Search Result

Search Results for " cyps "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T17022	Tebuconazole		P450 , Antifungal
	Tebuconazole is an agricultural azole fungicide. It can also inhibit CYP51 (IC50s: 0.9 and 1.3 μM for Candida albicans CYP51 and truncated Homo sapiens CYP51, respectively).		P450 , Antifungal
T10953	Dafadine-A		P450
	Dafadine-A is an analog of dafadine and a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans. Mammalian orthologs that also inhibit DAF-9 (CYP27A1).		P450
T7427	1-Ethynylnaphthalene		P450
	1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 IB1		P450
T21482	Uniconazole		P450 , ROS Kinase
	Uniconazole is a plant growth regulator that inhibit cytochrome P450 707As (Ki=68 nM). CYP707As is a major ABA catabolic enzyme that catabolize Abscisic acid, accordingly suppress gibberellin and sterol biosynthesis.		P450 , ROS Kinase
T9704	1-Ethynylpyrene		P450
	1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1(IC50=0.18 μM), 1A2(IC50 = 0.32 μM), and 2B1(IC50 = 0.04 μM).		P450
T11991	Mefentrifluconazole		P450 , Antifungal
	Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). Mefentrifluconazole is a novel azole derivative and ...		P450 , Antifungal
T7410	Furafylline		P450
	Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 µM),		P450
T1650	Chlorzoxazone	Paraflex,Chlorzoxazon	P450 , Potassium Channel
	Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.		P450 , Potassium Channel
T14841	BVT948		Phosphatase , P450 , Histone Methyltransferase
	BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A).		Phosphatase , P450 , Histone Methyltransferase
T16412	Oteseconazole	VT-1161	P450 , Antifungal
	Oteseconazole (VT-1161) is an orally active anti-fungal agent. Oteseconazole displays no obvious effect on human CYP51. It also potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM).		P450 , Antifungal
T1491	Atovaquone	Atavaquone	Others , P450 , Dehydrogenase , Antibiotic , Parasite
	Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.		Others , P450 , Dehydrogenase , Antibiotic , Parasite
T6260	AMG-208	AMG 208	P450 , c-Met/HGFR
	AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.		P450 , c-Met/HGFR
T7788	2-Phenyl-2-(1-piperidinyl)propane		Others
	2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine		Others
T27617	Inz-1		P450
	Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the path...		P450
T7618	Pyributicarb	TSH-888	P450
	Pyributicarb (TSH-888) is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).		P450
T9043	AS1810722		P450 , STAT
	AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM. It exhibits effective inhibition of CYP3A4, positioning it as a promising candidate f...		P450 , STAT
T6216	Abiraterone	CB-7598	P450
	Abiraterone (CB-7598) (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50: 4 nM).		P450
T4498	Stiripentol	BCX2600,Diacomit	P450
	Stiripentol (BCX2600) (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59/0.516 μM and IC50 of 1.58/3.29 μM...		P450
T1149	Fenofibrate	Procetofen,Lipanthyl,Lipantil	P450 , PPAR , Autophagy
	Fenofibrate (Lipanthyl) is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.		P450 , PPAR , Autophagy
T3585	TMS	(E)-2,3',4,5'-tetramethoxystilbene,2,3',4,5'-Tetramethoxystilbene	P450
	TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).		P450
T4188	SDZ285428	SDZ285-428	P450 , Parasite , Antifungal
	SDZ285428 is a CYP24A1 inhibitor.		P450 , Parasite , Antifungal
T12171	Nampt-IN-5		P450 , NAMPT
	Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .		P450 , NAMPT
T2196	Fipronil	Fluocyanobenpyrazole,Termidor	P450 , GluCls , GABA Receptor
	Fipronil (Fluocyanobenpyrazole) is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gat...		P450 , GluCls , GABA Receptor
T1434	Clarithromycin	A-56268	P450 , ribosome , MRP , Antibacterial , Antibiotic , Autophagy
	Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classif...
T0922	Zoxazolamine	NSC 24995,Contrazole	Others
	Zoxazolamine (NSC-24995) is a uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood.		Others
T5953	1-Aminobenzotriazole	3-Aminobenzotriazole,ABT	P450
	1-Aminobenzotriazole (ABT) (ABT) is a non-specific cytochrome P450 (CYP) inhibitor.		P450
