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Cat No. | Product Name | Synonyms | Targets |
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T39484 | BACE1-IN-6 | BACE1-IN-6 | |
BACE1-IN-6 is a BACE1 inhibitor with an IC 50 value of 1.5 nM. | |||
T10452 | BACE1-IN-4 | BACE | |
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2. | |||
T10451 | BACE1-IN-2 | BACE | |
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM). | |||
T10450 | BACE1-IN-1 | BACE | |
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2). | |||
T10453 | BACE1-IN-5 | Beta Amyloid , BACE | |
BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM aga... | |||
T73076 | BACE1-IN-10 | Beta-Secretase | |
BACE1-IN-10 is a potent inhibitor of BACE1, demonstrating sub-micromolar activity against recombinant BACE1 (rBACE1) [1]. | |||
T64074 | BACE1-IN-8 | ||
BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM). | |||
T63867 | BACE1-IN-12 | ||
BACE1-IN-12 is a potent BACE1 inhibitor (IC50: 8.9 μM) that can cross the blood-brain barrier. BACE1-IN-12 selectively inhibits BuChE (butylcholinesterase) activity (IC50: 3.2 μM). BACE1-IN-12 has potential for anti-Alzh... | |||
T79022 | BACE1-IN-13 | Beta-Secretase | |
BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hAβ42 cells (IC50 = 1.3 nM). It is considered safe for the cardiovascular ... | |||
T61956 | BACE1/2-IN-1 | ||
BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 has lower Pgp efflux ratio and improved passive permeability. The metabolic stability of BA... | |||
T62719 | AChE/BACE1/GSK3β-IN-1 | ||
AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 can be used to study Alzheimer's disease (AD). | |||
T6058 | LY2886721 | Beta-Secretase , BACE | |
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease. | |||
T7011 | Verubecestat | MK-8931 | Beta-Secretase , BACE |
Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor. | |||
T10449 | BACE-1 inhibitor 1 | Others | |
BACE-1 inhibitor 1 (Compound 8a) is an effective BACE-1 inhibitor (IC50: 56 nM). | |||
T12188 | NB-360 | BACE | |
NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cat... | |||
T2639 | LY2811376 | Beta Amyloid , Beta-Secretase , BACE | |
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition... | |||
T6772 | AZD3839 free base | AZD3839 | Beta-Secretase , BACE |
AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1. | |||
T4398 | LX2343 | Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy | |
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance. | |||
T3161L | BACE-IN-1 acetate | BACE-IN-1 acetate (350228-37-4,Free base) | BACE |
BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4,Free base)) has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. β-Site amyloid precursor protein (APP) c... | |||
T13253 | Umibecestat | CNP520 | BACE |
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of al... | |||
T12429 | PF-06751979 | BACE | |
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay). | |||
TQ0238 | Lanabecestat | LY3314814,AZD3293 | BACE |
Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM). | |||
T10292 | AM-6494 | BACE | |
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM). | |||
T28915 | TAK-070 | TAK070 | |
TAK-070 is a non-competitive inhibitor of BACE1. | |||
T25610 | Lanabecestat camsylate | LY 3314814 camsylate,LY-3314814 camsylate,LY3314814 camsylate | |
Lanabecestat camsylate is used as a BACE1 Inhibitor. | |||
T71098 | AZ3971 | ||
AZ3971 is a potent BACE1 inhibitor. AZ3971 blocks BACE1-mediated cleavage of APP and inhibits Aβ42 production HEK cells overexpressing the APP protein which carries the Swedish mutation (HEK.APPswe). | |||
T26715 | AZD-3289 | AZD 3289 | |
AZD-3289, a potent BACE1 inhibitor, is used potentially for the treatment of Alzheimer's disease. | |||
T62573 | AMG-8718 | ||
AMG-8718 is a selective, orally active and potent BACE1 inhibitor that acts on both BACE1 (IC50: 0.0007 μM) and BACE2 (IC50: 0.005 μM). AMG-8718 significantly reduces CSF and Aβ40 levels in the brain. | |||
