Search Result

Search Results for " ferroptosis "

Targets

119

Compounds

Natural Products

Libraries

Cat No.	Product Name	Synonyms	Targets
T72403	Ferroptosis inducer-1
	Ferroptosis inducer-1 is a Ferroptosis inducer with antitumor potential .
T82408	Ferroptosis-IN-3		Ferroptosis
	Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM). It exhibits radical scavenging abilities against DPPH and ABTS...		Ferroptosis
T79945	Ferroptosis-IN-1		Ferroptosis
	Ferroptosis-IN-1, a diterpene derived from A. campylantha, functions as a ferroptosis inhibitor with an EC50 of 10 μM and is utilized in the study of neuroinflammatory diseases [1].		Ferroptosis
T1710	Trolox		Apoptosis , Antioxidant , Ferroptosis , Reactive Oxygen Species
	Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.
T2376	Liproxstatin-1		Ferroptosis
	Liproxstatin-1 is a potent and selective inhibitor of iron death (IC50=22 nM). Liproxstatin-1 protects cells from iron death induced by iron death inducers (e.g., Erastin, RSL3).		Ferroptosis
T1765	Erastin		Ferroptosis , VDAC
	Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations. The product...		Ferroptosis , VDAC
T5343	UAMC-3203	UAMC 3203,UAMC3203	Ferroptosis
	UAMC-3203 is a potent and selective Ferroptosis inhibitor (IC50: 12 nM).		Ferroptosis
T4360	ML385		Others , Ferroptosis , Nrf2
	ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhibition of NRF2. ML385 also exhibits anti-tumor activity.		Others , Ferroptosis , Nrf2
T4066	FIN56		Ferroptosis
	FIN56 is a specific inducer of ferroptosis.		Ferroptosis
T1482	Ciclopirox	HOE296b	ATPase , Ferroptosis , Antibacterial , Autophagy , Antifungal
	Ciclopirox (HOE296b) exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. Ciclopirox is a synthetic, broad-spect...
T6243	U-73122	U73122	Phospholipase , Ferroptosis , Lipoxygenase
	U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.		Phospholipase , Ferroptosis , Lipoxygenase
T37314	JKE-1674		GPX
	JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.		GPX
T4309	CIL56	CA3	Ferroptosis , ROS
	CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyuns...		Ferroptosis , ROS
T8970	ML162		Ferroptosis , GPX , Glutathione Peroxidase
	ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)		Ferroptosis , GPX , Glutathione Peroxidase
T9073	SRS16-86		Ferroptosis
	SRS16-86 is a novel third-generation ferrostatin, is an inhibitor of ferroptosis.		Ferroptosis
T8662	UAMC-3203 hydrochloride		Ferroptosis
	UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.		Ferroptosis
T19467	NADPH tetracyclohexanamine	NADPH (tetracyclohexanamine)	Ferroptosis
	NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.		Ferroptosis
T7092	NADPH tetrasodium salt		Others , Ferroptosis , Endogenous Metabolite
	NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety of biological reactions. NADPH tetrasodium salt is also an end...		Others , Ferroptosis , Endogenous Metabolite
T1787	Levobupivacaine		Sodium Channel
	Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ...		Sodium Channel
T11631	IFSP1		Ferroptosis
	iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RS...		Ferroptosis
T0935	Butylated hydroxytoluene	BHT FCC/NF	Antioxidant , Ferroptosis
	Butylated hydroxytoluene (BHT FCC/NF) is an antioxidant widely used in food, cosmetics and industrial liquids. It is a ferroptosis inhibitor.		Antioxidant , Ferroptosis
T1565	Deferiprone	Deferidone,CP20	Others , HCV Protease , Ferroptosis , UGT
	Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.		Others , HCV Protease , Ferroptosis , UGT
T1564	Cisplatin	cis-Diaminodichloroplatinum,CDDP	DNA Alkylator/Crosslinker , Ferroptosis , DNA/RNA Synthesis , Autophagy
	Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also activates iron death and induces autophagy.
T2488	BAY 87-2243		Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
	BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).		Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
T6099	Setanaxib	GKT137831	NADPH-oxidase , Ferroptosis , NADPH
	Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.		NADPH-oxidase , Ferroptosis , NADPH
T8922	SRS11-92	AA9	Ferroptosis
	SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1		Ferroptosis
T4414	Eprenetapopt	APR-246,PRIMA-1Met	Apoptosis , Others , Ferroptosis , p53 , Autophagy
	Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of c...		Apoptosis , Others , Ferroptosis , p53 , Autophagy