T21425	Mephenytoin	Mesantoin,Methoin,Insulton,Phenantoin,Methylphenetoin	P450
	Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6.		P450
T13601	CDD3506	1-TRITYL-1H-IMIDAZOL-4-AMINE	P450
	CDD3506 (1-TRITYL-1H-IMIDAZOL-4-AMINE) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A.		P450
T13600	CDD3505	4-nitro-1-trityl-1H-imidazole	P450
	CDD3505 (4-nitro-1-trityl-1H-imidazole) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A.		P450
T6215	Abiraterone Acetate	Zytiga,CB7630	P450
	Abiraterone Acetate (CB7630) is an androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic castration-resistant PROSTATE CANCER.		P450
T7370	Talarozole	R115866	Others , P450 , Retinoid Receptor , Autophagy
	Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of...		Others , P450 , Retinoid Receptor , Autophagy
T0865	Ranitidine Hydrochloride	AH19065	P450 , Antibacterial , Histamine Receptor
	Ranitidine Hydrochloride (AH19065) is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enteroc...		P450 , Antibacterial , Histamine Receptor
T14186	17-ODYA	Alkynyl Stearic Acid	Others , PROTAC Linker
	17-ODYA (Alkynyl Stearic Acid) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T0679	Ketoconazole	R-41400,Xolegel,(±)-Ketoconazol,Extina	NADPH-oxidase , P450 , Hydroxylase , Antifungal , Ras
	Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.		NADPH-oxidase , P450 , Hydroxylase , Antifungal , Ras
T2088	APD668	APD 668	GPR , P450 , Potassium Channel
	APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively.		GPR , P450 , Potassium Channel
T7699	AZD7325	AZD-7325	P450 , GABA Receptor
	AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.		P450 , GABA Receptor
T2397	Topiroxostat	FYX-051	P450 , ROS , Xanthine Oxidase
	Topiroxostat (FYX-051) is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.		P450 , ROS , Xanthine Oxidase
T9054	RO6889678		HBV
	RO6889678 is HBV inhibitor with a complex ADME profile.		HBV
T3610	Ranitidine	HSDB 3925,Ranitidin	P450 , Antibacterial , Histamine Receptor
	Ranitidine (HSDB 3925) is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.		P450 , Antibacterial , Histamine Receptor
T1290	Oxiconazole nitrate	Ro 13-8996	Others , Antibiotic , Antifection , Antifungal
	Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole...		Others , Antibiotic , Antifection , Antifungal
T6246	Cobicistat	Tybost,GS-9350	P450 , HIV Protease
	Cobicistat (GS-9350) is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which it is used in combination, for the treatment of ...		P450 , HIV Protease
T4190	Ticlopidine	PCR 5332,Ticlid	ATPase , Adiponectin receptor
	Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.		ATPase , Adiponectin receptor
T8937	Soticlestat	TAK-935,OV935	P450
	Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.		P450
T1415	Gemfibrozil	CI-719,Jezil,Decrelip,Lopid	P450 , Adrenergic Receptor , PPAR
	Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi...		P450 , Adrenergic Receptor , PPAR
T1540	Doxepin hydrochloride	Toruan,Doxepin HCl,Aponal,Novoxapin	P450 , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor
	Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it ap...
T21507	7-Ethoxyresorufin	Resorufin ethyl ether	P450 , NO Synthase
	7-Ethoxyresorufin (Resorufin ethyl ether) (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.		P450 , NO Synthase
T0765	Fomepizole	Antizol-Vet,4-Methylpyrazole,Antizol	P450 , CAT , AChR
	Fomepizole (4-Methylpyrazole) is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole(4-Methylpyrazole) is a competitive inhibitor of alcohol dehydrogenase, the enzyme that cata...		P450 , CAT , AChR
T12146	N-Desmethyl-Apalutamide	N-Desmethyl Apalutamide	P450 , Androgen Receptor
	N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.		P450 , Androgen Receptor
T19526	Pradefovir mesylate	Pradefovir mesilate,Remofovir mesylate,Hepavir B	P450
	Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM.		P450
T2305	Isavuconazole	BAL-4815,RO-0094815	P450 , Antibiotic , Antifungal
	Isavuconazole (RO-0094815)(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557 with MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabr...		P450 , Antibiotic , Antifungal

