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Cat No. | Product Name | Synonyms | Targets |
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T9162 | CID1231538 | GPR | |
CID1231538 is a potent GPR35 antagonist. | |||
TP1051L | Protein Kinase C Peptide Substrate acetate | Protein Kinase C Peptide Substrate acetate(120253-69-2 free base) | Others |
Protein Kinase C Peptide Substrate acetate targets specific cell spacers ina manner that is dependent on second messengers and specific adaptor proteins in response to extracellular signals that activate g protein-couple... | |||
T7847 | Apelin-13 triTFA(217082-58-1(free base)) | Others | |
Apelin-13 triTFA is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM. | |||
T8538 | ML382 | Others | |
ML382 is a potent and selective MrgX1 positive allosteric modulator(EC50 : 190 nM). | |||
T5100 | DJ-V-159 | DJ-V159 | GPR , Androgen Receptor |
DJ-V-159 (DJ-V159) is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A). | |||
T1793 | MBX-2982 | GPR | |
MBX-2982 is a selective, orally-available GPR119 agonist, used for the treatment of diabetes. | |||
T36036 | CAY10786 | GPR52 antagonist-1 | GPR |
CAY10786 (GPR52 antagonist-1) is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM). | |||
T7389 | G15 | Estrogen Receptor/ERR | |
G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM) | |||
TP2073L | BigLEN (mouse) acetate | BigLEN (mouse) acetate (501036-69-7 Free base) | GPR |
BigLEN (mouse) acetate is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ∼0.5 nM. | |||
T12104 | MRGPRX1 agonist 1 | Others | |
MRGPRX1 agonist 1 is a highly potent MRGPRX1 (Mas-related G-protein-coupled receptor X1)agonist(EC50 of 50 nM). | |||
T5422 | CID 1375606 | CID-1375606,CID1375606 | Others |
CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27. characterized by a high level of conservation among vertebrates and a predominant expression in the central nervous system. | |||
T24850 | Takeda103A | CMPD103A,Takeda-103A,Takeda-103-A,CMPD-103A,Takeda 103 A | GRK |
Takeda103A (CMPD103A) is the GRK2-dependent bovine tubulin oxidation effective inhibitor. | |||
T4626L | TC-O 9311 | TCO-9311,TC-O9311,TCO 9311,TC-O 9311,TCO9311,TC-O-9311 | GPR |
TC-O 9311 (TCO-9311) is an effective agonist of GPR139 (EC50 = 39 nM in CHO-K1 cells expressing human GPR139). | |||
T61556 | GRK6-IN-2 | GRK | |
GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma. | |||
TP1982L | Neuropeptide S (Rat) acetate | Neuropeptide Y Receptor | |
Neuropeptide S (Rat) acetate is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor. Neuropeptide S (Rat) acetate can be used for the research of nervous system disease [1]. | |||
T19700 | IBC 293 | IBC293,IBC-293 | GPR |
IBC 293 is selective for GPR109B over niacin receptor GPR109A. IBC 293 is a highly selective agonist for GPR109B, a human orphan G-protein-coupled receptor expressed in adipocytes. | |||
T3498 | CCG215022 | GRK , PKA | |
CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively. | |||
T9857L | Vasopressin acetate | Vasopressin acetate (11000-17-2 Free base) | Endogenous Metabolite |
Vasopressin acetate, a cyclic nonapeptide, is synthesized centrally in the hypothalamus. Vasopressin acetate acts as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors. | |||
TP1914L1 | BAM (8-22) acetate | BAM (8-22) acetate(412961-36-5 free base) | Others |
BAM (8-22) acetate is a proteolytically cleaved product of proenkephalin A. BAM (8-22) acetate activates Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr... | |||
T9357 | Ro 5212773 | Epptb | Others |
Ro 5212773 (Epptb) is a selective TAAR1 antagonist. | |||
TP1074L | Neuropeptide FF acetate(99566-27-5 free base) | NPFF acetate | Neuropeptide Y Receptor |
Neuropeptide FF acetate(99566-27-5 free base) (NPFF acetate) is an octapeptide belonging to the RF amide family. NPFF interacts with G-protein-coupled receptors NPFF (1) and NPFF (2). | |||
T60199 | NCRW0005-F05 | GPR | |
