Home Tools
Log in
Cart

Search Result

Search Results for " g蛋白偶联受体 "

Targets

86

Compounds

5

Natural Products

6

Libraries

Cat No. Product Name Synonyms Targets
T9162 CID1231538 GPR
CID1231538 is a potent GPR35 antagonist.
TP1051L Protein Kinase C Peptide Substrate acetate Protein Kinase C Peptide Substrate acetate(120253-69-2 free base) Others
Protein Kinase C Peptide Substrate acetate targets specific cell spacers ina manner that is dependent on second messengers and specific adaptor proteins in response to extracellular signals that activate g protein-couple...
T7847 Apelin-13 triTFA(217082-58-1(free base)) Others
Apelin-13 triTFA is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM.
T8538 ML382 Others
ML382 is a potent and selective MrgX1 positive allosteric modulator(EC50 : 190 nM).
T5100 DJ-V-159 DJ-V159 GPR , Androgen Receptor
DJ-V-159 (DJ-V159) is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A).
T1793 MBX-2982 GPR
MBX-2982 is a selective, orally-available GPR119 agonist, used for the treatment of diabetes.
T36036 CAY10786 GPR52 antagonist-1 GPR
CAY10786 (GPR52 antagonist-1) is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).
T7389 G15 Estrogen Receptor/ERR
G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM)
TP2073L BigLEN (mouse) acetate BigLEN (mouse) acetate (501036-69-7 Free base) GPR
BigLEN (mouse) acetate is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ∼0.5 nM.
T12104 MRGPRX1 agonist 1 Others
MRGPRX1 agonist 1 is a highly potent MRGPRX1 (Mas-related G-protein-coupled receptor X1)agonist(EC50 of 50 nM).
T5422 CID 1375606 CID-1375606,CID1375606 Others
CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27. characterized by a high level of conservation among vertebrates and a predominant expression in the central nervous system.
T24850 Takeda103A CMPD103A,Takeda-103A,Takeda-103-A,CMPD-103A,Takeda 103 A GRK
Takeda103A (CMPD103A) is the GRK2-dependent bovine tubulin oxidation effective inhibitor.
T4626L TC-O 9311 TCO-9311,TC-O9311,TCO 9311,TC-O 9311,TCO9311,TC-O-9311 GPR
TC-O 9311 (TCO-9311) is an effective agonist of GPR139 (EC50 = 39 nM in CHO-K1 cells expressing human GPR139).
T61556 GRK6-IN-2 GRK
GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.
TP1982L Neuropeptide S (Rat) acetate Neuropeptide Y Receptor
Neuropeptide S (Rat) acetate is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor. Neuropeptide S (Rat) acetate can be used for the research of nervous system disease [1].
T19700 IBC 293 IBC293,IBC-293 GPR
IBC 293 is selective for GPR109B over niacin receptor GPR109A. IBC 293 is a highly selective agonist for GPR109B, a human orphan G-protein-coupled receptor expressed in adipocytes.
T3498 CCG215022 GRK , PKA
CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.
T9857L Vasopressin acetate Vasopressin acetate (11000-17-2 Free base) Endogenous Metabolite
Vasopressin acetate, a cyclic nonapeptide, is synthesized centrally in the hypothalamus. Vasopressin acetate acts as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.
TP1914L1 BAM (8-22) acetate BAM (8-22) acetate(412961-36-5 free base) Others
BAM (8-22) acetate is a proteolytically cleaved product of proenkephalin A. BAM (8-22) acetate activates Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr...
T9357 Ro 5212773 Epptb Others
Ro 5212773 (Epptb) is a selective TAAR1 antagonist.
TP1074L Neuropeptide FF acetate(99566-27-5 free base) NPFF acetate Neuropeptide Y Receptor
Neuropeptide FF acetate(99566-27-5 free base) (NPFF acetate) is an octapeptide belonging to the RF amide family. NPFF interacts with G-protein-coupled receptors NPFF (1) and NPFF (2).
T60199 NCRW0005-F05 GPR
NCRW0005-F05 is a potent agonist of orphan G-protein coupled receptor GPR139 with an IC 50 value of 0.21 μM. NCRW0005-F05 can be used to research diabetes, obesity and Parkinson's disease [1].
T63166 LSN3318839 LSN-3318839,LSN 3318839 Glucagon Receptor
LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can be used to lower blood glucose.
T10843 CMF019 Apelin receptor
CMF019 is a potent agonist of the Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ (pKis: 8.58, 8.49, and 8.71 for the human, rat, and mouse).
TP2296L TLQP 21 acetate Complement System
TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for human. TLQP 21 acetate is a VGF-derived peptide with endocrine a...
T9146 Ms48107 Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- Others
MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68). It is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion chann...