Compounds

Tebuconazole

T17022

Synonym:

Target: P450, Antifungal

Target: P450, ROS Kinase

Target: P450, Antifungal

Synonym: Paraflex,Chlorzoxazon

Target: P450, Potassium Channel

BVT948

T14841

Synonym:

Target: Phosphatase, P450, Histone Methyltransferase

Oteseconazole

T16412

Synonym: VT-1161

Target: P450, Antifungal

Atovaquone

T1491

Synonym: Atavaquone

Target: Others, P450, Dehydrogenase, Antibiotic, Parasite

AMG-208

T6260

Synonym: AMG 208

Target: P450, c-Met/HGFR

2-Phenyl-2-(1-piperidinyl)propane

Synonym: BCX2600,Diacomit

Target: P450

Fenofibrate

T1149

Synonym: Procetofen,Lipanthyl,Lipantil

Target: P450, PPAR, Autophagy

TMS

T3585

Synonym: (E)-2,3',4,5'-tetramethoxystilbene,2,3',4,5'-Tetramethoxystilbene

Target: P450, Parasite, Antifungal

Synonym: Fluocyanobenpyrazole,Termidor

Target: P450, GluCls, GABA Receptor

Clarithromycin

T1434

Synonym: A-56268

Target: P450, ribosome, MRP, Antibacterial, Antibiotic, Autophagy

Zoxazolamine

T0922

Synonym: NSC 24995,Contrazole

Target: Others

1-Aminobenzotriazole

T5953

Synonym: 3-Aminobenzotriazole,ABT

Target: P450

Mephenytoin

T21425

Synonym: Mesantoin,Methoin,Insulton,Phenantoin,Methylphenetoin

Target: P450

CDD3506

T13601

Synonym: 1-TRITYL-1H-IMIDAZOL-4-AMINE

Target: P450

CDD3505

T13600

Synonym: 4-nitro-1-trityl-1H-imidazole

Target: P450

Abiraterone Acetate

T6215

Synonym: Zytiga,CB7630

Target: Others, P450, Retinoid Receptor, Autophagy

Ranitidine Hydrochloride

T0865

Synonym: AH19065

Target: P450, Antibacterial, Histamine Receptor

17-ODYA

T14186

Synonym: Alkynyl Stearic Acid

Target: Others, PROTAC Linker

Ketoconazole

T0679

Synonym: R-41400,Xolegel,(±)-Ketoconazol,Extina

Target: NADPH-oxidase, P450, Hydroxylase, Antifungal, Ras

APD668

T2088

Synonym: APD 668

Target: GPR, P450, Potassium Channel

AZD7325

T7699

Synonym: AZD-7325

Target: P450, GABA Receptor

Topiroxostat

T2397

Synonym: FYX-051

Target: P450, ROS, Xanthine Oxidase

Synonym: HSDB 3925,Ranitidin

Target: P450, Antibacterial, Histamine Receptor

Oxiconazole nitrate

T1290

Synonym: Ro 13-8996

Target: Others, Antibiotic, Antifection, Antifungal

Cobicistat

T6246

Synonym: Tybost,GS-9350

Target: P450, HIV Protease

Ticlopidine

T4190

Synonym: PCR 5332,Ticlid

Target: ATPase, Adiponectin receptor

Soticlestat

T8937

Synonym: TAK-935,OV935

Target: P450

Gemfibrozil

T1415

Synonym: CI-719,Jezil,Decrelip,Lopid

Target: P450, Adrenergic Receptor, PPAR

Doxepin hydrochloride

T1540

Synonym: Toruan,Doxepin HCl,Aponal,Novoxapin

Target: P450, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor

7-Ethoxyresorufin

T21507

Synonym: Resorufin ethyl ether

Target: P450, NO Synthase

Fomepizole

T0765

Synonym: Antizol-Vet,4-Methylpyrazole,Antizol

Target: P450, CAT, AChR

N-Desmethyl-Apalutamide

T12146

Synonym: N-Desmethyl Apalutamide

Target: P450, Androgen Receptor

Pradefovir mesylate

T19526

Synonym: Pradefovir mesilate,Remofovir mesylate,Hepavir B

Target: P450

Isavuconazole

T2305

Synonym: BAL-4815,RO-0094815

Target: P450, Antibiotic, Antifungal

Cat No.	Product Name	Synonyms	Targets
T6S1894	Linderane		P450
	1. Linderane was characterized as a mechanism-based inactivator of CYP2C9.		P450
T3818	Fraxinol		Others , P450
	Fraxinol is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of 5, 7-dimethoxy-2h-chromen-2-one. It is generated by cyp1a2, cyp2a6, cyp2b6, cyp2c9, cyp2c19, and cyp2e1 enzymes via an...		Others , P450
T3696	Polygalaxanthone III		Others , P450
	Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.		Others , P450
T7970	7-Ethoxycoumarin		Others
	7-Ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1.		Others
T3669	Curcumenol	(+)-Curcumenol	P450
	Curcumenol ((+)-Curcumenol), one of the major components of Zedoary turmeric oil, is an antibiotic drug which has anti-Y, anti-inflammation activity. Curcumenol may be safely used without inducing metabolic drug-drug int...		P450
T5594	Cedrol		P450 , Antifungal
