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Search Result

Search Results for " gcgr "

35

Compounds

1

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T72621 GCGR antagonist 2
GCGR Antagonist 2, a Furan-2-carbohydrazide, serves as an orally active antagonist of the glucagon receptor. It exhibits affinity for the human glucagon receptor (hGluR) with a dissociation constant (Kd) of 2.3 nM and de...
TQ0124 BETP Glucagon Receptor
BETP is an agonist of GLP-1 receptor (EC50s: 0.66 and 0.755 μM for human and rat GLP-1 receptor).
T7364 NNC-0640 Glucagon Receptor
NNC-0640 is a negative allosteric modulator of Human Glucagon Receptor with an IC50 of 69.2 nM.
T8748 Exendin-4 acetate Glucagon Receptor
Exendin-4 acetate is a 39 amino acid peptide.Exendin-4 acetate is a long-acting GLP-1 receptor agonist(IC50 = 3.22 nM).
T19850 Semaglutide Glucagon Receptor
Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist(EC50 of 6.2 pM in a reporter assay using BHK cells expressing the human receptor).
T11845 LGD-6972 Glucagon Receptor
LGD-6972 is an antagonist of glucagon receptor.
TP2252 GLP-1 (9-36) amide Glucagon Receptor
antagonist at the human GLP-1 receptor
T9579 GLP-1 receptor agonist 9 Glucagon Receptor
1H-Benzimidazole-6-carboxylic acid is a GLP-1 receptor agonist.
T3422 GRA Ex-25 GRA-Ex-25 Glucagon Receptor
GRA Ex-25 (GRA-Ex-25) is an inhibitor of glucagon receptor.
T3967 Exendin-4 Exenatide,Exenatide Acetate Glucagon Receptor
Exendin-4 (Exenatide) is a glucagon-like peptide-1 receptor (GLP-1) agonist (IC50: 3.22 nM). Exenatide is a 39 amino acid peptide. Compared to GLP-1, exenatide has a longer half-life of 2.4 hours.
TP1039 Secretin (33-59), rat Secretin (rat) Glucagon Receptor
Secretin (33-59), rat (Secretin (rat)) is a classical hormone in the gastrointestinal system and a neuropeptide.
TP1469 Lixisenatide acetate (320367-13-3 free base) Lixisenatide acetate Glucagon Receptor
Lixisenatide acetate is a receptor agonist similar to glucagon-like peptide-1 (glp-1) for the treatment of type 2 diabetes mellitus (T2DM).
T6876 Liraglutide Liraglutidum,Victoza,Liraglutida,NN2211 Glucagon Receptor
Liraglutide (Liraglutida) is a long-acting GLP-1 receptor agonist.
TP2100 Avexitide Exendin-3 (9-39) amide,Exendin (9-39) Glucagon Receptor
Avexitide (Exendin-3 (9-39) amide) (Exendin (9-39)) is a specific and competitive antagonist of glucagon-like peptide-1 (GLP-1) receptor.
TQ0239 PF-06291874 Glucagon receptor antagonists-4 Glucagon Receptor
PF-06291874 (Glucagon receptor antagonists-4) (Glucagon receptor antagonists-4) is a highly effective and orally active antagonist of the glucagon receptor.
TP1376 GLP-1(7-37) acetate(106612-94-6 free base) GLP-1(7-37) acetate Others , Glucagon Receptor
Glp-1(7-37) acetate is an intestinal insulin hormone that enhances glucose-induced insulin secretion.
T15389L Glucagon (1-29), bovine, human, porcine hydrochloride Porcine glucagon hydrochloride,Glucagon hydrochloride Glucocorticoid Receptor , Glucagon Receptor
Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon (1-29), bovine, human, porcine hydrochloride(Po...
T60047 V-0219 Glucagon Receptor
V-0219 is a positive allosteric modulator of GLP-1 and can be used in studies about obesity-associated diabetes.
T3984 GLP-1(7-36), amide MKC 253,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide Glucagon Receptor
GLP-1(7-36), amide (MKC 253) is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and displays various antidiabetic effects by potentiating glucose-...
T76279 Retatrutide LY3437943 Glucagon Receptor
