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Search Results for " btk "

Targets

171

Compounds

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T9706 BTK inhibitor 17 BTK
BTK inhibitor 17 is a potent irreversible BTK inhibitor (IC50 = 2.1 nM). BTK inhibitor 17 can be used in rheumatoid arthritis studies.
T10629 Btk inhibitor 2 BGB-3111 analog BTK
Btk inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.
T35330 BTK inhibitor 1 BTK
BTK inhibitor 1 (Compound 27) is a BTK inhibitor (IC50: 0.11 nM) with an inhibitory effect on B-cell activation in hWB with an IC50 of 2 nM.
TQ0230 BTK IN-1 SNS062 analog BTK
BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).
T60542 BTK-IN-16 BTK
BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.
T40185 BTK inhibitor 19
BTK inhibitor 19 is a highly selective, covalent BTK inhibitor ( IC 50 = 2.7 nM).
T39612 BTK-IN-5
BTK-IN-5 is a covalent BTK inhibitor for treating medical conditions such as cardiovascular diseases, respiratory diseases, inflammation, and diabetes.
T9813 JAK3/BTK-IN-2 JAK , BTK
JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor. JAK3/ BTk-in-2 inhibits both BTK and JAK3, which are two important targets IN autoimmune diseases. JAK3/ BTk-in-2 simultaneously inhibits the BTK/JAK3 signaling pathway, sho...
T9814 JAK3/BTK-IN-1 JAK , BTK
JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important targets in autoimmune diseases. JAK3/ BTk-in-1 simultaneously inh...
T36297 Btk inhibitor 1 hydrochloride
Btk inhibitor 1 Hcl is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor.IC50 value:Target: BtkFrom PCT Int. Appl. (2012), WO 2012158843 A2 20121122. [1]. PCT Int. Appl. (2012), WO 2012158843 A2 20121122.
T10628 BTK inhibitor 13 Others
BTK inhibitor 13 (compound 8) is an effective and selective BTK inhibitor(IC50: 1.2 nM).
T14956 CHMFL-BTK-01 BTK
CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.
T10627 BTK inhibitor 10 Others
BTK inhibitor 10 is a potent and orally active BTK inhibitor. It has the potential for rheumatoid arthritis treatment.
T62716 BTK-IN-10
BTK-IN-10 is a potent inhibitor of BTK, acting on wild-type BTK (IC50<5 nM) or mutant BTK (C481S) (IC50<5 nM).
T73276 BTK-IN-23
BTK-IN-23 is a BTK inhibitor ( IC 50 : 12.8 nM). BTK-IN-23 also inhibits BLX and BMX with IC 50 s of 35.6 and 5.7 nM respectively. BTK-IN-23 shows improved kinase selectivity compared to Ibrutinib [1] .
T75124 BTK-IN-24
BTK-IN-24 (compound 195) is a potent BTK inhibitor via a ubiquitin proteolytic pathway [1] .
T63810 BTK-IN-7
BTK-IN-7 is a selective and potent BTK inhibitor with an IC50 value of 4.0 nM. BTK-IN-7 exhibits high selectivity at both the enzymatic (ITK>250-fold, EGFR>2500-fold) and cellular levels (ITK>227-fold, EGFR27-fold). BTK-...
T63173 BTK-IN-8
BTK-IN-8 is a potent, selective, peripheral covalent BTK inhibitor with an IC50 value of 0.22 nM and a Kd value of 0.91 nM. BTK-IN-8 exhibits good potency in whole blood CD69 cells with an IC50 value of 0.029 μM.
T73275 BTK-IN-22
BTK-IN-22 is a BTK inhibitor ( IC 50 : 0.9 nM). BTK-IN-22 also inhibits BLX and BMX with IC 50 s of 1.4 and 1.2 nM respectively. BTK-IN-22 shows improved kinase selectivity compared to Ibrutinib [1]
T72664 BTK inhibitor 20
BTK inhibitor 20 is a potent BTK inhibitor with an IC 50 of 8 nM .
T62472 BTK-IN-6
BTK-IN-6 is a potent inhibitor of Bruton's tyrosine kinase (BTK). BTK-IN-6 has shown research potential in immune diseases, cardiovascular diseases, cancer, viral infections, inflammation, metabolic/endocrine dysfunction...
T73303 BTK-IN-17
BTK-IN-17 is a selective and orally active BTK inhibitor with an IC 50 value of 13.7 nM. BTK-IN-17 decreases the expression of p-BTK Y223 and p-PLCγ2 Y1217 . BTK-IN-17 shows anti-inflammatory effects .
T73318 BTK-IN-18
BTK-IN-18 is a potent, reversible BTK inhibitor with an IC 50 of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo .
T73319 BTK-IN-19
BTK-IN-19 is a reversible BTK inhibitor with an IC 50 of <0.001 μM .
T63182 BTK-IN-15
BTK-IN-15 is a novel, orally active Bruton's tyrosine kinase (BTK) inhibitor that inhibits BTK (IC50: 0.7 nM). BTK-IN-15 induces apoptosis in cancer cells and has good kinase selectivity and anti-tumour activity.