	Cedrol is a cedrane sesquiterpenoid and a tertiary alcohol,Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively)		P450 , Antifungal
T37784	2,6-Dimethylquinoline		P450
	2,6-Dimethylquinoline is a natural product extracted from the roots of Peucedantu praeruptorum. 2,6-Dimethylquinoline is an inhibitor of CYP1A2 and CYP2B6 with an IC50 of 3.3 and 480 µM, respectively.		P450
TN1650	Friedelin		P450 , NOS , Caspase , Prostaglandin Receptor
	Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.		P450 , NOS , Caspase , Prostaglandin Receptor
TQ0191	Dihydromethysticin	(+)-Dihydromethysticin	P450
	Dihydromethysticin ((+)-Dihydromethysticin) is a kavalactone found in Piper methysticum. It has marked activity on the induction of CYP3A23.		P450
T2854	Phillyrin	Forsythin	P450 , Influenza Virus , AMPK
	Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activ...		P450 , Influenza Virus , AMPK
T3149	Salvianolic Acid C		Others , P450
	Salvianolic Acid C is extracted from the root of Salvia miltiorrhiza, a perennial plant in the genus Salvia.		Others , P450
T8038	7-Ethoxy-4-Methylcoumarin		Others
	7-Ethoxy-4-Methylcoumarin is considered an inhibitor of enzymes in cells and has been used in studies of enzyme inhibition and has been used to study the effects of various drugs on the human body.		Others
T5778	5,7-DIMETHOXYFLAVONE		Anti-infection , P450
	5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential.		Anti-infection , P450
T0595	Naringin	Naringoside	Mitophagy , P450 , Endogenous Metabolite , Autophagy
	Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.		Mitophagy , P450 , Endogenous Metabolite , Autophagy
T2926	Schizandrin A		P450 , Virus Protease , Autophagy
	Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM and a Ki of 5.83 μM.		P450 , Virus Protease , Autophagy
TN1343	8-Geranyloxypsoralen		Anti-infection , P450 , BACE
	8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal act...		Anti-infection , P450 , BACE
T5S2343	Acetylshikonin	Acetyl shikonin	Others , P450 , AChE
	1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang...		Others , P450 , AChE
T3776	Rhapontigenin	Protigenin	P450 , Antibacterial , Antifungal
	Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. R...		P450 , Antibacterial , Antifungal
T3668	Galangin	Norizalpinin,3,5,7-Trihydroxyflavone	ERK , P450 , NF-κB , Autophagy
	Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.		ERK , P450 , NF-κB , Autophagy
T5786	TETRAHYDROPIPERINE	Cosmoperine	P450 , TRP/TRPV Channel
	Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.		P450 , TRP/TRPV Channel
T5S0669	Bergamottin	5-Geranoxypsoralen,Bergamotine,Bergaptin	P450
	1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A<sup>y</sup>diabetic mice.		P450
T2770	Gentiopicroside	Gentiopicrin	P450 , HCV Protease
	Gentiopicroside (Gentiopicrin), a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; has antianti-inflammatorya...		P450 , HCV Protease
T2143	Bergapten	5-Methoxypsoralen	P450 , Autophagy
	Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.		P450 , Autophagy
T1704	Diosmetin	Luteolin 4-methyl ether	P450 , Trk receptor
	Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist.		P450 , Trk receptor
T7938	Quinidine		Parasite
	Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria.		Parasite
T11218	ε-Viniferin	epsilon-Viniferin	P450
	ε-Viniferin (epsilon-Viniferin) a dimer of resveratrol, shows the inhibitory effects of epsilon-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, CYP3A4 and CYP4A activities.		P450
T3736	Olivetol	5-Pentylresorcinol,5-n-Amylresorcinol	Cannabinoid Receptor , P450 , IκB/IKK
	Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabinol. Olivetol has an...		Cannabinoid Receptor , P450 , IκB/IKK
T3401	Ginsenoside F1	20(S)-Ginsenoside F1	P450 , Endogenous Metabolite
	Ginsenoside F1 (20(S)-Ginsenoside F1) is an enzymatically modified derivative of ginsenoside Rg1, showing competitive inhibition of the activity of CYP3A4 and a weaker inhibition of the activity of CYP2D6.		P450 , Endogenous Metabolite
