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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10276L | AKT Kinase Inhibitor HCl | AKT Kinase Inhibitor HCl(842148-40-7 Free base) | Akt |
AKT Kinase Inhibitor HCl is an Akt inhibitor with antitumor activity. | |||
T3346 | AKT inhibitor VIII | AKTi-1/2 | Apoptosis , Akt |
AKT inhibitor VIII (AKTi-1/2) is a highly specific Akt1/2 inhibitor (IC50: 58/210 nM). The selectivity for Akt1 is higher about 36-fold than Akt3. | |||
T10276 | AKT Kinase Inhibitor | Akt | |
AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner. | |||
T25017 | AKT-I-1 | Akt | |
AKT-I-1 is a selective and reversible inhibitor of Akt1. | |||
T23695 | Akt-I-1,2 | Akt | |
Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2. | |||
T36310 | AKT-IN-6 | INCB-047775 | Akt |
AKT-IN-6 (INCB-047775) has an inhibitory effect on ATK. Akt is an important component of cellular signaling for growth factors, cytokines, and other cell stimuli. Abnormal Akt activation has been associated with the deve... | |||
T9393 | (E)-Akt inhibitor-IV | (E)-AKTIV,CS-1992 | Akt |
(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt. | |||
T4489 | AKT-IN-1 | AZD26,AZD-26,AZD 26 | Akt |
AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 μM). | |||
T60564 | PI3K/Akt/mTOR-IN-2 | Apoptosis , Akt , PI3K , mTOR | |
PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor.PI3K/Akt/mTOR-IN-2 has anticancer effects and is selective for MDA-MB-231 cells with an IC50 of 2.29 μM.PI3K/Akt/mTOR-IN-2 exhibits anticancer activity and induces c... | |||
T5508 | PF-AKT400 | AKT protein kinase inhibitor | Akt |
PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt. | |||
T3467 | Miransertib | ARQ-092,AKT inhibitor 2 | Akt , Parasite |
Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor. | |||
T23694 | Akt Inhibitor X | aktX,CCG 206734,Akt Inhibitor-X,CCG-206734,10-DEBC hydrochloride | |
Akt Inhibitor X is a cell-permeable and reversible inhibitor of Akt phosphorylation. | |||
T10275 | AKT-IN-3 | Akt | |
AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kin... | |||
T10274 | AKT-IN-2 | Akt | |
AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1). | |||
TP2175 | Akt/SKG Substrate Peptide | Others | |
substrate for Akt/PKB | |||
T71272 | PI3K/Akt-IN-C89 | ||
PI3K/Akt-IN-C89 is a novel Inhibitor of the PI3K-Akt Pathway, Inducing Autophagy of Female Germline Stem Cells. | |||
T62771 | AKT-IN-9 | ||
AKT-IN-9 is a potent inhibitor of AKT. AKT-IN-9 has potential for breast and prostate cancer research. | |||
T63211 | AKT-IN-10 | ||
AKT-IN-10 is a potent AKT inhibitor that has shown research potential in breast and prostate cancers. Among them is protein kinase B (PKB, also known as AKT), which is central to PI3K/AKT/mTOR signaling in cells and whos... | |||
T62807 | AKT-IN-7 | ||
AKT-IN-7 (compound 1-P1) is a potent inhibitor of AKT. AKT-IN-7 has potential for cancer research. | |||
T63039 | AKT-IN-13 | ||
AKT-IN-13 (compound 4b) is a potent inhibitor of Akt, acting on Akt1 (IC50: 1.6 nM), Akt2 (IC50: 2.4 nM) and Akt3 (IC50: 0.3 nM). AKT-IN-13 can be used in anticancer research. | |||
T61680 | AKT-IN-5 | ||
AKT-IN-5 (Example 8) is a chemical compound known as an Akt inhibitor, specifically targeting Akt1 and Akt2. Its potency is reflected in IC50 values of 450 nM and 400 nM for Akt1 and Akt2, respectively [1]. | |||
T63653 | AKT-IN-11 | ||
AKT-IN-11 is one of the most potent antibacterial agents against human hepatocellular carcinoma Bel-7402 cell line (IC50: 1.15 μM). | |||
T64603 | Akt Antibody #9272R | ||
Akt Antibody #9272R is a useful organic compound for research related to life sciences and the catalog number is T64603. | |||
T78913 | AKT-IN-18 | Akt | |
AKT-IN-18, an Akt inhibitor, demonstrates an IC50 value of 69.45 μM in A549 cells, effectively impeding Akt activity. It promotes apoptosis and is suitable for use in non-small cell lung cancer research [1]. | |||
T62842 | AKT-IN-8 | ||
AKT-IN-8 is a potent inhibitor of AKT, acting on AKT1 (IC50: 4.46 nM), AKT2 (IC50: 2.44 nM) and AKT3 (IC50: 9.47 nM). | |||
T62997 | PI3K/AKT-IN-1 | ||
