3
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1903 | Dabrafenib | GSK2118436A,GSK2118436 | Raf |
Dabrafenib (GSK2118436A) is a selective inhibitor of mutated forms of BRAF kinase (IC50s: 0.7/5 nM for B-Raf (V600E)/C-Raf). | |||
T8474 | Dabrafenib Mesylate | GSK 2118436B,GSK2118436 Mesylate | Raf |
Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively). | |||
T63210 | Everafenib | ||
Everafenib is a potent BRAF inhibitor that crosses the blood-brain barrier and also inhibits the MAPK pathway. Everafenib inhibits the activity of a range of V600EBRAF melanoma cell lines (IC50: 2-10 nM) and is more effe... |