T2S1434	Bergaptol	5-Hydroxyfuranocoumarin,4-Hydroxybergapten,5-Hydroxypsoralen	P450
	1. Bergaptol (4-Hydroxybergapten) shows very good radical scavenging activity. 2. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.		P450
TN1078	Seneciphylline		P450 , GST
	Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutat...		P450 , GST
T3797	Isosilybin	Isosilybinin,Isosilibinin,Silymarin,Silybin B,Q-100795	P450
	Isosilybin (Isosilibinin) and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patients.		P450
T2840	Phloracetophenone	2,4,6-trihydroxyacetophenone,1-(2,4,6-Trihydroxyphenyl)ethanone	Others , P450 , Antibacterial , Antibiotic
	Phloracetophenone (1-(2,4,6-Trihydroxyphenyl)ethanone) has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.		Others , P450 , Antibacterial , Antibiotic
TJS1159	Chrysosplenetin	Chrysosptertin B	P450 , Ferroptosis , P-gp
	Chrysosplenetin is a metabolic inhibitor of artemisinin.		P450 , Ferroptosis , P-gp
T8079	α-Terpinyl acetate	Terpinyl Acetate	Others , P450
	α-Terpinyl acetate is a natural compound found in several essential oils, is a flavouring agent.		Others , P450
T3735	Tetrahydrocurcumin	Sabiwhite,Tetrahydrodiferuloylmethane,HZIV 81-2,Tetrahydro Curcumin	P450 , Endogenous Metabolite , Autophagy
	Tetrahydrocurcumin (HZIV 81-2), a major metabolite of curcumin, has strong antioxidant and cardioprotective properties.		P450 , Endogenous Metabolite , Autophagy
T1011	Itraconazole	R51211	P450 , Hedgehog/Smoothened , Antibiotic , Autophagy , Antifungal
	Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
TN6848	Piperonylic acid	2H-1,3-benzodioxole-5-carboxylic acid	P450
	Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic acid selectively inactivate the CYP73...		P450
T7132	(Rac)-Brassinazole	BRASSINAZOLE	P450
	(Rac)-Brassinazole are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell division. Brassinazole is a triazole-type brassinosteroid biosynth...		P450
T3811	Ginsenoside C-K	Ginsenoside compound K,Ginsenoside K	P450 , cell cycle arrest , COX , NO Synthase
	Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.		P450 , cell cycle arrest , COX , NO Synthase
T2878	Ginsenoside Rd	Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII	P450 , Calcium Channel , NF-κB , COX , Endogenous Metabolite
	Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
T7056	Dronedarone	SR 33589	P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy
	Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T6S0923	Hypericin	Hypericine,Cyclosan	Apoptosis , Antiviral , Influenza Virus , Tyrosine Kinases , Antibacterial , PKC
	1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL...
T2175	Apigenin	C.I. Natural Yellow 1,4',5,7-Trihydroxyflavone,NSC 83244,Apigenol,LY 080400	P450 , Autophagy
	Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothing qualities as a sedative, mild analgesic and sle...		P450 , Autophagy
T5582	β-Apo-8'-carotenal	trans-β-apo-8'-carotenal,Apocarotenal	Others , P450
	β-Apo-8'-carotenal (Apocarotenal) is a carotenoid found in spinach and citrus fruits. Apocarotenal is used in fat-based food (margarine, sauces, salad dressing), beverages, dairy products, and sweets.		Others , P450
T8125	Quinidine sulfate dihydrate	Chinidin Sodium,β-quinine Sodium,Pitayine Sodium,Quinidine sulfate	P450
	Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor		P450
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
TN1023	Miltirone		P450 , GABA Receptor
	Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.		P450 , GABA Receptor
TN5278	Zederone		NADPH-oxidase , P450 , TNF , Nrf2 , Antifection
	Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that...		NADPH-oxidase , P450 , TNF , Nrf2 , Antifection
TN6524	Irilone
	Irilone has immunomodulatory, and α-amylase inhibitory activities, it exhibits the selective inhibition toward CYP3 A4 rather than other major human CYPs. Irilone exhibited prominent antioxidant activities with the IC50 ...

