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Cat No. | Product Name | Synonyms | Targets |
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T22260 | Aminopurvalanol A | CDK | |
Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n... | |||
T1753 | D-64131 | Microtubule Associated | |
D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM. | |||
T9812 | Tubulin inhibitor 24 | Microtubule Associated | |
Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization. | |||
T12575 | Unesbulin | PTC596 | Apoptosis , BMI-1 |
Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1). | |||
T19664 | ON1231320 | GBO-006 | Apoptosis , PLK |
ON1231320 (GBO-006) is a Polo-like kinase 2 (PLK2) inhibitor. | |||
T8342 | BRD9876 | Others , Kinesin , Microtubule Associated | |
BRD9876 is a selective inhibitor of MM1S growth. | |||
T3459 | VK3-OCH3 | 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na | Others |
VK3-OCH3 (2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na) is a selective antitumor agent via heme oxygenase (HO-1) related mechanisms; Vitamine K3 analogue. | |||
T4189 | 4-Oxofenretinide | 3-Keto fenretinide | cell cycle arrest |
4-Oxofenretinide (3-Keto fenretinide) , a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis. | |||
T10723 | CDC25B-IN-1 | ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate | Phosphatase |
CDC25B-IN-1 is an inhibitor of CDC25B with a Ki of 8.5 μM. CDC25B-IN-1 increases the G2/M phase by inhibiting cell proliferation and colony formation. | |||
T3485 | Probimane | AT-2153,MM-159 | Others |
Probimane (AT-2153) had Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation in human tumor cell lines with MST-16. | |||
T78701 | Tubulin inhibitor 32 | Apoptosis | |
Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase. | |||
T63732 | EGFR-IN-3 | Apoptosis , EGFR | |
EGFR-IN-3 is an EGFR inhibitor with potential antitumour activity.EGFR-IN-3 inhibits EGFRwt-TK and induces apoptosis (cell death), which can cause cells to block in the G2/M phase. | |||
T5699 | SSE15206 | Apoptosis , Microtubule Associated | |
SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells. | |||
T9595 | LP-261 | Microtubule Associated | |
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest. | |||
T6864 | Ixabepilone | BMS 247550,Ixempra,Azaepothilone B,BMS 247550-1 | Apoptosis , Microtubule Associated |
Ixabepilone (Azaepothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell ... | |||
T64923 | Sodium citrate | Citrosodine,Natrocitral | Others |
Sodium citrate (Natrocitral) is the sodium salt of citric acid.Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Sodium citrate cause oxidative damage of the liver by means of the d... | |||
T60129 | MT189 | Antiproliferative agent-14 | Microtubule Associated |
MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the abilit... | |||
T67746 | IMS2186 | Others | |
IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects. IMS2186 reduces the... | |||
T77729 | MY-1076 | Apoptosis , YAP | |
MY-1076 is a potent YAP inhibitor with antigastric cancer activity.MY-1076 dose-dependently induced G2/M phase block, induced YAP degradation and apoptosis, and inhibited microtubule protein polymerization.MY-1076 inhibi... | |||
T23601 | ABC1183 | ABC 1183,ABC-1183 | GSK-3 , CDK |
ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen ... | |||
T28886 | Suprafenacine | N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide | Microtubule Associated |
Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) is a cell-permeable microtubule destabilizer that induces cell cycle arrest and apoptosis in G2/M phase. Suprafenacine ... | |||
T16750 | Rigosertib | ON-01910 | Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src |
Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina... | |||
T8756 | KRAS inhibitor-9 | DUN09716 | Apoptosis , Ras |
KRAS inhibitor-9 (DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS ... | |||
T4451 | Estramustine phosphate sodium | Ro 21-8837/001,Estramustine phosphate disodium | Apoptosis , Microtubule Associated |
Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle. | |||
T77647 | Tubulin polymerization-IN-43 | Apoptosis , Microtubule Associated | |
Tubulin polymerization-IN-43 is an inhibitor of tubulin polymerisation.Tubulin polymerization-IN-43 has multiple effects, disrupting the cellular microtubule network by targeting the colchicine locus and promoting cell c... | |||
T27407 | GDC0575 monohydrochloride | ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575 | Chk |
GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells by... | |||