Retatrutide (LY3437943) is a triple agonist of the glucagon receptor, glucose-dependent insulinotropic polypeptide receptor, and glucagon-like peptide-1 receptor (GLP-1R), and inhibits GCGR, GIPR, and GLP-1R.Retatrutide ...
T76279L1 Retatrutide sodium salt Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt Glucagon Receptor
Retatrutide sodium salt is a potent triple agonist peptide for glucagon receptor (GCGR), glucose-dependent proinsulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) Retatrutide sodium s...
T78097L Mazdutide acetate（2259884-03-0 free base） Mazdutide acetate（2259884-03-0 free base）,OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate Glucagon Receptor
Mazdutide acetate is a potent co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR), a gastrin-regulating hormone analog.Mazdutide acetate stimulates insulin secretion from mouse pancreatic islets, an...
T24620 PF-06372222 PF-0637222,PF0637222,PF 0637222
PF-06372222 is a small-molecule negative allosteric modulator of the glucagon receptor (GCGR). PF-06372222 is also an antagonist for glucagon-like peptide-1 receptor GLP-1R, which inhibits glucagon secretion and glucose...
T76668 FC382K10W15 TFA
FC382K10W15 TFA, a glucagon analogue and GLP-1R/GCGR agonist, holds promise for research in type 2 diabetes [1].
T76876 Volagidemab
Volagidemab, a monoclonal antibody (mAb) that antagonizes the glucagon receptor (GCGR), is utilized in researching Type 1 Diabetes (T1D) [1] [2].
T76279L Retatrutide TFA
Retatrutide (LY3437943) TFA is a triple agonist peptide targeting the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Demonstrating i...
T80084 Retatrutide acetate LY3437943 acetate
Retatrutide acetate (LY3437943) is a peptide that serves as a triple agonist for the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). ...
T78097 Mazdutide IBI-362,LY-3305677,OXM-3
Mazdutide (IBI-362; LY-3305677), a synthetic oxyntomodulin analog, serves as a glucagon-like peptide-1 (GLP-1R)/glucagon receptor (GCGR) co-agonist. Demonstrating safety and tolerability, Mazdutide is utilized in obesity...
T74421 Pemvidutide
Pemvidutide, a dual GLP-1R/GCGR agonist, significantly lowers body weight, liver fat, and serum lipids, holding promise for non-alcoholic steatohepatitis (NASH) and obesity research [1].
T76862 Crotedumab
Crotedumab (REGN1193), a fully human IgG4 monoclonal antibody, selectively binds to and inhibits the glucagon receptor (GCGR) with a dissociation constant (K D) of 0.1 nM, making it a potent candidate for diabetes resear...
T78658 Pemvidutide TFA
Pemvidutide (TFA), a GLP-1R/GCGR dual agonist, effectively reduces body weight, liver fat, and serum lipid levels, and is utilized in research on non-alcoholic steatohepatitis (NASH) and obesity [1].
T76328 Oxyntomodulin (swine)
Oxyntomodulin (swine), a peptide hormone secreted from the gastrointestinal tract after meals, serves as a dual agonist for the GLP-1 receptor (GLP-1R) and glucagon receptor (GCGR). It plays a critical role in appetite s...
T80079 Mazdutide TFA LY-3305677 TFA,IBI-362 TFA,OXM-3 TFA
Mazdutide (IBI-362; LY-3305677) TFA is a dual agonist for the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR), also recognized as a long-acting synthetic oxyntomodulin analog. It demonstrates a...
T37223 Glucagon Receptor Antagonist I
Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor anta...
T36380 GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)
GLP-1 amide is a peptide hormone cleaved from proglucagon in the pancreas.1,2 Mice lacking the glucagon receptor (Gcgr-/-) have approximately nine-fold higher levels of total GLP-1 amide, including GLP-1 (1-36) amide and...

