Search Result

Search Results for " bcr "

Targets

132

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T72958	BCR-ABL-IN-7		Bcr-Abl
	BCR-ABL-IN-7 is a WT and T315I mutant ABL kinase inhibitor.BCR-ABL-IN-7 potently inhibits WT and T315I mutant ABL kinase activity.BCR-ABL-IN-7 can be used in chronic myelogenous leukemia (CML) research.		Bcr-Abl
T39732	BCR-ABL-IN-3
	BCR-ABL-IN-3 is a highly effective and irreversibly binding inhibitor of Bcr-Abl, displaying a remarkable potency with an IC50 value of ≤100 nM for Ba/F3 Bcr-Abl T3151. This compound exhibits significant anti-cancer acti...
T13832	PROTAC BCR-ABL1 ligand 1		Others
	PROTAC BCR-ABL1 ligand 1 is the ligand of PROTAC .		Others
T10489	BCR-ABL-IN-2		Others
	BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I).		Others
T10488	BCR-ABL-IN-1		Bcr-Abl
	BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.		Bcr-Abl
T73941	PROTAC BCR-ABL1 ligand 1
	GMB-475, also known as PROTAC BCR-ABL1 ligand 1, allosterically targets and binds to the BCR-ABL1 protein. It effectively recruits the E3 ligase Von Hippel-Lindau, leading to the ubiquitination and subsequent degradation...
T63332	BCR-ABL-IN-5
	BCR-ABL-IN-5 is a Bcr-Abl (Breakpoint cluster region-Abelson) kinase inhibitor that acts on Bcr-AblWT (IC50: 0.014 μM) and Bcr-AblT3151 (IC50: 0.45 μM) and exhibits some anti-proliferative effects on leukemic cells. effe...
T61324	BCR-ABL1-IN-1
	BCR-ABL1-IN-1 is a highly potent and orally bioavailable inhibitor, displaying remarkable specificity towards ABL kinase. Notably, this compound holds significant promise for delineating the precise involvement of ABL ki...
T63450	BCR-ABL-IN-6
	BCR-ABL-IN-6 (9h) is an imatinib derivative and a selective inhibitor of Bcr-Abl kinase that acts on Bcr-AblWT (IC50: 4.6 nM) and Bcr-AblT3151 (IC50: 277 nM). BCR-ABL-IN-6 (9h) was able to be used in the study of chronic...
T82909	BCR-ABL-IN-8		Bcr-Abl
	BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].		Bcr-Abl
T63932	BCR-ABL-IN-4
	BCR-ABL-IN-4 is a BCR-ABLL inhibitor that exhibits anticancer activity.BCR-ABL-IN-4 has an inhibitory effect on cancer cell growth and is able to act on K562 cells (IC50: 0.67 nM) and BCR-ABL T315I-transfected Ba/F3 cell...
T77974	PROTAC BCR-ABL Degrader-1		PROTACs
	PROTAC BCR-ABL Degrader-1 (compound PROTAC 1), featuring a 2-oxoethyl linker, promotes Bcr-Abl degradation through the ubiquitin-proteasome pathway and demonstrates antiproliferative effects on K562 cells, suggesting its...		PROTACs
T8882	Vodobatinib	K-0706	Bcr-Abl
	Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.		Bcr-Abl
T3071	Olverembatinib	GZD 824	Bcr-Abl
	Olverembatinib (GZD 824) is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT, IC50: 0.34 nM) and Bcr-Abl(T315I, IC50: 0.68 nM).		Bcr-Abl
T8488	GMB-475		Bcr-Abl
	GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitinati...		Bcr-Abl
T21785	AG957		Bcr-Abl
	Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1].		Bcr-Abl
T5177	Asciminib	ABL001	Bcr-Abl
	Asciminib (ABL001) (ABL001) is a potent and selective Bcr-Abl inhibitor (Kd: 0.5–0.8nM).		Bcr-Abl
T17267	XL228		IGF-1R , Bcr-Abl , Src , Aurora Kinase
	XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).		IGF-1R , Bcr-Abl , Src , Aurora Kinase
T2429	Olverembatinib dimesylate	GZD824 Dimesylate,HQP1351	Bcr-Abl
	Olverembatinib dimesylate (GZD824 Dimesylate) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I).		Bcr-Abl
T3063	PD173955	PD-173955,PD 173955	Apoptosis , Bcr-Abl , Src
	PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR and PKC.		Apoptosis , Bcr-Abl , Src
T6300	Degrasyn	WP1130	Apoptosis , JAK , Bcr-Abl , DUB , Autophagy
	Degrasyn (WP1130) (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (without affecting 20S proteasome) and activator of transcri...		Apoptosis , JAK , Bcr-Abl , DUB , Autophagy
T1803	GNF-5	GNF 5	SARS-CoV , Bcr-Abl
	GNF-5 is a specific non-ATP competitive inhibitor of Bcr-Abl (IC50: 0.22±0.1 uM, Wild-type Abl). It is an analog of GNF-2 with improved pharmacokinetic properties.		SARS-CoV , Bcr-Abl
T11916	Lyn-IN-1	Bafetinib analog	Bcr-Abl , Src
	Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and Lyn		Bcr-Abl , Src
T2302	CNX-774	CNX 774	BTK
	CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).		BTK
T3196	GNF-7	GNF7	Bcr-Abl , ACK , AChR
	GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.		Bcr-Abl , ACK , AChR
T4320	Flumatinib	HHGV678	Bcr-Abl , PDGFR , c-Kit
	Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.		Bcr-Abl , PDGFR , c-Kit
T2802	Nocodazole	R17934,Oncodazole	Apoptosis , Microtubule Associated , Bcr-Abl , Autophagy , CRISPR/Cas9
	Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis.
T11898	LXH254		Raf
	LXH254 is a potent C-Raf and B-Raf inhibitor.		Raf
T4337	PCI 29732	PCI29732,PCI-29732	Others , BCRP , BTK
	PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.		Others , BCRP , BTK
T0152	Bosutinib	SKI-606	Bcr-Abl , Src , Autophagy
	Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.		Bcr-Abl , Src , Autophagy
T2341	KW-2449	KW2449	Apoptosis , FGFR , FLT , JAK , Bcr-Abl , Src , c-Kit , Aurora Kinase
	KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.
T1524	Nilotinib	Tasigna,AMN107	Bcr-Abl , Autophagy
	Nilotinib (AMN107) is a second-generation Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.		Bcr-Abl , Autophagy
T2640	Rebastinib	DCC2036,DCC 2036,DCC-2036	Apoptosis , FLT , Bcr-Abl , Src
	DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit. Re...		Apoptosis , FLT , Bcr-Abl , Src
T1448	Dasatinib	BMS-354825	Apoptosis , Bcr-Abl , Src , c-Kit , Autophagy
	Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive. Dasatinib has antitumor activity and is used in the treatment of leukemia and ly...		Apoptosis , Bcr-Abl , Src , c-Kit , Autophagy
T1817	GNF-2	GNF2	SARS-CoV , Bcr-Abl
	GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl.		SARS-CoV , Bcr-Abl