T78157 | PARP-1-IN-3 | Apoptosis , PARP | |
PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inflammatory activity, induces apoptosis, and arrests the cell... | |||
T2090 | Lexibulin | CYT-997 | Apoptosis , Reactive Oxygen Species , Microtubule Associated |
Lexibulin (CYT-997)(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this... | |||
T3124 | Carbendazim | Bavistin,Carbendazole,Mercarzole | Antifungal |
Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspec... | |||
T41163 | ZNL 02-096 | Pomalidomide-C3-adavosertib | Apoptosis , Wee1 |
ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL ... | |||
T0009 | Flubendazole | Flumoxanal,Flumoxane,NSC 313680,Fluvermal | Apoptosis , Microtubule Associated , Parasite |
Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans. | |||
T19661 | 8-Chloroadenosine | NSC 354258,8-Cl-Ado,NSC354258,NSC-354258 | AMPK |
8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Ch... | |||
T0440 | Oxcarbazepine | GP 47680 | Apoptosis , Sodium Channel |
Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity. | |||
T5818 | Rigosertib sodium | Rigosertib,Estybon,ON-01910 | Apoptosis , PLK , PI3K |
Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3. | |||
T71259 | GNE-900 | GNE900,GNE 900 | Apoptosis , Chk |
GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 ... | |||
T13901 | SS28 | Microtubule Associated | |
SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. | |||
T29449 | 5-AcTMF | 5-ATMF,5-ATAN,5 ATMF | |
5-AcTMF is an inducer of G2/M arrest, apoptosis and autophagy in cancer cells. | |||
T30768 | CB-403 | UNII-4V9Q0C88UK,CB403,CB 403 | |
CB-403 is a cinnamaldehyde derivative that has antitumor effects by blocking cell cycle progression in the G2/M phase. | |||
T31004 | Compound 8H | Compound-8H,Compound 8-H,Compound 343 | |
Compound 8H is an inducer of G2/M-phase cell cycle arrest and cell death in cancer cell lines. | |||
TQ0016 | NKP-1339 | IT-139,KP-1339 | DNA/RNA Synthesis |
NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. | |||
T23726 | WB-308 | WB308 | |
WB-308 is an EGFR inhibitor that acts by decreasing NSCLC cell proliferation and colony formation and causing G2/M arrest and apoptosis. | |||
T13227 | Tubulin inhibitor 1 | Microtubule Associated | |
Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the G2/M phase. | |||
T83020 | Antiproliferative agent-37 | ||
Antiproliferative agent-37 (compound 10J) inhibits cell proliferation by arresting cells at the G2/M phase of the cell cycle [1]. | |||
T73413 | Cadein1 | ||
Cadein1, an isoquinolinium derivative, induces G2/M phase delay and caspase-dependent apoptosis in cancer cells lacking functional p53. | |||
T62458 | EGFR-IN-56 | ||
EGFR-IN-56 (Compound 13a) is a potent inhibitor of EGFR, acting on EGFRT790M (IC50: 541.7 nM) and EGFRT790M/L858R (IC50: 132.1 nM). EGFR-IN-56 blocks the cell cycle of cancer cells in the G2/M phase and induces EGFR-IN-5... | |||
T23817 | BPTQ | B-P-T-Q | |
BPTQ is a typical intercalator of DNA that acts by inducing a dose-dependent inhibitory effect on the proliferation of cancer cells by arresting cells at the S and G2/M phase. | |||
T79463 | Antitumor agent-110 | Apoptosis | |
Antitumor Agent-110 (Compound 13), an imidazotetrazine anticancer agent, exhibits excellent permeability. It halts the cell cycle at the G2/M phase and induces apoptosis [1]. | |||
T72817 | Colibactin 742 | ||
Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leads to G2/M arrest. | |||
T61129 | Tubulin polymerization-IN-27 | ||
Tubulin polymerization-IN-27 (compound 5j) is an inhibitor of tubulin polymerization. It has the ability to halt the cell cycle specifically at the G2/M phase and also induce apoptosis [1]. | |||
T64034 | Antitumor agent-45 | ||
Antitumor agent-45 has an inhibitory effect on c-Met expression and is able to block A549 cells in the G0/G1 and G2/M phases and induce apoptosis. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TQ0089 | Juglanin | Apoptosis , JNK , Autophagy | |
Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells. | |||
T5669 | Citric acid monohydrate | Others | |
Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients a... | |||
T5S0636 | Citric acid | Citro,Citretten | Apoptosis , Others , Endogenous Metabolite , Antibacterial , Antibiotic |
1. Citric acid (Citro) (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. 2. Citric acid denture cleansers can reduce C. albicans biofilm accumulation and cell viabili... | |||
T2764 | (S)-10-Hydroxycamptothecin | 10-Hydroxycamptothecin,10-HCPT | Apoptosis , Topoisomerase |