NCRW0005-F05 is a potent agonist of orphan G-protein coupled receptor GPR139 with an IC 50 value of 0.21 μM. NCRW0005-F05 can be used to research diabetes, obesity and Parkinson's disease [1]. | |||
T63166 | LSN3318839 | LSN-3318839,LSN 3318839 | Glucagon Receptor |
LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can be used to lower blood glucose. | |||
T10843 | CMF019 | Apelin receptor | |
CMF019 is a potent agonist of the Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ (pKis: 8.58, 8.49, and 8.71 for the human, rat, and mouse). | |||
TP2296L | TLQP 21 acetate | Complement System | |
TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for human. TLQP 21 acetate is a VGF-derived peptide with endocrine a... | |||
T9146 | Ms48107 | Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- | Others |
MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68). It is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion chann... | |||
T11411 | GLPG1205 | GPR , Others | |
GLPG1205 is a potent, orally active GPR84 (G protein-coupled receptor) antagonist with anti-inflammatory activity. GLPG1205 shows good PK/PD characteristics and can be used to study pulmonary fibrosis. | |||
T9609 | GRK5-IN-2 | GRK | |
GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor. It regulates the expression and/or release of insulin and is useful for the metabolic disease research. | |||
T38807L | [Lys8, Lys9]-Neurotensin (8-13) acetate | Neurotensin Receptor | |
[Lys8, Lys9]-Neurotensin (8-13) acetate, a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 r... | |||
T37496L | Alamandine TFA | RAAS | |
Alamandine TFA , a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine TFA targets to protect the kidney and heart through anti-h... | |||
TP2279L | Obestatin (rat) acetate | GHSR | |
Obestatin (rat) acetate is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin (rat) acetate has anti-inflammatory, anti-myocardial infarction and antioxidant properties. Obestatin (rat) acetate supp... | |||
T38651 | Lauryl maltose neopentyl glycol | LMNG | |
Lauryl maltose neopentyl glycol (LMNG) is a detergent that solubilizes and stabilizes membrane proteins. lauryl maltose neopentyl glycol extracts intact membrane proteins from membranes, thereby improving the stability o... | |||
T4369 | SCH-23390 hydrochloride | R-(+)-SCH23390 hydrochloride | Potassium Channel , Dopamine Receptor , 5-HT Receptor |
SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM). | |||
T1781 | GW9508 | GW 9508 | GPR , Potassium Channel |
GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner. | |||
T50088 | N-phenylthiophene-2-carboximidamide | Others | |
N-phenylthiophene-2-carboximidamide is an organic compound of the thiophene derivative class that has been used in the synthesis of a variety of organic compounds, including pharmaceuticals and agrochemicals. It also fun... | |||
T11044 | Dihydromunduletone | DHM | GPR |
Dihydromunduletone (DHM) is an adhesion G protein-coupled receptor (aGPCR) antagonist that acts as a chemical probe for the inhibition of GPR56 and GPR114/ADGRG5, which have similar tethered agonists. | |||
T8752 | BAR 501 impurity | GPCR19 | |
BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 μM) induces a 150% increase in luciferase act... | |||
T3513 | GSK180736A | GSK180736 | ROCK , GRK , PKA |
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM). | |||
T38287 | C3a Receptor Agonist | C3a receptor agonist 1,Complement 3a Receptor Agonist | Complement System |
C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestin... | |||
T22986 | MK 1903 | GPR | |
MK 1903 is a potent and selective complete agonist for the hydroxy-carboxylic acid receptor 2 (HCA2). HCA2 is also known as G protein-coupled receptor 109A(GPR109A). MK 1903 reduced Foschlin-induced cAMP production in un... | |||
T22794 | G36 | G-36 | Estrogen Receptor/ERR |
G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 nM, respectively). G36 has no detectable binding activity to... | |||
