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Cat No. | Product Name | Synonyms | Targets |
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T22089 | HPI 1 | Hedgehog/Smoothened | |
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a... | |||
T24159 | IHR-1 | IHR 1 | Smo |
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. | |||
T15370 | GANT 58 | NSC 75503 | Hedgehog/Smoothened |
GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM). | |||
T3070 | GANT 61 | NSC 136476,GANT61 | Hedgehog/Smoothened , Autophagy |
GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2. | |||
T64332 | Glimepiride sulfonamide | Immunology/Inflammation related | |
Glimepiride sulfonamide is an antiinflammatory agent. | |||
T28757 | Sergliflozin etabonate | GW-869682,GW-869682X,KGT-1251,GW869682X,GW869682,KGT1251 | SGLT |
Sergliflozin etabonate (KGT-1251) is an inhibitor of SGLT2 and can be used in studies about type 2 diabetes and obesity. | |||
T27841 | Lobeglitazone Sulfate | CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang | NOD |
Lobeglitazone Sulfate(CKD-501 Sulfate) is a novel thiazolidinedione with anti-inflammatory activity that inhibits LPS-induced NLRP3 inflammasome activation and hepatic inflammation, and can be used in the study of type 2... | |||
T68053 | Denagliptin | GW823093 | DPP-4 |
Denagliptin is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor for the treatment of endocrine Ü metabolic diseases and can be used in the study of type 2 diabetes. | |||
T28501 | Ragaglitazar | NNC61-0029,NN-622,(-)-DRF-2725,NNC-61-0029,NN 622,NNC 61-0029 | PPAR |
Ragaglitazar(NNC-61-0029) is a potent dual PPARα and PPARγ agonist that has shown potent lipid-lowering and insulin sensitizing effects in animal models.Ragaglitazar can be used to study type 2 diabetes. | |||
T2296 | Trelagliptin succinate | SYR-472 succinate,SYR472 | Proteasome , DPP-4 |
Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (T2D). | |||
T0191 | Linagliptin | BI 1356 | Ferroptosis , Proteasome , DPP-4 , Autophagy |
Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. | |||
T1782 | Canagliflozin | JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754 | SGLT |
Canagliflozin (JNJ 28431754AAA), a sodium-glucose transporter 2( SGLT2) and P-Glycoprotein inhibitor, is used in type 2 diabetes. | |||
T2351 | Fasiglifam | TAK875 | GPR |
Fasiglifam (TAK875) is a potent, selective and orally bioavailable GPR40 agonist. | |||
T1527 | Gliclazide | S1702,SE1702 | Potassium Channel |
Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the pancreas to release insulin. | |||
T5903 | Sitagliptin Intermediate 2 | ||
Sitagliptin Intermediate 2 is a useful organic compound that has been used in life science related research. | |||
T0371 | Gliquidone | AR-DF 26,Glurenorm | Potassium Channel |
Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater binding affinity to SUR1 and increased potency compared... | |||
T1634 | Glibenclamide | Glyburide | Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy |
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide. | |||
T3547 | Sotagliflozin | LX-4211,LP-802034 | SGLT |
Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity. | |||
T4460 | Dapagliflozin ((2S)-1,2-propanediol, hydrate) | BMS-512148 (2S)-1,2-propanediol, hydrate,Dapagliflozin propanediol monohydrate | SGLT |
Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). It is in development for the tre... | |||
T16083 | Mizagliflozin | GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base | SGLT |
Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca... | |||
T17044 | Tesaglitazar | PPAR | |
Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα and human PPARα were 13.4 μM and 3.6 μM, respectively, and 0... | |||
T1603 | Glipizide | CP 28720,K 4024 | Potassium Channel , PPAR , ABC |
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity. | |||
T4999 | Ertugliflozin | MK-8835,PF-04971729 | SGLT |
PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2). | |||
T1782L | Canagliflozin hemihydrate | JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754 | SGLT |
Canagliflozin hemihydrate (TA 7284) is a drug of the gliflozin class or subtype 2 sodium-glucose transport inhibitors used for the treatment of type 2 diabetes. SGLT2 is responsible for at least 90% of renal glucose reab... | |||
T0127 | Glimepiride | Glimperide,HOE-490 | Potassium Channel |
Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity. | |||
T3170 | Troglitazone | CS-045,Romozin,Rezulin,Romglizone,Noscal,Prelay | Apoptosis , Ferroptosis , PPAR , Autophagy |
Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity. | |||
T2389 | Dapagliflozin | BMS-512148 | SGLT , HIF |
Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. | |||
T38843 | Enavogliflozin | DWP-16001 | SGLT |
Enavogliflozin (DWP-16001) is an orally available small molecule and sodium glucose transporter 2 inhibitor. | |||
T67849 | O-Desethyl Dapagliflozin | Empagliflozin-4 | SGLT |
O-Desethyl Dapagliflozin (Empagliflozin-4) is a SGLT2 inhibitor, IC50=33nM. | |||
T12710 | Retagliptin Phosphate | SP 2086 | Proteasome , DPP-4 |
Retagliptin Phosphate (SP 2086) is pharmaceutical composition of DPP-4 inhibitor, for treating type-2 diabetes. | |||
T26986 | Cevoglitazar | LBM-642,LBM 642,LBM642 | PPAR |
Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys. | |||
T21587 | Muraglitazar | Pargluva,BMS-298585 | PPAR |
Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM r... | |||
T28743 | Seglitide acetate | MK 678,MK678,MK-678 | Somatostatin |
Seglitide acetate (MK-678) is a selective agonist of sst2 somatostatin receptor. | |||
T4639 | Azemiglitazone | MSDC 0602 | Mitochondrial Metabolism , mTOR |
Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes. | |||
T1766 | Empagliflozin | BI 10773 | SGLT |
Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6. Empagliflozin is used for the treatment of type 2 diabetes. | |||
T3104 | Globalagliatin | LY2608204 | Glucokinase |
Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2. | |||
T0214L | Pioglitazone hydrochloride | U-72107E,AD 4833,U 72107A,Pioglitazone HCl | Ferroptosis , PPAR |
Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. | |||
T2316 | Omarigliptin | MK-3102 | Proteasome , DPP-4 |
Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency. | |||
T2401 | Alogliptin Benzoate | SYR 322,Alogliptin(SYR-322)benzoate | Ferroptosis , Proteasome , DPP-4 |
Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may inhibit inflammatory responses by preventing the... | |||
T7369 | Gemigliptin | LC15-0444 | Proteasome , DPP-4 |
Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.) | |||
T8493 | Ingliforib | GPi 296,CP 368296 | Phosphorylase |
Ingliforib (CP 368296) is a novel glycogen phosphorylase inhibitor,has antihyperglycemic and cardioprotective properties. | |||
T67852 | Linagliptin Methyldimer | Proteasome | |
Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM. | |||
T5016 | Tofogliflozin (hydrate) | Tofogliflozin hydrate,CSG-452 hydrate | SGLT , Reactive Oxygen Species , ROS |
Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2). | |||
T77781 | Lotiglipron | PF-07081532 | Glucagon Receptor |
Lotiglipron (PF-07081532) is an orally active and potent GLP-1R agonist that reduces blood glucose and body weight and may be useful in the study of type 2 diabetes mellitus (T2DM) and obesity. | |||
T7217 | Bexagliflozin | THR-1442,EGT1442,EGT0001442 | SGLT |
Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively | |||
T1088 | Repaglinide | AG-EE 388 ZW,AG-EE 623ZW | Potassium Channel , PPAR |
Repaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically appare... | |||
T8239 | Cromoglicic acid | Others | |
Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells. | |||
T0334 | Rosiglitazone | BRL49653 | Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy |
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer. | |||
T1875 | Atglistatin | Lipase | |
Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the concentration up to 50 μM. | |||
T0214 | Pioglitazone | U 72107 | Ferroptosis , PPAR |
Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury. |
Cat No. | Product Name | Synonyms | Targets |
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T6723 | Voglibose | AO 128,Glustat,Basen | Glucosidase |
Voglibose (Glustat), an N-substituted derivative of valiolamine, exhibits excellent inhibitory activity against α-glucosidases and action against hyperglycemia and various disorders caused by hyperglycemia. | |||
T1529 | Miglitol | BAY1099,BAY-m1099 | Others |
Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity. | |||
T5542 | Tiglic acid | Sabadillic acid,Tiglinic acid,Cevadic acid | Endogenous Metabolite , HSV |
Tiglic acid (Cevadic acid) is a thick, syrupy poisonous liquid, C5H8O2, derived from croton oil, having a spicy odor and used in making perfumes and flavoring agents | |||
TN1694 | Gliotoxin | Apoptosis , NF-κB , Wnt/beta-catenin , COX , PKA , Antibacterial , Antifection | |
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. | |||
TN5409 | Maglifloenone | Denudatone | |