PI3K/AKT-IN-1 is a potent, dual PI3K/AKT inhibitor that acts on PI3Kγ (IC50: 6.99 μM), PI3Kδ (IC50: 4.01 μM) and AKT (IC50: 3.36 μM). PI3K/AKT-IN-1 induces caspase 3-dependent apoptosis by inhibiting the PI3K/AKT pathway... | |||
T72104 | AKT Kinase Inhibitor hydrochloride | ||
AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity . | |||
T61756 | APN/AKT-IN-1 | ||
APN/AKT-IN-1 is a potent dual inhibitor of aminopeptidase N (APN) and protein kinase B (AKT), exhibiting IC50 values of 0.21 μM and 0.27 μM for APN and AKT inhibition, respectively. This compound effectively suppresses t... | |||
T79905 | Akt/ROCK-IN-1 | ROCK | |
Akt/ROCK-IN-1 (B12) is a dual inhibitor targeting Akt and ROCK, exhibiting IC50 values of 0.023 nM and 1.47 nM, respectively. It possesses antitumor efficacy against neuroblastoma [1]. | |||
T72880 | PI3K/AKT-IN-2 | ||
PI3K/AKT-IN-2, a dual inhibitor of PI3K and AKT, prevents the epithelial-mesenchymal transition (EMT) and promotes apoptosis. Additionally, it impedes tubulin polymerization. | |||
T64583 | Phospho-Akt (Ser473) Antibody #9271R | ||
Phospho-Akt (Ser473) Antibody #9271R is a useful organic compound for research related to life sciences and the catalog number is T64583. | |||
T63455 | PI3K/Akt/mTOR-IN-3 | ||
PI3K/Akt/mTOR-IN-3 is a potent inhibitor of PI3K/Akt/mTOR. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 cells (IC50: 0.77 μM), HeLa cells (IC50: 1.23 μM) and HepG2 cells (IC50: 4.57 μM). PI3K/Akt/mTOR-IN-3 inhibite... | |||
T75719 | Akt/SKG Substrate Peptide TFA | ||
Akt/SKG Substrate Peptide TFA is a synthetic peptide designed as a substrate specifically for Akt/PKB and is not phosphorylated by p70S6K or MAPK1 [1]. | |||
T72227 | PI3K/Akt/CREB activator 1 | ||
PI3K/Akt/CREB Activator 1 is a potent, orally active compound that acts as an activator for the PI3K/Akt/CREB pathway. It enhances neuronal proliferation, induces differentiation of Neuro-2a cells into neuron-like morpho... | |||
T62078 | Akt/NF-κB/JNK-IN-1 | ||
Akt/NF-κB/JNK-IN-1 (Compound 2i) is an inhibitor of Akt, NF-κB and JNK signalling pathways.Akt/NF-κB/JNK-IN-1 exhibits an inhibitory effect on nitric oxide production (IC50: 3.15 μM) and shows anti-inflammatory effects. | |||
T78838 | Akt/NF-κB/MAPK-IN-1 | p38 MAPK | |
Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity. This compound exerts anti-inflammatory effects by impeding the Akt/NF-κB a... | |||
T8427 | Borussertib | Akt | |
Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt) | |||
T14034 | 3CAI | Akt | |
3CAI is a potent and specific AKT1 and AKT2 inhibitor which showed significant inhibition of AKT in an in vitro kinase assay and suppressed expression of AKT direct downstream targets such as mTOR and GSK3β as well as in... | |||
T8969 | API-1 | NSC177223 | Akt |
API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis . | |||
T14072 | A-443654 | ERK , VEGFR , GSK-3 , FLT , Casein Kinase , MAPK , Akt , PKA , Chk , CDK , Src , PKC , S6 Kinase | |
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM). | |||
T7315 | BAY1125976 | Akt | |
BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay) | |||
T3132 | SC66 | Apoptosis , Akt | |
SC66 is a AKT inhibitor in HepG2, HA22T/VGH, and PLC/PRF/5 cells (IC50: about 0.75 μg/ml, at 72 h). | |||
T6139 | A-674563 | A674563 | ERK , GSK-3 , Akt , PKA , CDK |
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. | |||
T34632 | SH-5 | SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II | |
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IκBα kinase activation. | |||
T27624 | Iptakalim Hydrochloride | Potassium Channel , AChR | |
Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2... | |||
T2423 | P7C3-A20 | Others | |
P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity. | |||
T1920 | Capivasertib | AZD5363 | Akt , PKA , mTOR , Autophagy |
Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity. Capivasertib has antitumor activity for the treatment of breast cancer. | |||
T7953 | BpV(HOpic) | bpV (HOpic) | PTEN |
BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM). | |||
T2042 | CTX-0294885 | Others | |
CTX-0294885, a novel bisanilino pyrimidine, exhibits inhibitory activity against a broad range of kinases in vitro and is further developed into a Sepharose-supported kinase capture reagent. | |||