Compounds

GCGR antagonist 2
T72621
Synonym:
Target:
BETP
TQ0124
Synonym:
Target: Glucagon Receptor
NNC-0640
T7364
Synonym:
Target: Glucagon Receptor
Exendin-4 acetate
T8748
Synonym:
Target: Glucagon Receptor
Semaglutide
T19850
Synonym:
Target: Glucagon Receptor
LGD-6972
T11845
Synonym:
Target: Glucagon Receptor
GLP-1 (9-36) amide
TP2252
Synonym:
Target: Glucagon Receptor
GLP-1 receptor agonist 9
T9579
Synonym:
Target: Glucagon Receptor
GRA Ex-25
T3422
Synonym: GRA-Ex-25
Target: Glucagon Receptor
Exendin-4
T3967
Synonym: Exenatide,Exenatide Acetate
Target: Glucagon Receptor
Secretin (33-59), rat
TP1039
Synonym: Secretin (rat)
Target: Glucagon Receptor
Lixisenatide acetate (320367-13-3 free base)
TP1469
Synonym: Lixisenatide acetate
Target: Glucagon Receptor
Liraglutide
T6876
Synonym: Liraglutidum,Victoza,Liraglutida,NN2211
Target: Glucagon Receptor
Avexitide
TP2100
Synonym: Exendin-3 (9-39) amide,Exendin (9-39)
Target: Glucagon Receptor
PF-06291874
TQ0239
Synonym: Glucagon receptor antagonists-4
Target: Glucagon Receptor
GLP-1(7-37) acetate(106612-94-6 free base)
TP1376
Synonym: GLP-1(7-37) acetate
Target: Others, Glucagon Receptor
Glucagon (1-29), bovine, human, porcine hydrochloride
T15389L
Synonym: Porcine glucagon hydrochloride,Glucagon hydrochloride
Target: Glucocorticoid Receptor, Glucagon Receptor
V-0219
T60047
Synonym:
Target: Glucagon Receptor
GLP-1(7-36), amide
T3984
Synonym: MKC 253,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide
Target: Glucagon Receptor
Retatrutide
T76279
Synonym: LY3437943
Target: Glucagon Receptor
Retatrutide sodium salt
T76279L1
Synonym: Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt
Target: Glucagon Receptor
Mazdutide acetate（2259884-03-0 free base）
T78097L
Synonym: Mazdutide acetate（2259884-03-0 free base）,OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate
Target: Glucagon Receptor
PF-06372222
T24620
Synonym: PF-0637222,PF0637222,PF 0637222
Target:
FC382K10W15 TFA
T76668
Synonym:
Target:
Volagidemab
T76876
Synonym:
Target:
Retatrutide TFA
T76279L
Synonym:
Target:
Retatrutide acetate
T80084
Synonym: LY3437943 acetate
Target:
Mazdutide
T78097
Synonym: IBI-362,LY-3305677,OXM-3
Target:
Pemvidutide
T74421
Synonym:
Target:
Crotedumab
T76862
Synonym:
Target:
Pemvidutide TFA
T78658
Synonym:
Target:
Oxyntomodulin (swine)
T76328
Synonym:
Target:
Mazdutide TFA
T80079
Synonym: LY-3305677 TFA,IBI-362 TFA,OXM-3 TFA
Target:
Glucagon Receptor Antagonist I
T37223
Synonym:
Target:
GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)
T36380
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T3896 Shanzhiside methyl ester Glucagon Receptor
Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling.

Natural Products

Shanzhiside methyl ester
T3896
Synonym:
Target: Glucagon Receptor

Recombinant Proteins

Species：
Human (2)
Mouse (1)
Expression System：
E. coli (2)
HEK293 (1)
Tag：
N-terminal 10xHis-tagged and C-terminal Myc-tagged (2)
N-terminal GST-tagged (1)
Cat No. Product Name Species Expression System
TMPH-01383 GCGR Protein, Human, Recombinant (His & Myc) Human HEK293
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and g...
TMPH-02675 GCGR Protein, Mouse, Recombinant (GST) Mouse E. coli
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and g...
TMPH-01382 GCGR Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and g...
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