T22553	Adaphostin	1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410	Bcr-Abl
	Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.		Bcr-Abl
T16545	Pivanex	Pivalyloxymethyl butyrate,AN-9	Apoptosis , HDAC , Bcr-Abl
	Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.		Apoptosis , HDAC , Bcr-Abl
T6311	Bafetinib	NS-187,INNO-406	Bcr-Abl , Src , Autophagy
	Bafetinib (INNO-406) (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and less effective to c-Kit and PDGFR.		Bcr-Abl , Src , Autophagy
T3068	AT9283	J-504568	Apoptosis , FLT , JAK , Bcr-Abl , Aurora Kinase , Autophagy
	AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).
T4191	Multi-kinase inhibitor 1	Multi-kinase inhibitor I	Others , Bcr-Abl , PDGFR , c-Kit
	Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.		Others , Bcr-Abl , PDGFR , c-Kit
T14871	Carboxyamidotriazole Orotate	L-651582 Orotate,CAI Orotate	Calcium Channel
	Carboxyamidotriazole Orotate (L-651582 Orotate) is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate (L-651582 Orotate) is the o...		Calcium Channel
T6230	Imatinib	STI571,CGP057148B,ST-1571	SARS-CoV , Bcr-Abl , PDGFR , c-Kit , Autophagy
	Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit with oral activity. Imatinib has antitumor activity for the tre...		SARS-CoV , Bcr-Abl , PDGFR , c-Kit , Autophagy
T4053	AST 487	NVP-AST 487	VEGFR , FLT , c-RET , Bcr-Abl , c-Kit
	AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.		VEGFR , FLT , c-RET , Bcr-Abl , c-Kit
T1448L	Dasatinib monohydrate	BMS-354825 Monohydrate	Apoptosis , Bcr-Abl , Src , c-Kit , Ephrin Receptor , Autophagy
	Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activit...
T1621	Imatinib Mesylate	ST-1571 Mesylate,STI-571,CGP-57148B	Bcr-Abl , PDGFR , c-Kit , Autophagy
	Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR, respectively).		Bcr-Abl , PDGFR , c-Kit , Autophagy
T2372	Ponatinib	AP24534	VEGFR , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Autophagy
	Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively).		VEGFR , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Autophagy
T2147	Nilotinib monohydrochloride monohydrate	Nilotinib (monohydrochloride monohydrate),AMN107 (monohydrochloride monohydrate)	Bcr-Abl , Autophagy
	Nilotinib monohydrochloride monohydrate (Nilotinib (monohydrochloride monohydrate)) is significantly potent BCR-ABL against, is a second generation tyrosine kinase inhibitor (TKI), and is active against many BCR-ABL muta...		Bcr-Abl , Autophagy
T1925	PLX647		c-Fms , c-Kit
	PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).		c-Fms , c-Kit
T7861	Flumatinib mesylate	HHGV678 mesylate	Bcr-Abl , PDGFR , c-Kit
	Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.		Bcr-Abl , PDGFR , c-Kit
T2693	AG1024	Tyrphostin AG 1024,Tyrphostin,AGS 200	Apoptosis , IGF-1R
	AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).		Apoptosis , IGF-1R