Maglifloenone is a natural product of Magnolia, Magnoliaceae. The catalog number is TN5409 and the CAS number is 82427-77-8. Maglifloenone can be used as a reference standard. | |||
TN3362 | Aglinin A | Others | |
Aglinin A displays moderate cytotoxicity against all the three cancer cell lines((NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines). | |||
TN3520 | Bisdethiobis(methylthio)gliotoxin | PAFR | |
Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist. | |||
T82341 | Ganglioside GM1 | ||
Ganglioside GM1, a member of the ganglioside family, serves as a functional tissue receptor for Cholera Toxin1 [1] and is utilized in neurological disease research. | |||
T82277 | GM1a Ganglioside oligosaccharide | ||
GM1a Ganglioside oligosaccharide, a semisynthetic derivative of ganglioside GM1, serves as the natural receptor for cholera toxin and is crucial for both general growth regulation and the coupling of hormone-induced resp... | |||
T74200 | Glicophenone | ||
Glicophenone, an antibacterial agent, demonstrates minimum inhibitory concentrations (MICs) of 32 μg/mL against multiple strains, including MRSA OM481, MRSA OM505, MRSA OM584, MRSA OM623, and MSSA 209P [1]. | |||
T35741 | Gliovirin | ||
Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the pa... | |||
TN6086 | Machigline | ||
Machigline is a natural product for research related to life sciences. The catalog number is TN6086 and the CAS number is 87264-30-0. | |||
T31935 | Gliorosein | ||
Gliorosein is a biohcemical. | |||
T82339 | Gangliotetraose | Gg4 | |
Gangliotetraose (Gg4), a tetrasccharide, predominantly comprises GM1 and its sialylated derivatives, which play a crucial role in modulating nuclear Ca2+ efflux and maintaining lower nuclear Ca2+ levels in differentiated... | |||
TN4137 | Glicoricone | MAO | |
Glicoricone acts as a partial estrogen antagonist. Glicoricone inhibited the monoamine oxidase with the IC50 values of 6.0 x 10(-5)-1.4 x 10(-4) M. | |||
TN1379 | Alphitolic acid | NF-κB , Akt , p53 | |
Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotoxicity against cancer cells. |
Cat No. | Product Name | Species | Expression System |
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TMPY-01457 | GLIPR1 Protein, Human, Recombinant (His) | Human | HEK293 |
Glioma pathogenesis-related protein 1, also known as Protein RTVP-1, GLIPR1 and GLIPR, is a single-pass membrane protein which belongs to theCRISP family. GLIPR1 / RTVP-1 was expressed in high levels in glioblastomas,... | |||
TMPY-03940 | GLIPR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Glioma pathogenesis-related protein 1, also known as Protein RTVP-1, GLIPR1 and GLIPR, is a single-pass membrane protein which belongs to theCRISP family. GLIPR1 / RTVP-1 was expressed in high levels in glioblastomas,... | |||
TMPY-01384 | Endoglin/CD105 Protein, Human, Recombinant (His) | Human | HEK293 |
Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD... | |||
TMPY-00783 | Endoglin/CD105 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD... | |||
TMPH-02321 | GLI1 Protein, Human, Recombinant (His) | Human | E. coli |
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sl... | |||
TMPK-00359 | Endoglin/CD105 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis... | |||
TMPJ-00361 | Endoglin Protein, Human, Recombinant (Trx & His) | Human | E. coli |
Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, a... | |||
TMPY-04227 | Gliomedin Protein, Human, Recombinant (hFc) | Human | HEK293 |
TMPY-01615 | Endoglin/CD105 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD... | |||
TMPY-06725 | Jug r 1 Protein, English walnut, Recombinant | English walnut | E. coli |
TMPH-03646 | Omega-gliadin Protein, Triticum monococcum, Recombinant (E. coli, GST) | Triticum monococcum | E. coli |
TMPH-03647 | Omega-gliadin Protein, Triticum monococcum, Recombinant (GST) | Triticum monococcum | Yeast |
TMPY-03345 | Sonic Hedgehog Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein tha... | |||
TMPY-02905 | Sonic Hedgehog Protein, Human, Recombinant (aa 1-197, His) | Human | HEK293 |
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein tha... | |||
TMPY-02832 | Sonic Hedgehog Protein, Human, Recombinant (aa 198-462, His) | Human | HEK293 |
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein tha... |
Cat No. | Product Name | ||
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L7840 | High Solubility FragLite Fragment Library | 796 compounds | |
The highly soluble halogenated fragment library contains 796 halogenated fragment compounds. |