Natural Products

Synonym: (+)-Curcumenol

Target: P450, Antifungal

2,6-Dimethylquinoline

Target: P450, NOS, Caspase, Prostaglandin Receptor

Dihydromethysticin

TQ0191

Synonym: (+)-Dihydromethysticin

Target: P450, Influenza Virus, AMPK

7-Ethoxy-4-Methylcoumarin

Target: Anti-infection, P450

Naringin

T0595

Synonym: Naringoside

Target: Mitophagy, P450, Endogenous Metabolite, Autophagy

Schizandrin A

T2926

Synonym:

Target: P450, Virus Protease, Autophagy

8-Geranyloxypsoralen

TN1343

Synonym:

Target: Anti-infection, P450, BACE

Acetylshikonin

T5S2343

Synonym: Acetyl shikonin

Target: Others, P450, AChE

Rhapontigenin

T3776

Synonym: Protigenin

Target: P450, Antibacterial, Antifungal

Galangin

T3668

Synonym: Norizalpinin,3,5,7-Trihydroxyflavone

Target: ERK, P450, NF-κB, Autophagy

TETRAHYDROPIPERINE

T5786

Synonym: Cosmoperine

Target: P450, TRP/TRPV Channel

Bergamottin

T5S0669

Synonym: 5-Geranoxypsoralen,Bergamotine,Bergaptin

Target: P450

Gentiopicroside

T2770

Synonym: Gentiopicrin

Target: P450, HCV Protease

Bergapten

T2143

Synonym: 5-Methoxypsoralen

Target: P450, Autophagy

Diosmetin

T1704

Synonym: Luteolin 4-methyl ether

Target: P450, Trk receptor

Synonym: epsilon-Viniferin

Target: P450

Olivetol

T3736

Synonym: 5-Pentylresorcinol,5-n-Amylresorcinol

Target: Cannabinoid Receptor, P450, IκB/IKK

Ginsenoside F1

T3401

Synonym: 20(S)-Ginsenoside F1

Target: P450, Endogenous Metabolite

Bergaptol

T2S1434

Synonym: 5-Hydroxyfuranocoumarin,4-Hydroxybergapten,5-Hydroxypsoralen

Synonym: Isosilybinin,Isosilibinin,Silymarin,Silybin B,Q-100795

Target: P450

Phloracetophenone

T2840

Synonym: 2,4,6-trihydroxyacetophenone,1-(2,4,6-Trihydroxyphenyl)ethanone

Target: Others, P450, Antibacterial, Antibiotic

Chrysosplenetin

TJS1159

Synonym: Chrysosptertin B

Target: P450, Ferroptosis, P-gp

α-Terpinyl acetate

T8079

Synonym: Terpinyl Acetate

Target: Others, P450

Tetrahydrocurcumin

T3735

Synonym: Sabiwhite,Tetrahydrodiferuloylmethane,HZIV 81-2,Tetrahydro Curcumin

Target: P450, Endogenous Metabolite, Autophagy

Itraconazole

T1011

Synonym: R51211

Target: P450, Hedgehog/Smoothened, Antibiotic, Autophagy, Antifungal

Piperonylic acid

TN6848

Synonym: 2H-1,3-benzodioxole-5-carboxylic acid

Target: P450

(Rac)-Brassinazole