Compounds

PROTAC BCR-ABL1 ligand 1

PROTAC BCR-ABL1 ligand 1

PROTAC BCR-ABL Degrader-1

Target: IGF-1R, Bcr-Abl, Src, Aurora Kinase

Olverembatinib dimesylate

T2429

Synonym: GZD824 Dimesylate,HQP1351

Target: Bcr-Abl

PD173955

T3063

Synonym: PD-173955,PD 173955

Target: Apoptosis, Bcr-Abl, Src

Degrasyn

T6300

Synonym: WP1130

Target: Apoptosis, JAK, Bcr-Abl, DUB, Autophagy

GNF-5

T1803

Synonym: GNF 5

Target: SARS-CoV, Bcr-Abl

Lyn-IN-1

T11916

Synonym: Bafetinib analog

Target: Bcr-Abl, Src

Target: Bcr-Abl, ACK, AChR

Flumatinib

T4320

Synonym: HHGV678

Target: Bcr-Abl, PDGFR, c-Kit

Nocodazole

T2802

Synonym: R17934,Oncodazole

Target: Apoptosis, Microtubule Associated, Bcr-Abl, Autophagy, CRISPR/Cas9

Synonym: PCI29732,PCI-29732

Target: Others, BCRP, BTK

Bosutinib

T0152

Synonym: SKI-606

Target: Bcr-Abl, Src, Autophagy

KW-2449

T2341

Synonym: KW2449

Target: Apoptosis, FGFR, FLT, JAK, Bcr-Abl, Src, c-Kit, Aurora Kinase

Nilotinib

T1524

Synonym: Tasigna,AMN107

Target: Bcr-Abl, Autophagy

Rebastinib

T2640

Synonym: DCC2036,DCC 2036,DCC-2036

Target: Apoptosis, FLT, Bcr-Abl, Src

Dasatinib

T1448

Synonym: BMS-354825

Target: Apoptosis, Bcr-Abl, Src, c-Kit, Autophagy

GNF-2

T1817

Synonym: GNF2

Target: SARS-CoV, Bcr-Abl

Adaphostin

T22553

Synonym: 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410

Target: Bcr-Abl

Pivanex

T16545

Synonym: Pivalyloxymethyl butyrate,AN-9

Target: Apoptosis, HDAC, Bcr-Abl

Bafetinib

T6311

Synonym: NS-187,INNO-406

Target: Bcr-Abl, Src, Autophagy

AT9283

T3068

Synonym: J-504568

Target: Apoptosis, FLT, JAK, Bcr-Abl, Aurora Kinase, Autophagy

Multi-kinase inhibitor 1

T4191

Synonym: Multi-kinase inhibitor I

Target: Others, Bcr-Abl, PDGFR, c-Kit

Carboxyamidotriazole Orotate

T14871

Synonym: L-651582 Orotate,CAI Orotate

Target: Calcium Channel

Imatinib

T6230

Synonym: STI571,CGP057148B,ST-1571

Target: SARS-CoV, Bcr-Abl, PDGFR, c-Kit, Autophagy

AST 487

T4053

Synonym: NVP-AST 487

Target: VEGFR, FLT, c-RET, Bcr-Abl, c-Kit

Dasatinib monohydrate

T1448L

Synonym: BMS-354825 Monohydrate

Target: Apoptosis, Bcr-Abl, Src, c-Kit, Ephrin Receptor, Autophagy

Imatinib Mesylate

T1621

Synonym: ST-1571 Mesylate,STI-571,CGP-57148B

Target: Bcr-Abl, PDGFR, c-Kit, Autophagy

Ponatinib

T2372

Synonym: AP24534

Target: VEGFR, FGFR, Bcr-Abl, PDGFR, Src, c-Kit, Autophagy

Nilotinib monohydrochloride monohydrate

T2147

Synonym: Nilotinib (monohydrochloride monohydrate),AMN107 (monohydrochloride monohydrate)

Target: Bcr-Abl, Autophagy

Synonym: HHGV678 mesylate

Target: Bcr-Abl, PDGFR, c-Kit

AG1024

T2693

Synonym: Tyrphostin AG 1024,Tyrphostin,AGS 200

Target: Apoptosis, IGF-1R

Cat No.	Product Name	Synonyms	Targets
T3S1553	Trans-Cinnamaldehyde	Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein	COX , Endogenous Metabolite
	1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells...		COX , Endogenous Metabolite

