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Cat No. | Product Name | Synonyms | Targets |
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T74658 | HBPC–GSH | ||
HBPC-GSH, a derivative of glutathione, functions as an inhibitor for the glyoxalase system, specifically inhibiting cGloI and cGloII with IC50 values of 0.6μM and 1.6μM, respectively. This compound is utilized in antimal... | |||
T80056 | Glutathione Peroxidase | GSH-Px,EC 1.11.1.9 | Glutathione Peroxidase |
Glutathione Peroxidase (GSH-Px; EC 1.11.1.9), a member of the peroxidase family, catalyzes the oxidation of reduced glutathione (GSH) to oxidized glutathione (GSSG) by forming a disulfide bridge, concurrently reducing hy... | |||
T7831 | Nitecapone | Others , Transferase | |
Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver) | |||
T38155 | N-Acetyl-D-cysteine | Reactive Oxygen Species | |
N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group. | |||
T21480 | Diethylmaleate | Maleic acid, diethyl ester,DIETHYL MALEATE | NF-κB |
Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. | |||
T14042 | 4-P-PDOT | 4-phenyl-2- propionamidotetralin | Melatonin Receptor , MT Receptor |
4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist. | |||
T1052 | Proglumide | cholecystokinin | |
Proglumide (Binoside) is a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. Proglumide is a drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is... | |||
T70601 | MDK03855 | ||
MDK03855, also known as A2AR antagonist 19, is an adenosine A2A receptor (A2AR) antagonist. MDK03855 has CAS#1454903-85-5. The last five digit of CAS# was used for name. | |||
T71439 | Opc 4392 | ||
Opc 4392 is an agonist of presynaptic dopamine D(2) receptor. | |||
T5371 | L-BUTHIONINE-(S,R)-SULFOXIMINE | L-Butionine sulfoximine | Others , Ferroptosis |
L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH. | |||
T28804 | Slingshot inhibitor D3 | JHN76359 | Others |
Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot. | |||
T38968 | GSHtracer | ||
GSHtracer is a ratiometric probe designed for the quantification of glutathione (GSH) concentrations. This probe demonstrates a measurable shift in its excitation-emission profile, specifically from 520/580 nm to 430/510... | |||
T3646 | RSL3 | RSL3 1S,1S,3R-RSL3 | Ferroptosis , GPX , Glutathione Peroxidase |
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that is selective for tumor cells carrying oncogenic RAS. | |||
T19028 | Monochlorobimane | mBBr,Chlorobimane | |
Monochlorobimane (mBBr) is a fluorescent dye with a λex value of 380 nm and a λem value of 470 nm.Monochlorobimane can be used to measure glutathione (GSH) in cells. | |||
T77650 | Topoisomerase II inhibitor 14 | Apoptosis , Antioxidant , Topoisomerase , NO Synthase | |
Topoisomerase II inhibitor 14 is a potent topoisomerase II inhibitor with anticancer and antioxidant activities.Topoisomerase II inhibitor 14 induces apoptosis and blocks the cell cycle in S phase.Topoisomerase II inhibi... | |||
T5365 | Oxothiazolidinecarboxylic acid | Oxothiazolidine carboxylate,Procysteine | Antioxidant |
Oxothiazolidinecarboxylic acid (Procysteine) is a precursor to glutathione (GSH) which is an important antioxidant in plants, animals, and fungi. | |||
T35689 | MTP 131 acetate | Others | |
MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... | |||
T34605 | Selenodiglutathione | Seleno-di-glutathione,Bis(glutathione) selenide | |
Selenodiglutathione is a primary Se metabolite conjugated with two glutathione (GSH) moieties. | |||
T78616 | Glutathione ethyl ester | Reactive Oxygen Species | |
Glutathione ethyl ester, a cell-permeable GSH donor, enhances the in vitro production of embryos by bolstering antioxidative defense, thereby ensuring an effective GSH supply to the oocyte [1]. | |||
T36173 | L-Glutathione, oxidized (sodium salt) | ||
Glutathione can occur in reduced (GSH), oxidized (GSSG), or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell. GSSG is the oxidized fo... | |||
T74064 | Ent-Kaurene | ||