T13862 | Recilisib | Ex-RAD,ON 01210 | Akt , PI3K |
Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5654 | Musk ketone | Others | |
Musk ketone can induce the growth repression and the apoptosis of cancer cells. Musk ketone increases activity of glutathione S-transferase and thus may prove to be useful cancer chemoprotectant. | |||
T2S2215 | Crebanine | Apoptosis , Others , Akt | |
1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat... | |||
TN1891 | Lupiwighteone | Apoptosis , BCL , PARP , Caspase | |
Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells. | |||
T7190 | Actein | Apoptosis , Akt , JNK , Autophagy | |
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in... | |||
TN1079 | Deoxyelephantopin | NF-κB | |
Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling | |||
T6677 | Sophocarpine | ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT | |
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. | |||
TL0006 | Cichoric Acid | Dicaffeoyltartaric acid,Chicoric Acid | Reactive Oxygen Species , HIV Protease |
Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and ... | |||
T5S0896 | Loureirin A | Akt , PI3K | |
Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related pept... | |||
T17280 | (Z)-Guggulsterone | Apoptosis , VEGFR , Akt | |
(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis. | |||
TN1433 | Batatasin III | FAK , Others , Akt | |
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-... | |||
T5S1982 | Periplocin | Periplocoside | Apoptosis , Others |
1. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. 2. Periplocin is used for treatment of rheumato... | |||
T5S0658 | Corynoxine | Autophagy | |
Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells. | |||
TN1644 | Flavanomarein | Others | |
Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea... | |||
T3844 | Deltonin | ERK , Others , Akt , Endogenous Metabolite | |
Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM), mouse C26 cells (IC50: 1.22 μM), and human MDA-MB-231 cells (IC50: 1.58 μM). | |||
T6S0781 | Phellodendrine | Phallodendrin | Others , NF-κB , Akt |
1. Phellodendrine (Phallodendrin) has anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. | |||
T13803 | N-Oleoyl glycine | Cannabinoid Receptor , Akt , Endogenous Metabolite , PPAR | |
N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte | |||
T6817 | Deguelin | (-)-Deguelin,(-)-cis-Deguelin | Apoptosis , Akt , PI3K , Autophagy |
Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family. | |||
T3861 | Isobavachalcone | Corylifolinin,Isobacachalcone | Apoptosis , Others , Reactive Oxygen Species , Akt , Autophagy |
Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in brain diseases associated with inflammation. | |||
T2791 | Pectolinarin | Apoptosis , Others , NO Synthase , Prostaglandin Receptor , Interleukin | |
Pectolinarin is a Cirsium isolate with anti-inflammatory activity. | |||
T5S0506 | Rotundic acid | Rutundic acid | Apoptosis , Others , p38 MAPK , Akt , mTOR |
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c... | |||
T3895 | Polyphyllin I | Apoptosis , Akt , JNK , PDK , mTOR , Autophagy | |
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha... | |||
T2798 | Esculetin | Aesculetin,Cichorigenin | Lipoxygenase , Akt , PI3K |
Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lip... | |||
T6S0619 | Pachymic acid | 3-O-Acetyltumulosic acid | ERK , Akt |
Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways. | |||
TN1968 | N-Feruloyloctopamine | N-Feruloyloctopamine | p38 MAPK , Akt |
N-Feruloyloctopamine is a natural product. | |||
TN1911 | Marein | transporter , Akt , HDAC , AMPK | |
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ... | |||
T7912 | (−)-Myrtenal | (1R)-(−)-Myrtenal | Others |
(−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats. | |||
T2746 | Sophocarpine monohydrate | Sophocarpine | Apoptosis , Influenza Virus , Akt , PI3K , AMPK , Autophagy |
Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. | |||
TN4761 | Phellamurin | P-gp | |
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini... | |||
T2S0500 | Ilexsaponin A | Ilexsaponin A1 | Others |
