Search Result

Search Results for " cftr "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T2355	CFTR(inh)-172	CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172	CFTR , Autophagy
	CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.		CFTR , Autophagy
T10776	CFTR corrector 4		CFTR
	CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface a...		CFTR
T5312	CFTR corrector 2	FDL169	CFTR , Autophagy
	CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.		CFTR , Autophagy
T63806	CFTR corrector 8		CFTR
	CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic...		CFTR
T60653	CFTR corrector 9		CFTR
	CFTR Corrector 9, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, is employed in the research of cystic fibrosis (CF) and related CFTR-associated disorders [1].		CFTR
T1874	PPQ-102	PPQ102,CFTR Inhibitor,PPQ 102	CFTR , Autophagy
	PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).		CFTR , Autophagy
T37686	CFTR corrector 6
	CFTR corrector 6 is a highly effective CFTR potentiator utilized in research on cystic fibrosis (CF) and related CFTR-associated disorders[1]. This potent compound exhibits potentiation activity on the Cystic Fibrosis Tr...
T79578	CFTR corrector 12		CFTR
	CFTR Corrector 12 (Compound 17C), a bithiazole derivative, functions as a CFTR corrector by remedying certain folding-defective mutants of the channel that regulates chloride transport across the plasma membrane. Additio...		CFTR
T2451	GlyH-101	GlyH 101	CFTR , Autophagy
	GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.		CFTR , Autophagy
T3135	KM11060		CFTR , Autophagy
	KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane.		CFTR , Autophagy
T1805	Ataluren	PTC124	CFTR , Autophagy
	Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and olde...		CFTR , Autophagy
T9499	Icenticaftor	QBW251	CFTR
	Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.		CFTR
T14935	Elexacaftor	VX-445	CFTR , Autophagy
	Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.		CFTR , Autophagy
T16681	Nesolicaftor	PTI-428	CFTR , Autophagy
	Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.		CFTR , Autophagy
T2588	Ivacaftor	Ivacaftor (VX-770),VX-770	CFTR , Autophagy
	Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.		CFTR , Autophagy
T10591	BPO-27 racemate	BPO-27 (racemate)	CFTR , Autophagy
	BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.		CFTR , Autophagy
T2486	IOWH-032	IOWH032,IOWH 032	CFTR , Autophagy
	IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.		CFTR , Autophagy
T7083	GLPG1837	ABBV-974	CFTR , Autophagy
	GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.		CFTR , Autophagy
T2595	Lumacaftor	VX-809,VRT 826809	CFTR , Autophagy
	Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).		CFTR , Autophagy
T1634	Glibenclamide	Glyburide	Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
	Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T2263	Tezacaftor	VX661	CFTR , Autophagy
	Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.		CFTR , Autophagy
T16516	PG01	Phenylglycine-01	CFTR
	PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.PG01 increases ΔF508...		CFTR
T10591L	(R)-BPO-27		CFTR , Autophagy
	(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.		CFTR , Autophagy
T30293	Bamocaftor	VX-659	CFTR
	Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function. Combined use of tezacaftor and VX-561 for the treatment of c...		CFTR
T20341	DNDS		CFTR
	DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).		CFTR
T29041	UCCF-853	UCCF853,UCCF 853	CFTR
	UCCF-853 is a small-molecule CFTR modulator that can be used to study cystic fibrosis.		CFTR
T26955	Cavosonstat	N91115,N 91115,N-91115	GSNOR , CFTR
	Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor that promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stabilization.Cavosonstat ...		GSNOR , CFTR
T31014	Corrector C4	Corr 4a,Corrector C-4,Corr4a,Corrector C 4,Corr-4a	Others
	Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and protein homeostasis.		Others
T29114	VRT-532	CFpot-532,CFpot-532)	CFTR
	VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Arylsulfatase B (ARSB), which is necessary to reduce the accumulation of sulphate glyc...		CFTR
T77604	WAY-326766		CFTR
	WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).		CFTR
T36519	Posenacaftor sodium
	Posenacaftor (PTI-801) sodium, a cystic fibrosis transmembrane regulator (CFTR) modulator, corrects CFTR protein folding and trafficking. It is utilized in researching cystic fibrosis (CF)[1].
T39596	Dirocaftor	PTI-808
	Dirocaftor (PTI-808) is a CFTR potentiator that augments CFTR protein function via the activation of chloride channels. Dirocaftor holds potential utility for research pertaining to cystic fibrosis (CF).
T78240	(R)-Elexacaftor	(R)-VX-445	CFTR
	(R)-Elexacaftor, an enantiomer of Elexacaftor, functions as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It exhibits an EC50 of 0.29 µM for the CFTR dF508 mutation [1].		CFTR
T62630	Posenacaftor
	Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulatory protein (CFTR) regulator. Posenacaftor corrects the folding and transport of CFTR proteins and can be used to study cystic fibrosis (CF).
T25898	Olacaftor	VX 440,VX-440,VX440
	Olacaftor, also known as VX-440, is a protein modulator of cystic fibrosis transmembrane regulator (CFTR).
T13705	GLPG2451		Cysteine Protease
	GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1 nM).		Cysteine Protease
T35925	(R)-Posenacaftor sodium
	(R)-Posenacaftor ((R)-PTI-801) sodium, the R enantiomer of Posenacaftor, is a cystic fibrosis transmembrane regulator (CFTR) protein modulator. It corrects the folding and trafficking of the CFTR protein, and is utilized...
T40386	CP-628006
	CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.
T29040	UCCF-029	UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029
	UCCF-029 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR).
T74417	Vanzacaftor
	Vanzacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator researched for cystic fibrosis treatment.
T13742L	Ivacaftor hydrate	VX-770 hydrate	Others
	Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment.		Others
T22252	Galicaftor		Others
	ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF).		Others
T13742	Ivacaftor benzenesulfonate	VX-770 benzenesulfonate	Others
	Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator.		Others
T19788	Piretanide	Eurelix,Tauliz,Arelix
	Piretanide is a time- and voltage-dependent blocker of CFTR Cl(-) currents. Piretanide also acts as a loop diuretic.
T27098	Ivacaftor-D9	deutivacaftor,CTP-656
	CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.
T73827	NJH-2-057
	NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR .
T72860	(R)-Olacaftor	(R)-VX-440
	(R)-Olacaftor ((R)-VX-440), a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulator, shows promising potential in cystic fibrosis (CF) research.
T39633	Navocaftor	GLPG 3067,ABBV-3067
	Navocaftor, as a cystic fibrosis transmembrane regulator ( CFTR ), is a protein modulator (US 20200377491 Al, example 1).
T61702	SRI-37240
	SRI-37240 is a powerful inhibitor of premature termination codons (PTCs). It effectively suppresses CFTR nonsense mutations and induces changes in cellular translation termination at PTCs in HEK293T cells. Additionally, ...
T70232	3,4-Dephostatin
	3,4-Dephostatin is an inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain.