Ent-Kaurene, a diterpenoid, induces ROS (reactive oxygen species) accumulation by targeting antioxidant proteins and depleting GSH (glutathione), leading to apoptosis and ferroptosis [1]. | |||
T75000 | Mal-Pc | Reactive Oxygen Species | |
Mal-Pc, a phthalocyanine-based molecular photosensitizer featuring maleimides, interacts with GSH to diminish its levels and decrease aggregation, enhancing the ROS (Reactive Oxygen Species)-dependent efficacy of photody... | |||
T82498 | Eftansomatropin alfa | ||
Eftansomatropin alfa, an antibody that targets the growth hormone receptor (GSH), is a fusion protein comprising GH1 and the Fc region of IGHG4 [1]. | |||
T28488 | Quinuronium Sulfate | Pirevan,Zothelone,Acaprin | |
Quinuronium sulfate is a drug used to treat Babesia divergens infections in calves. It did not prevent treated animals from being disease carriers. It may also cause hepatic centrilobular fatty degeneration, but no deple... | |||
T35454 | γ-Glu-Cys (ammonium salt) | ||
γ-Glu-Cys is an intermediate in glutathione (GSH) synthesis.1It is formed by ATP-dependent condensation of cysteine and glutamate by γ-glutamylcysteine synthetase. γ-Glu-Cys is also an essential component of phytochelati... | |||
T74895 | Anti-inflammatory agent 31 | ||
Anti-inflammatory agent 31 (enone 17), an andrographolide derivative, acts as an anti-inflammatory agent by inhibiting NF-κB activation through the upstream blockade of PI3K/Akt and ERK1/2 MAPK pathways. It effectively r... | |||
T69073 | COTC | ||
COTC is a bacterial metabolite that has anticancer activity and inhibits glyoxalase in the presence of glutathione (GSH) and the proliferation of HeLa cells, as well as reduces tumor growth and improves survival in an Eh... | |||
T74364 | SDOX | Topoisomerase | |
SDOX, a Doxorubicin (DOX) prodrug, selectively releases the active agent, DOX, in tumor cells with elevated glutathione (GSH) levels, thereby reducing inadvertent adverse effects on healthy tissues while maintaining ther... | |||
T36514 | QD-394 | ||
QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to... | |||
T11357 | Gamma-glutamylcysteine TFA | γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA) | IL Receptor |
Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), a crucial dipeptide in glutathione (GSH) synthesis and a vital cofactor for the enzyme glutathione peroxidase (GPx), significantly modulates inflammatory response... | |||
T73421 | CPT-Se3 | Topoisomerase | |
CPT-Se3, a camptothecin (CPT) seleno-derivative, exhibits enhanced anticancer efficacy by effectively killing cancer cells and hindering tumor proliferation. This compound diminishes the GSH/GSSG ratio and total thiols w... | |||
T38206 | 3-Cysteinylacetaminophen (trifluoroacetate salt) | APAP-Cys,3-(cysteine-S-yl)acetaminophen,3-Cysteinylacetaminophen (trifluoroacetate salt) | |
3-Cysteinylacetaminophen is an acetaminophen-protein adduct formed during the metabolism of acetaminophen.[1],[2] 3-Cysteinylacetaminophen has been found in isolated human serum following therapeutic and supratherapeutic... | |||
T79388 | Anticancer agent 154 | Reactive Oxygen Species | |
Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causing mitochondrial damage, and promotes cell apoptosis and DNA damage. It triggers ferroptosis by depleting GSH, diminishing GPX4 express... | |||
T61312 | Antioxidant agent-3 | ||
Antioxidant agent-3 (Compound 14q), a potent antioxidant, exhibits strong scavenging activity against DPPH radicals and ABTS+ radicals, with IC50 values of 26.58 μM and 30.31 μM, respectively. Additionally, it enhances t... | |||
T37720 | Difluorinated H2S Fluorescent Probe 1 | ||
Difluorinated H2S probe 1 is a fluorescent probe for hydrogen sulfide (H2S).1It selectively fluoresces in the presence of H2S over Zn2+, Fe3+, S2O32-, ClO-, SO32-, H2O2, NO2-, cysteine (Cys), homocysteine (Hcy), and glut... | |||
T81485 | Phoenixin-14 TFA | PNX-14 TFA | |
Phoenixin-14 TFA (PNX-14) is a blood-brain barrier (BBB)-penetrable neuropeptide with anxiolytic, cardioprotective, and neuroprotective properties. It modulates pituitary gonadotrophin release by enhancing gonadotropin-r... | |||