T6821	Dp44mT		Apoptosis , Others , Ferroptosis
	Dp44mT, a effective iron chelator, has selective antitumor activity.		Apoptosis , Others , Ferroptosis
T0191	Linagliptin	BI 1356	Ferroptosis , Proteasome , DPP-4 , Autophagy
	Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.		Ferroptosis , Proteasome , DPP-4 , Autophagy
T6192	Alogliptin	SYR-322	Ferroptosis , Proteasome , DPP-4
	Alogliptin (SYR-322)(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9.		Ferroptosis , Proteasome , DPP-4
T8375	ML-210	CID 49766530	Ferroptosis , GPX , Glutathione Peroxidase , Ras
	ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity		Ferroptosis , GPX , Glutathione Peroxidase , Ras
T5364	TBHQ	tert-Butylhydroquinone	Apoptosis , ERK , Others , Ferroptosis , Nrf2 , Autophagy
	TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.		Apoptosis , ERK , Others , Ferroptosis , Nrf2 , Autophagy
T1934	Bay 11-7085	BAY 11-7083	Apoptosis , IκB/IKK , Ferroptosis , NF-κB
	Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).		Apoptosis , IκB/IKK , Ferroptosis , NF-κB
T0477	Zileuton	Abbott 64077,A 64077	Ferroptosis , Lipoxygenase , COX
	Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; ca...		Ferroptosis , Lipoxygenase , COX
T1114	Ciclopirox olamine	Ciclopirox ethanolamine	ATPase , Others , Ferroptosis , Antibacterial , Antifungal
	Ciclopirox olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities.
T3646	RSL3	RSL3 1S,1S,3R-RSL3	Ferroptosis , GPX , Glutathione Peroxidase
	RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that is selective for tumor cells carrying oncogenic RAS.		Ferroptosis , GPX , Glutathione Peroxidase
T1847	Necrostatin-1	Nec-1,Necrostatin 1	Indoleamine 2,3-Dioxygenase (IDO) , Ferroptosis , Autophagy , RIP kinase
	Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO.
T6500	Ferrostatin-1	Ferrostatin 1,Ferrostatin-1 (Fer-1)	Ferroptosis , Antifungal
	Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death. Ferrostatin-1 potently inhibits Erastin-induced iron death in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and anti...		Ferroptosis , Antifungal
T1457	Deferasirox	ICL 670,CGP-72670	Others , Ferroptosis , Antibacterial
	Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.		Others , Ferroptosis , Antibacterial
T0907	Sulfasalazine	NSC 667219,Azulfidine	Apoptosis , Ferroptosis , NF-κB , COX , Antibacterial , Antibiotic , Autophagy
	Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T7530	PD146176	NSC168807	Ferroptosis , Lipoxygenase , Autophagy
	PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology...		Ferroptosis , Lipoxygenase , Autophagy
T3109	SP600125	1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone	Apoptosis , Ferroptosis , Trk receptor , JNK , Aurora Kinase , Autophagy
	SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive properties. SP600125 inhibits autophagy and induces apoptosis.
T0214	Pioglitazone	U 72107	Ferroptosis , PPAR
	Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury.		Ferroptosis , PPAR
T27061	CP-24879 hydrochloride	CP-24879 HCl	Others
	CP-24879 hydrochloride (CP-24879 HCl), a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic an...		Others
T0078	Lapatinib	GSK572016,GW572016	EGFR , Ferroptosis , Autophagy
	Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity. Lapatinib has antitumor activity and can be used to treat advanced or metastatic breast cancer with HER2 overexpression.		EGFR , Ferroptosis , Autophagy
T1885	Siramesine hydrochloride	Lu 28-179 hydrochloride	Ferroptosis , Sigma receptor , lysosomal autophagy
	Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.		Ferroptosis , Sigma receptor , lysosomal autophagy
T0093L	Sorafenib	Bay 43-9006	Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
	Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. Sorafenib has antitumor activity...
T3170	Troglitazone	CS-045,Romozin,Rezulin,Romglizone,Noscal,Prelay	Apoptosis , Ferroptosis , PPAR , Autophagy
	Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.		Apoptosis , Ferroptosis , PPAR , Autophagy
T1622	Rosiglitazone maleate	BRL 49653C,BRL 49653	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T6954	PRIMA-1	2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1	Apoptosis , Others , Ferroptosis , Autophagy
	PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.		Apoptosis , Others , Ferroptosis , Autophagy

