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Search Results for " beta-secretase "

Targets

21

Compounds

8

Natural Products

9

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T2639 LY2811376 Beta Amyloid , Beta-Secretase , BACE
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition...
T12188 NB-360 BACE
NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cat...
T13253 Umibecestat CNP520 BACE
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of al...
T6058 LY2886721 Beta-Secretase , BACE
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
T11175 Elenbecestat E2609 Beta-Secretase , BACE
Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.
T4398 LX2343 Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.
T6772 AZD3839 free base AZD3839 Beta-Secretase , BACE
AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
T7011 Verubecestat MK-8931 Beta-Secretase , BACE
Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
T3285 Eslicarbazepine Acetate Zebinix,Aptiom,BIA 2-093,Exalief,Stedesa Beta-Secretase , Sodium Channel
Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conve...
T40260 β-Secretase Inhibitor II
β-Secretase Inhibitor II is a tripeptide aldehyde compound that acts as an inhibitor of β-Secretase. It exhibits a simple structure and has an inhibitory potency of IC50 = 700 nM against total Aβ and IC50 = 2.5 μM specif...
T39251 β-Secretase Inhibitor I
β-Secretase Inhibitor I is a highly potent inhibitor of the β-secretase enzyme. This compound exhibits exceptional inhibitory activity while also demonstrating a significant reduction in cardiovascular and liver toxicity...
T13434 β-Secretase Inhibitor IV Others
β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).
T3161 β-Secretase inhibitor-STA Beta-Secretase
BACE-IN-1 is amyloid precursor protein beta-secretase inhibitor
T11362 Gamma-Secretase Modulators γ-Secretase Modulators,Amyloid-β production inhibitor Others
gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.
T83616 SEW06622 BACE , AChE
SEW06622 is a potent inhibitor of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) and is a potential candidate for the treatment of Alzheimer's disease.
T6870 L-685458 L-685,458 Apoptosis , Gamma-secretase
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
T28390 PF9238 PF 9238,PF-9238
PF9238 is an inhibitor of beta-secretase I. PF9238 has a CatD potency of 12 uM in vivo.
T24924 Umibecestat HCl (1387560-01-1 free base) CNP 520,Umibecestat HCl,Umibecestat hydrochloride,CNP520,CNP-520
Umibecestat is a beta-secretase inhibitor. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies.
T71899 Verubecestat TFA
Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therap...
T70104 Verubecestat tosylate
Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therap...
T69664 Umibecestat HCl
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD...
Cat No. Product Name Synonyms Targets
T5S2361 Epiberberine ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe...
T3769 Tenuifolin Others , Beta-Secretase , AChE
Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.
T8179 Aloeresin D Beta-Secretase , BACE
Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).
TN2190 Scoulerine Apoptosis , Beta-Secretase , BACE , Parasite
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
T2S1181 Aloenin Aloenin A,Aloearbonaside Beta-Secretase , AChR
1. Aloenin (Aloenin A) and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.
TN2217 Sophoflavescenol Others , Beta-Secretase , BACE , PDE , AChR , AChE
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity witho...
T8306 Epiberberine chloride Epiberberine (chloride) Reactive Oxygen Species , Beta-Secretase , BACE , AChR , AChE
Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM).
T3682 (-)-Catechin gallate (-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate Others , COX
(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallat...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-01238 POLQ Protein, Human, Recombinant (His) Human Baculovirus
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamm...
TMPY-03065 BACE2 Protein, Mouse, Recombinant (His) Mouse HEK293
BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is th...
TMPJ-00358 DR6 Protein, Mouse, Recombinant (hFc & His) Mouse Human Cells
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may ...
TMPY-03884 Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) Human E. coli
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-03885 Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) Human E. coli
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-00668 APP/Protease nexin-II Protein, Human, Recombinant (hFc) Human HEK293
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-02110 Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) Human E. coli
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-02221 Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) Human E. coli
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPJ-00782 Amyloid Precursor Protein, Human, Recombinant (hFc) Human Human Cells
Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and...
TargetMol