T11411 GLPG1205 GPR , Others
GLPG1205 is a potent, orally active GPR84 (G protein-coupled receptor) antagonist with anti-inflammatory activity. GLPG1205 shows good PK/PD characteristics and can be used to study pulmonary fibrosis.
T9609 GRK5-IN-2 GRK
GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor. It regulates the expression and/or release of insulin and is useful for the metabolic disease research.
T38807L [Lys8, Lys9]-Neurotensin (8-13) acetate Neurotensin Receptor
[Lys8, Lys9]-Neurotensin (8-13) acetate, a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 r...
T37496L Alamandine TFA RAAS
Alamandine TFA , a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine TFA targets to protect the kidney and heart through anti-h...
TP2279L Obestatin (rat) acetate GHSR
Obestatin (rat) acetate is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin (rat) acetate has anti-inflammatory, anti-myocardial infarction and antioxidant properties. Obestatin (rat) acetate supp...
T38651 Lauryl maltose neopentyl glycol LMNG
Lauryl maltose neopentyl glycol (LMNG) is a detergent that solubilizes and stabilizes membrane proteins. lauryl maltose neopentyl glycol extracts intact membrane proteins from membranes, thereby improving the stability o...
T4369 SCH-23390 hydrochloride R-(+)-SCH23390 hydrochloride Potassium Channel , Dopamine Receptor , 5-HT Receptor
SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM).
T1781 GW9508 GW 9508 GPR , Potassium Channel
GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.
T50088 N-phenylthiophene-2-carboximidamide Others
N-phenylthiophene-2-carboximidamide is an organic compound of the thiophene derivative class that has been used in the synthesis of a variety of organic compounds, including pharmaceuticals and agrochemicals. It also fun...
T11044 Dihydromunduletone DHM GPR
Dihydromunduletone (DHM) is an adhesion G protein-coupled receptor (aGPCR) antagonist that acts as a chemical probe for the inhibition of GPR56 and GPR114/ADGRG5, which have similar tethered agonists.
T8752 BAR 501 impurity GPCR19
BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 μM) induces a 150% increase in luciferase act...
T3513 GSK180736A GSK180736 ROCK , GRK , PKA
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM).
T38287 C3a Receptor Agonist C3a receptor agonist 1,Complement 3a Receptor Agonist Complement System
C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestin...
T22986 MK 1903 GPR
MK 1903 is a potent and selective complete agonist for the hydroxy-carboxylic acid receptor 2 (HCA2). HCA2 is also known as G protein-coupled receptor 109A(GPR109A). MK 1903 reduced Foschlin-induced cAMP production in un...
T22794 G36 G-36 Estrogen Receptor/ERR
G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 nM, respectively). G36 has no detectable binding activity to...
T22070 DBIBB LPA Receptor
DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of acute radiation syndrome caused by high intensity gamma ra...
T9857 Vasopressin antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP) Endogenous Metabolite
Vasopressin (argipressin), a cyclic nine-peptide synthesized by hypothalamic neurons, is one of the hormones involved in peptide prohormone synthesis. Vasopressin is involved in the regulation process of hypothalamic-pit...
T7656 Apelin-13
Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 ...
T63404 Xelaglifam
Xelaglifam is a potent agonist of G protein-coupled receptor 40 (GPR40) and exhibits hypoglycemic effects.
T7616 A 779 A 779(3TFA) RAAS
A 779 is a potent antagonist of the G-protein-coupled receptor Mas, the Ang1-7 receptor, which is distinct from conventional AngII.
T62444 NBI-27914
NBI-27914 is a potent and selective CRFR1 antagonist. The CRF receptors CRFR1 and CRFR2 are members of the G protein-coupled receptor superfamily.
T80197 Vasopressin Dimer (parallel) (TFA) Vasopressin Receptor
Vasopressin Dimer (parallel) TFA, a parallel dimer of Vasopressin, has the capability to activate four G protein-coupled receptors—namely, V1aR, V1bR, V2R, and OTR [1].
T80198 Vasopressin Dimer (anti-parallel) (TFA) Vasopressin Receptor
Vasopressin Dimer (anti-parallel) TFA, an anti-parallel dimer form of vasopressin, has the capability to activate four G protein-coupled receptors: V1aR, V1bR, V2R, and OTR [1].
T82258 GRL018-21
GRL018-21 is a potent, highly selective inhibitor of G protein-coupled receptor kinase 5 (GRK5), exhibiting an IC50 of 10 nM [1].