Compounds

Ferroptosis inducer-1

Target: Ferroptosis

Ferroptosis-IN-1

T79945

Synonym:

Target: Ferroptosis

Trolox

T1710

Synonym:

Target: Apoptosis, Antioxidant, Ferroptosis, Reactive Oxygen Species

Liproxstatin-1

T2376

Synonym:

Target: Ferroptosis

Erastin

T1765

Synonym:

Target: Ferroptosis, VDAC

UAMC-3203

T5343

Synonym: UAMC 3203,UAMC3203

Target: Ferroptosis

ML385

T4360

Synonym:

Target: Others, Ferroptosis, Nrf2

FIN56

T4066

Synonym:

Target: Ferroptosis

Ciclopirox

T1482

Synonym: HOE296b

Target: ATPase, Ferroptosis, Antibacterial, Autophagy, Antifungal

U-73122

T6243

Synonym: U73122

Target: Phospholipase, Ferroptosis, Lipoxygenase

Target: Ferroptosis, ROS

ML162

T8970

Synonym:

Target: Ferroptosis, GPX, Glutathione Peroxidase

SRS16-86

T9073

Synonym:

Target: Ferroptosis

UAMC-3203 hydrochloride

T8662

Synonym:

Target: Ferroptosis

NADPH tetracyclohexanamine

T19467

Synonym: NADPH (tetracyclohexanamine)

Target: Ferroptosis

NADPH tetrasodium salt

T7092

Synonym:

Target: Others, Ferroptosis, Endogenous Metabolite

Levobupivacaine

T1787

Synonym:

Target: Sodium Channel

iFSP1

T11631

Synonym:

Target: Ferroptosis

Butylated hydroxytoluene

T0935

Synonym: BHT FCC/NF

Target: Antioxidant, Ferroptosis

Deferiprone

T1565

Synonym: Deferidone,CP20

Target: Others, HCV Protease, Ferroptosis, UGT

Cisplatin

T1564

Synonym: cis-Diaminodichloroplatinum,CDDP

Target: DNA Alkylator/Crosslinker, Ferroptosis, DNA/RNA Synthesis, Autophagy

BAY 87-2243

T2488

Synonym:

Target: Ferroptosis, HIF/HIF Prolyl-Hydroxylase, HIF

Setanaxib

T6099

Synonym: GKT137831

Target: NADPH-oxidase, Ferroptosis, NADPH

SRS11-92

T8922

Synonym: AA9

Target: Ferroptosis

Eprenetapopt

T4414

Synonym: APR-246,PRIMA-1Met

Target: Apoptosis, Others, Ferroptosis, p53, Autophagy

Dp44mT

T6821

Synonym:

Target: Apoptosis, Others, Ferroptosis

Linagliptin

T0191

Synonym: BI 1356

Target: Ferroptosis, Proteasome, DPP-4, Autophagy

Alogliptin

T6192

Synonym: SYR-322

Target: Ferroptosis, Proteasome, DPP-4

ML-210

T8375

Synonym: CID 49766530

Target: Ferroptosis, GPX, Glutathione Peroxidase, Ras

TBHQ

T5364

Synonym: tert-Butylhydroquinone

Target: Apoptosis, ERK, Others, Ferroptosis, Nrf2, Autophagy

Bay 11-7085

T1934

Synonym: BAY 11-7083

Target: Apoptosis, IκB/IKK, Ferroptosis, NF-κB

Zileuton

T0477

Synonym: Abbott 64077,A 64077

Target: Ferroptosis, Lipoxygenase, COX

Ciclopirox olamine

T1114

Synonym: Ciclopirox ethanolamine

Target: ATPase, Others, Ferroptosis, Antibacterial, Antifungal

RSL3

T3646

Synonym: RSL3 1S,1S,3R-RSL3

Target: Ferroptosis, GPX, Glutathione Peroxidase

Necrostatin-1

T1847

Synonym: Nec-1,Necrostatin 1

Target: Indoleamine 2,3-Dioxygenase (IDO), Ferroptosis, Autophagy, RIP kinase

Ferrostatin-1

T6500

Synonym: Ferrostatin 1,Ferrostatin-1 (Fer-1)

