cd246 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3079	GSK1838705A		IGF-1R , JNK , S6 Kinase , ALK
	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases.		IGF-1R , JNK , S6 Kinase , ALK
T11254	F-1		ROS , ALK , ROS Kinase
	F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathwa...		ROS , ALK , ROS Kinase
T15612	JH-VIII-157-02		Microtubule Associated , ALK
	JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L...		Microtubule Associated , ALK
T1962	ASP3026	ASP 3026	Apoptosis , ALK
	ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS.		Apoptosis , ALK
T2612	CEP-28122		ALK
	CEP-28122 is a highly potent and selective orally active ALK inhibitor.		ALK
T16153	MS4078		ALK , Ligand for E3 Ligase
	MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.		ALK , Ligand for E3 Ligase
T4257	Belizatinib	TSR-011	Trk receptor , ALK
	Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.		Trk receptor , ALK
T3621	Brigatinib	AP-26113	EGFR , FLT , ROS , IGF-1R , ALK
	Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.		EGFR , FLT , ROS , IGF-1R , ALK
T4015	HG-14-10-04		ALK
	HG-14-10-04 is a potent and specific ALK inhibitor.		ALK
T1791	Ceritinib	LDK378	Serine Protease , IGF-1R , ALK
	Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).		Serine Protease , IGF-1R , ALK
T3059	ALK-IN-1	AP26113,Brigatinib,AP26113-analog	EGFR , IGF-1R , ALK
	ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.		EGFR , IGF-1R , ALK
T6409	ALK kinase inhibitor-1	SAR348830	Others
	SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.		Others
T13416	ZX-29		ALK
	ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect.		ALK
T1661	Crizotinib	PF-02341066	c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
	Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.		c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
T4071	Repotrectinib	TPX-0005,TPX 0005,TPX0005	Trk receptor , ROS , Src , ALK , ROS Kinase
	Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.		Trk receptor , ROS , Src , ALK , ROS Kinase
T3550	X-376	Ensartinib,X-396	c-Met/HGFR , ALK
	X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inh...		c-Met/HGFR , ALK
T2655	CEP-37440	CEP37440	FAK , ALK
	CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).		FAK , ALK
T2641	KRCA-0008	KRCA 0008,KRCA0008	ACK , ALK
	KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.		ACK , ALK
T16708	R-268712		ALK , TGF-beta/Smad
	R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor.		ALK , TGF-beta/Smad
T3041	ALK inhibitor 2		FAK , ALK
	ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.		FAK , ALK
T1967	AZD-3463	ALK/IGF1R inhibitor	Apoptosis , IGF-1R , ALK , Autophagy
	AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.		Apoptosis , IGF-1R , ALK , Autophagy
T10285	ALK inhibitor 1		FAK , IGF-1R , ALK
	ALK inhibitor 1 is a selective ALK kinase inhibitor.		FAK , IGF-1R , ALK
T8399	Crizotinib hydrochloride	PF-02341066 hydrochloride	c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
	Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)		c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
T22324	Ensartinib hydrochloride	Ensartinib dihydrochloride,X-396 dihydrochloride	Others , Trk receptor , c-Met/HGFR , ALK
	Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both...		Others , Trk receptor , c-Met/HGFR , ALK
T1791L	Ceritinib dihydrochloride	LDK378 dihydrochloride	IGF-1R , ALK
	Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, InsR, and STK22D (IC50 values of 8, 7...		IGF-1R , ALK
T3678	Entrectinib	RXDX-101,NMS-E628	Trk receptor , ROS , ALK , Autophagy , ROS Kinase
	Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectini...		Trk receptor , ROS , ALK , Autophagy , ROS Kinase
T3061	Lorlatinib	PF-6463922,PF-06463922,Loratinib	Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
	Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.		Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
T1936	Alectinib	RG-7853,AF802,CH5424802,AF-802	VEGFR , Tyrosine Kinases , ALK
	Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.		VEGFR , Tyrosine Kinases , ALK
T8387	Alectinib hydrochloride	CH5424802 (Hydrochloride),AF-802 (Hydrochloride),RO5424802 (Hydrochloride)	ALK
	Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)		ALK

Compounds

GSK1838705A

T3079

Synonym:

Target: IGF-1R, JNK, S6 Kinase, ALK

F-1

T11254

Synonym:

Target: ROS, ALK, ROS Kinase

JH-VIII-157-02

T15612

Synonym:

Target: Microtubule Associated, ALK

ASP3026

T1962

Synonym: ASP 3026

Target: Apoptosis, ALK

Target: ALK, Ligand for E3 Ligase

Belizatinib

T4257

Synonym: TSR-011

Target: Trk receptor, ALK

Brigatinib

T3621

Synonym: AP-26113

Target: EGFR, FLT, ROS, IGF-1R, ALK

Target: Serine Protease, IGF-1R, ALK

ALK-IN-1

T3059

Synonym: AP26113,Brigatinib,AP26113-analog

Target: EGFR, IGF-1R, ALK

ALK kinase inhibitor-1

Target: c-Met/HGFR, ROS, ALK, Autophagy, ROS Kinase

Repotrectinib

T4071

Synonym: TPX-0005,TPX 0005,TPX0005

Target: Trk receptor, ROS, Src, ALK, ROS Kinase

X-376

T3550

Synonym: Ensartinib,X-396

Target: c-Met/HGFR, ALK

Synonym: KRCA 0008,KRCA0008

Target: ALK, TGF-beta/Smad

Synonym: ALK/IGF1R inhibitor

Target: Apoptosis, IGF-1R, ALK, Autophagy

ALK inhibitor 1

T10285

Synonym:

Target: FAK, IGF-1R, ALK

Crizotinib hydrochloride

T8399

Synonym: PF-02341066 hydrochloride

Target: c-Met/HGFR, ROS, ALK, Autophagy, ROS Kinase

Ensartinib hydrochloride

T22324

Synonym: Ensartinib dihydrochloride,X-396 dihydrochloride

Target: Others, Trk receptor, c-Met/HGFR, ALK

Ceritinib dihydrochloride

T1791L

Synonym: LDK378 dihydrochloride

Target: IGF-1R, ALK

Entrectinib

T3678

Synonym: RXDX-101,NMS-E628

Target: Trk receptor, ROS, ALK, Autophagy, ROS Kinase

Lorlatinib

T3061

Synonym: PF-6463922,PF-06463922,Loratinib

Target: Apoptosis, Tyrosine Kinases, ROS, ALK, ROS Kinase

Alectinib

T1936

Synonym: RG-7853,AF802,CH5424802,AF-802

Target: VEGFR, Tyrosine Kinases, ALK

Alectinib hydrochloride

T8387

Synonym: CH5424802 (Hydrochloride),AF-802 (Hydrochloride),RO5424802 (Hydrochloride)

Target: ALK

Cat No.	Product Name	Synonyms	Targets
T8152	6-Demethoxytangeretin		MAPK , ALK
	6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.		MAPK , ALK

Cat No.	Product Name	Species	Expression System
TMPK-00927	ALK Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in...

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Targets

Compounds

Natural Products

Recombinant Proteins

Compounds

Natural Products

Recombinant Proteins