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Search Results for " bace1 "

49

Compounds

15

Natural Products

12

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T39484 BACE1-IN-6 BACE1-IN-6
BACE1-IN-6 is a BACE1 inhibitor with an IC 50 value of 1.5 nM.
T10452 BACE1-IN-4 BACE
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
T10451 BACE1-IN-2 BACE
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
T10450 BACE1-IN-1 BACE
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
T10453 BACE1-IN-5 Beta Amyloid , BACE
BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM aga...
T73076 BACE1-IN-10 Beta-Secretase
BACE1-IN-10 is a potent inhibitor of BACE1, demonstrating sub-micromolar activity against recombinant BACE1 (rBACE1) [1].
T64074 BACE1-IN-8
BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM).
T63867 BACE1-IN-12
BACE1-IN-12 is a potent BACE1 inhibitor (IC50: 8.9 μM) that can cross the blood-brain barrier. BACE1-IN-12 selectively inhibits BuChE (butylcholinesterase) activity (IC50: 3.2 μM). BACE1-IN-12 has potential for anti-Alzh...
T79022 BACE1-IN-13 Beta-Secretase
BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hAβ42 cells (IC50 = 1.3 nM). It is considered safe for the cardiovascular ...
T61956 BACE1/2-IN-1
BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 has lower Pgp efflux ratio and improved passive permeability. The metabolic stability of BA...
T62719 AChE/BACE1/GSK3β-IN-1
AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 can be used to study Alzheimer's disease (AD).
T6058 LY2886721 Beta-Secretase , BACE
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
T7011 Verubecestat MK-8931 Beta-Secretase , BACE
Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
T10449 BACE-1 inhibitor 1 Others
BACE-1 inhibitor 1 (Compound 8a) is an effective BACE-1 inhibitor (IC50: 56 nM).
T12188 NB-360 BACE
NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cat...
T2639 LY2811376 Beta Amyloid , Beta-Secretase , BACE
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition...
T6772 AZD3839 free base AZD3839 Beta-Secretase , BACE
AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
T4398 LX2343 Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.
T3161L BACE-IN-1 acetate BACE-IN-1 acetate (350228-37-4,Free base) BACE
BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4,Free base)) has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. β-Site amyloid precursor protein (APP) c...
T13253 Umibecestat CNP520 BACE
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of al...
T12429 PF-06751979 BACE
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
TQ0238 Lanabecestat LY3314814,AZD3293 BACE
Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).
T10292 AM-6494 BACE
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
T28915 TAK-070 TAK070
TAK-070 is a non-competitive inhibitor of BACE1.
T25610 Lanabecestat camsylate LY 3314814 camsylate,LY-3314814 camsylate,LY3314814 camsylate
Lanabecestat camsylate is used as a BACE1 Inhibitor.
T71098 AZ3971
AZ3971 is a potent BACE1 inhibitor. AZ3971 blocks BACE1-mediated cleavage of APP and inhibits Aβ42 production HEK cells overexpressing the APP protein which carries the Swedish mutation (HEK.APPswe).
T26715 AZD-3289 AZD 3289
AZD-3289, a potent BACE1 inhibitor, is used potentially for the treatment of Alzheimer's disease.
T62573 AMG-8718
AMG-8718 is a selective, orally active and potent BACE1 inhibitor that acts on both BACE1 (IC50: 0.0007 μM) and BACE2 (IC50: 0.005 μM). AMG-8718 significantly reduces CSF and Aβ40 levels in the brain.
T39955 JNJ-67569762
JNJ-67569762 is a selective BACE1 inhibitor targeting the S3 pocket ( IC 50 = 2.7 nM).
T70711 AZD-3839 hemifumarate
AZD-3839 hemifumarate is a potent and selective BACE1 inhibitor and clinical candidate for the treatment of Alzheimer's disease.
T68377 GRL-8234
GRL-8234 is a small-molecule BACE1 inhibitor that reverses memory impairments and age-related cognitive decline.
T62455 β-Secretase Inhibitor III
β-Secretase Inhibitor III is a highly selective inhibitor of BACE1 with a Ki value of 0.13 nM.
T80128 RE(EDANS)EVNLDAEFK(DABCYL)R Beta-Secretase
RE (EDANS) EVNLDAEFK (DABCYL) R is a double-labeled peptide with EDANS and DABCYL, functioning as a fluorescent substrate for BACE1 with an emission wavelength of 360 nm and an excitation wavelength of 528 nm. Its utilit...
T70366 PF-06663195
PF-06663195 is a potent inhibitor of β-site amyloid precursor protein (APP) Cleaving Enzyme 1 (BACE1, β-Secretase 1).
T10014 (1α,1'S,4β)-Lanabecestat (1α,1'S,4β)-AZD3293 Others
(1α,1'S,4β)-Lanabecestat is a Beta site APP Cleaving Enzymel (BACE1) inhibitor, and has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay), respectively.
T79422 BuChE-IN-8
BuChE-IN-8 (compound 19c), a butyrylcholinesterase (BuChE) inhibitor, exhibits an IC50 value of 559 nM and concurrently inhibits human β-secretase (BACE1) and Aβ40 aggregation. It also demonstrates notable antiamnesic pr...
T14338 Atabecestat JNJ-54861911 BACE
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a ...
T70807 Lanabecestat HCl
Lanabecestat, also known as AZD3293 and LY3314814, is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. AZD3293 displayed significant do...
T40393 OM99-2 OM99-2
OM99-2 is an eight-residue peptidomimetic with a high affinity for human brain memapsin 2, exhibiting a Ki value of 9.58 nM. This compound represents a significant advancement in the development of BACE1 inhibitors and h...
T70104 Verubecestat tosylate
Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therap...
T79423 BuChE-IN-9
BuChE-IN-9 (compound 22a), an eqBuChE (equine serum-derived butyrylcholinesterase) inhibitor, exhibits potent activity with an IC50 of 173 nM. In addition to eqBuChE, it also inhibits human BACE1, Aβ aggregation, and mou...
T71899 Verubecestat TFA
Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therap...
T37661 LY 2886721 Hydrochloride
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin a...
T40165 OM99-2 TFA OM99-2 TFA
OM99-2 TFA is an eight-residue peptidomimetic compound, functioning as a tight-binding inhibitor of human brain memapsin 2. It exhibits a high affinity for the target with a Ki value of 9.58 nM, making it a promising can...
T70800 Elenbecestat free base
Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and proto...
T78739 PD07
PD07 is an orally active acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 of 0.29 μM against human AChE, and demonstrates inhibition of cholinesterases (ChEs), β-site amyloid precursor protein cleaving enzyme 1 ...
T35975 6,9-Dichloro-1,2,3,4-tetrahydroacridine
6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids...
T61049 AChE-IN-11
AChE-IN-11 (compound 5C) can be used in the Alzheimer's disease research with neuroprotective effects and good antioxidant activity (ORAC = 2.5 eq). AChE-IN-11 is a good multifunctional agent with IC 50 values of 7.9 μM...
T13434 β-Secretase Inhibitor IV Others
β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).

