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Cat No. | Product Name | Synonyms | Targets |
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T6972 | RS-1 | DNA/RNA Synthesis | |
RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies. | |||
T6872 | L755507 | Adrenergic Receptor , CRISPR/Cas9 | |
L755507 is an effective, selective agonist of β3-AR(IC50=35 nM). | |||
T2802 | Nocodazole | R17934,Oncodazole | Apoptosis , Microtubule Associated , Bcr-Abl , Autophagy , CRISPR/Cas9 |
Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis. | |||
T6276 | KU-57788 | NU7441 | DNA-PK , CRISPR/Cas9 |
NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM). | |||
T1724 | SCR7 pyrazine | SCR7 | Apoptosis , DNA/RNA Synthesis , CRISPR/Cas9 |
SCR7 pyrazine (SCR7) enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ). | |||
T1416 | Zidovudine | Azidothymidine,NSC 602670,ZDV,AZT | HIV Protease , Reverse Transcriptase , Telomerase , CRISPR/Cas9 |
Zidovudine (ZDV) is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This age... | |||
T4420 | 4-Hydroxytamoxifen | ICI 79280,(Z)-4-hydroxy Tamoxifen,trans-4-Hydroxytamoxifen | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer rese... | |||
T3340 | SCR7 | Apoptosis , DNA/RNA Synthesis , CRISPR/Cas9 | |
SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ). | |||
T74639 | TT3 | ||
TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery [1] [2] . | |||
T60520 | Cas9-IN-3 | ||
Cas9-IN-3 is a potent inhibitor of Cas9 with IC50 of 28 μM. CRISPR/Cas systems have revolutionized gene editing in several species [1]. | |||
T81513 | Peptide A5K acetate | ||
Peptide A5K acetate, an INF7-TAT derivative, facilitates CRISPR RNP delivery to T cells and effectively enhances Cas9 RNP transport to natural killer (NK) cells [1]. | |||
T39810 | CEM114 | ||
CEM114 is a potent chemical compound known as a chemical epigenetic modifier (CEM). It functions by employing CRISPR-Cas9 systems to harness endogenous chromatin machinery, thereby exerting its epigenetic modifying effec... | |||
T74449 | N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide | ||
N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3 . TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery [1] [2] . |
Cat No. | Product Name | Synonyms | Targets |
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T6062 | Brefeldin A | BFA,Ascotoxin,Cyanein,Decumbin | ATPase , Mitophagy , Antibiotic , Autophagy , HSV , CRISPR/Cas9 |
Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activ... |
Cat No. | Product Name | Species | Expression System |
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TMPY-05346 | CRISPR-Cas9 Protein, Streptococcus pyogenes, Recombinant (His) | Streptococcus pyogenes | Baculovirus-Insect Cells |