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Cat No. | Product Name | Synonyms | Targets |
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T10901 | Curcumin-d6 | Turmeric yellow D6,Natural Yellow 3 D6,Curcumin D6,Diferuloylmethane D6 | Others |
Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxi... | |||
T8055 | TFEB activator 1 | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,RPN77612 | Others , Autophagy |
TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease. | |||
T74279 | Curcumin monoglucuronide | ||
Curcumin monoglucuronide, a glucuronic acid conjugate and in vivo metabolite of curcumin, is utilized in the study of curcumin's metabolism and the exploration of its pharmaceutical development. It holds promise for canc... | |||
T74716 | Curcumin 5-8 | ||
Curcumin 5-8 (CUR5-8), a naturally active analog of curcumin (CUR), exhibits potent oral activity. It effectively inhibits lipid droplet formation, enhances autophagy, and reduces apoptosis. Additionally, Curcumin 5-8 ha... | |||
T78519 | Curcumin-β-D-glucuronide | Others | |
Curcumin-β-D-glucuronide, a principal metabolite detected in hepatic tissue and portal blood following oral consumption of Curcumin, is utilized in colon cancer research [1] [2]. | |||
T83881 | 4-(3,4-Difluorobenzo)curcumin | CDF | |
4-(3,4-Difluorobenzo)curcumin (CDF) is a semisynthetic coumarin noted for its antiparasitic and anticancer properties. It effectively reduces the population of Vero cells infected by T. gondii promastigotes and amastigot... | |||
T40423 | L48H37 | ||
L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interactio... | |||
T19853 | Dimethoxycurcumin | Veratrylcurcuminoid | Others |
Dimethoxycurcumin (Veratrylcurcuminoid) is an analog of curcumin with more metabolical stability. Dimethoxycurcumin induces epigenetic changes in leukemia cells and the expression of promoter methylated genes. | |||
T13135 | Tetrahydrocurcumin D6 | HZIV 81-2 D6 | Others |
Tetrahydrocurcumin D6 is a deuterium labeled Tetrahydrocurcumin. Tetrahydrocurcumin displays inhibitory activity for CYP2C9 and CYP3A4. | |||
T6537 | HO-3867 | HO3867 | Apoptosis , STAT |
HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor. | |||
T7374 | 2-HBA | Caspase , NADPH | |
2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. | |||
T1993 | J-147 | J147 | Epigenetic Reader Domain , Dopamine Receptor , Monoamine Oxidase |
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate... | |||
T50107 | Ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate | Others | |
ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate is a synthetic compound belonging to the curcumin family. It is involved in the regulation of immune response and inflammation through ... | |||
T20303 | Dibenzalacetone | AI3-00896,AI3 00896,AI300896 | |
Dibenzylideneacetone is a synthetic curcumin analog. It leads to apoptotic cell death in Leishmania donovani. | |||
T71208 | GO-Y078 | ||
GO-Y078 is an antiangiogenic curcumin analog which inhibits actin stress fiber formation, thereby resulting in mobility inhibition. | |||
T38307 | Tetranor-PGJM | ||
Tetranor-PGJM is a metabolite of prostaglandin D2 and is associated with the anti-inflammatory effects of curcumin. | |||
T81177 | Ser@TPP@CUR | ||
Ser nM TPP nM CUR, a derivative of Curcumin, notably mitigates damage in renal tubular epithelial cells and enhances renal function in mice with acute kidney injury (AKI). This compound holds potential for AKI research a... | |||
T37148 | TML-6 | ||
TML-6, an oral curcumin derivative, demonstrates inhibitory effects on the synthesis of β-amyloid precursor protein and β-amyloid (Aβ). Additionally, TML-6 exhibits upregulation of Apo E, suppression of NF-κB and mTOR, a... | |||
T61181 | Pentagamavunon-1 | ||
Pentagamavunon-1 (PGV-1) is an oral Curcumin analog that effectively induces apoptosis through multiple molecular mechanisms. It primarily targets and inhibits key angiogenic factors, including cyclooxygenase-2 (COX-2) a... | |||
T78158 | MitoCur-1 | Others | |
MitoCur-1, a curcumin analogue, acts as an inhibitor of mitochondrial antioxidative enzyme thioredoxin reductase 2 (TrxR2), possessing electrophilic characteristics with mitochondrial-targeting capabilities. This compoun... | |||
T36015 | PDMP (hydrochloride) | ||
PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase. PDMP has two adjacent chiral centers (C1 and C2) allowing for the formation of four possible isomers. PDMP contains all fo... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1516 | Curcumin | Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow | Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy |
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant... | |||
T6S1688 | (1E,6E)-Bis(demethoxy)curcumin | Curcumin III,Didemethoxycurcumin,BDMC | Apoptosis , Others , Autophagy |
(1E,6E)-Bis(demethoxy)curcumin (Curcumin III) is a natural demethoxy derivative of curcumin,with anti-inflammatory and anti-cancer activities. | |||
TL0007 | Bisdemethoxycurcumin | Curcumin III,Didemethoxycurcumin | Epigenetic Reader Domain , Wnt/beta-catenin |
Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by mac... | |||
T6S1683 | Demethoxycurcumin | Curcumin II,Desmethoxycurcumin,Monodemethoxycurcumin | Apoptosis , Antioxidant , Antibacterial , Autophagy |
1. Demethoxycurcumin (Desmethoxycurcumin) has antioxidant activity. 2. Demethoxycurcumin has anti-inflammatory activity. 3. Demethoxycurcumin has anti-proliferative activity. 4. Demethoxycurcumin has anti-acanthamoebic e... | |||
T3735 | Tetrahydrocurcumin | Sabiwhite,Tetrahydrodiferuloylmethane,HZIV 81-2,Tetrahydro Curcumin | P450 , Endogenous Metabolite , Autophagy |
Tetrahydrocurcumin (HZIV 81-2), a major metabolite of curcumin, has strong antioxidant and cardioprotective properties. | |||
TN2269 | Tetramethylcurcumin | Apoptosis , STAT | |
Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also inhibits colony formation in soft agar, cell invasion, and e... | |||
T3S1701 | Dihydrocurcumin | PPAR , Fatty Acid Synthase | |
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, incr... | |||
TQ0214 | Dimethylcurcumin | ASC-J9,GO-Y025 | Androgen Receptor |
Dimethylcurcumin (ASC-J9) (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion. | |||
TQ0288 | Hexahydrocurcumin | Reactive Oxygen Species , ROS , COX | |
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1. | |||
T3S1692 | Octahydrocurcumin | Anti-infection , NF-κB , Reactive Oxygen Species , ROS | |
Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechanism of inhibiting NF-kB translocation to the nucleus. Octahy... | |||
T4803 | (E/Z)-Demethoxycurcumin | Others | |
Demethoxycurcumin is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. | |||
T11034 | Di-O-methyldemethoxycurcumin | IL Receptor | |
Di-O-methyldemethoxycurcumin is a Curcumin analog isolated from medicinal plant turmeric di-orthomethyldemethoxycurcumin, anti-inflammatory and antioxidant properties Inhibition of IL-6 production, EC50 is 16.20μg/mL. | |||
TN3741 | Cyclocurcumin | TNF , ROS | |
Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method. It m... | |||
TN5760 | 3''-Demethylhexahydrocurcumin | 5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(3,4-dihydroxyphenyl)heptan-3-one | |
3''-Demethylhexahydrocurcumin is a natural product for research related to life sciences. The catalog number is TN5760 and the CAS number is 881008-71-5. | |||
TN5656 | 5"-Methoxyhexahydrocurcumin | ||
5"-Methoxyhexahydrocurcumin is a natural product for research related to life sciences. The catalog number is TN5656 and the CAS number is 138870-96-9. | |||
T82640 | Cyclobisdemethoxycurcumin | ||
Cyclobisdemethoxycurcumin exhibits antioxidant properties, demonstrated by its half maximal inhibitory concentrations (IC50s) of approximately 250 μM in the DPPH radical scavenging assay and 15-20 μM in the 2-DR oxidatio... | |||
T38499 | κ-Carrageenan | ||
κ-Carrageenan, a natural polymer found predominantly in red seaweeds, can serve as an effective drug carrier for delivering curcumin to cancer cells and inducing apoptosis. Additionally, κ-Carrageenan holds promise as a ... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00090 | UGT71C1 Protein, Arabidopsis thaliana, Recombinant (E. coli, His) | Arabidopsis thaliana | E. coli |
Possesses quercetin 7-O-glucosyltransferase and 3'-O-glucosyltransferase activities in vitro. Also active in vitro on benzoates and benzoate derivatives. Glucosylates other secondary metabolites in vitro like trans-resve... | |||
TMPH-00091 | UGT71C1 Protein, Arabidopsis thaliana, Recombinant (Baculovirus, His) | Arabidopsis thaliana | Yeast |
Possesses quercetin 7-O-glucosyltransferase and 3'-O-glucosyltransferase activities in vitro. Also active in vitro on benzoates and benzoate derivatives. Glucosylates other secondary metabolites in vitro like trans-resve... |
Cat No. | Product Name | ||
---|---|---|---|
L6100 | Polyphenolic Natural Product Library | 640 compounds | |
A unique collection of 640 natural polyphenolic compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L6750 | PBCRBS Traditional Chinese Medicine Compound Library | 588 compounds | |
A unique collection of 588 compounds derived from traditional Chinese medicines (TCMs) for promoting blood circulation and removing blood stasis. |