T82972 | Argininosuccinic acid disodium | Reactive Oxygen Species | |
Argininosuccinic acid disodium, involved in the urea cycle's fourth step, is cleaved by argininosuccinate lyase (ASL) into arginine and fumarate. It diminishes reduced glutathione (GSH) levels and elevates reactive oxyge... | |||
T38370 | CAY10731 | ||
CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).[1] Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm... | |||
T73422 | CPT-Se4 | Topoisomerase | |
CPT-Se4, a seleno-derivative of Camptothecin (CPT), exhibits enhanced efficacy in cancer cell eradication and tumor suppression. It reduces the GSH/GSSG balance and total thiol content while increasing ROS concentrations... | |||
T36073 | S-Acetyl-L-glutathione | ||
S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-... | |||
T69978 | Brostallicin HCl | ||
Brostallicin is a synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having form... | |||
T36610 | (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine | ||
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP r... | |||
T81233 | S-(p-Nitrobenzyl)glutathione | ||
S-(p-Nitrobenzyl)glutathione acts as a competitive inhibitor of glutathionase. Rat kidney microsomes convert this compound into associated cysteine derivatives. It serves as a research tool in investigating the catabolis... | |||
T36507 | Tetrachlorohydroquinone | ||
Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of re... | |||
T83768 | Zofenoprilat | Zofenopril-SH,SQ 26,333 | |
Zofenoprilat, an angiotensin-converting enzyme (ACE; IC50 = 8 nM for rabbit lung enzyme) inhibitor and the active metabolite of the prodrug zofenopril, effectively counters angiotensin I- or bradykinin-induced contractio... |
Cat No. | Product Name | Synonyms | Targets |
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T1085 | L-Glutathione reduced | GSH,Isethion,Glutathione,γ-L-Glutamyl-L-cysteinyl-glycine,Glutathion,Tathion | Ferroptosis , Reactive Oxygen Species , Endogenous Metabolite , Glutathione reductase |
L-Glutathione reduced (Glutathione) is a naturally occurring tripeptide found in cells as an endogenous antioxidant that scavenges oxygen free radicals. L-Glutathione reduced is a cofactor for certain enzymes and is invo... | |||
T2800 | L-Theanine | Apoptosis , Others | |
L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis and is known to promote relaxation without sedation. | |||
T7024 | Qingyangshengenin | Qingyangshengenin A,Cynanchagenin | Others |
Qingyangshengenin (Cynanchagenin) is a steroid used in the preparation of antiepileptic agents. | |||
TMS1461 | Qingyangshengenin B | Otophylloside B | Beta Amyloid |
Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mR... | |||
TN5301 | Qingyangshengenin 3-O-α-L-cymaropyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside | ||
Qingyangshengenin 3-O-α-L-cymaropyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside is a natural product for research related to life sciences. The catalog number is TN5301 and the ... | |||
TMS1460 | Qingyangshengenin A | Others | |
Qingyangshengenin A is a natural product for research related to life sciences. The catalog number is TMS1460 and the CAS number is 106644-33-1. | |||
TN5094 | Tangshenoside I | Glucokinase | |
Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as the index compound. It has α-glucosidase inhibition activity... | |||
TN4432 | Liangshanin A | Others | |
Liangshanin A is a natural product for research related to life sciences. The catalog number is TN4432 and the CAS number is 122717-54-8. | |||
TN5309 | Qingyangshengenin 3-O-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranoside | ||
Qingyangshengenin 3-O-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranoside is a natural product for research related to life sciences. The catalog number is TN5309 and the CAS number is 1186628-87-4. | |||