Compounds

CFTR(inh)-172

T2355

Synonym: CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172

Target: CFTR, Autophagy

Target: CFTR, Autophagy

Synonym: PPQ102,CFTR Inhibitor,PPQ 102

Target: CFTR, Autophagy

Target: CFTR, Autophagy

KM11060

T3135

Synonym:

Target: CFTR, Autophagy

Ataluren

T1805

Synonym: PTC124

Target: CFTR, Autophagy

Target: CFTR, Autophagy

Nesolicaftor

T16681

Synonym: PTI-428

Target: CFTR, Autophagy

Ivacaftor

T2588

Synonym: Ivacaftor (VX-770),VX-770

Target: CFTR, Autophagy

BPO-27 racemate

T10591

Synonym: BPO-27 (racemate)

Target: CFTR, Autophagy

IOWH-032

T2486

Synonym: IOWH032,IOWH 032

Target: CFTR, Autophagy

GLPG1837

T7083

Synonym: ABBV-974

Target: CFTR, Autophagy

Lumacaftor

T2595

Synonym: VX-809,VRT 826809

Target: CFTR, Autophagy

Glibenclamide

T1634

Synonym: Glyburide

Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy

Tezacaftor

T2263

Synonym: VX661

Target: CFTR, Autophagy

PG01

T16516

Synonym: Phenylglycine-01

Target: CFTR, Autophagy

Synonym: UCCF853,UCCF 853

Target: CFTR

Cavosonstat

T26955

Synonym: N91115,N 91115,N-91115

Target: GSNOR, CFTR

Corrector C4

T31014

Synonym: Corr 4a,Corrector C-4,Corr4a,Corrector C 4,Corr-4a

Target: Others

VRT-532

T29114

Synonym: CFpot-532,CFpot-532)

Synonym: VX 440,VX-440,VX440

Target: Cysteine Protease

(R)-Posenacaftor sodium

Synonym: UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029

Synonym: VX-770 hydrate

Ivacaftor benzenesulfonate

T13742

Synonym: VX-770 benzenesulfonate

Target: Others

Piretanide

T19788

Synonym: Eurelix,Tauliz,Arelix

Target:

Ivacaftor-D9

T27098

Synonym: deutivacaftor,CTP-656

Synonym: GLPG 3067,ABBV-3067

Cat No.	Product Name	Synonyms	Targets
T2S1837	Steviol	NSC 226902,Hydroxydehydrostevic acid	Others
	1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif...		Others
TN1834	Kobusin		Others , NOS , NF-κB
	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and ...		Others , NOS , NF-κB

Natural Products

Steviol

T2S1837

Synonym: NSC 226902,Hydroxydehydrostevic acid

Target: Others, NOS, NF-κB

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03629	Syntaxin 8 Protein, Human, Recombinant (His)	Human	HEK293
	STX8, also known as syntaxin 8, directly interacts with HECTd3. STX8 forms the SNARE complex with syntaxin 7, vti1b and endobrevin. STX8 belongs to the syntaxin family. Members of this family are key molecules implicated...
TMPH-01578	KRT18 Protein, Human, Recombinant (His)	Human	HEK293
	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT...
TMPH-01577	KRT18 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT...
TMPY-03986	PIST Protein, Human, Recombinant (His)	Human	E. coli
	GOPC, also known as PIST, interacts specifically with TC1 (a Rho-family small GTPase)] as a binding partner for Rhotekin. Rhotekin associates with PIST in vitro and both polarized and non-polarized MDCK (Madin-Darby cani...
TMPH-01260	AMFR Protein, Human, Recombinant (hFc)	Human	HEK293
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01259	AMFR Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-02478	PRKAA1 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus
	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
TMPH-02479	PRKAA1 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...