(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma. | |||
T3981 | Acacetin | 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin | Apoptosis , IAP , COX , Autophagy |
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models. | |||
TN2058 | Persicogenin | Anti-infection | |
Persicogenin has anticancer, antimutagenic, and antileishmanial activities, it can inhibit the proliferation of mouse tsFT210 cancer cells, it mainly inhibits cell cycle at the G2/M phase in a dose-dependent manner. | |||
TN2554 | 1-Monopalmitin | Glyceryl palmitate | Apoptosis |
1-Monopalmitin (Glyceryl palmitate) is a small molecule compound extracted from Mougeotia nummuloides and Spirulina major with potential antitumor activity, inhibiting proliferation of A549 and SPC-A1 cells, and inducing... | |||
T4S1335 | Daphnoretin | Dephnoretin,Thymelol | Influenza Virus , Caspase , PKC |
1. Daphnoretin (Thymelol) has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through ... | |||
TN2254 | Taccalonolide A | Apoptosis , Microtubule Associated | |
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these ... | |||
T3S0081 | Oxypeucedanin | (+-)-Oxypeucedanin,Oxypeucadanin | Potassium Channel |
1. Oxypeucedanin ((+-)-Oxypeucedanin) has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeucedanin is a kind of open-channel blocke... | |||
T5S1952 | 9-Methoxycamptothecin | Apoptosis , Topoisomerase | |
9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition. | |||
T6S2315 | Polyphyllin VI | Apoptosis , Antibacterial , Pyroptosis | |
1. Polyphyllin VI has hemostasis , expectorant , bacteriostasis, anticytotoxic, anti pregnancy kill sperm effects. | |||
T2966 | Beta-Sitosterol | Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost | Apoptosis , Lipase , Endogenous Metabolite |
Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol foun... | |||
T5497 | AMAROGENTIN | Apoptosis , AMPK | |
Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis | |||
T7032 | Eupatorin | Others , P450 | |
Eupatorin has antiproliferative and antiangiogenic effects. Eupatorin has antiproliferative and cytostatic effects on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. Eupatorin-induced cell death is ... | |||
T3824 | Jaceosidin | Apoptosis , BCL , COX , UGT | |
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway... | |||
T0186 | Docetaxel trihydrate | RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate | Apoptosis , BCL , Microtubule Associated |
Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor i... | |||
T3895 | Polyphyllin I | Apoptosis , Akt , JNK , PDK , mTOR , Autophagy | |
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha... | |||
T5S0055 | Chelidonine | Helidonine,Khelidonin,Stylophorin | Apoptosis , Others , Influenza Virus |
1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model ... | |||
T81818 | Metachromins X | ||
Metachromin X, a sesquiterpene quinone, halts the cell cycle of HeLa/Fucci2 cells at the S/G2/M phase [1]. | |||
TN4154 | Gomisin L1 | Others | |
(-)-Gomisin L1 induces G2/M arrest and apoptosis in human ovarian cancer cells. | |||
T75698 | Xylopine | ||
Xylopine, an aporphine alkaloid, exhibits cytotoxic effects on cancer cells by inducing oxidative stress, provoking G2/M cell cycle arrest, and triggering apoptosis [1]. | |||
T72965 | Inuviscolide | ||
Inuviscolide, an apoptosis inducer, demonstrates the capacity to induce G2/M arrest in human melanoma cell lines. Exhibiting both antineoplastic and anti-inflammatory activities, this compound shows potential in cancer t... | |||
TN6547 | Angustifoline | ||
Angustifoline has activity against gram-positive bacteria. It inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stim... | |||
TN5336 | 9-Oxo-10,11-dehydroageraphorone | 4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone | |
9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell ... | |||
T75569 | Xerophilusin B | ||
Xerophilusin B, isolated from Isodon xerophilus as an anticancer agent, demonstrates antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines. It induces G2/M cell cycle arrest and mediates apopt... | |||
TN5190 | Tryprostatin A | Topoisomerase , Antifection | |
Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mammalian cell cycle at the G2/M phase. | |||
TN2344 | Swainsonine | Tridolgosir | Apoptosis , Others , Antibiotic |
Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arres... | |||
TN1953 | Morusinol | ERK , MEK , Autophagy , Ras | |
Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, and exerts antitumor activity by inducing autophagy, G2/M c... | |||