TN5306 | Qingyangshengenin 3-O-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranoside | ||
Qingyangshengenin 3-O-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranoside is a natural product for research related to life sciences. The catalog number is TN5306 and the CAS number is 1186628-88... | |||
Fr14207 | (-)-Isopulegol | Others | |
Isopulegol has antioxidant, and neuroactive properties. It also has gastroprotective effects induced by isopulegol appear to be mediated, at least in part, by endogenous prostaglandins, K+ATP channel opening and antioxid... | |||
T5S1097 | Neferine | (R)-1,2-Dimethoxyaporphine,(-)-Neferine | Apoptosis , NF-κB , Autophagy |
1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to a... | |||
T6S0735 | Flavokawain B | Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone | Apoptosis , Others |
1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, in... | |||
T60789 | L-Cystine dihydrochloride | ||
L-Cystine dihydrochloride is a sulfur-containing precursor of glutathione (GSH) synthesis. The homeostasis of L-Cystine dihydrochloride is important for GSH functions. L-Cystine can be used as a cell culture ingredient [... | |||
TN4779 | Physalin O | IκB/IKK | |
Physalin O possesses anti-inflammatory activity, it exhibited conjugating abilities with GSH and also showed significant nitric oxide (NO) production inhibiting activities. | |||
T82046 | Irisquinone | ||
Irisquinone, a natural anticancer agent, also acts as a radiation sensitizer for cancer therapies. It diminishes glutathione (GSH) levels and hampers the repair of single-strand DNA breaks [1] [2] [3]. | |||
T5S0313 | Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside | Liquiritin apioside | Others , TNF |
Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress, might be as p... | |||
T83915 | Norbixin hydrate | ||
Norbixin, a carotenoid found in B. orellana, exhibits various biological activities including binding to the peroxisome proliferator-activated receptor γ (PPARγ) with a Ki of 1.15 µM in a cell-free assay. At a dosage of ... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00979 | GSH-S Protein, Human, Recombinant (His) | Human | E. coli |
Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glyci... | |||
TMPH-00073 | ADH2 Protein, Arabidopsis thaliana, Recombinant (His) | Arabidopsis thaliana | E. coli |
Plays a central role in formaldehyde detoxification. | |||
TMPH-00912 | ADH5 Protein, Human, Recombinant (GST) | Human | E. coli |
ADH5 Protein, Human, Recombinant (GST) is expressed in E. coli. | |||
TMPJ-01002 | SGSH Protein, Human, Recombinant (His) | Human | Human Cells |
N-Sulphoglucosamine Sulphohydrolase (SGSH) is an important member of the sulfatase family which is involved in the degradation of heparin sulfate. SGSH binds one calcium ion per subunit as a cofactor. SGSH catalyzes N-su... | |||
TMPH-01397 | LANCL1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during norma... | |||
TMPY-06971 | GGT1 Protein, Human, Recombinant (His) | Human | HEK293 |
GGT1 belongs to the gamma-glutamyltransferase protein family. Many members of this family have not yet been fully characterized and some of which may represent pseudogenes. GGT1 is composed of a heavy chain and a light c... | |||
TMPY-03115 | GGT1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
GGT1 belongs to the gamma-glutamyltransferase protein family. Many members of this family have not yet been fully characterized and some of which may represent pseudogenes. GGT1 is composed of a heavy chain and a light c... | |||
TMPY-04022 | BOLA1 Protein, Human, Recombinant (His) | Human | E. coli |
BOLA1 is a mitochondrial protein that counterbalances the effect of L-buthionine-(S,R)-sulfoximine (BSO)-induced glutathione (GSH) depletion on the mitochondrial thiol redox potential. Furthermore, overexpression of BOLA... | |||
TMPH-01711 | ABCC1 Protein, Human, Recombinant (His) | Human | E. coli |
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs a... | |||
TMPY-02299 | ALDH3A1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (... |