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Cat No. | Product Name | Synonyms | Targets |
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T8535 | GAK inhibitor 49 | Serine/threonin kinase | |
GAK inhibitor 49 is a highly selective and ATP-competitive cyclin G associated kinase (GAK) inhibitor (IC50: 56 nM; Ki: 0.54 nM ). | |||
T8987 | Epiblastin A | Casein Kinase | |
Epiblastin A is an inhibitor of Casein Kinase 1 (CK1). Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs). | |||
T8796 | CAN508 | CDK | |
CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 and 20 μM, respectively.CAN50... | |||
T4182 | Lavendustin B | Tyrosinase , transporter , HIV Protease | |
Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75). | |||
T8230 | PNU112455A hydrochloride | PNU 112455A | CDK |
PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively. | |||
T21302 | UNC569 | UNC 569 | TAM Receptor |
UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amoun... | |||
T4348 | Syk Inhibitor II | 5-HT Receptor , Syk | |
Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM). | |||
T12642L | Simurosertib | TAK-931 | CDK |
Simurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM). | |||
T5414 | Glumetinib | SCC244 | c-Met/HGFR |
Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM). | |||
T14943 | CGP60474 | VEGFR , CDK , PKC | |
CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently. | |||
T7673 | ATH686 | ATH 686 | Apoptosis , FLT |
ATH686 is an potent and selective Inhibitor of FLT3. | |||
T5125 | LY3200882 | TGF-beta/Smad | |
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). | |||
T1817 | GNF-2 | GNF2 | SARS-CoV , Bcr-Abl |
GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl. | |||
T3109 | SP600125 | 1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone | Apoptosis , Ferroptosis , Trk receptor , JNK , Aurora Kinase , Autophagy |
SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive properties. SP600125 inhibits autophagy and induces apoptosis. | |||
T7322 | Theliatinib | EGFR | |
Theliatinib, a potent and highly selective EGFR inhibitor, with anti-tumor activity. Ki of 0.05 nM for wild type EGFR, and IC50s of 3 and 22 nM for EGFR and EGFR T790M/L858R mutant, respectively. | |||
T12477 | Uzansertib phosphate | INCB053914 phosphate | Pim |
Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24 nM, 30 nM, 0.12 nM , respectively). | |||
T1977 | Dorsomorphin | Compound C,BML-275 | AMPK , Autophagy , TGF-beta/Smad |
Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy, and possesses antitumor ... | |||
T3186 | NU2058 | O6-(Cyclohexylmethyl)guanine,O(6)-Cyclohexylmethylguanine | Topoisomerase , CDK |
NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity. | |||
T8376 | PKCβ inhibitor 1 | KUN79359 | Apoptosis , PKC |
PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively). | |||
T8976 | PD-089828 | EGFR , FGFR , PDGFR , Src | |
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 ... | |||
T24111 | GSK3i XIII | GSK3 inhibitor XIII,GSK3iXIII,GSK3i-XIII | GSK-3 |
GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor. | |||
T6019 | Volasertib | BI 6727 | Apoptosis , PLK |
Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM). | |||
T6223 | U0126-EtOH | U0126 Ethanol,U0126 | Mitophagy , Influenza Virus , MEK , Autophagy |
U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM). | |||
T6626 | PF-3758309 | PF-309,PF-03758309,PF 3758309 | Apoptosis , PAK |
PF-3758309 (PF-03758309) (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition. | |||
T15781 | LP-935509 | Serine/threonin kinase , AAK1 (AP2 associated kinase 1) | |
LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is also an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-... | |||
T9040 | Aurora kinase inhibitor-2 | IUN-70219,Aurora Kinase Inhibitor II | Aurora Kinase |
Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M). | |||
T2518 | ARRY-380 (analog ) | HER2-Inhibitor-1,ARRY380,ARRY-380 analog | EGFR , HER |
ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor. | |||
T4327 | Prexasertib dihydrochloride | LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368 | Apoptosis , Chk , S6 Kinase |
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively. | |||
T4230 | PF-3758309 hydrochloride | PF-03758309 hydrochloride | Apoptosis , PAK |
PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd... | |||
T23127 | PD-161570 | PD 161570 | EGFR , FGFR , PDGFR , Src |
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, a... | |||
T2253 | TCS PIM-1 1 | SC 204330 | Pim |
TCS PIM-1 1 (SC 204330)(sc-204330) is a effective and specific ATP-competitive Pim-1 kianse inhibitor (IC50: 50 nM) , exhibits good specific over MEK1/MEK2 and Pim-2(IC50s >20, 000 nM). | |||
T10898 | Samuraciclib hydrochloride | ICEC0942 hydrochloride,CT7001 hydrochloride | Apoptosis , CDK |
Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h... | |||
T8416 | Capmatinib xHCl | INCB28060,Capmatinib hydrochloride(free base),INC280 | c-Met/HGFR |
