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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T74814 | PKM2/PDK1-IN-1 | ||
PKM2/PDK1-IN-1, one of shikonin thioether derivatives, is a dual inhibitor of PKM2 / PDK1 . PKM2/PDK1-IN-1 inhibits the proliferation of NSCLC cells, and induces apoptosis . PKM2/PDK1-IN-1 induces intercellular ROS produ... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2897 | (Rac)-Shikonin | (±)-Shikonin,Alkanet extract,Anchusin,Anchusa acid | Others |
(Rac)-Shikonin (Anchusin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics,... | |||
T1125 | Shikonin | NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid | TNF , NF-κB , Chloride channel , HIV Protease , PKM |
Shikonin (Anchusa acid) is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathway and inhibit TNF-α. Shikonin decreases exo... | |||
TN2439 | (2-Methylbutyryl)shikonin | Others | |
(2-Methylbutyryl)shikonin is a natural product from Lithospermum erythrorhizon Sieb. et Zucc. | |||
T4958 | (-)-Alkannin | Alkannin,Shikonin | Apoptosis , PI3K |
(-)-Alkannin (Shikonin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, a... | |||
T1121 | Podofilox | Podophyllotoxin,(+)-Shikonin | Microtubule Associated , Topoisomerase |
Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irrit... | |||
T5S2343 | Acetylshikonin | Acetyl shikonin | Others , P450 , AChE |
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang... |