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Cat No. | Product Name | Synonyms | Targets |
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T3499 | Remodelin | Histone Acetyltransferase | |
Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10. | |||
T12098 | MOZ-IN-2 | Histone Acetyltransferase | |
MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM). | |||
T5468 | YF-2 | Others , Epigenetic Reader Domain , Histone Acetyltransferase | |
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively | |||
T4679 | WM-1119 | WM1119 | Histone Acetyltransferase |
WM-1119 is a highly potent, selective KAT6A/B inhibitor | |||
T15216 | EML 425 | Epigenetic Reader Domain , Histone Acetyltransferase | |
EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively). | |||
T15405 | GNE-781 | Epigenetic Reader Domain | |
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively). | |||
T14073 | A-485 | Epigenetic Reader Domain , Histone Acetyltransferase | |
A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively). | |||
T2452 | C646 | Apoptosis , Epigenetic Reader Domain , Histone Acetyltransferase , Autophagy | |
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay). | |||
T11807 | L002 | Others , Histone Acetyltransferase , STAT | |
L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By ... | |||
T11563 | Histone Acetyltransferase Inhibitor II | Epigenetic Reader Domain , Histone Acetyltransferase | |
Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells. | |||
T6811 | CPI-637 | CPI 637 | Epigenetic Reader Domain , Histone Acetyltransferase |
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor. | |||
T8344 | CPTH2 | Apoptosis , Histone Acetyltransferase | |
CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network. | |||
T6133 | Remodelin hydrobromide | Remodelin,Remodelin HBR | RAAS , Histone Acetyltransferase |
Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. | |||
T3969 | I-CBP112 | Epigenetic Reader Domain , Histone Acetyltransferase | |
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains. | |||
T4362 | WM-8014 | MOZ-IN-3 | Histone Acetyltransferase |
WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases. | |||
T9541 | CTB | Cholera Toxin B subunit | Epigenetic Reader Domain |
CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells. | |||
T8778 | TTK21 | Epigenetic Reader Domain | |
TTK21 is an activator of CBP/p300 histone acetyltransferase activity. | |||
T6908 | NSC 228155 | NSC228155 | EGFR , Epigenetic Reader Domain , DNA/RNA Synthesis , Histone Acetyltransferase |
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation. | |||
T6584 | MG 149 | MG149,Tip60 HAT inhibitor | Apoptosis , Others , Epigenetic Reader Domain , Histone Acetyltransferase |
MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM). | |||
T6668 | SGC-CBP30 | Epigenetic Reader Domain , Histone Acetyltransferase | |
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM). | |||
T7856 | Naphthol AS-E | nAS-E | Epigenetic Reader Domain , Histone Acetyltransferase |
Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor. | |||
T12345 | CBP/p300-IN-3 | P300/CBP-IN-3 | Histone Acetyltransferase |
CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase. | |||
T9102 | WM-3835 | Apoptosis , Histone Methyltransferase , Histone Acetyltransferase | |
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation. | |||
T8658 | NEO2734 | EP31670 | Epigenetic Reader Domain , Histone Acetyltransferase |
NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains). | |||
T9167 | PF-9363 | CTX-3648 | Histone Acetyltransferase |
PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer. | |||
T3217 | PF-CBP1 hydrochloride | PF-CBP1 HCl | Epigenetic Reader Domain , Histone Acetyltransferase |
PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively. | |||
T9373 | DCH36_06 | (5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | Apoptosis , Epigenetic Reader Domain , Histone Acetyltransferase |
DCH36_06 ((5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione) as a bona fide is a potent p300/CBP inhibitor | |||
T28471 | PU139 | PU 139,PU-139 | Histone Acetyltransferase |
PU139 is a novel inhibitor of histone acetyltransferase (HAT). | |||
T10901 | Curcumin-d6 | Turmeric yellow D6,Natural Yellow 3 D6,Curcumin D6,Diferuloylmethane D6 | Others |
Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxi... | |||
T69963 | Birabresib dihydrate | ||
Birabresib dihydrate was initially developed by Mitsubishi Tanabe Pharma Corporation, but then was licensed by OncoEthix, privately held biotechnology company. OTX015 is a selective bromodomains: BRD2, BRD3, and BRD4 inh... | |||
T36626 | Lys-CoA | ||
Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo. Lau et a... |
Cat No. | Product Name | Synonyms | Targets |
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T11366 | Garcinol | Apoptosis , Endogenous Metabolite , Histone Acetyltransferase , AChR , AChE | |
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone... | |||
TN1150 | Procyanidin B3 | Histone Acetyltransferase | |
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity. | |||
T6389 | Anacardic Acid | 6-pentadecylsalicylic Acid,Hydroginkgolic acid | Others , Epigenetic Reader Domain , Histone Acetyltransferase , Antibacterial |
Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostagland... | |||
T0065 | Acetaminophen | 4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol | COX , Endogenous Metabolite , Histone Acetyltransferase |
Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity. | |||
T1516 | Curcumin | Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow | Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy |
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant... |
Cat No. | Product Name | ||
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L8300 | Chromatin Modification Compound Library | 256 compounds | |
A unique collection of 256 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS); |