Target: Ferroptosis, Antifungal

Deferasirox

T1457

Synonym: ICL 670,CGP-72670

Target: Others, Ferroptosis, Antibacterial

Sulfasalazine

T0907

Synonym: NSC 667219,Azulfidine

Target: Apoptosis, Ferroptosis, NF-κB, COX, Antibacterial, Antibiotic, Autophagy

PD146176

T7530

Synonym: NSC168807

Target: Ferroptosis, Lipoxygenase, Autophagy

SP600125

T3109

Synonym: 1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone

Target: Apoptosis, Ferroptosis, Trk receptor, JNK, Aurora Kinase, Autophagy

Pioglitazone

T0214

Synonym: U 72107

Target: Ferroptosis, PPAR

CP-24879 hydrochloride

T27061

Synonym: CP-24879 HCl

Target: Others

Lapatinib

T0078

Synonym: GSK572016,GW572016

Target: EGFR, Ferroptosis, Autophagy

Siramesine hydrochloride

T1885

Synonym: Lu 28-179 hydrochloride

Target: Ferroptosis, Sigma receptor, lysosomal autophagy

Sorafenib

T0093L

Synonym: Bay 43-9006

Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy

Troglitazone

T3170

Synonym: CS-045,Romozin,Rezulin,Romglizone,Noscal,Prelay

Target: Apoptosis, Ferroptosis, PPAR, Autophagy

Rosiglitazone maleate

T1622

Synonym: BRL 49653C,BRL 49653

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

PRIMA-1

T6954

Synonym: 2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1

Target: Apoptosis, Others, Ferroptosis, Autophagy

Cat No.	Product Name	Synonyms	Targets
T3S1447	Arteannuin B		SARS-CoV , Ferroptosis
	1. Arteannuin B has potent antimalarial activity.		SARS-CoV , Ferroptosis
T2887	Trigonelline	Trigenolline	Apoptosis , Others , Ferroptosis , Endogenous Metabolite
	Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.		Apoptosis , Others , Ferroptosis , Endogenous Metabolite
T6468	D-glutamine		Mitophagy , Ferroptosis , Endogenous Metabolite , GluR , Autophagy
	D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
T5515	Hemin	Hemin chloride	Mitophagy , Ferroptosis , Autophagy
	Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme deficiency in patients, thereby inhibiting δ-aminolevulini...		Mitophagy , Ferroptosis , Autophagy
T2858	Baicalein	5,6,7-Trihydroxyflavone	Ferroptosis , Influenza Virus , ROS , Xanthine Oxidase
	Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.		Ferroptosis , Influenza Virus , ROS , Xanthine Oxidase
T0433	Artesunate	WR-256283	Virus Protease , Ferroptosis , STAT , Parasite
	Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is on the World Heal...		Virus Protease , Ferroptosis , STAT , Parasite
T5687	WITHAFERIN A		Ferroptosis , NF-κB
	WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer.		Ferroptosis , NF-κB
T1207	Lovastatin	MK-803,Mevinolin	Ferroptosis , HMG-CoA Reductase , Autophagy
	Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.		Ferroptosis , HMG-CoA Reductase , Autophagy
TJS2190	Nordihydroguaiaretic acid	NDGA,Dihydronorguaiaretic Acid	Antioxidant , Ferroptosis , Lipoxygenase , Autophagy
	Nordihydroguaiaretic acid (NDGA) (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibito...		Antioxidant , Ferroptosis , Lipoxygenase , Autophagy
T6947	Piperlongumine	PPLGM,Piplartine	Apoptosis , ERK , Ferroptosis , Reactive Oxygen Species , ROS , Antibacterial , Autophagy
	Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
T1922	Pseudolaric Acid B		Apoptosis , p38 MAPK , Ferroptosis , HBV , Autophagy , Antifungal
	Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.
T2O2733	L-Cystine	Cystine Acid,cystine	Antioxidant , Ferroptosis , Endogenous Metabolite
	L-Cystine (Cystine Acid) is not considered one of the 20 amino acids, L-Cystine (Cystine Acid) is a sulfur-containing derivative obtained from oxidation of cysteine amino acid thiol side chains. It functions as an antiox...		Antioxidant , Ferroptosis , Endogenous Metabolite
THS1455	DihydroarteMisinic acid	Dihydro-Artmisinic Acid	Ferroptosis , Parasite
	DihydroarteMisinic acid (Dihydro-Artmisinic Acid) is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal herb that is widely used to treat Malaria.		Ferroptosis , Parasite
T2856	(-)-Epicatechin	L-Epicatechin,Epicatechin,(-)-Epicatechol	Ferroptosis , COX , Endogenous Metabolite
	(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.		Ferroptosis , COX , Endogenous Metabolite
T2796	Coenzyme Q10	Ubiquinone-10,CoQ10	Ferroptosis , Reactive Oxygen Species , Endogenous Metabolite
	Coenzyme Q10 (CoQ10) (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.
TJS1159	Chrysosplenetin	Chrysosptertin B	P450 , Ferroptosis , P-gp
	Chrysosplenetin is a metabolic inhibitor of artemisinin.		P450 , Ferroptosis , P-gp
T0877	Gallic acid	3,4,5-Trihydroxybenzoic acid,Gallate,Benzoic acid	Apoptosis , Ferroptosis , Reactive Oxygen Species , ROS , COX , Endogenous Metabolite
	Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T1644	Dopamine hydrochloride	Dopamine HCl,ASL279	Ferroptosis , Dopamine Receptor , 5-HT Receptor , Endogenous Metabolite
	Dopamine hydrochloride (ASL279) is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine hydrochloride binds to alpha-1- and b...
T0326L	L-Glutamine	L-Glutamic acid 5-amide	Ferroptosis , Endogenous Metabolite , GluR
	L-Glutamine (L-Glutamic acid 5-amide) , a non-essential amino acid, is synthesized from glutamic acid and ammonia.		Ferroptosis , Endogenous Metabolite , GluR
T1297	Eugenol	4-Allylguaiacol,Allylguaiacol,4-Allyl-2-methoxyphenol,Eugenic acid	Apoptosis , Ferroptosis , Reactive Oxygen Species , Antibacterial , Parasite
	Eugenol (Allylguaiacol) is a Standardized Chemical Allergen. The physiologic effect of eugenol is by means of Increased Histamine Release and Cell-mediated Immunity.
T0392	Artemisinin	Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,Artemisinine	HCV Protease , Ferroptosis , Akt , Parasite
	Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium ...		HCV Protease , Ferroptosis , Akt , Parasite
T20819	Ammonium iron(III) citrate	Ferric ammonium citrate	Others , Ferroptosis
	Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload leading to cellular iron death and enhances protein production.		Others , Ferroptosis
T0875	Acetylcysteine	N-Acetyl-L-cysteine,LNAC,NAC	Apoptosis , TNF , Ferroptosis , Influenza Virus , Reactive Oxygen Species , ROS , Endogenous Metabolite
	Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus thickness, and has anti-influenza viral activity.
T0672	Pravastatin sodium	CS-514 Sodium,CS-514 (sodium)	Ferroptosis , HMG-CoA Reductase , Autophagy
	Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.		Ferroptosis , HMG-CoA Reductase , Autophagy
T0326	DL-Glutamine	Glutamin,DL-Gl,(±)-Glutamine,2-amino-4-carbamoylbutanoic acid	Ferroptosis , Amino Acids and Derivatives , Endogenous Metabolite
	DL-Glutamine (2-amino-4-carbamoylbutanoic acid), a non-essential amino acid, exists abundantly throughout the body and is participated in many metabolic processes. It is synthesized from glutamic acid and ammonia, and is...
T5679	(E)-Ferulic acid	trans-Ferulic acid,(E)-Coniferic acid	BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite
	(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr...
TMA2394	DL-alpha-Tocopherol	DL-α-Tocopherol,Alpha-Tochopherol,Ephanyl	Antioxidant , Ferroptosis
	DL-alpha-Tocopherol (Ephanyl) is a synthetic vitamin E that protects skin fibroblasts from the cytotoxic effects of UV light and has antioxidant properties.		Antioxidant , Ferroptosis
T0687	Simvastatin	MK-0733,MK 733	Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy
	Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc...
T2A2497	L-Glutamic acid	(S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,glutacid,Glutaminol	Apoptosis , Ferroptosis , Endogenous Metabolite , iGluR
	L-Glutamic acid (Glutaminol) acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.		Apoptosis , Ferroptosis , Endogenous Metabolite , iGluR
T1516	Curcumin	Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow	Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy
	Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant...
T2870	Matrine	Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.		Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
T6871	L-Glutamic acid monosodium salt	Monosodium glutamate,Glutacyl,Glutavene,Ajinomoto,MSG	Apoptosis , Ferroptosis , GluR , iGluR
	L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.		Apoptosis , Ferroptosis , GluR , iGluR
T1085	L-Glutathione reduced	GSH,Isethion,Glutathione,γ-L-Glutamyl-L-cysteinyl-glycine,Glutathion,Tathion	Ferroptosis , Reactive Oxygen Species , Endogenous Metabolite , Glutathione reductase
	L-Glutathione reduced (Glutathione) is a naturally occurring tripeptide found in cells as an endogenous antioxidant that scavenges oxygen free radicals. L-Glutathione reduced is a cofactor for certain enzymes and is invo...
T1648	α-Vitamin E	Dexrabeprazole Sodium,Vitamin E,Alpha-Tocopherol,D-α-Tocopherol,5,7,8-Trimethyltocol,(+)-alpha-Tocopherol	Others , Ferroptosis , Influenza Virus , Reactive Oxygen Species , Endogenous Metabolite , Antibacterial , PKC , GST
	α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
TN5770	Gingerenone A		Nrf2
	Gingerenone A is an effective Nrf2-Gpx4 activator. It is a small molecule compound isolated from ginger. It has anti-cancer activity, can prolong the cell cycle of cancer cells, and can inhibit dextran sodium sulfate (DS...		Nrf2
T79940	Moracin N		Glutathione Peroxidase
	Moracin N, a ferroptosis inhibitor derived from mulberry leaves, exhibits neuroprotective activity by mitigating oxidative stress [1].		Glutathione Peroxidase