T79113 BTK-IN-25 BTK
BTK-IN-25 (compound 71) is a potent BTK inhibitor, demonstrating an IC50 of 0.77 nM against BTK(C481S) and achieving an IC50 of 1 nM in DOHH2 cells [1].
T63254 BTK-IN-11
BTK-IN-11 is a potent inhibitor of BTK. BTK-IN-11 has shown potential for research in diseases related to autoimmune diseases, inflammatory diseases or cancer.
T64042 BTK inhibitor 18
BTK inhibitor 18 is a selective, potent, covalent, orally active Btk inhibitor (IC50: 142 nM) that exhibits anti-inflammatory effects.
T63179 BTK-IN-9
BTK-IN-9 is a reversible inhibitor of BTK that shows strong anti-proliferative effects in condyloma cells.BTK-IN-9 specifically disrupts mitochondrial membrane potential, increases reactive oxygen species levels in Z138 ...
T79812 BTK-IN-27 BTK
BTK-IN-27 (example 8), a potent BTK inhibitor with an IC50 of 0.2 nM, demonstrates anti-proliferative effects in TMD8 cells with an IC50 of less than 5 nM. It is suitable for the research of various conditions including ...
T78782 PROTAC BTK Degrader-6 BTK
PROTAC BTK Degrader-6 (Compound 15), with a DC50 of 3.18 nM, exhibits anti-inflammatory properties by inhibiting NF-κB activation and suppressing the expression of pro-inflammatory cytokines, such as IL-1β and IL-6 [1].
T74636 PROTAC BTK Degrader-1
PROTAC BTK Degrader-1 is a potent, selective and orally active PROTAC BTK degrader with an IC 50 value of 34.51 nM and 64.56 nM for BTK WT and BTK-481S, respectively. PROTAC BTK Degrader-1 effectively reduces BTK protein...
T62813 JAK3/BTK-IN-6
JAK3/BTK-IN-6 is a potent dual inhibitor of BTK (IC50: 0.6 nM) and JAK3 (IC50: 0.4 nM).JAK3/BTK-IN-6 exhibits good metabolic stability in human liver microsomes.JAK3/BTK-IN-6 can be used to study blood and immune disease...
T79067 PROTAC BTK Degrader-3 PROTACs
PROTAC BTK Degrader-3 is a potent degrader of Bruton's tyrosine kinase (BTK), exhibiting a DC50 (median degradation concentration) of 10.9 nM in Mino cells. This compound shows promise for research into B-cell malignanci...
T79292 PROTAC BTK Degrader-5 BTK
PROTAC BTK Degraders-5 (Compound 3e) is a selective Bruton's tyrosine kinase (BTK) degrader with a DC50 of 7.0 nM in JeKo-1 cells, demonstrating specificity by not affecting CRBN neosubstrates. It also exhibits antiproli...
T73868 PROTAC BTK Degrader-2
PROTAC BTK Degrader-2 is a potent BTK PROTAC degrader. PROTAC BTK Degrader-2 effectively reduces BTK protein levels [1] .
T62234 JAK3/BTK-IN-3
JAK3/BTK-IN-3 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets in autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway has a synergistic effect and JAK3/BTK-IN-3 has sh...
T62153 JAK3/BTK-IN-5
JAK3/BTK-IN-5 is a potent inhibitor of JAK3/BTK. where BTK and JAK3 are two key targets in autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway has a synergistic effect and JAK3/BTK-IN-5 has po...
T62553 JAK3/BTK-IN-4
JAK3/BTK-IN-4 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets in autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signaling pathway has a synergistic effect and JAK3/BTK-IN-4 has pot...
T16730 Remibrutinib BTK
Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib is an effective and orally active Bruton tyrosine kinase inhibitor (IC50: 1 nM). Remibrutinib has the potential for Chronic urticar...
T1976 RN486 BTK
RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).
T5138 BMS-986142 BTK
BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).
T16157 MT-802 BTK , PROTACs
MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).
T36287 Pirtobrutinib BTK
Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to t...
T10625 IBT6A BTK
IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.
T10626 (Rac)-IBT6A Others , BTK
(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.
T2472 CGI-1746 BTK , Autophagy
CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.
TQ0242 Fenebrutinib GDC-0853 BTK
Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).
T5407 Branebrutinib BMS986195 BTK
Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family (IC50 <1 nM for BTK).
T12542 Rilzabrutinib PRN1008 EGFR , Others , HER , BTK
Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).