Compounds

CID1231538
T9162
Synonym:
Target: GPR
Protein Kinase C Peptide Substrate acetate
TP1051L
Synonym: Protein Kinase C Peptide Substrate acetate(120253-69-2 free base)
Target: Others
Apelin-13 triTFA(217082-58-1(free base))
T7847
Synonym:
Target: Others
ML382
T8538
Synonym:
Target: Others
DJ-V-159
T5100
Synonym: DJ-V159
Target: GPR, Androgen Receptor
MBX-2982
T1793
Synonym:
Target: GPR
CAY10786
T36036
Synonym: GPR52 antagonist-1
Target: GPR
G15
T7389
Synonym:
Target: Estrogen Receptor/ERR
BigLEN (mouse) acetate
TP2073L
Synonym: BigLEN (mouse) acetate (501036-69-7 Free base)
Target: GPR
MRGPRX1 agonist 1
T12104
Synonym:
Target: Others
CID 1375606
T5422
Synonym: CID-1375606,CID1375606
Target: Others
Takeda103A
T24850
Synonym: CMPD103A,Takeda-103A,Takeda-103-A,CMPD-103A,Takeda 103 A
Target: GRK
TC-O 9311
T4626L
Synonym: TCO-9311,TC-O9311,TCO 9311,TC-O 9311,TCO9311,TC-O-9311
Target: GPR
GRK6-IN-2
T61556
Synonym:
Target: GRK
Neuropeptide S (Rat) acetate
TP1982L
Synonym:
Target: Neuropeptide Y Receptor
IBC 293
T19700
Synonym: IBC293,IBC-293
Target: GPR
CCG215022
T3498
Synonym:
Target: GRK, PKA
Vasopressin acetate
T9857L
Synonym: Vasopressin acetate (11000-17-2 Free base)
Target: Endogenous Metabolite
BAM (8-22) acetate
TP1914L1
Synonym: BAM (8-22) acetate(412961-36-5 free base)
Target: Others
Ro 5212773
T9357
Synonym: Epptb
Target: Others
Neuropeptide FF acetate(99566-27-5 free base)
TP1074L
Synonym: NPFF acetate
Target: Neuropeptide Y Receptor
NCRW0005-F05
T60199
Synonym:
Target: GPR
LSN3318839
T63166
Synonym: LSN-3318839,LSN 3318839
Target: Glucagon Receptor
CMF019
T10843
Synonym:
Target: Apelin receptor
TLQP 21 acetate
TP2296L
Synonym:
Target: Complement System
ms48107
T9146
Synonym: Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro-
Target: Others
GLPG1205
T11411
Synonym:
Target: GPR, Others
GRK5-IN-2
T9609
Synonym:
Target: GRK
[Lys8, Lys9]-Neurotensin (8-13) acetate
T38807L
Synonym:
Target: Neurotensin Receptor
Alamandine TFA
T37496L
Synonym:
Target: RAAS
Obestatin (rat) acetate
TP2279L
Synonym:
Target: GHSR
Lauryl maltose neopentyl glycol
T38651
Synonym: LMNG
Target:
SCH-23390 hydrochloride
T4369
Synonym: R-(+)-SCH23390 hydrochloride
Target: Potassium Channel, Dopamine Receptor, 5-HT Receptor
GW9508
T1781
Synonym: GW 9508
Target: GPR, Potassium Channel
N-phenylthiophene-2-carboximidamide
T50088
Synonym:
Target: Others
Dihydromunduletone
T11044
Synonym: DHM
Target: GPR
BAR 501 impurity
T8752
Synonym:
Target: GPCR19
GSK180736A
T3513
Synonym: GSK180736
Target: ROCK, GRK, PKA
C3a Receptor Agonist
T38287
Synonym: C3a receptor agonist 1,Complement 3a Receptor Agonist