Natural Products

Arteannuin B

T3S1447

Synonym:

Target: SARS-CoV, Ferroptosis

Trigonelline

T2887

Synonym: Trigenolline

Target: Apoptosis, Others, Ferroptosis, Endogenous Metabolite

D-glutamine

T6468

Synonym:

Target: Mitophagy, Ferroptosis, Endogenous Metabolite, GluR, Autophagy

Hemin

T5515

Synonym: Hemin chloride

Target: Mitophagy, Ferroptosis, Autophagy

Baicalein

T2858

Synonym: 5,6,7-Trihydroxyflavone

Target: Ferroptosis, Influenza Virus, ROS, Xanthine Oxidase

Artesunate

T0433

Synonym: WR-256283

Target: Virus Protease, Ferroptosis, STAT, Parasite

WITHAFERIN A

T5687

Synonym:

Target: Ferroptosis, NF-κB

Lovastatin

T1207

Synonym: MK-803,Mevinolin

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Nordihydroguaiaretic acid

TJS2190

Synonym: NDGA,Dihydronorguaiaretic Acid

Target: Antioxidant, Ferroptosis, Lipoxygenase, Autophagy

Piperlongumine

T6947

Synonym: PPLGM,Piplartine

Target: Apoptosis, ERK, Ferroptosis, Reactive Oxygen Species, ROS, Antibacterial, Autophagy

Pseudolaric Acid B

T1922

Synonym:

Target: Apoptosis, p38 MAPK, Ferroptosis, HBV, Autophagy, Antifungal

L-Cystine

T2O2733

Synonym: Cystine Acid,cystine

Target: Antioxidant, Ferroptosis, Endogenous Metabolite

DihydroarteMisinic acid

THS1455

Synonym: Dihydro-Artmisinic Acid

Target: Ferroptosis, Parasite

(-)-Epicatechin

T2856

Synonym: L-Epicatechin,Epicatechin,(-)-Epicatechol

Target: Ferroptosis, COX, Endogenous Metabolite

Coenzyme Q10

T2796

Synonym: Ubiquinone-10,CoQ10

Target: Ferroptosis, Reactive Oxygen Species, Endogenous Metabolite

Chrysosplenetin

TJS1159

Synonym: Chrysosptertin B

Target: P450, Ferroptosis, P-gp

Gallic acid

T0877

Synonym: 3,4,5-Trihydroxybenzoic acid,Gallate,Benzoic acid

Target: Apoptosis, Ferroptosis, Reactive Oxygen Species, ROS, COX, Endogenous Metabolite