Natural Products

trans-Cinnamaldehyde

T3S1553

Synonym: Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein

Target: COX, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPH-01002	BCAP31 Protein, Human, Recombinant (GST)	Human	E. coli
	Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeti...
TMPH-00550	Epstein-Barr virus (strain B95-8) BCRF1 Protein (His & Myc)	EBV	E. coli
	Plays a role in masking infected cells for immune recognition by cytotoxic T-lymphocytes. Down-regulates the expression of the host TAP1 gene (transporter associated with antigen processing), thereby affecting the transp...
TMPY-04083	Siglec-2/CD22 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPY-05566	Siglec-2/CD22 Protein, Human, Recombinant (His, Solution)	Human	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPY-05201	Siglec-2/CD22 Protein, Human, Recombinant	Human	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPY-02034	Siglec-2/CD22 Protein, Human, Recombinant (His)	Human	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPJ-00113	CD79B Protein, Human, Recombinant (hFc)	Human	Human Cells
	CD79B is a single-pass type I membrane protein. CD79B contains one Ig-like V-type domain and one ITAM domain. CD79B is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the...
TMPY-01235	CD5 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05260	PD-1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr...
TMPY-04342	PD-1 Protein, Canine, Recombinant (His)	Canine	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr...
TMPY-00897	PD-1 Protein, Human, Recombinant (His)	Human	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr...
TMPY-05815	PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated	Canine	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr...
TMPY-04898	PD-1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr...
TMPY-05395	PD-1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr...
TMPY-00996	PD-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr...
TMPY-05079	PD-1 Protein, Human, Recombinant (mFc)	Human	HEK293
	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr...
TMPH-00544	Epstein-Barr virus (strain B95-8) LMP2 Protein (His & SUMO)	EBV	E. coli
	Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-as...
TMPH-01330	FCRL3 Protein, Human, Recombinant (His)	Human	E. coli
	Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimu...
TMPJ-00898	CD72 Protein, Human, Recombinant (Trx & His)	Human	E. coli
	B-Cell Differentiation Antigen CD72 (CD72) is a single-pass type II membrane protein. CD72 exists as a disulfide-linked homodimer and contains one C-type lectin domain. CD72 is expressed on B lineage cells, NK cells, mon...
TMPH-00344	CD20 Protein, Canine, Recombinant (His & Myc)	Canine	E. coli
	B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium...
TMPY-02191	BLNK Protein, Human, Recombinant (His)	Human	HEK293
	B-cell linker protein, also known as B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte p...
TMPH-02551	CD20 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium...
TMPK-00327	CD19 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)	Cynomolgus,Rhesus macaque	HEK293
	CD19 is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses.Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases th...
TMPY-00349	Siglec-2/CD22 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPY-03895	Siglec-2/CD22 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPY-05223	Siglec-2/CD22 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPY-00158	Siglec-2/CD22 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPY-03360	Siglec-2/CD22 Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPY-05316	Siglec-2/CD22 Protein, Human, Recombinant (aa 176-687, His), Biotinylated	Human	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPY-05598	Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPY-00407	Siglec-2/CD22 Protein, Rat, Recombinant (His)	Rat	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPY-03566	Siglec-2/CD22 Protein, Human, Recombinant (aa 176-687, His)	Human	HEK293
	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPJ-00112	CD79B Protein, Human, Recombinant (His & Avi), Biotinylated	Human	Human Cells
	CD79B is a single-pass type I membrane protein. CD79B contains one Ig-like V-type domain and one ITAM domain. CD79B is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the...
TMPH-02271	BTK Protein, Human, Recombinant (His)	Human	Baculovirus
	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activatio...
TMPK-00115	CD79B Protein, Human, Recombinant (His & Avi)	Human	HEK293
	CD79B (also known as B29, Ig beta and B cell antigen receptor complex-associated protein beta-chain) is a 36-40 kDa member of the Ig-Superfamily. It is required in cooperation with CD79A for initiation of the signal tran...
TMPJ-00862	CD79B Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	CD79B is a single-pass type I membrane protein. CD79B contains one Ig-like V-type domain and one ITAM domain. CD79B is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the...
TMPJ-00118	CD79B Protein, Rhesus macaque, Recombinant (hFc)	Rhesus Macaque	Human Cells
	CD79B is a single-pass type I membrane protein. CD79B contains one Ig-like V-type domain and one ITAM domain. CD79B is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the...
TMPH-01788	NFE2L2 Protein, Human, Recombinant (His)	Human	E. coli
	Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzyme...
TMPJ-01323	NTAL Protein, Human, Recombinant (His)	Human	Human Cells
	Linker for Activation of T-Cells Family Member 2 (LAT2) is a single-pass type III membrane protein. LAT2 is highly expressed in the spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. LAT2 is invol...
TMPJ-00307	BLK Protein, Human, Recombinant (His)	Human	E. coli
	Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling...
TMPH-01213	DNASE1L3 Protein, Human, Recombinant (His)	Human	Baculovirus
	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA...
TMPH-01212	DNASE1L3 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA...
TMPH-01214	DNASE1L3 Protein, Human, Recombinant	Human	E. coli
	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA...
TMPJ-00181	PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	Human Cells
	Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell pr...
TMPJ-00184	CD20 Protein, Human, Recombinant (Flag)	Human	Human Cells
	CD20 is a 33-37 kDa non-glycosylated protein expressed on the surface of normal and malignant B lymphocytes, and belongs to the MS4A (membrane-spanning 4-domain family A) protein family. CD20 protein consists of four hyd...
TMPJ-00185	CD20 Protein, Human, Recombinant (His & Flag)	Human	Human Cells
	CD20 is a 33-37 kDa non-glycosylated protein expressed on the surface of normal and malignant B lymphocytes, and belongs to the MS4A (membrane-spanning 4-domain family A) protein family. CD20 protein consists of four hyd...
TMPY-01334	CD5 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05422	CD5 Protein, Human, Recombinant (hFc)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05589	CD5 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
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C-ABL/ABL1 Protein, Human, Recombinant (GST)

