokinase 2 inhibitor 1 Hexokinase
Benitrobenrazide (Hexokinase 2 inhibitor 1) is a hexokinase 2 inhibitor with anticancer and antitumor activity.Benitrobenrazide inhibits the growth of tumors and can be used in cancer research.
T5882 3-Bromopyruvic acid Hexokinase II Inhibitor II, 3-BP,Bromopyruvic acid Apoptosis , Hexokinase , Autophagy
3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinu...
T76111 Hexokinase (ScHEX1)
Hexokinase (ScHEX1) is a glycolytic enzyme hexokinase that is inhibited by n-acetylglucosamine. Inhibition of Hexokinase (ScHEX1) by n-acetylglucosamine leads to its separation from the mitochondrial outer membrane, resu...
T16479 PF-04937319 Others , Glucokinase
PF-04937319 is an activator of glucokinase (EC50 =154.4  μM). PF-04937319 maintains glucose-lowering efficacy while mitigating the risk of hypoglycemia observed with many other glucokinase activators. PF-04937319 can be ...
T3104 Globalagliatin LY2608204 Glucokinase
Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
TQ0055 AMG-3969 Glucokinase
AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
T3312 AM-2394 AM2394 Glucokinase
AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximatel...
T26712 AZD-1656 AZD 1656 Glucokinase
AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2 diabetes.
T15159 Dorzagliatin HMS5552 Glucokinase
Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
T12056 MK-0941 free base Glucokinase
MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.
T0239 Lonidamine AF1890,DICA,Diclondazolic Acid Apoptosis , Hexokinase , Mitochondrial Metabolism
Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).
T15654 Ketohexokinase inhibitor 1 PF-06835919 Others
Ketohexokinase inhibitor 1 is a ketohexokinase inhibitor (IC50s: 8.4 nM and 66 nM for KHK-C and KHK-A, respectively).
T72092 2-Deoxy-D-glucose 6-phosphate disodium
2-Deoxy-D-glucose 6-phosphate disodium, a derivative of 2-Deoxy-D-glucose, is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of...
T83889 C-02
C-02, a proteolysis-targeting chimera (PROTAC) that combines the hexokinase inhibitor lonidamine with the cereblon ligand thalidomide, effectively induces the degradation of hexokinase 2 in 786-O and PANC-1 cells at a co...
T35683 2-deoxy-D-Glucose-13C6 2-deoxy-D-Glucose-13C6
2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits h...
T65387 Paromomycin, sulfate (1:1)
Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven...
Cat No. Product Name Synonyms Targets
T19500 Palmitelaidic Acid trans-Palmitoleic acid,9-trans-Hexadecenoic acid Glucokinase , AMPK , PPAR
Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.
T6742 2-Deoxy-D-glucose 2-Deoxy-D-arabino-hexose,2-deoxyglucose,D-Arabino-2-deoxyhexose,Ba 2758,NSC 15193,2-DG Apoptosis , Hexokinase , HSV
2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.
T4900 Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate (±)-Jasmonic Acid methyl ester,(±)-Methyl Jasmonate Others , Endogenous Metabolite
Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate ((±)-Jasmonic Acid methyl ester)induces the synthesis of proteinase inhibitors in plant leaves. In cancer cells, it suppresses proliferation and induces apoptosis. Mo...
T5113 L-GLUCOSE L-(-)-Glucose Others
L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose is not bioavailable to cells as an energy source because it cannot be phosphorylated by hexokinase.
T4726 D-Glucose 6-phosphate sodium G6P sodium salt,D-Glucose 6-phosphate sodium salt,Sodium Glucose-6-Phosphate Others , Endogenous Metabolite
In cells, D-glucose 6-phosphate (G6P) is generated when glucose is phosphorylated by hexokinase or glucokinase or by the conversion of glucose-1-phosphate by phosphoglucomutase during glycogenolysis. G6P lies at the begi...
T5069 D-Glucose 6-phosphate potassium salt Others
D-Glucose 6-phosphate potassium is the potassiu salt form of D-glucose 6-phosphate, which is a glucose sugar phosphorylated at the hydroxy group on carbon 6.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04462 HK3 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Hexokinase-3, also known as Hexokinase type III, HKIII, and HK3, is a protein that belongs to the hexokinase family. Hexokinase-3 / HK3 is an enzyme that in humans is encoded by the HK2 gene. Hexokinases phosphorylate gl...
TMPY-04394 Glucokinase Protein, Human, Recombinant Human E. coli
Glucokinase belongs to the bacterial glucokinase family. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in ...
TMPH-02747 Ketohexokinase/KHK Protein, Mouse, Recombinant (His) Mouse E. coli
Bifunctional enzyme that possesses chorismate synthase and intrinsic flavin reductase activity, it uses NADPH to reduce FMN.
TMPH-01585 Ketohexokinase/KHK Protein, Human, Recombinant (GST) Human E. coli
May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.
TMPY-06752 HK2 Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of the glycolysis pathway, expresses at a high level in cancer cells compared with normal cells. HK2 provides a new target for cancer therapy due to its pivota...
TMPY-06763 HK2 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of the glycolysis pathway, expresses at a high level in cancer cells compared with normal cells. HK2 provides a new target for cancer therapy due to its pivota...
Cat No. Product Name
L2520 Glycometabolism Compound Library

708 compounds
708 glycometabolism-related comounds, can be used for HTS and HCT;
TargetMol