Dopamine hydrochloride

T1644

Synonym: Dopamine HCl,ASL279

Target: Ferroptosis, Dopamine Receptor, 5-HT Receptor, Endogenous Metabolite

L-Glutamine

T0326L

Synonym: L-Glutamic acid 5-amide

Target: Ferroptosis, Endogenous Metabolite, GluR

Eugenol

T1297

Synonym: 4-Allylguaiacol,Allylguaiacol,4-Allyl-2-methoxyphenol,Eugenic acid

Target: Apoptosis, Ferroptosis, Reactive Oxygen Species, Antibacterial, Parasite

Artemisinin

T0392

Synonym: Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,Artemisinine

Target: HCV Protease, Ferroptosis, Akt, Parasite

Ammonium iron(III) citrate

T20819

Synonym: Ferric ammonium citrate

Target: Others, Ferroptosis

Acetylcysteine

T0875

Synonym: N-Acetyl-L-cysteine,LNAC,NAC

Target: Apoptosis, TNF, Ferroptosis, Influenza Virus, Reactive Oxygen Species, ROS, Endogenous Metabolite

Pravastatin sodium

T0672

Synonym: CS-514 Sodium,CS-514 (sodium)

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

DL-Glutamine

T0326

Synonym: Glutamin,DL-Gl,(±)-Glutamine,2-amino-4-carbamoylbutanoic acid

Target: Ferroptosis, Amino Acids and Derivatives, Endogenous Metabolite

(E)-Ferulic acid

T5679

Synonym: trans-Ferulic acid,(E)-Coniferic acid

Target: BCL, Ferroptosis, Wnt/beta-catenin, Endogenous Metabolite

DL-alpha-Tocopherol

TMA2394

Synonym: DL-α-Tocopherol,Alpha-Tochopherol,Ephanyl

Target: Antioxidant, Ferroptosis

Simvastatin

T0687

Synonym: MK-0733,MK 733

Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy

L-Glutamic acid

T2A2497

Synonym: (S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,glutacid,Glutaminol

Target: Apoptosis, Ferroptosis, Endogenous Metabolite, iGluR

Curcumin

T1516

Synonym: Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow

Target: Mitophagy, Epigenetic Reader Domain, Ferroptosis, Influenza Virus, Nrf2, Histone Acetyltransferase, HDAC, Autophagy

Matrine

T2870

Synonym: Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine

Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy

L-Glutamic acid monosodium salt

T6871

Synonym: Monosodium glutamate,Glutacyl,Glutavene,Ajinomoto,MSG

Target: Apoptosis, Ferroptosis, GluR, iGluR

L-Glutathione reduced

T1085

Synonym: GSH,Isethion,Glutathione,γ-L-Glutamyl-L-cysteinyl-glycine,Glutathion,Tathion

Target: Ferroptosis, Reactive Oxygen Species, Endogenous Metabolite, Glutathione reductase

α-Vitamin E

T1648

Synonym: Dexrabeprazole Sodium,Vitamin E,Alpha-Tocopherol,D-α-Tocopherol,5,7,8-Trimethyltocol,(+)-alpha-Tocopherol

Target: Others, Ferroptosis, Influenza Virus, Reactive Oxygen Species, Endogenous Metabolite, Antibacterial, PKC, GST

Target: Glutathione Peroxidase

Cat No.	Product Name
L8700	Ferroptosis Compound Library	800 compounds
	A unique collection of 800 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；
L8710	Cuproptosis Compound Library	411 compounds
	TargetMol’s Cuproptosis Compound Library is a collection of 411 compounds related to copper-dependent death that can be used to study its mechanism and related diseases.

Libraries

Ferroptosis Compound Library

L8700

Compounds: 800

Cuproptosis Compound Library

L8710

Compounds: 411