Compounds

BACE1-IN-6
T39484
Synonym: BACE1-IN-6
Target:
BACE1-IN-4
T10452
Synonym:
Target: BACE
BACE1-IN-2
T10451
Synonym:
Target: BACE
BACE1-IN-1
T10450
Synonym:
Target: BACE
BACE1-IN-5
T10453
Synonym:
Target: Beta Amyloid, BACE
BACE1-IN-10
T73076
Synonym:
Target: Beta-Secretase
BACE1-IN-8
T64074
Synonym:
Target:
BACE1-IN-12
T63867
Synonym:
Target:
BACE1-IN-13
T79022
Synonym:
Target: Beta-Secretase
BACE1/2-IN-1
T61956
Synonym:
Target:
AChE/BACE1/GSK3β-IN-1
T62719
Synonym:
Target:
LY2886721
T6058
Synonym:
Target: Beta-Secretase, BACE
Verubecestat
T7011
Synonym: MK-8931
Target: Beta-Secretase, BACE
BACE-1 inhibitor 1
T10449
Synonym:
Target: Others
NB-360
T12188
Synonym:
Target: BACE
LY2811376
T2639
Synonym:
Target: Beta Amyloid, Beta-Secretase, BACE
AZD3839 free base
T6772
Synonym: AZD3839
Target: Beta-Secretase, BACE
LX2343
T4398
Synonym:
Target: Beta Amyloid, Beta-Secretase, BACE, PI3K, Autophagy
BACE-IN-1 acetate
T3161L
Synonym: BACE-IN-1 acetate (350228-37-4,Free base)
Target: BACE
Umibecestat
T13253
Synonym: CNP520
Target: BACE
PF-06751979
T12429
Synonym:
Target: BACE
Lanabecestat
TQ0238
Synonym: LY3314814,AZD3293
Target: BACE
AM-6494
T10292
Synonym:
Target: BACE
TAK-070
T28915
Synonym: TAK070
Target:
Lanabecestat camsylate
T25610
Synonym: LY 3314814 camsylate,LY-3314814 camsylate,LY3314814 camsylate
Target:
AZ3971
T71098
Synonym:
Target:
AZD-3289
T26715
Synonym: AZD 3289
Target:
AMG-8718
T62573
Synonym:
Target:
JNJ-67569762
T39955
Synonym:
Target:
AZD-3839 hemifumarate
T70711
Synonym:
Target:
GRL-8234
T68377
Synonym:
Target:
β-Secretase Inhibitor III
T62455
Synonym:
Target:
RE(EDANS)EVNLDAEFK(DABCYL)R
T80128
Synonym:
Target: Beta-Secretase
PF-06663195
T70366
Synonym:
Target:
(1α,1'S,4β)-Lanabecestat
T10014
Synonym: (1α,1'S,4β)-AZD3293
Target: Others
BuChE-IN-8
T79422
Synonym:
Target:
Atabecestat
T14338
Synonym: JNJ-54861911
Target: BACE
Lanabecestat HCl
T70807
Synonym:
Target:
OM99-2
T40393
Synonym: OM99-2
Target:
Verubecestat tosylate
T70104
Synonym:
Target:
BuChE-IN-9
T79423
Synonym:
Target:
Verubecestat TFA
T71899
Synonym:
Target:
LY 2886721 Hydrochloride
T37661
Synonym:
Target:
OM99-2 TFA
T40165
Synonym: OM99-2 TFA
Target:
Elenbecestat free base
T70800
Synonym:
Target:
PD07
T78739
Synonym:
Target:
6,9-Dichloro-1,2,3,4-tetrahydroacridine
T35975
Synonym:
Target:
AChE-IN-11
T61049
Synonym:
Target:
β-Secretase Inhibitor IV
T13434
Synonym:
Target: Others
Cat No. Product Name Synonyms Targets
TN1472 Cassiaside Beta-Secretase , BACE
Cassiaside is a naphthyl ketone glycoside that inhibits BACE1 (IC50= 4.45 μM; Ki=9.85 μM).Cassiaside exhibits significant hepatoprotective effects against galactosamine injury and has potential anti-Alzheimer's disease (...
TN1799 Isorubrofusarin-6-O-β-gentiobioside Isorubrofusarin 10-gentiobioside BACE , AChR
Isorubrofusarin-6-O-β-gentiobioside is derived from from Cassia obtusifolia Linn seeds and shows promising inhibitory activity against AChE and BACE1.
TN2190 Scoulerine Apoptosis , Beta-Secretase , BACE , Parasite
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
T8179 Aloeresin D Beta-Secretase , BACE
Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).
T4115 Auraptene 7-geranyloxycoumarin MMP , BACE