Target: Complement System
MK 1903
T22986
Synonym:
Target: GPR
G36
T22794
Synonym: G-36
Target: Estrogen Receptor/ERR
DBIBB
T22070
Synonym:
Target: LPA Receptor
Vasopressin
T9857
Synonym: antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP)
Target: Endogenous Metabolite
Apelin-13
T7656
Synonym:
Target:
Xelaglifam
T63404
Synonym:
Target:
A 779
T7616
Synonym: A 779(3TFA)
Target: RAAS
NBI-27914
T62444
Synonym:
Target:
Vasopressin Dimer (parallel) (TFA)
T80197
Synonym:
Target: Vasopressin Receptor
Vasopressin Dimer (anti-parallel) (TFA)
T80198
Synonym:
Target: Vasopressin Receptor
GRL018-21
T82258
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T5077 Deoxycholic acid sodium salt Sodium deoxycholate,Sodium Desoxycholate Endogenous Metabolite , GPCR19
Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
T1571 Estriol NSC-12169,Oestriol Estrogen Receptor/ERR , Estrogen/progestogen Receptor , MRP , Endogenous Metabolite
Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is...
T29078 Ursodeoxycholic acid sodium UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium FXR , Endogenous Metabolite , GPCR19
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting it...
T2965 Deoxycholic acid Cholorebic,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic Endogenous Metabolite , GPCR19
Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorptio...
T21500 Sphingosine-1-phosphate S1P Endogenous Metabolite , S1P Receptor , LPL Receptor
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger that mobilises Ca2+ as an extracellular ligand for G-protei...
Cat No. Product Name
L2700 Adrenergic Receptor-Targeted Compound Library

219 compounds
A unique collection of 219 bioactive compounds specifically targeting adrenergic receptors, effective tool for screening new drugs or new target identification;
L1500 GPCR Compound Library

1633 compounds
A unique collection of 1633 GPCR-active agents for high throughput screening and high content screening for GPCR drug discovery, and new GPCR target identification and research;
L1580 GPCR Compound Library Plus

338 compounds
Well-chosen 338 GPCR targeting compounds with unique structures;
L2800 Serotonin Receptor-Targeted Compound Library

275 compounds
A unique collection of 275 compounds targeting serotonin receptors for high throughput screening and high content screening;
L4660 Anti-Nervous System Disease Library

1246 compounds
Well-chosen 1246 compounds with unique structures targeting nervous system;
L2600 Neuronal Signaling Compound Library

2540 compounds
A unique collection of 2540 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs;
TargetMol