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Search Results for " hats "

Targets

31

Compounds

5

Natural Products

1

Libraries

Cat No. Product Name Synonyms Targets
T3499 Remodelin Histone Acetyltransferase
Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.
T12098 MOZ-IN-2 Histone Acetyltransferase
MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).
T5468 YF-2 Others , Epigenetic Reader Domain , Histone Acetyltransferase
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
T4679 WM-1119 WM1119 Histone Acetyltransferase
WM-1119 is a highly potent, selective KAT6A/B inhibitor
T15216 EML 425 Epigenetic Reader Domain , Histone Acetyltransferase
EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
T15405 GNE-781 Epigenetic Reader Domain
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).
T14073 A-485 Epigenetic Reader Domain , Histone Acetyltransferase
A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively).
T2452 C646 Apoptosis , Epigenetic Reader Domain , Histone Acetyltransferase , Autophagy
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T11807 L002 Others , Histone Acetyltransferase , STAT
L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By ...
T11563 Histone Acetyltransferase Inhibitor II Epigenetic Reader Domain , Histone Acetyltransferase
Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells.
T6811 CPI-637 CPI 637 Epigenetic Reader Domain , Histone Acetyltransferase
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
T8344 CPTH2 Apoptosis , Histone Acetyltransferase
CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network.
T6133 Remodelin hydrobromide Remodelin,Remodelin HBR RAAS , Histone Acetyltransferase
Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
T3969 I-CBP112 Epigenetic Reader Domain , Histone Acetyltransferase
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T4362 WM-8014 MOZ-IN-3 Histone Acetyltransferase
WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.
T9541 CTB Cholera Toxin B subunit Epigenetic Reader Domain
CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.
T8778 TTK21 Epigenetic Reader Domain
TTK21 is an activator of CBP/p300 histone acetyltransferase activity.
T6908 NSC 228155 NSC228155 EGFR , Epigenetic Reader Domain , DNA/RNA Synthesis , Histone Acetyltransferase
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
T6584 MG 149 MG149,Tip60 HAT inhibitor Apoptosis , Others , Epigenetic Reader Domain , Histone Acetyltransferase
MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
T6668 SGC-CBP30 Epigenetic Reader Domain , Histone Acetyltransferase
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T7856 Naphthol AS-E nAS-E Epigenetic Reader Domain , Histone Acetyltransferase
Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
T12345 CBP/p300-IN-3 P300/CBP-IN-3 Histone Acetyltransferase
CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase.
T9102 WM-3835 Apoptosis , Histone Methyltransferase , Histone Acetyltransferase
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
T8658 NEO2734 EP31670 Epigenetic Reader Domain , Histone Acetyltransferase
NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
T9167 PF-9363 CTX-3648 Histone Acetyltransferase
PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
T3217 PF-CBP1 hydrochloride PF-CBP1 HCl Epigenetic Reader Domain , Histone Acetyltransferase
PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.
T9373 DCH36_06 (5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Apoptosis , Epigenetic Reader Domain , Histone Acetyltransferase
DCH36_06 ((5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione)  as a bona fide is a potent p300/CBP inhibitor
T28471 PU139 PU 139,PU-139 Histone Acetyltransferase
PU139 is a novel inhibitor of histone acetyltransferase (HAT).
T10901 Curcumin-d6 Turmeric yellow D6,Natural Yellow 3 D6,Curcumin D6,Diferuloylmethane D6 Others
Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxi...
T69963 Birabresib dihydrate
Birabresib dihydrate was initially developed by Mitsubishi Tanabe Pharma Corporation, but then was licensed by OncoEthix, privately held biotechnology company. OTX015 is a selective bromodomains: BRD2, BRD3, and BRD4 inh...
T36626 Lys-CoA
Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo. Lau et a...

Compounds

Remodelin
T3499
Synonym:
Target: Histone Acetyltransferase
MOZ-IN-2
T12098
Synonym:
Target: Histone Acetyltransferase
YF-2
T5468
Synonym:
Target: Others, Epigenetic Reader Domain, Histone Acetyltransferase
WM-1119
T4679
Synonym: WM1119
Target: Histone Acetyltransferase
EML 425
T15216
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
GNE-781
T15405
Synonym:
Target: Epigenetic Reader Domain
A-485
T14073
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
C646
T2452
Synonym:
Target: Apoptosis, Epigenetic Reader Domain, Histone Acetyltransferase, Autophagy
L002
T11807
Synonym:
Target: Others, Histone Acetyltransferase, STAT
Histone Acetyltransferase Inhibitor II
T11563
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
CPI-637
T6811
Synonym: CPI 637
Target: Epigenetic Reader Domain, Histone Acetyltransferase
CPTH2
T8344
Synonym:
Target: Apoptosis, Histone Acetyltransferase
Remodelin hydrobromide
T6133
Synonym: Remodelin,Remodelin HBR
Target: RAAS, Histone Acetyltransferase
I-CBP112
T3969
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
WM-8014
T4362
Synonym: MOZ-IN-3
Target: Histone Acetyltransferase
CTB
T9541
Synonym: Cholera Toxin B subunit
Target: Epigenetic Reader Domain
TTK21
T8778
Synonym:
Target: Epigenetic Reader Domain
NSC 228155
T6908
Synonym: NSC228155
Target: EGFR, Epigenetic Reader Domain, DNA/RNA Synthesis, Histone Acetyltransferase
MG 149
T6584
Synonym: MG149,Tip60 HAT inhibitor
Target: Apoptosis, Others, Epigenetic Reader Domain, Histone Acetyltransferase
SGC-CBP30
T6668
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
Naphthol AS-E
T7856
Synonym: nAS-E
Target: Epigenetic Reader Domain, Histone Acetyltransferase
CBP/p300-IN-3
T12345
Synonym: P300/CBP-IN-3
Target: Histone Acetyltransferase
WM-3835
T9102
Synonym:
Target: Apoptosis, Histone Methyltransferase, Histone Acetyltransferase
NEO2734
T8658
Synonym: EP31670
Target: Epigenetic Reader Domain, Histone Acetyltransferase
PF-9363
T9167
Synonym: CTX-3648
Target: Histone Acetyltransferase
PF-CBP1 hydrochloride
T3217
Synonym: PF-CBP1 HCl
Target: Epigenetic Reader Domain, Histone Acetyltransferase
DCH36_06
T9373
Synonym: (5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Target: Apoptosis, Epigenetic Reader Domain, Histone Acetyltransferase
PU139
T28471
Synonym: PU 139,PU-139
Target: Histone Acetyltransferase
Curcumin-d6
T10901
Synonym: Turmeric yellow D6,Natural Yellow 3 D6,Curcumin D6,Diferuloylmethane D6
Target: Others
Birabresib dihydrate
T69963
Synonym:
Target:
Lys-CoA
T36626
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T11366 Garcinol Apoptosis , Endogenous Metabolite , Histone Acetyltransferase , AChR , AChE
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone...
TN1150 Procyanidin B3 Histone Acetyltransferase
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
T6389 Anacardic Acid 6-pentadecylsalicylic Acid,Hydroginkgolic acid Others , Epigenetic Reader Domain , Histone Acetyltransferase , Antibacterial
Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostagland...
T0065 Acetaminophen 4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol COX , Endogenous Metabolite , Histone Acetyltransferase
Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity.
T1516 Curcumin Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant...
Cat No. Product Name
L8300 Chromatin Modification Compound Library

256 compounds
A unique collection of 256 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS);
TargetMol