TMPY-04396

Species: Human

Expression System: Baculovirus-Insect Cells

BCAP31 Protein, Human, Recombinant (GST)

TMPH-01002

Species: Human

Expression System: E. coli

Epstein-Barr virus (strain B95-8) BCRF1 Protein (His & Myc)

TMPH-00550

Species: EBV

Expression System: E. coli

Siglec-2/CD22 Protein, Mouse, Recombinant (His)

TMPY-04083

Species: Mouse

Expression System: HEK293

Siglec-2/CD22 Protein, Human, Recombinant (His, Solution)

TMPY-05566

Species: Human

Expression System: HEK293

Siglec-2/CD22 Protein, Human, Recombinant

TMPY-05201

Species: Human

Expression System: HEK293

Siglec-2/CD22 Protein, Human, Recombinant (His)

TMPY-02034

Species: Human

Expression System: HEK293

CD79B Protein, Human, Recombinant (hFc)

TMPJ-00113

Species: Human

Expression System: Human Cells

CD5 Protein, Human, Recombinant (His)

TMPY-01235

Species: Human

Expression System: HEK293

PD-1 Protein, Cynomolgus, Recombinant (His)

TMPY-05260

Species: Cynomolgus

Expression System: HEK293

PD-1 Protein, Canine, Recombinant (His)

TMPY-04342

Species: Canine

Expression System: HEK293

PD-1 Protein, Human, Recombinant (His)

TMPY-00897

Species: Human

Expression System: HEK293

PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated

TMPY-05815

Species: Canine

Expression System: HEK293

PD-1 Protein, Human, Recombinant (hFc)

TMPY-04898

Species: Human

Expression System: HEK293

PD-1 Protein, Mouse, Recombinant (hFc)

TMPY-05395

Species: Mouse

Expression System: HEK293

PD-1 Protein, Mouse, Recombinant (His)

TMPY-00996

Species: Mouse

Expression System: HEK293

PD-1 Protein, Human, Recombinant (mFc)

TMPY-05079

Species: Human

Expression System: HEK293

Epstein-Barr virus (strain B95-8) LMP2 Protein (His & SUMO)

TMPH-00544

Species: EBV

Expression System: E. coli

FCRL3 Protein, Human, Recombinant (His)

TMPH-01330

Species: Human

Expression System: E. coli

CD72 Protein, Human, Recombinant (Trx & His)

TMPJ-00898

Species: Human

Expression System: E. coli

CD20 Protein, Canine, Recombinant (His & Myc)

TMPH-00344

Species: Canine

Expression System: E. coli

BLNK Protein, Human, Recombinant (His)