T39955 | JNJ-67569762 | ||
JNJ-67569762 is a selective BACE1 inhibitor targeting the S3 pocket ( IC 50 = 2.7 nM). | |||
T70711 | AZD-3839 hemifumarate | ||
AZD-3839 hemifumarate is a potent and selective BACE1 inhibitor and clinical candidate for the treatment of Alzheimer's disease. | |||
T68377 | GRL-8234 | ||
GRL-8234 is a small-molecule BACE1 inhibitor that reverses memory impairments and age-related cognitive decline. | |||
T62455 | β-Secretase Inhibitor III | ||
β-Secretase Inhibitor III is a highly selective inhibitor of BACE1 with a Ki value of 0.13 nM. | |||
T80128 | RE(EDANS)EVNLDAEFK(DABCYL)R | Beta-Secretase | |
RE (EDANS) EVNLDAEFK (DABCYL) R is a double-labeled peptide with EDANS and DABCYL, functioning as a fluorescent substrate for BACE1 with an emission wavelength of 360 nm and an excitation wavelength of 528 nm. Its utilit... | |||
T70366 | PF-06663195 | ||
PF-06663195 is a potent inhibitor of β-site amyloid precursor protein (APP) Cleaving Enzyme 1 (BACE1, β-Secretase 1). | |||
T10014 | (1α,1'S,4β)-Lanabecestat | (1α,1'S,4β)-AZD3293 | Others |
(1α,1'S,4β)-Lanabecestat is a Beta site APP Cleaving Enzymel (BACE1) inhibitor, and has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay), respectively. | |||
T79422 | BuChE-IN-8 | ||
BuChE-IN-8 (compound 19c), a butyrylcholinesterase (BuChE) inhibitor, exhibits an IC50 value of 559 nM and concurrently inhibits human β-secretase (BACE1) and Aβ40 aggregation. It also demonstrates notable antiamnesic pr... | |||
T14338 | Atabecestat | JNJ-54861911 | BACE |
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a ... | |||
T70807 | Lanabecestat HCl | ||
Lanabecestat, also known as AZD3293 and LY3314814, is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. AZD3293 displayed significant do... | |||
T40393 | OM99-2 | OM99-2 | |
OM99-2 is an eight-residue peptidomimetic with a high affinity for human brain memapsin 2, exhibiting a Ki value of 9.58 nM. This compound represents a significant advancement in the development of BACE1 inhibitors and h... | |||
T70104 | Verubecestat tosylate | ||
Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therap... | |||
T79423 | BuChE-IN-9 | ||
BuChE-IN-9 (compound 22a), an eqBuChE (equine serum-derived butyrylcholinesterase) inhibitor, exhibits potent activity with an IC50 of 173 nM. In addition to eqBuChE, it also inhibits human BACE1, Aβ aggregation, and mou... | |||
T71899 | Verubecestat TFA | ||
Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therap... | |||
T37661 | LY 2886721 Hydrochloride | ||
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin a... | |||
T40165 | OM99-2 TFA | OM99-2 TFA | |
OM99-2 TFA is an eight-residue peptidomimetic compound, functioning as a tight-binding inhibitor of human brain memapsin 2. It exhibits a high affinity for the target with a Ki value of 9.58 nM, making it a promising can... | |||
T70800 | Elenbecestat free base | ||
Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and proto... | |||
T78739 | PD07 | ||
PD07 is an orally active acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 of 0.29 μM against human AChE, and demonstrates inhibition of cholinesterases (ChEs), β-site amyloid precursor protein cleaving enzyme 1 ... | |||
T35975 | 6,9-Dichloro-1,2,3,4-tetrahydroacridine | ||
6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids... | |||
T61049 | AChE-IN-11 | ||
AChE-IN-11 (compound 5C) can be used in the Alzheimer's disease research with neuroprotective effects and good antioxidant activity (ORAC = 2.5 eq). AChE-IN-11 is a good multifunctional agent with IC 50 values of 7.9 μM... | |||
T13434 | β-Secretase Inhibitor IV | Others | |
β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1472 | Cassiaside | Beta-Secretase , BACE | |
Cassiaside is a naphthyl ketone glycoside that inhibits BACE1 (IC50= 4.45 μM; Ki=9.85 μM).Cassiaside exhibits significant hepatoprotective effects against galactosamine injury and has potential anti-Alzheimer's disease (... | |||