TN1617 | Ergosta-4,6,8(14),22-tetraen-3-one | BCL , Caspase , p53 | |
Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, these results would be useful... | |||
T75602 | Albanol B | ||
Albanol B, an arylbenzofuran derivative, is extracted from mulberries and demonstrates multifarious biological activities, including anti-Alzheimer's, anti-bacterial, and antioxidant effects. It inhibits the proliferatio... | |||
T36961 | Malformin C | ||
Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human... | |||
TN5639 | Rocaglaol | Ferrugin,Aglaiastatin A | |
Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylatio... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00604 | CDTA Protein, E. coli, Recombinant (His) | E. coli | E. coli |
CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for ... | |||
TMPH-00605 | CDTB Protein, E. coli, Recombinant (His & Myc & SUMO) | E. coli | E. coli |
Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arres... | |||
TMPH-03269 | COMMD5 Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the ... | |||
TMPH-03748 | KAT14 Protein, Human, Recombinant (His) | Human | E. coli |
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltrans... | |||
TMPY-02046 | PFDN1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1... | |||
TMPY-03989 | PFDN1 Protein, Human, Recombinant (His) | Human | E. coli |
PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1... | |||
TMPY-03655 | GADD45G Protein, Human, Recombinant | Human | E. coli |
GADD45G, also known as CR6, is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G re... | |||
TMPJ-00988 | SEPHS1 Protein, Human, Recombinant (His) | Human | Human Cells |
Selenophosphate synthetase 1 (SEPHS1) belongs to the selenophosphate synthase 1 family, Class II subfamily. It has four different isoforms by alternative splicing. Isoform 1 and isoform 2 are gradually expressed during t... | |||
TMPY-03672 | Survivin Protein, Human, Recombinant | Human | E. coli |
BIRC5, also known as Survivin and EPR-1, is a member of theIAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-... | |||
TMPH-01849 | Human parvovirus B19 (isolate AU) Non-capsid protein NS-1 (His & SUMO) | HPV B19 | E. coli |
Multifunctional protein essential for viral DNA replication, which cooperatively interacts with the viral DNA origin of replication and transactivates several promoters including the viral p6 promoter. Binds the origin o... | |||
TMPH-00028 | Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP) | AAV-2 | E. coli |
Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a... | |||
TMPY-04775 | CDK1 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved prote... | |||
TMPY-04549 | CDK1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved prote... | |||
TMPY-02496 | Rad6/UBE2A Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication ... | |||
TMPH-00536 | Epstein-Barr virus (strain AG876) EBNA2 Protein (His & Myc) | EBV | Yeast |
Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes inc... | |||
TMPH-01520 | HIV-1 (group M, subtype K, isolate 96CM-MP535) Protein Vpr (His & Myc) | HIV-1 | E. coli |
During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 ... | |||
TMPY-04547 | PBK/TOPK Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the chara... | |||
TMPH-01519 | HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc) | HIV-1 | E. coli |
During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 ... | |||
TMPH-02533 | BIRC5 Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation durin... | |||
TMPH-02532 | BIRC5 Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation durin... | |||
TMPH-02815 | Nucleophosmin Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome ... | |||
TMPY-04389 | MAP3K8 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that ... | |||
TMPY-04542 | CDK2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinas... | |||
TMPY-02113 | 14-3-3 sigma Protein, Mouse, Recombinant | Mouse | E. coli |
14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells.... | |||
TMPY-01263 | 14-3-3 sigma Protein, Human, Recombinant (GST) | Human | E. coli |
14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells.... | |||
TMPY-01275 | 14-3-3 sigma Protein, Human, Recombinant | Human | E. coli |
14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells.... | |||
TMPH-02613 | ATF-5 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific respo... |
Cat No. | Product Name | ||
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L8100 | Cell Cycle Compound Library | 695 compounds | |
A unique collection of 695 cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS); |