1. Ilexsaponin A (Ilexsaponin A1) shows protective effects on ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. | |||
T5574 | Guggulsterone | Guggulsterone E&Z | Apoptosis , FXR , Akt , Caspase , JNK , Autophagy |
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen. | |||
T4S0498 | Glaucocalyxin A | Wangzaozin B,Leukamenin F | Apoptosis , Akt , Caspase , PI3K |
1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi... | |||
TN1405 | Arnicolide D | Akt , Caspase , PI3K , STAT , mTOR | |
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path... | |||
T0760 | Cholesterol | Cholesterin,Cholesteryl alcohol | Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR |
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us... | |||
T3001 | Honokiol | NSC 293100 | ERK , HCV Protease , MEK , Akt , Autophagy |
Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2. | |||
T0724 | Formononetin | Biochanin B,Flavosil,Formononetol | Apoptosis , FGFR |
Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus. | |||
T3826 | Polygalasaponin F | NF-κB , TLR , Akt , PI3K | |
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po... | |||
T2P2810 | Methyl Linoleate | Linoleic acid methyl ester,Telfairic Acid methyl ester | Antioxidant |
Methyl Linoleate (Telfairic Acid methyl ester) linoleate has antioxidant activity. | |||
T6427 | Butein | 2’,3,4,4’-tetrahydroxy Chalcone | Apoptosis , EGFR , Others , PDE , Autophagy |
Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR. | |||
T2790 | Oridonin | NSC-250682,Rubescenin,Isodonol,Rubescensin A | Akt , Antibacterial |
Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2. | |||
T2789 | Scutellarin | Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide | Akt , HIV Protease , STAT |
Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signal... | |||
T5740 | 25(R,S)-Ruscogenin | (25RS)-Ruscogenin | Others , HIF |
25(R,S)-Ruscogenin is a natual product. | |||
T2974 | Cyclovirobuxine D | CVB-D,Bebuxine,Cyclovirobuxin D | Apoptosis , Others , Akt , mTOR , Autophagy |
Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla. | |||
T4S21320 | ISOGINKGETIN | 4',4'''-Dimethylamentoflavone | MMP , Others |
1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti... | |||
T8160 | EGCG Octaacetate | Others , Antibacterial | |
EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities. | |||
T0392 | Artemisinin | Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,Artemisinine | HCV Protease , Ferroptosis , Akt , Parasite |
Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium ... | |||
T13265 | Urolithin B | ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK | |
Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical fruits, and medicinal herbs. Urolithin B inhibits NF-κB activit... | |||
T2P2806 | Hederacolchiside A1 | Raddeanoside R13 | Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR |
Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacol... | |||
TN3500 | Beta-Amyrone | β-Amyron | COX , AChR , PPAR , Antifection |
beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through inhibiting the expression of COX-2. beta-Amyrone exhibits a... | |||
T0518 | Methacycline hydrochloride | Rondomycin,Methacycline HCl | ribosome , Antibacterial , Antibiotic |
Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period. | |||
T3981 | Acacetin | 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin | Apoptosis , IAP , COX , Autophagy |
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models. | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04552 | AKT1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ... | |||
TMPY-04446 | AKT3 Protein, Mouse, Recombinant (aa 106-479) | Mouse | Baculovirus-Insect Cells |
v-akt murine thymoma viral oncogene homolog 3 (AKT3), also known as PKB-GAMMA, with AKT1/PKBalpha, AKT2/PKBbeta, are the memerbers of Akt kinase family, share extensive structural similarity and perform common as well as... | |||
TMPY-04574 | AKT3 Protein, Mouse, Recombinant (aa 106-479, His & GST) | Mouse | Baculovirus-Insect Cells |
v-akt murine thymoma viral oncogene homolog 3 (AKT3), also known as PKB-GAMMA, with AKT1/PKBalpha, AKT2/PKBbeta, are the memerbers of Akt kinase family, share extensive structural similarity and perform common as well as... | |||