T7132

Synonym: BRASSINAZOLE

Target: P450

Ginsenoside C-K

T3811

Synonym: Ginsenoside compound K,Ginsenoside K

Target: P450, cell cycle arrest, COX, NO Synthase

Ginsenoside Rd

T2878

Synonym: Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII

Target: P450, Calcium Channel, NF-κB, COX, Endogenous Metabolite

Dronedarone

T7056

Synonym: SR 33589

Target: P450, Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, AChR, Autophagy

Hypericin

T6S0923

Synonym: Hypericine,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Apigenin

T2175

Synonym: C.I. Natural Yellow 1,4',5,7-Trihydroxyflavone,NSC 83244,Apigenol,LY 080400

Target: P450, Autophagy

β-Apo-8'-carotenal

T5582

Synonym: trans-β-apo-8'-carotenal,Apocarotenal

Target: Others, P450

Quinidine sulfate dihydrate

T8125

Synonym: Chinidin Sodium,β-quinine Sodium,Pitayine Sodium,Quinidine sulfate

Target: P450

Schisandrol B

T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Miltirone

TN1023

Synonym:

Target: P450, GABA Receptor

Zederone

TN5278

Synonym:

Target: NADPH-oxidase, P450, TNF, Nrf2, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00048	CYPA Protein, Mouse, Recombinant	Mouse	E. coli
	Peptidyl-prolyl cis-trans isomerase A is a cytoplasm protein which belongs to the cyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins(CyPs) are a family of proteins found in organisms ranging from prokary...
TMPY-01593	Cyclophilin A Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Peptidyl-prolyl cis-trans isomerase A, also known as PPIase A, Rotamase A, Cyclophilin A, Cyclosporin A-binding protein, PPIA and CYPA, is a cytoplasm protein that belongs to the cyclophilin-type PPIase family and PPIase...
TMPY-02177	Cyclophilin A Protein, Human, Recombinant (His)	Human	E. coli
	Peptidyl-prolyl cis-trans isomerase A, also known as PPIase A, Rotamase A, Cyclophilin A, Cyclosporin A-binding protein, PPIA and CYPA, is a cytoplasm protein that belongs to the cyclophilin-type PPIase family and PPIase...

CYPA Protein, Mouse, Recombinant

TMPJ-00048

Species: Mouse

Expression System: E. coli

Cyclophilin A Protein, Mouse, Recombinant (His)

TMPY-01593

Species: Mouse

Expression System: E. coli

Cyclophilin A Protein, Human, Recombinant (His)

TMPY-02177

Species: Human

Expression System: E. coli