T22070 | DBIBB | LPA Receptor | |
DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of acute radiation syndrome caused by high intensity gamma ra... | |||
T9857 | Vasopressin | antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP) | Endogenous Metabolite |
Vasopressin (argipressin), a cyclic nine-peptide synthesized by hypothalamic neurons, is one of the hormones involved in peptide prohormone synthesis. Vasopressin is involved in the regulation process of hypothalamic-pit... | |||
T7656 | Apelin-13 | ||
Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 ... | |||
T63404 | Xelaglifam | ||
Xelaglifam is a potent agonist of G protein-coupled receptor 40 (GPR40) and exhibits hypoglycemic effects. | |||
T7616 | A 779 | A 779(3TFA) | RAAS |
A 779 is a potent antagonist of the G-protein-coupled receptor Mas, the Ang1-7 receptor, which is distinct from conventional AngII. | |||
T62444 | NBI-27914 | ||
NBI-27914 is a potent and selective CRFR1 antagonist. The CRF receptors CRFR1 and CRFR2 are members of the G protein-coupled receptor superfamily. | |||
T80197 | Vasopressin Dimer (parallel) (TFA) | Vasopressin Receptor | |
Vasopressin Dimer (parallel) TFA, a parallel dimer of Vasopressin, has the capability to activate four G protein-coupled receptors—namely, V1aR, V1bR, V2R, and OTR [1]. | |||
T80198 | Vasopressin Dimer (anti-parallel) (TFA) | Vasopressin Receptor | |
Vasopressin Dimer (anti-parallel) TFA, an anti-parallel dimer form of vasopressin, has the capability to activate four G protein-coupled receptors: V1aR, V1bR, V2R, and OTR [1]. | |||
T82258 | GRL018-21 | ||
GRL018-21 is a potent, highly selective inhibitor of G protein-coupled receptor kinase 5 (GRK5), exhibiting an IC50 of 10 nM [1]. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5077 | Deoxycholic acid sodium salt | Sodium deoxycholate,Sodium Desoxycholate | Endogenous Metabolite , GPCR19 |
Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity. | |||
T1571 | Estriol | NSC-12169,Oestriol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , MRP , Endogenous Metabolite |
Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is... | |||
T29078 | Ursodeoxycholic acid sodium | UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium | FXR , Endogenous Metabolite , GPCR19 |
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting it... | |||
T2965 | Deoxycholic acid | Cholorebic,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic | Endogenous Metabolite , GPCR19 |
Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorptio... | |||
T21500 | Sphingosine-1-phosphate | S1P | Endogenous Metabolite , S1P Receptor , LPL Receptor |
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger that mobilises Ca2+ as an extracellular ligand for G-protei... |
Cat No. | Product Name | ||
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L2700 | Adrenergic Receptor-Targeted Compound Library | 219 compounds | |
A unique collection of 219 bioactive compounds specifically targeting adrenergic receptors, effective tool for screening new drugs or new target identification; | |||
L1500 | GPCR Compound Library | 1633 compounds | |
A unique collection of 1633 GPCR-active agents for high throughput screening and high content screening for GPCR drug discovery, and new GPCR target identification and research; | |||
L1580 | GPCR Compound Library Plus | 338 compounds | |
Well-chosen 338 GPCR targeting compounds with unique structures; | |||
L2800 | Serotonin Receptor-Targeted Compound Library | 275 compounds | |
A unique collection of 275 compounds targeting serotonin receptors for high throughput screening and high content screening; | |||
L4660 | Anti-Nervous System Disease Library | 1246 compounds | |
Well-chosen 1246 compounds with unique structures targeting nervous system; | |||
L2600 | Neuronal Signaling Compound Library | 2540 compounds | |
A unique collection of 2540 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs; |