dpp-iv — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11526	DPP-IV-IN-2	H-Lys(4-nitro-Z)-pyrrolidide	DPP-4
	DPP-IV-IN-2 (H-Lys(4-nitro-Z)-pyrrolidide) is an inhibitor of both DP8/9 and dipeptidyl peptidase IV (IC50s: 0.1 and 0.95 μM).		DPP-4
T10082	DPP-IV-IN-1		Others
	DPP-IV-IN-1 is an effective inhibitor of dipeptidyl peptidase IV (DPP-IV), a serine protease (IC50: 4.6 nM).		Others
T74978	DPP IV/hCA II-IN-1
	DPP IV/hCA II-IN-1 is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA), exhibiting an IC50 of 0.049 μM for DPP IV and K_i values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and...
T1502	Vildagliptin	NVP-LAF 237,LAF237	Apoptosis , Ferroptosis , Proteasome , DPP-4
	Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolit...		Apoptosis , Ferroptosis , Proteasome , DPP-4
T25340	Diprotin A	Ile-Pro-Ile	DPP-4
	Diprotin A (Ile-Pro-Ile) (Ile-Pro-Ile) is a dipeptidyl peptidase IV (DPP-IV) inhibitor.		DPP-4
T78410	Gly-Pro-AMC hydrobromide	Gly-Pro-AMC HCl
	Gly-Pro-AMC hydrobromide (Gly-Pro-AMC HCl) is a specific fluorescent dye used in cytofluorescence assays to detect Dipeptidyl peptidase IV (DPP-IV) activity.
T78223	γ-Glu-Tyr	gamma-Glutamyltyrosine,gamma-GLU-TYR
	γ-Glu-Tyr (gamma-Glutamyltyrosine) is a kokumi peptide with competitive inhibition of dipeptidyl peptidase-IV (DPP-IV) and is used in the study of diabetes mellitus.
T0242L	Sitagliptin phosphate monohydrate	MK-0431,MK-0431 phosphate monohydrate	Proteasome , DPP-4 , Autophagy
	Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.		Proteasome , DPP-4 , Autophagy
T68053	Denagliptin	GW823093	DPP-4
	Denagliptin is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor for the treatment of endocrine Ü metabolic diseases and can be used in the study of type 2 diabetes.		DPP-4
T1674	Nateglinide	A4166,Senaglinide	Potassium Channel , Proteasome , PPAR
	Nateglinide (Senaglinide) is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare ins...		Potassium Channel , Proteasome , PPAR
T11049	Diprotin A TFA	Ile-Pro-Pro (TFA)	Others
	Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).		Others
T31378	Denagliptin tosylate	GSK-823093,GSK 823093,GW-823093,GW 823093,GSK823093,GW823093
	Denagliptin (GW823093 or GSK-823093) is a dipeptidyl peptidase IV (DPP-IV) inhibitor.
T63698	PK44 phosphate
	PK44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50: 15.8 nM).
T13826	Prodipine hydrochloride		Others
	Prodipine hydrochloride for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit (IC50 of 4.5 μM and 30 μM, respectively).		Others
T26850	BMS-538305 HCl	BMS-538305,BMS538305,BMS 538305,BMS-538305 hydrochloride
	BMS-538305 is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP-IV).
T61414	DPP-4 inhibitor 3
	Compound 5a, also known as DPP-4 inhibitor 3, is a powerful dipeptidyl peptidase IV (DPP-IV) inhibitor, demonstrating an IC50 value of 0.75 nM. It exhibits outstanding antioxidant and insulinotropic activity [1].
T63964	DPP-4/GPR119 modulator 2
	DPP-4/GPR119 modulator 2 is an inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50: 0.22 μM) and an agonist of GPR119 (EC50: 0.95 μM).
T79911	O-Benzoylhydroxylamine
	O-Benzoyl hydroxylamine exhibits properties as a dipeptidyl peptidase-IV (DPP-IV) inhibitor and demonstrates antidiabetic effects[1].
T11450	Gosogliptin	PF-00734200,PF-734200	Others
	Gosogliptin is a potent and selective dipeptidyl peptidase-IV (DPP-IV) inhibitor.		Others
T26941	Camegliptin	RO-4876904-001,R1579,RG1579,RO-4876904,R-1579,RG-1579
	Cameglipti, a dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type 2 diabetes.
T82178	H-Pro-Pro-Gln-OH
	H-Pro-Pro-Gln-OH is an oligopeptide that exhibits potent inhibitory activity against dipeptidyl peptidase-IV (DPP-IV) [1].
T71354	AMG-222 tosylate
	AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.
T27598	Imigliptin Dihydrochloride	Imigliptin
	Imigliptin Dihydrochloride, a selective dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type II diabetes.
T22747	DPPI 1c hydrochloride		Others
	DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (IC50 = 104 nM) that shows selectivity over enzymes with DPP-like activity (IC50 > 30 μM).		Others
T74528	DPP-4/GPR119 modulator 1
	DPP-4/GPR119 modulator 1 (Compound 22) is an orally active compound that functions as both a dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist. It demonstrates a glucose-lowering effect in blood and exhibits ...
T21691	NVP DPP 728 dihydrochloride
	NVP-DPP728 is a potent, reversible, nitrile-dependent inhibitor of dipeptidyl peptidase IV (DPP-IV), demonstrating an inhibition constant (K i) of 11 nM for human DPP-IV amidolytic activity. By inhibiting the degradation...
T61076	Vildagliptin dihydrate
	Vildagliptin dihydrate (LAF237 dihydrate) is a powerful and stable dipeptidyl peptidase IV (DPP-IV) inhibitor, demonstrating selectivity with an IC50 of 3.5 nM in human Caco-2 cells. This compound exhibits exceptional or...
T39481	NVP-DPP728 dihydrochloride	NVP-DPP728 dihydrochloride
	NVP-DPP728 dihydrochloride is a highly potent, selective, and orally active inhibitor of dipeptidyl peptidase IV (DPP-IV), with a binding affinity (K i ) of 11 nM. This compound proves useful for investigating diabetes m...
T13069	Talabostat isomer mesylate		Others
	Talabostat isomer mesylate is an isomer of talabostat mesylate. Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available inhibitor of dipeptidyl peptidase IV (DPP-IV)(Ki of 0.18 nM).		Others
T68652	Carmegliptin dihydrochloride
	Carmegliptin dihydrochloride is the salt form of Camegliptin (free base), also known as RG-1579 and RO4876904, a dipeptidyl peptidase IV (DPP-4) inhibitor potentially for the treatment of type 2 diabetes.
T68863	MK-0626 free base
	MK-0626 is a Dipeptidyl peptidase IV (DPP-4) inhibitor, improving neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric oxide synthetase expression.
T30169	ASP-8497	UNII-GC7THT248G,ASP8497,ASP 8497
	ASP8497 is a potent, long-acting DPP-IV inhibitor that improves glucose tolerance by elevating GLP-1 levels in a glucose-dependent insulin-stimulating manner. The compound is used as a therapeutic agent for impaired gluc...
T73875	Fotagliptin benzoate
	Fotagliptin benzoate, a Dipeptidyl Peptidase IV (DPP-4) inhibitor with an inhibitory concentration (IC50) of 2.27 nM, demonstrates significant safety in both rat and dog models. It is utilized in Type 2 diabetes mellitus...
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 ...
T79608	DPP		JAK
	DPP, a Platinum(IV) complex with a pterostilbene-derived axial ligand, inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, demonstrating antiproliferative activity. It activates caspase-3 and cleaved poly ADP-ri...		JAK
T68491	Melogliptin
	Melogliptin, also known as EMD-675992 and GRC-8200, is a potent and selective a dipeptidyl peptidase IV (DPP-IV) inhibitor potentially for treatment of type II diabetes. Melogliptin significantly reduced HbA1c from b...

