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Search Result

Search Results for " atm/atr "

Targets

ATM/ATR ATM/ATR

21

Compounds

1

Natural Products

6

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T3032 VE-821 ATR Inhibitor IV ATM/ATR
VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).
T5175 Azd1390 ATM/ATR
AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes.
T2685 KU-55933 ATM Kinase Inhibitor ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
T6612 NU6027 ATM/ATR , DNA-PK , CDK
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.
T3338 Ceralasertib AZD6738 ATM/ATR
Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.
T1958 AZ20 ATM/ATR , mTOR
AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.
T4443 AZ32 ATM/ATR
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
T6770 AZD0156 Apoptosis , ATM/ATR
AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.
T1821 CGK733 CGK 733 ATM/ATR
CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.
T6261 CP-466722 CP 466722,CP466722 ATM/ATR
CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.
T2084 ETP-46464 ATM/ATR , DNA-PK , PI3K , mTOR
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
T7318 Elimusertib BAY-1895344 ATM/ATR
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target...
T7122 AZD-7648 DNA-PK
AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.
T1923 BRD4770 Histone Methyltransferase
BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.
T6100 Torin 2 Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 2...
T19671 AZ31 AZ 31,AZ-31 ATM/ATR
AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK f...
T62083 Camonsertib ATR inhibitor 4,RP-3500 ATM/ATR
Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effects. Camonsertib is 30 times more selective for ATR than mTOR...
T2433 NU 7026 NU7026,DNA-PK Inhibitor II,LY293646 Apoptosis , ATM/ATR , DNA-PK , PI3K
NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.
T68845 Americanin A
Americanin A natural thrombin inhibitor, suppressing melanin synthesis, regulating the ATM/ATR signaling pathway and the Skp2-p27 axis in human colon cancer cells.
T73301 ATR-IN-20
ATR-IN-20, a potent ATM/ATR inhibitor, showcases an IC50 value of 3 nM. It also exhibits inhibitory activity against mTOR with an IC50 of 18 nM, while maintaining selectivity over PI3Kα (100 nM), ATM (100 nM), and DNA-PK...
T62290 SKLB-197
SKLB-197 is able to act on ATR (IC50: 0.013 μM), but has little or no activity on the other 402 protein kinases. In vitro and in vivo, SKLB-197 has shown significant antitumour effects against ATM-deficient tumours.
Cat No. Product Name Synonyms Targets
TN1673 Garcinone C ATM/ATR , CDK , STAT , AChR , Antifection
Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effe...

Natural Products

Garcinone C
TN1673
Synonym:
Target: ATM/ATR, CDK, STAT, AChR, Antifection

Recombinant Proteins

Species：
Human (4)
Cynomolgus (1)
Mouse (1)
Expression System：
E. coli (3)
Baculovirus-Insect Cells (2)
HEK293 (1)
Tag：
GST (1)
His (1)
His,GST (1)
N-6His (1)
Tag Free (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPY-02953 TEM8/ANTXR1 Protein, Human, Recombinant (hFc) Human HEK293
ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are ser...
TMPY-03976 EEF1E1 Protein, Human, Recombinant (His) Human E. coli
EEF1E1, also known as AIMP3 and p18, is a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, EEF1E1 is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex...
TMPJ-00870 NCK1 Protein, Human, Recombinant (His) Human E. coli
Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, ...
TMPY-04368 Chk1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)...
TMPY-04433 Chk1 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)...
TMPY-02228 P53 Protein, Cynomolgus, Recombinant Cynomolgus E. coli
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and...
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