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Cat No. | Product Name | Synonyms | Targets |
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T2516 | Amuvatinib | MP470,HPK 56 | Apoptosis , FLT , c-Met/HGFR , c-RET , DNA/RNA Synthesis , PDGFR , c-Kit |
Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity. | |||
T50098 | TIQ-A | PARP | |
TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in m... | |||
T6892 | Niraparib tosylate | MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate | Apoptosis , PARP |
Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor. | |||
T3231 | Niraparib | MK-4827 | Apoptosis , Others , PARP |
Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis. | |||
T70873 | M3541 | Apoptosis , ATM/ATR | |
M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by binding to ATM.M3541 prevents activation of DNA damage che... | |||
T23974 | DDRI-18 | DDRI18,DDRI 18 | DNA/RNA Synthesis |
DDRI-18 is a novel small molecule inhibitor that regulates the DNA damage response with sensitizing and anticancer activities, inhibits non-homologous end-joining (NHEJ) DNA repair and enhances the cytotoxicity of antica... | |||
T3353 | Niraparib hydrochloride | MK-4827 hydrochloride,MK-4827 (hydrochloride) | Apoptosis , Others , PARP |
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of... | |||
T5425 | ML367 | Epigenetic Reader Domain | |
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization and acts as a probe molecule that has low micromolar inhibitory activity | |||
T21320 | Methoxyamine HCl | TRC102,TRC 102,Methoxyamine,TRC-102 | Others |
Methoxyamine HCl (Methoxyamine) covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. Methoxyamine is... | |||
T10406 | Tuvusertib | M1774,ATR inhibitor 1 | Apoptosis , ATM/ATR , Others , Chk |
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks... | |||
T80207 | Tetrapeptide | DNA/RNA Synthesis | |
Tetrapeptide, an α-MSH analogue, stimulates melanin production and mitigates DNA damage by attenuating reactive oxidative species generation and augmenting DNA photoproduct repair [1]. | |||
T40931 | FEN1-IN-2 | FEN1-IN-2 | Others |
FEN1-IN-2 is a selective and potent inhibitor of flap endonuclease 1 (FEN1), inhibits FEN1 and XPG, has potential anticancer activity, and can be used to study DNA damage repair. | |||
T62511 | AZ3391 | ||
AZ3391 is a quinoxaline derivative that is a potent inhibitor of PARP. AZ3391 has potential for the study of diseases and conditions occurring in central nervous system tissues (e.g., brain and spinal cord). | |||
T63555 | ATR-IN-6 | ||
ATR-IN-6 is a potent inhibitor of ATR. ATR is a protein kinase that is involved in genome stability and DNA damage repair and is a member of the PIKK family. aTR-IN-6 has shown potential for ATR kinase-mediated diseases ... | |||
T63923 | ATR-IN-5 | ||
ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair. ATR is a member of the PIKK family, a class of protein kinases involved in genome stabili... | |||
T78787 | PARP-1/2-IN-2 | PARP | |
PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound... | |||
T60649 | AV-153 free base | ||
AV-153 free base is a 1,4-dihydropyridine (1,4-DHP) derivative. AV-153 free base is an antimutagenic with anti-cancer activity. AV-153 free base interacts with cytosine and thymine and has an influence on poly(ADP)ribosy... | |||
T79647 | VEGFR/PARP-IN-1 | PARP | |
VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively. It impairs DNA damage repair pathways, promotes apoptosis, and halts cells in the G2/M phase. Thi... | |||
T83854 | BRC4wt TFA | ||
BRC4wt, an acetylated peptide originating from the BRC4 repeat within human BRCA2 (1521-1536), acts as an inhibitor of the BRCA2 and RAD51 protein-protein interaction. When linked to the cationic cell-penetrating peptide... | |||
T62540 | PARP1/BRD4-IN-2 | ||
PARP1/BRD4-IN-2 is a potent and selective inhibitor of PARP1 (IC50: 197 nM) and BRD4 (IC50: 238 nM).PARP1/BRD4-IN-2 inhibits DNA damage repair, blocks the G0/G1 cell cycle transition, and induces apoptosis.PARP1/BRD4-IN-... |
Cat No. | Product Name | ||
---|---|---|---|
L3900 | DNA Damage & Repair Compound Library | 937 compounds | |
A unique collection of 937 DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L3980 | DNA Damage and Repair Compound Library Plus | 667 compounds | |
Well-chosen 667 compounds with unique structures targeting DNA damage & repair; | |||
L8600 | Ubiquitination Compound Library | 214 compounds | |
A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening; |