TMPY-04387 | AKT2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
AKT (AK mouse plus Transforming or Thymoma) is a frequent oncogene expressed in most tissues which includes three isoforms AKT1, AKT2, and AKT3. Hyperactivation of AKT signaling is a central key in many human cancer prog... | |||
TMPY-04553 | AKT3 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
v-akt murine thymoma viral oncogene homolog 3 (AKT3), also known as PKB-GAMMA, with AKT1/PKBalpha, AKT2/PKBbeta, are the memerbers of Akt kinase family, share extensive structural similarity and perform common as well as... | |||
TMPY-05592 | ULBP-2 Protein, Human, Recombinant(aa 1-217, His&AVI),Biotinylated | Human | HEK293 |
NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is e... | |||
TMPY-02333 | ULBP-2 Protein, Human, Recombinant (His) | Human | HEK293 |
NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is e... | |||
TMPJ-00059 | IL-7 Protein, Human, Recombinant (His) | Human | Human Cells |
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions... | |||
TMPY-01413 | Cripto Protein, Human, Recombinant (His) | Human | HEK293 |
Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hy... | |||
TMPY-04898 | PD-1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-05395 | PD-1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-00996 | PD-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-05079 | PD-1 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-05260 | PD-1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-04342 | PD-1 Protein, Canine, Recombinant (His) | Canine | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-00897 | PD-1 Protein, Human, Recombinant (His) | Human | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-05815 | PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated | Canine | HEK293 |
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr... | |||
TMPY-04829 | G-CSF Protein, Human, Recombinant | Human | HEK293 |
Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial... | |||
TMPY-05636 | G-CSF Protein, Mouse, Recombinant | Mouse | HEK293 |
Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial... | |||
TMPY-02518 | TCL1A Protein, Human, Recombinant (His) | Human | E. coli |
T-cell leukemia/lymphoma protein 1A (abbreviated for TCL1A) is a member of the TCL1 family. TCL1 protooncogene is expressed in CD3-CD4-CD8-precursor T cells and is extinguished at the CD4+CD8+stage of thymocyte developme... | |||
TMPH-02497 | Adipolin Protein, Mouse, Recombinant (His) | Mouse | Baculovirus |
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via... | |||
TMPH-01347 | FSHR Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | |||
TMPH-01348 | FSHR Protein, Human, Recombinant (His) | Human | HEK293 |
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | |||
TMPH-02496 | Adipolin Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via... | |||
TMPK-00136 | ULBP-2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, E... | |||
TMPK-00723 | RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in glio... | |||
TMPK-01263 | B7-H7 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
B7-H7, also known as HHLA2 (HERV-H LTR-associating 2), is a member of the B7 family of immune regulatory proteins.Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances ... | |||
TMPK-00351 | RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc) | Human | HEK293 |
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in glio... | |||
TMPH-01231 | DIP2A Protein, Human, Recombinant (His) | Human | Baculovirus |
Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-re... | |||
TMPH-01230 | DIP2A Protein, Human, Recombinant (hFc) | Human | HEK293 |
Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-re... | |||
TMPH-02842 | CD133/PROM1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epit... | |||
TMPH-00001 | CD133/PROM1 Protein-VLP, Human, Recombinant (His) | Human | HEK293 |
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epit... | |||
TMPK-01034 | SEMA4B Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling p... | |||
TMPK-00926 | Noggin/NOG Protein, Mouse, Recombinant (His & Flag) | Mouse | HEK293 |