Capmatinib xHCl (INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor, potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activit... | |||
T1963 | Capmatinib | NVP-INC280,INC-280,INCB28060 | Apoptosis , c-Met/HGFR |
Capmatinib (INCB28060) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity. | |||
T8825 | Capmatinib 2HCl.H2O | INCB28060 2HCl.H2O,INC-280 2HCl.H2O,NVP-INC280 2HCl.H2O | c-Met/HGFR |
Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity. | |||
T4260 | Capmatinib 2HCl | INC-280 2HCl,INCB28060 2HCl | c-Met/HGFR |
Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-... | |||
T9207 | GW406108X | GW108X | Kinesin , Autophagy |
GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux. | |||
T4310 | Prexasertib | LY2606368 | Apoptosis , Chk |
Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. | |||
T1764 | Adezmapimod | PB 203580,RWJ 64809,SB203580 | Mitophagy , p38 MAPK , Autophagy |
Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive. Adezmapimod possesses autophagy and mitochondrial autophagy activating activity. Adezmapimod displays more than 100... | |||
T1725 | Y-27632 dihydrochloride | Y-27632 2HCl | ROCK , Apoptosis |
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. | |||
T6146 | Dorsomorphin dihydrochloride | BML-275 2HCl,Compound C dihydrochloride,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride | AMPK , Autophagy , TGF-beta/Smad |
Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases. | |||
T5049 | NVP-BSK805 | NVP-BSK805 2HCl,BSK 805 | Tyrosine Kinases , JAK |
NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor. | |||
T40577 | TAK1-IN-3 | TAK1-IN-3 | MAPK |
TAK1-IN-3 is a potent ATP-competitive TAK1 inhibitor. | |||
T12102 | Mps1-IN-1 | Others | |
Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM ) | |||
T3535 | ML240 | p97 | |
ML240 is a selective, ATP-competitive p97 inhibitor. | |||
T8819 | SU-9516 | CDK | |
SU9516 is a selectively potent ATP-competitive inhibitor of CDKs. | |||
T15454 | GW843682X | GW843682 | VEGFR , PLK , CDK , PDGFR , Aurora Kinase |
GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM). | |||
T2421 | SKLB1002 | VEGFR | |
SKLB1002 is a potent and ATP-competitive VEGFR2 inhibitor with IC50 of 32 nM. | |||
T2313 | MPI-0479605 | Apoptosis , Kinesin | |
MPI-0479605 is an ATP competitive and selective inhibitor. | |||
T15579 | INDY | 1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one | DYRK |
INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively. |
Cat No. | Product Name | Synonyms | Targets |
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TN2019 | Orobol | 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon | BCL , Caspase , PI3K |
Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibit... | |||
T3419 | Chelerythrine chloride | Apoptosis , BCL , PKC , Autophagy | |
Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. | |||
T0465 | Ellagic acid | Gallogen,Elagostasine | Hedgehog/Smoothened , Casein Kinase , Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , PKA , Syk , PKC , Carbonic Anhydrase |
Ellagic acid (Gallogen) is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used... | |||
T25192 | Butyrolactone I | Olomoucin | CDK |
Butyrolactone I (Olomoucin) is an ATP-competitive inhibitor of CDK and cdc2 kinase family. Butyrolactone I shows antitumor effects in non-small cell lung, small cell lung, and prostate cancer cell lines. | |||
T6680 | Staurosporine | Antibiotic AM-2282,AM-2282,CGP 41251 | Apoptosis , PKA , Antibacterial , Antibiotic , Src , PKC , Antifungal |
Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces... | |||
T11590 | (-)-Hydroxycitric acid | Garcinia acid | ATP Citrate Lyase |
(-)-Hydroxycitric acid (Garcinia acid) (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. It is a potent and competitive inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses fatty aci... | |||
T8270 | Deserpidine | Harmonyl | RAAS |
Deserpidine (Harmonyl) is only found in individuals that have used or taken this drug. It is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive propertie... | |||
T23772 | Balanol | Ophiocordin,BA1,Azepinostatin,(-)-Balanol,(3R-trans)-Balanol | |
Balanol is an ATP-competitive Protein Kinase C and Protein Kinase A inhibitor. | |||
T10764 | Cercosporamide | (-)-Cercosporamide | Others |
Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor. | |||
T40562 | 24-Methylenecycloartanyl ferulate | ||
24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-... | |||
T8305 | Ellagic acid (hydrate) | Ellagic Acid hydrate | Antioxidant , Casein Kinase |
Ellagic acid (hydrate) is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM). | |||
TN1751 | Hydroxycitric acid | ERK , p38 MAPK , Fatty Acid Synthase | |
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyas... | |||
T16896 | SL 0101-1 | SL0101 | S6 Kinase |
SL 0101-1 (SL0101) is a selective, efficient, reversible and ATP-competitive inhibitor of p90 ribosomal S6 kinase (RSK) that can permeate cell membranes, with an IC50 value of 89 nM for RSK.SL 0101-1 (SL0101) is also a p... |