hsp27 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7265	HSP27 inhibitor J2	J2	HSP
	HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function.		HSP
T8858	DTHIB		HSP
	DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.		HSP
T16350	NSC-87877		Apoptosis , Phosphatase
	NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).		Apoptosis , Phosphatase
T6911	NSC-87877 disodium	NSC87877	Apoptosis , Phosphatase
	NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduce...		Apoptosis , Phosphatase
T15031	CYM50260		Others , LPL Receptor
	CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.		Others , LPL Receptor
T12871	Talmapimod	SCIO-469	p38 MAPK
	Talmapimod (SCIO-469) is an selective, orally active, and ATP-competitive p38α inhibitor with IC50 of 9 nM and 90 nM for p38α and p38β, respectively. Talmapimod exhibits at least 2000-fold selectivity over a panel of 20 ...		p38 MAPK
T1308	Orphenadrine hydrochloride	Mebedrol,Mephenamin	Sodium Channel , NMDAR , Norepinephrine , iGluR , Histamine Receptor
	Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T6618	Orphenadrine Citrate	Flexon,Flexoject,Banflex	AChR , iGluR
	Orphenadrine Citrate (Flexon) is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.		AChR , iGluR
T3594	ML346		HSP
	ML346 is a novel activator of Hsp70.		HSP
T74433	Apatorsen sodium
	Apatorsen (sodium) is an antisense oligonucleotide that targets Hsp27 mRNA, effectively inhibiting the production of Hsp27 protein.
T71597	JCC76
	JCC76 is a selective inhibitor of heat shock protein 27 (Hsp27). JCC76 inhibits the proliferation of human epidermal growth factor 2 (Her2).
T74434	Apatorsen
	Apatorsen, an antisense oligonucleotide, targets Hsp27 mRNA to inhibit Hsp27 protein production by binding to it.
T71965	KRIBB3
	KRIBB3 is novel and potent microtubule inhibitor with potential anticancer activity. KRIBB3 has anti-migratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 inhibits tumor cell migration and invasion by blocki...
T81783	MK2-IN-5	Hsp25 kinase inhibitor,Mk2 pseudosubstrate	ERK
	MK2-IN-5, a pseudosubstrate of Mk2 with an inhibition constant (K_i) of 8 μM, selectively targets the protein interaction domain of the MAPK pathway and inhibits the phosphorylation of HSP25 and HSP27 [1] [2] [3].		ERK
T21795	CRT5
	CRT5, a pyrazine benzamide, is a potent and selective PKD inhibitor. The VEGF-induced phosphorylation of three PKD substrates (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively), histone deacetylase 5, CREB...

Compounds

HSP27 inhibitor J2

T7265

Target: Apoptosis, Phosphatase

NSC-87877 disodium

T6911

Synonym: NSC87877

Target: Apoptosis, Phosphatase

CYM50260

T15031

Synonym:

Target: Others, LPL Receptor

Orphenadrine hydrochloride

T1308

Synonym: Mebedrol,Mephenamin

Target: Sodium Channel, NMDAR, Norepinephrine, iGluR, Histamine Receptor

Orphenadrine Citrate

T6618

Synonym: Flexon,Flexoject,Banflex

Synonym: Hsp25 kinase inhibitor,Mk2 pseudosubstrate

Cat No.	Product Name	Synonyms	Targets
T67708	Thiolutin	Acetopyrrothin	Antibacterial , Antibiotic
	Thiolutin (Acetopyrrothin) is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces the phosphorylation of Hsp27 rapidly.

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00693	HSP27/HSPB1 Protein, Human, Recombinant (His)	Human	E. coli
	Heat shock protein beta-1 (HSPB1, also known as HSP27) is a small heat shock protein involved in many cellular processes and reportedly protects cells against oxidative stress. This protein is expressed only in insulin-d...
TMPY-02087	IL-24 Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin-24 (IL-24) also known as Melanoma differentiation-associated gene 7 protein (MDA-7) is a member of the IL10 family of cytokines. IL-24/MDA-7/IL24 can induce apoptosis selectively in various cancer cells. Over...
TMPY-05177	IL-24 Protein, Human, Recombinant (mFc)	Human	HEK293
	Interleukin-24 (IL-24) also known as Melanoma differentiation-associated gene 7 protein (MDA-7) is a member of the IL10 family of cytokines. IL-24/MDA-7/IL24 can induce apoptosis selectively in various cancer cells. Over...