TMPY-02191

Species: Human

Expression System: HEK293

CD20 Protein, Mouse, Recombinant (His)

TMPH-02551

Species: Mouse

Expression System: Yeast

CD19 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

TMPK-00327

Species: Cynomolgus,Rhesus macaque

Expression System: HEK293

Siglec-2/CD22 Protein, Rhesus, Recombinant (His)

TMPY-00349

Species: Rhesus

Expression System: HEK293

Siglec-2/CD22 Protein, Mouse, Recombinant (hFc)

TMPY-03895

Species: Mouse

Expression System: HEK293

Siglec-2/CD22 Protein, Human, Recombinant (His), Biotinylated

TMPY-05223

Species: Human

Expression System: HEK293

Siglec-2/CD22 Protein, Rat, Recombinant (hFc)

TMPY-00158

Species: Rat

Expression System: HEK293

Siglec-2/CD22 Protein, Rhesus, Recombinant (hFc)

TMPY-03360

Species: Rhesus

Expression System: HEK293

Siglec-2/CD22 Protein, Human, Recombinant (aa 176-687, His), Biotinylated

TMPY-05316

Species: Human

Expression System: HEK293

Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated

TMPY-05598

Species: Human

Expression System: HEK293

Siglec-2/CD22 Protein, Rat, Recombinant (His)

TMPY-00407

Species: Rat

Expression System: HEK293

Siglec-2/CD22 Protein, Human, Recombinant (aa 176-687, His)

TMPY-03566

Species: Human

Expression System: HEK293

CD79B Protein, Human, Recombinant (His & Avi), Biotinylated

TMPJ-00112

Species: Human

Expression System: Human Cells

BTK Protein, Human, Recombinant (His)

TMPH-02271

Species: Human

Expression System: Baculovirus

CD79B Protein, Human, Recombinant (His & Avi)

TMPK-00115

Species: Human

Expression System: HEK293

CD79B Protein, Mouse, Recombinant (hFc)

TMPJ-00862

Species: Mouse

Expression System: Human Cells

CD79B Protein, Rhesus macaque, Recombinant (hFc)

TMPJ-00118

Species: Rhesus Macaque

Expression System: Human Cells

NFE2L2 Protein, Human, Recombinant (His)

TMPH-01788

Species: Human

Expression System: E. coli

NTAL Protein, Human, Recombinant (His)

TMPJ-01323

Species: Human

Expression System: Human Cells

BLK Protein, Human, Recombinant (His)

TMPJ-00307

Species: Human

Expression System: E. coli

DNASE1L3 Protein, Human, Recombinant (His)

TMPH-01213

Species: Human

Expression System: Baculovirus

DNASE1L3 Protein, Human, Recombinant (His & Myc)

TMPH-01212

Species: Human

Expression System: E. coli

DNASE1L3 Protein, Human, Recombinant

TMPH-01214

Species: Human

Expression System: E. coli

PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPJ-00181

Species: Human

Expression System: Human Cells

CD20 Protein, Human, Recombinant (Flag)

TMPJ-00184

Species: Human

Expression System: Human Cells

CD20 Protein, Human, Recombinant (His & Flag)

TMPJ-00185

Species: Human

Expression System: Human Cells

CD5 Protein, Mouse, Recombinant (His)

TMPY-01334

Species: Mouse

Expression System: HEK293

CD5 Protein, Human, Recombinant (hFc)

TMPY-05422

Species: Human

Expression System: HEK293

CD5 Protein, Human, Recombinant (His & Avi)

TMPY-05589

Species: Human

Expression System: HEK293

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Cat No.	Product Name
L6750	PBCRBS Traditional Chinese Medicine Compound Library		588 compounds
	A unique collection of 588 compounds derived from traditional Chinese medicines (TCMs) for promoting blood circulation and removing blood stasis.

Libraries

PBCRBS Traditional Chinese Medicine Compound Library

L6750

Compounds: 588