Compounds

BTK inhibitor 17
T9706
Synonym:
Target: BTK
Btk inhibitor 2
T10629
Synonym: BGB-3111 analog
Target: BTK
BTK inhibitor 1
T35330
Synonym:
Target: BTK
BTK IN-1
TQ0230
Synonym: SNS062 analog
Target: BTK
BTK-IN-16
T60542
Synonym:
Target: BTK
BTK inhibitor 19
T40185
Synonym:
Target:
BTK-IN-5
T39612
Synonym:
Target:
JAK3/BTK-IN-2
T9813
Synonym:
Target: JAK, BTK
JAK3/BTK-IN-1
T9814
Synonym:
Target: JAK, BTK
Btk inhibitor 1 hydrochloride
T36297
Synonym:
Target:
BTK inhibitor 13
T10628
Synonym:
Target: Others
CHMFL-BTK-01
T14956
Synonym:
Target: BTK
BTK inhibitor 10
T10627
Synonym:
Target: Others
BTK-IN-10
T62716
Synonym:
Target:
BTK-IN-23
T73276
Synonym:
Target:
BTK-IN-24
T75124
Synonym:
Target:
BTK-IN-7
T63810
Synonym:
Target:
BTK-IN-8
T63173
Synonym:
Target:
BTK-IN-22
T73275
Synonym:
Target:
BTK inhibitor 20
T72664
Synonym:
Target:
BTK-IN-6
T62472
Synonym:
Target:
BTK-IN-17
T73303
Synonym:
Target:
BTK-IN-18
T73318
Synonym:
Target:
BTK-IN-19
T73319
Synonym:
Target:
BTK-IN-15
T63182
Synonym:
Target:
BTK-IN-25
T79113
Synonym:
Target: BTK
BTK-IN-11
T63254
Synonym:
Target:
BTK inhibitor 18
T64042
Synonym:
Target:
BTK-IN-9
T63179
Synonym:
Target:
BTK-IN-27
T79812
Synonym:
Target: BTK
PROTAC BTK Degrader-6
T78782
Synonym:
Target: BTK
PROTAC BTK Degrader-1
T74636
Synonym:
Target:
JAK3/BTK-IN-6
T62813
Synonym:
Target:
PROTAC BTK Degrader-3
T79067
Synonym:
Target: PROTACs
PROTAC BTK Degrader-5
T79292
Synonym:
Target: BTK
PROTAC BTK Degrader-2
T73868
Synonym:
Target:
JAK3/BTK-IN-3
T62234
Synonym:
Target:
JAK3/BTK-IN-5
T62153
Synonym:
Target:
JAK3/BTK-IN-4
T62553
Synonym:
Target:
Remibrutinib
T16730
Synonym:
Target: BTK
RN486
T1976
Synonym:
Target: BTK
BMS-986142
T5138
Synonym:
Target: BTK
MT-802
T16157
Synonym:
Target: BTK, PROTACs
Pirtobrutinib
T36287
Synonym:
Target: BTK
IBT6A
T10625
Synonym:
Target: BTK
(Rac)-IBT6A
T10626
Synonym:
Target: Others, BTK
CGI-1746
T2472
Synonym:
Target: BTK, Autophagy
Fenebrutinib
TQ0242
Synonym: GDC-0853
Target: BTK
Branebrutinib
T5407
Synonym: BMS986195
Target: BTK
Rilzabrutinib
T12542
Synonym: PRN1008
Target: EGFR, Others, HER, BTK
1 2 3 4

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-02271 BTK Protein, Human, Recombinant (His) Human Baculovirus
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell ...
TMPH-02037 Human rhinovirus 1B (HRV-1B) Genome polyprotein (His & Myc) HRV-1B E. coli
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activatio...
TMPY-05249 ITK Protein, Human, Recombinant (Actived By LCK, GST) Human Baculovirus-Insect Cells
IL-2-inducible T cell kinase is a member of the protein kinase superfamily, Tyr protein kinase family, and TEC subfamily. It contains 1 Btk-type zinc finger, 1 PH domain, 1 protein kinase domain, 1 SH2 domain, and 1 SH3 ...
TMPY-04570 ITK Protein, Mouse, Recombinant (aa 351-619, His & GST) Mouse Baculovirus-Insect Cells
IL-2-inducible T cell kinase is a member of the protein kinase superfamily, Tyr protein kinase family, and TEC subfamily. It contains 1 Btk-type zinc finger, 1 PH domain, 1 protein kinase domain, 1 SH2 domain, and 1 SH3 ...
TMPH-02664 Aldolase C Protein, Mouse, Recombinant (His) Mouse Yeast
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors an...
TargetMol