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer G... | |||
TMPK-00925 | Noggin/NOG Protein, Mouse, Recombinant | Mouse | HEK293 |
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer G... | |||
TMPK-00538 | Osteopontin Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Ovarian cancer is one of the most lethal malignant tumors in women. Secreted phosphoprotein 1 (SPP1) plays an important role in some cancer types. The expression of SPP1 was higher in epithelial ovarian cancer tissues th... | |||
TMPK-00732 | WISP1/CCN4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and se... | |||
TMPH-01559 | IL-26 Protein, Human, Recombinant (His) | Human | Yeast |
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expre... | |||
TMPH-01560 | IL-26 Protein, Human, Recombinant (His & Trx) | Human | E. coli |
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expre... | |||
TMPK-00676 | Osteopontin Protein, Human, Recombinant (aa 17-300, His) | Human | HEK293 |
Ovarian cancer is one of the most lethal malignant tumors in women. Secreted phosphoprotein 1 (SPP1) plays an important role in some cancer types. The expression of SPP1 was higher in epithelial ovarian cancer tissues th... | |||
TMPY-02398 | TLE3 Protein, Human, Recombinant (aa 484-772, GST) | Human | E. coli |
The association between high TLE3 expression and a favorable response to taxane-containing chemotherapy regimens was validated in patients with non-serous ovarian cancer. That TLE3 expression may serve as a marker of che... | |||
TMPK-00474 | IL-22RA1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component o... | |||
TMPY-03111 | PIK3IP1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
PIK3IP1 contains 1 kringle domain and is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepatocellular carcinoma. PI3K is a well-known regulator of cell division, motility, me... | |||
TMPY-04899 | OGN/Osteoglycin Protein, Human, Recombinant (His) | Human | HEK293 |
OGN (Osteoglycin) is a Protein Coding gene. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. It belongs to the small leucine-rich proteoglycan (SLRP) family. The encoded protei... | |||
TMPY-02334 | ULBP-2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is e... | |||
TMPY-04933 | PIK3IP1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
PIK3IP1 contains 1 kringle domain and is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepatocellular carcinoma. PI3K is a well-known regulator of cell division, motility, me... | |||
TMPY-06828 | Claudin-18 Protein, Human, Recombinant (CLDN18.1) | Human | HEK293 |
Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a... | |||
TMPY-06596 | Claudin-18.2 Protein-VLP, Human, Recombinant | Human | HEK293 |
Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a... | |||
TMPY-06942 | Claudin-18 Protein, Human, Recombinant (His & Strep) | Human | HEK293 |
Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a... | |||
TMPY-06822 | Claudin-18 Protein, Human, Recombinant (CLDN18.2), Fluorescent | Human | HEK293 |
Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a... | |||
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Cat No. | Product Name | ||
---|---|---|---|
L1300 | PI3K-AKT-mTOR Compound Library | 425 compounds | |
A unique collection of 425 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling; | |||
L3400 | Clinical Compound Library | 3480 compounds | |
A unique collection of 3480 compounds in clinical trial phases for high throughput screening (HTS) and high content screening (HCS); | |||
L2195 | Anti-Prostate Cancer Compound Library | 2096 compounds | |
2096 compounds associated with prostate cancer that can be used for high-throughput and high-content screening. | |||
L2193 | Anti-Liver Cancer Compound Library | 1816 compounds | |
1816 species of compounds related to liver cancer that can be used in anti-liver cancer drug development and pharmacological studies. | |||
L8500 | HIF-1 Signaling Pathway Compound Library | 1352 compounds | |
A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies; | |||
L2191 | Anti-Breast Cancer Compound Library | 1965 compounds | |
A unique collection of 1965 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study; |