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits le...
T3394 Timosaponin BII Prototimosaponin A III Beta Amyloid , Others , BACE
Timosaponin BII (Prototimosaponin A III) has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-regulation of BACE1 and reduced the...
TN1343 8-Geranyloxypsoralen Anti-infection , P450 , BACE
8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal act...
T3914 Saikosaponin C Beta Amyloid , Caspase
Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
T5S2361 Epiberberine ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe...
T6S1683 Demethoxycurcumin Curcumin II,Desmethoxycurcumin,Monodemethoxycurcumin Apoptosis , Antioxidant , Antibacterial , Autophagy
1. Demethoxycurcumin (Desmethoxycurcumin) has antioxidant activity. 2. Demethoxycurcumin has anti-inflammatory activity. 3. Demethoxycurcumin has anti-proliferative activity. 4. Demethoxycurcumin has anti-acanthamoebic e...
T8306 Epiberberine chloride Epiberberine (chloride) Reactive Oxygen Species , Beta-Secretase , BACE , AChR , AChE
Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM).
T2759 Loganin Loganoside Apoptosis , NF-κB , BACE , AChR , AChE
Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent free-radical-scavenging activity and inhibitor...
TN2131 Questin BACE , Antibacterial , AChR , AChE
Questin is an antimicrobial agent derived from Aspergillus florescens with an antimicrobial activity profile that inhibits V. harveyi, V. anguillarum, V. cholerae and V. parahemolyticus with MIC values of 31.25 µg/mL, 62...
TN4399 Kushenol C SGLT , NF-κB , ROS , BACE , Antifection
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphyloco...
TN2217 Sophoflavescenol Others , Beta-Secretase , BACE , PDE , AChR , AChE
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity witho...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-00652 BACE1 Protein, Human, Recombinant Human HEK293
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPY-00651 BACE1 Protein, Human, Recombinant (hFc) Human HEK293
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPY-00678 BACE1 Protein, Mouse, Recombinant (His) Mouse HEK293
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPY-00752 BACE1 Protein, Human, Recombinant (His) Human HEK293
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPK-00998 SEZ6 Protein, Human, Recombinant (His) Human HEK293
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o...
TMPK-00997 SEZ6 Protein, Human, Recombinant (hFc) Human HEK293
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o...
TMPK-00996 SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o...
TMPK-01065 SEZ6 Protein, Mouse, Recombinant (His) Mouse HEK293
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o...
TMPK-00541 SEZ6 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o...
TMPH-02284 USP26 Protein, Human, Recombinant (His) Human E. coli
It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannos...
TMPY-02001 RTN4 Protein, Human, Recombinant (GST) Human E. coli
Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that...
TMPH-01163 CXCL5 Protein, Human, Recombinant (His) Human E. coli
RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in th...
TargetMol