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Search Results for " escc "

Targets

10

Compounds

3

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T9636 Dalpiciclib SHR-6390 CDK
Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophag...
T2455 PFK-015 PFK15,PFK 015 Glucokinase , Autophagy
PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).
T0866 Propafenone Rythmol,Propafenonum Potassium Channel , MRP , Sodium Channel
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity....
T21312 Afatinib Afatinib free base,BIBW 2992 EGFR , Autophagy
Afatinib (BIBW 2992) is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively).
T1773 Afatinib Dimaleate BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate EGFR , HER , Autophagy
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act...
T37535 Camrelizumab SHR-1210
Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up to 3 nM and is inhibitory to PD-1/PD-L1 with an IC50 of 0.7...
T74997 ERK-IN-6
ERK-IN-6 (compound 6g) is an potent anti-proliferation agent against esophageal squamous cell carcinoma ( ESCC ). ERK-IN-6 induces cell apoptosis via ERK pathway. ERK-IN-6 can be used for the research of ESCC [1] .
T76997 Socazolimab
Socazolimab (ZKAB001) is an anti- PD-L1 monoclonal antibody. Socazolimab has lasting safety and efficacy in the treatment of recurrent or metastatic cervical cancer . Socazolimab also has potential applications in small ...
T64075 Afatinib oxalate
Afatinib (BIBW 2992) oxalate is an irreversible, orally active bispecific inhibitor of the ErbB family (EGFR and HER2) that acts on EGFRwt (IC50: 0.5 nM), EGFRL858R (IC50: 0.4 nM), EGFRL858R/T790M ( IC50: 10 nM) and HER2...
T72912 (R)-Afatinib (R)-BIBW 2992
(R)-Afatinib ((R)-BIBW 2992) is the Afatinib isomer. Afatinib is an orally active, potent and irreversible dual specificity inhibitor of ErbB family ( EGFR and HER2 ), with IC 50 values of 0.5 nM, 0.4 nM, 10 nM and 14 n...
Cat No. Product Name Synonyms Targets
T5684 Ethyl 3,4-dihydroxybenzoate Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
TN6651 Picrasidine Q
Picrasidine Q has the capacity of anti-cell transformation and anti-cancer, it might be a chemopreventive and chemotherapeutic agent by direct targeting FGFR2 and inhibiting cell proliferation of ESCC cells.
T75569 Xerophilusin B
Xerophilusin B, an anticancer agent isolated from Isodon xerophilus , exhibits antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines, induces G2/M cell cycle arrest, and mediates apoptosis [1]...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-03459 CRIP2 Protein, Human, Recombinant Human Baculovirus-Insect Cells
CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth mus...
TMPY-03342 CRIP2 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth mus...
TMPY-02129 Transglutaminase 3/TGM3 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Transglutaminases (TGase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between proteins or peptides. Transglutamina...
TMPY-01204 SMYD2 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
SET and MYND domain-containing protein 2, also known as HSKM-B, SMYD2, and KMT3C, is a member of the SMYD protein family. It contains one MYND-type zinc finger and one SET domain. Not much is known about SMYD2. However, ...
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