Compounds

DPP-IV-IN-2

T11526

Synonym: H-Lys(4-nitro-Z)-pyrrolidide

Synonym: NVP-LAF 237,LAF237

Target: Apoptosis, Ferroptosis, Proteasome, DPP-4

Gly-Pro-AMC hydrobromide

T78410

Synonym: Gly-Pro-AMC HCl

Target:

γ-Glu-Tyr

T78223

Synonym: gamma-Glutamyltyrosine,gamma-GLU-TYR

Target:

Sitagliptin phosphate monohydrate

T0242L

Synonym: MK-0431,MK-0431 phosphate monohydrate

Target: Proteasome, DPP-4, Autophagy

Synonym: A4166,Senaglinide

Target: Potassium Channel, Proteasome, PPAR

Diprotin A TFA

T11049

Synonym: Ile-Pro-Pro (TFA)

Target: Others

Denagliptin tosylate

T31378

Synonym: GSK-823093,GSK 823093,GW-823093,GW 823093,GSK823093,GW823093

Prodipine hydrochloride

Synonym: BMS-538305,BMS538305,BMS 538305,BMS-538305 hydrochloride

DPP-4/GPR119 modulator 2

T63964

Synonym:

Target:

O-Benzoylhydroxylamine

Synonym: PF-00734200,PF-734200

Target: Others

Camegliptin

T26941

Synonym: RO-4876904-001,R1579,RG1579,RO-4876904,R-1579,RG-1579

Imigliptin Dihydrochloride

T27598

Synonym: Imigliptin

Target:

DPPI 1c hydrochloride

T22747

Synonym:

Target: Others

DPP-4/GPR119 modulator 1

T74528

Synonym:

Target:

NVP DPP 728 dihydrochloride

T21691

Synonym:

Target:

Vildagliptin dihydrate

T61076

Synonym:

Target:

NVP-DPP728 dihydrochloride

T39481

Synonym: NVP-DPP728 dihydrochloride

Target:

Talabostat isomer mesylate

T13069

Synonym:

Target: Others

Carmegliptin dihydrochloride

Synonym: UNII-GC7THT248G,ASP8497,ASP 8497

Cat No.	Product Name	Targets
TN1418	Azaleatin	DPP-4
	Azaleatin is a natural product from Rhododendron simsii. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for type-2 diabetes and obesity studies.	DPP-4
T39219	Ficusonolide
	Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.
T81898	Lyciumamide A
	DPP-IV-IN-5, derived from Lycium barbarum fruits, demonstrates moderate agonistic activity towards peroxisome proliferator-activated receptor (PPARγ), showing EC50 values between 10.09 and 44.26 μM, and exhibits inhibito...

Cat No.	Product Name	Species	Expression System
TMPH-03279	DPP4/CD26 Protein, Rat, Recombinant (His & SUMO)	Rat	E. coli
	Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, ...
TMPK-00377	DPPIV/CD26 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)	Cynomolgus,Rhesus macaque	HEK293
	CD26/dipeptidyl peptidase (DPP)IV is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primary tumors and also metast...

Search Result

Targets

Compounds

Natural Products

Recombinant Proteins

Compounds

Natural Products

Recombinant Proteins