16
6
6
1
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T69625 | Benitrobenrazide | Hexokinase 2 inhibitor 1 | Hexokinase |
Benitrobenrazide (Hexokinase 2 inhibitor 1) is a hexokinase 2 inhibitor with anticancer and antitumor activity.Benitrobenrazide inhibits the growth of tumors and can be used in cancer research. | |||
T5882 | 3-Bromopyruvic acid | Hexokinase II Inhibitor II, 3-BP,Bromopyruvic acid | Apoptosis , Hexokinase , Autophagy |
3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinu... | |||
T76111 | Hexokinase (ScHEX1) | ||
Hexokinase (ScHEX1) is a glycolytic enzyme hexokinase that is inhibited by n-acetylglucosamine. Inhibition of Hexokinase (ScHEX1) by n-acetylglucosamine leads to its separation from the mitochondrial outer membrane, resu... | |||
T16479 | PF-04937319 | Others , Glucokinase | |
PF-04937319 is an activator of glucokinase (EC50 =154.4 μM). PF-04937319 maintains glucose-lowering efficacy while mitigating the risk of hypoglycemia observed with many other glucokinase activators. PF-04937319 can be ... | |||
T3104 | Globalagliatin | LY2608204 | Glucokinase |
Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2. | |||
TQ0055 | AMG-3969 | Glucokinase | |
AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM). | |||
T3312 | AM-2394 | AM2394 | Glucokinase |
AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximatel... | |||
T26712 | AZD-1656 | AZD 1656 | Glucokinase |
AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2 diabetes. | |||
T15159 | Dorzagliatin | HMS5552 | Glucokinase |
Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes. | |||
T12056 | MK-0941 free base | Glucokinase | |
MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes. | |||
T0239 | Lonidamine | AF1890,DICA,Diclondazolic Acid | Apoptosis , Hexokinase , Mitochondrial Metabolism |
Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK). | |||
T15654 | Ketohexokinase inhibitor 1 | PF-06835919 | Others |
Ketohexokinase inhibitor 1 is a ketohexokinase inhibitor (IC50s: 8.4 nM and 66 nM for KHK-C and KHK-A, respectively). | |||
T72092 | 2-Deoxy-D-glucose 6-phosphate disodium | ||
2-Deoxy-D-glucose 6-phosphate disodium, a derivative of 2-Deoxy-D-glucose, is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of... | |||
T83889 | C-02 | ||
C-02, a proteolysis-targeting chimera (PROTAC) that combines the hexokinase inhibitor lonidamine with the cereblon ligand thalidomide, effectively induces the degradation of hexokinase 2 in 786-O and PANC-1 cells at a co... | |||
T35683 | 2-deoxy-D-Glucose-13C6 | 2-deoxy-D-Glucose-13C6 | |
2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits h... | |||
T65387 | Paromomycin, sulfate (1:1) | ||
Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T19500 | Palmitelaidic Acid | trans-Palmitoleic acid,9-trans-Hexadecenoic acid | Glucokinase , AMPK , PPAR |
Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue. | |||
T6742 | 2-Deoxy-D-glucose | 2-Deoxy-D-arabino-hexose,2-deoxyglucose,D-Arabino-2-deoxyhexose,Ba 2758,NSC 15193,2-DG | Apoptosis , Hexokinase , HSV |
2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity. | |||
T4900 | Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate | (±)-Jasmonic Acid methyl ester,(±)-Methyl Jasmonate | Others , Endogenous Metabolite |
Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate ((±)-Jasmonic Acid methyl ester)induces the synthesis of proteinase inhibitors in plant leaves. In cancer cells, it suppresses proliferation and induces apoptosis. Mo... | |||
T5113 | L-GLUCOSE | L-(-)-Glucose | Others |
L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose is not bioavailable to cells as an energy source because it cannot be phosphorylated by hexokinase. | |||
T4726 | D-Glucose 6-phosphate sodium | G6P sodium salt,D-Glucose 6-phosphate sodium salt,Sodium Glucose-6-Phosphate | Others , Endogenous Metabolite |
In cells, D-glucose 6-phosphate (G6P) is generated when glucose is phosphorylated by hexokinase or glucokinase or by the conversion of glucose-1-phosphate by phosphoglucomutase during glycogenolysis. G6P lies at the begi... | |||
T5069 | D-Glucose 6-phosphate potassium salt | Others | |
D-Glucose 6-phosphate potassium is the potassiu salt form of D-glucose 6-phosphate, which is a glucose sugar phosphorylated at the hydroxy group on carbon 6. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04462 | HK3 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Hexokinase-3, also known as Hexokinase type III, HKIII, and HK3, is a protein that belongs to the hexokinase family. Hexokinase-3 / HK3 is an enzyme that in humans is encoded by the HK2 gene. Hexokinases phosphorylate gl... | |||
TMPY-04394 | Glucokinase Protein, Human, Recombinant | Human | E. coli |
Glucokinase belongs to the bacterial glucokinase family. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in ... | |||
TMPH-02747 | Ketohexokinase/KHK Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Bifunctional enzyme that possesses chorismate synthase and intrinsic flavin reductase activity, it uses NADPH to reduce FMN. | |||
TMPH-01585 | Ketohexokinase/KHK Protein, Human, Recombinant (GST) | Human | E. coli |
May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. | |||
TMPY-06752 | HK2 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of the glycolysis pathway, expresses at a high level in cancer cells compared with normal cells. HK2 provides a new target for cancer therapy due to its pivota... | |||
TMPY-06763 | HK2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of the glycolysis pathway, expresses at a high level in cancer cells compared with normal cells. HK2 provides a new target for cancer therapy due to its pivota... |
Cat No. | Product Name | ||
---|---|---|---|
L2520 | Glycometabolism Compound Library | 708 compounds | |
708 glycometabolism-related comounds, can be used for HTS and HCT; |