protacs — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4495	DBET1		Epigenetic Reader Domain
	dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.		Epigenetic Reader Domain
T5440	Dbet57		Epigenetic Reader Domain
	dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2		Epigenetic Reader Domain
T5395	BSJ-03-123		CDK
	BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.		CDK
T5130	DBET6		Apoptosis , Epigenetic Reader Domain
	dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.		Apoptosis , Epigenetic Reader Domain
T5442	A1874		Epigenetic Reader Domain , PROTACs
	A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.		Epigenetic Reader Domain , PROTACs
T5435	ARV-771		Epigenetic Reader Domain
	ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively[1].		Epigenetic Reader Domain
T5434	ARV-825		Epigenetic Reader Domain
	ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested.		Epigenetic Reader Domain
T16157	MT-802		BTK , PROTACs
	MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).		BTK , PROTACs
T18787	TD-165		Others , Ligand for E3 Ligase
	TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].		Others , Ligand for E3 Ligase
T8488	GMB-475		Bcr-Abl
	GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitinati...		Bcr-Abl
T17350	ACBI1		Apoptosis , Epigenetic Reader Domain , PROTACs
	ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in ...		Apoptosis , Epigenetic Reader Domain , PROTACs
T17069	THAL-SNS-032		CDK
	THAL-SNS-032 is a selective CDK9 degrader PROTAC.		CDK
T13954	UNC6852		Histone Methyltransferase , Ligands for Target Protein for PROTAC
	UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
T9370	DCBP-1		Epigenetic Reader Domain , Ligand for E3 Ligase
	dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.		Epigenetic Reader Domain , Ligand for E3 Ligase
T36694	XY028-140	XY028-140	CDK , Ligand for E3 Ligase
	XY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereblon and CDK.		CDK , Ligand for E3 Ligase
T9117	BSJ-4-116		CDK , Ligand for E3 Ligase
	BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).		CDK , Ligand for E3 Ligase
T5436	MZ 1		Epigenetic Reader Domain
	MZ 1 is a BRD4 protein degrader based on PROTAC technology.		Epigenetic Reader Domain
T39695	ARD-2128		Androgen Receptor
	ARD-2128 is a highly potent, orally bioavailable PROTAC (proteolysis-targeting chimera) degrader of the androgen receptor (AR), effectively diminishing AR protein levels, suppressing AR-regulated gene expression in tumor...		Androgen Receptor
T13721	Homo-PROTAC cereblon degrader 1		Others , Ligand for E3 Ligase
	Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.		Others , Ligand for E3 Ligase
T13722	Homo-PROTAC pVHL30 degrader 1		Others , Ligand for E3 Ligase
	Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.		Others , Ligand for E3 Ligase
T5437	Gefitinib-based PROTAC 3		EGFR
	Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectivel...		EGFR
T16153	MS4078		ALK , Ligand for E3 Ligase
	MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.		ALK , Ligand for E3 Ligase
T8745	PROTAC BRAF-V600E degrader-1	Compound 23	Raf
	PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.		Raf
T39710	ARV-471	Vepdegestrant	Estrogen Receptor/ERR
	ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.		Estrogen Receptor/ERR
T11980	MD-224		Mdm2 , E1/E2/E3 Enzyme , PROTACs
	MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.		Mdm2 , E1/E2/E3 Enzyme , PROTACs
T5439	BRD4 degrader AT1		Epigenetic Reader Domain
	BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.		Epigenetic Reader Domain
T5438	PROTAC CDK9 Degrader-1		CDK
	PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.		CDK
T18794	Tetrazine-Ph-NHCO-C3-NHS ester		Others , PROTAC Linker
	Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-derived linker for PROTACs synthesis.		Others , PROTAC Linker
T15203	EGNHS	EGS crosslinker	Others
	EGNHS (EGS crosslinker) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].		Others
T18566	Propargyl-PEG12-bromide		Others , PROTAC Linker
	Propargyl-PEG12-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].		Others , PROTAC Linker
T18568	Propargyl-PEG11-methane		Others , PROTAC Linker
	Propargyl-PEG11-methane is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1].		Others , PROTAC Linker
T39268	Azido-PEG4-azide	Azido-PEG4-azide	PROTAC Linker
	Azido-PEG4-azide is a PEG-based PROTAC linker that can be used to synthesize PROTACs.		PROTAC Linker
T15839	M-PEG12-amine		Others
	m-PEG12-amine is a PEG-based PROTAC linker and a non-cleavable 12 unit PEG ADC linker employed in the synthesis of PROTACs[1] and antibody-drug conjugates (ADCs)[2].		Others
T14250	Amino-PEG8-amine		Others
	Amino-PEG8-amine is a pegylated based PROTAC linker that can be used in the synthesis of PROTACs. It is a conjugate PEG derivative containing two amino (NH2) groups.		Others
T14450	Azido-PEG4-hydrazide		Others
	Azido-PEG4-hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome sys...		Others
T18031	Hydroxy-PEG10-acid	HO-PEG10-CH2CH2COOH	Others , PROTAC Linker
	Hydroxy-PEG10-acid (HO-PEG10-CH2CH2COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1].		Others , PROTAC Linker
T38543	5-(Biotinamido)pentylamine		PROTAC Linker
	5-(Biotinamido)pentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.		PROTAC Linker
T18171	M-PEG24-NH2		Others , PROTAC Linker
	m-PEG24-NH2 is a PEG-based PROTAC linker. m-PEG24-NH2 can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T18215	M-PEG7-Br		Others , PROTAC Linker
	m-PEG7-Br is a PEG-based PROTAC linker. m-PEG7-Br can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T18151	M-PEG16-alcohol		Others , PROTAC Linker
	m-PEG16-alcohol is a PEG-based PROTAC linker. m-PEG16-alcohol can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T18132	M-PEG12-acid		Others , PROTAC Linker
	m-PEG12-acid is a PEG-based PROTAC linker. m-PEG12-acid can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T18009	HO-PEG13-OH		Others , PROTAC Linker
	HO-PEG13-OH is a PEG-based PROTAC linker. HO-PEG13-OH can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T18222	M-PEG8-O-alkyne		Others , PROTAC Linker
	m-PEG8-O-alkyne is a PEG-based PROTAC linker. m-PEG8-O-alkyne can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T17964	Fmoc-NH-PEG10-acid		Others , PROTAC Linker
	Fmoc-NH-PEG10-acid is a PEG-based PROTAC linker. Fmoc-NH-PEG10-acid can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T18788	Tert-Butyl 11-aminoundecanoate		PROTAC Linker
	tert-Butyl 11-aminoundecanoate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].		PROTAC Linker
T18226	M-PEG9-CH2COOH		Others , PROTAC Linker
	m-PEG9-CH2COOH is a PEG-based PROTAC linker. m-PEG9-CH2COOH can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T18153	M-PEG16-Br		Others , PROTAC Linker
	m-PEG16-Br is a PEG-based PROTAC linker. m-PEG16-Br can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T18161	M-PEG2-Br		Others , PROTAC Linker
	m-PEG2-Br is a PEG-based PROTAC linker. m-PEG2-Br can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T18202	M-PEG4-SH		Others , PROTAC Linker
	m-PEG4-SH is a PEG-based PROTAC linker. m-PEG4-SH can be used in the synthesis of PROTACs.		Others , PROTAC Linker
T18125	M-PEG11-Br		Others , PROTAC Linker
	m-PEG11-Br is a PEG-based PROTAC linker. m-PEG11-Br can be used in the synthesis of PROTACs.		Others , PROTAC Linker