TN1799 | Isorubrofusarin-6-O-β-gentiobioside | Isorubrofusarin 10-gentiobioside | BACE , AChR |
Isorubrofusarin-6-O-β-gentiobioside is derived from from Cassia obtusifolia Linn seeds and shows promising inhibitory activity against AChE and BACE1. | |||
TN2190 | Scoulerine | Apoptosis , Beta-Secretase , BACE , Parasite | |
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. | |||
T8179 | Aloeresin D | Beta-Secretase , BACE | |
Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM). | |||
T4115 | Auraptene | 7-geranyloxycoumarin | MMP , BACE |
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits le... | |||
T3394 | Timosaponin BII | Prototimosaponin A III | Beta Amyloid , Others , BACE |
Timosaponin BII (Prototimosaponin A III) has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-regulation of BACE1 and reduced the... | |||
TN1343 | 8-Geranyloxypsoralen | Anti-infection , P450 , BACE | |
8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal act... | |||
T3914 | Saikosaponin C | Beta Amyloid , Caspase | |
Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation. | |||
T5S2361 | Epiberberine | ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE | |
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe... | |||
T6S1683 | Demethoxycurcumin | Curcumin II,Desmethoxycurcumin,Monodemethoxycurcumin | Apoptosis , Antioxidant , Antibacterial , Autophagy |
1. Demethoxycurcumin (Desmethoxycurcumin) has antioxidant activity. 2. Demethoxycurcumin has anti-inflammatory activity. 3. Demethoxycurcumin has anti-proliferative activity. 4. Demethoxycurcumin has anti-acanthamoebic e... | |||
T8306 | Epiberberine chloride | Epiberberine (chloride) | Reactive Oxygen Species , Beta-Secretase , BACE , AChR , AChE |
Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM). | |||
T2759 | Loganin | Loganoside | Apoptosis , NF-κB , BACE , AChR , AChE |
Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent free-radical-scavenging activity and inhibitor... | |||
TN2131 | Questin | BACE , Antibacterial , AChR , AChE | |
Questin is an antimicrobial agent derived from Aspergillus florescens with an antimicrobial activity profile that inhibits V. harveyi, V. anguillarum, V. cholerae and V. parahemolyticus with MIC values of 31.25 µg/mL, 62... | |||
TN4399 | Kushenol C | SGLT , NF-κB , ROS , BACE , Antifection | |
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphyloco... | |||
TN2217 | Sophoflavescenol | Others , Beta-Secretase , BACE , PDE , AChR , AChE | |
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity witho... |
Cat No. | Product Name | Species | Expression System |
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TMPY-00652 | BACE1 Protein, Human, Recombinant | Human | HEK293 |
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c... | |||
TMPY-00651 | BACE1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c... | |||
TMPY-00678 | BACE1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c... | |||
TMPY-00752 | BACE1 Protein, Human, Recombinant (His) | Human | HEK293 |
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c... | |||
TMPK-00998 | SEZ6 Protein, Human, Recombinant (His) | Human | HEK293 |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o... | |||
TMPK-00997 | SEZ6 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o... | |||
TMPK-00996 | SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o... | |||
TMPK-01065 | SEZ6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o... | |||
TMPK-00541 | SEZ6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o... | |||
TMPH-02284 | USP26 Protein, Human, Recombinant (His) | Human | E. coli |
It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannos... | |||
TMPY-02001 | RTN4 Protein, Human, Recombinant (GST) | Human | E. coli |
Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that... | |||
TMPH-01163 | CXCL5 Protein, Human, Recombinant (His) | Human | E. coli |
RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in th... |